6AR2

Structure of human SLMAP FHA domain in complex with pMST2

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00498	e6ar2A1	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: PF00498	ECOD (1.6)
B	PF00498	e6ar2B1	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: PF00498	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00498	FHA domain (FHA)	FHA domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Sarcolemmal membrane-associated protein	-	multicellular organismal process system process muscle contraction muscle system process regulation of biological process regulation of cellular process regulation of membrane depolarization during cardiac muscle cell action potential membrane depolarization during action potential biological regulation membrane depolarization during cardiac muscle cell action potential action potential regulation of membrane depolarization membrane depolarization cellular process multicellular organismal process system process muscle contraction muscle system process regulation of biological process regulation of cellular process regulation of membrane depolarization during cardiac muscle cell action potential membrane depolarization during action potential biological regulation membrane depolarization during cardiac muscle cell action potential action potential regulation of membrane depolarization membrane depolarization cellular process regulation of biological quality cardiac muscle cell action potential regulation of membrane potential regulation of membrane depolarization during action potential regulation of localization transport monoatomic ion transmembrane transport sodium ion transmembrane transport regulation of monoatomic ion transmembrane transport regulation of sodium ion transport regulation of sodium ion transmembrane transport metal ion transport monoatomic cation transmembrane transport localization monoatomic ion transport monoatomic cation transport regulation of metal ion transport regulation of transport regulation of monoatomic ion transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport regulation of monoatomic cation transmembrane transport sodium ion transport protein localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane regulation of transmembrane transporter activity regulation of transporter activity regulation of sodium ion transmembrane transporter activity regulation of voltage-gated sodium channel activity regulation of monoatomic ion transmembrane transporter activity regulation of cation channel activity regulation of molecular function	cell periphery sarcolemma plasma membrane membrane cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle endoplasmic reticulum smooth endoplasmic reticulum cytoplasm intracellular membrane-bounded organelle endomembrane system cell periphery sarcolemma plasma membrane membrane cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle endoplasmic reticulum smooth endoplasmic reticulum cytoplasm intracellular membrane-bounded organelle endomembrane system centrosome microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle
C, D	ASP-GLY-TPO-MET-LYS-ARG	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups enzyme regulator activity protein serine/threonine kinase activator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity identical protein binding protein binding protein serine kinase activity cation binding magnesium ion binding metal ion binding protein serine/threonine kinase activity	regulation of protein stability biological regulation regulation of biological quality protein stabilization developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development cellular response to stimulus regulation of biological process regulation of cellular process regulation of protein stability biological regulation regulation of biological quality protein stabilization developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway cell communication cellular process signal transduction Wnt signaling pathway cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein tetramerization protein-containing complex assembly cellular component organization or biogenesis positive regulation of DNA-binding transcription factor activity cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process apoptotic process cell death programmed cell death negative regulation of signaling regulation of canonical Wnt signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process regulation of signaling regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of programmed cell death regulation of apoptotic process positive regulation of biological process regulation of programmed cell death positive regulation of apoptotic process positive regulation of cellular process regulation of MAPK cascade intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette MAPK cascade regulation of growth regulation of developmental growth regulation of developmental process developmental growth negative regulation of developmental process growth organ growth negative regulation of organ growth negative regulation of developmental growth negative regulation of growth regulation of organ growth regulation of multicellular organismal process negative regulation of multicellular organismal process cellular developmental process primitive hemopoiesis hemopoiesis animal organ development cell development embryo development embryonic hemopoiesis cell differentiation embryonic organ development protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport embryonic epithelial tube formation chordate embryonic development tube formation epithelial tube formation tube morphogenesis embryo development ending in birth or egg hatching epithelial tube morphogenesis morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis neural tube formation anatomical structure formation involved in morphogenesis extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway apoptotic signaling pathway positive regulation of cell communication positive regulation of signal transduction positive regulation of response to stimulus positive regulation of JNK cascade JNK cascade positive regulation of MAPK cascade regulation of JNK cascade positive regulation of intracellular signal transduction positive regulation of signaling protein phosphorylation organonitrogen compound metabolic process phosphorylation macromolecule modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process fat cell differentiation positive regulation of fat cell differentiation regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation regulation of fat cell differentiation negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation regulation of protein binding positive regulation of protein binding regulation of binding positive regulation of binding phosphatidylinositol 3-kinase/protein kinase B signal transduction protein localization to microtubule cytoskeleton protein localization to microtubule organizing center protein localization to cytoskeleton protein localization to centrosome regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction heart development endocardium development circulatory system development positive regulation of apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of extrinsic apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of apoptotic signaling pathway hepatocyte apoptotic process epithelial cell apoptotic process cell differentiation involved in embryonic placenta development placenta development reproductive process developmental process involved in reproduction in utero embryonic development embryonic placenta development hippo signaling regulation of cell differentiation involved in embryonic placenta development regulation of reproductive process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle centrosome microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle protein-containing complex membrane-bounded organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle centrosome microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle protein-containing complex membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
A, B	IPR000253	Forkhead-associated (FHA) domain	Domain
C, D	IPR036674	p53-like tetramerisation domain superfamily	Homologous Superfamily
C, D	IPR000719	Protein kinase domain	Domain
C, D	IPR017441	Protein kinase, ATP binding site	Binding Site
C, D	IPR011524	SARAH domain	Domain
C, D	IPR024205	Mst1/2 SARAH domain	Domain
C, D	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
C, D	IPR049568	Mst2, SARAH domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q14BN4	Brugada syndrome adenoma hereditary spastic paraplegia malignant pancreatic neoplasm ovarian cancer primitive neuroectodermal tumor tuberculosis atypical teratoid rhabdoid tumor chronic obstructive pulmonary disease hypertrophic pyloric stenosis medulloblastoma pancreatic ductal adenocarcinoma rheumatoid arthritis breast cancer glioblastoma Brugada syndrome adenoma hereditary spastic paraplegia malignant pancreatic neoplasm ovarian cancer primitive neuroectodermal tumor tuberculosis atypical teratoid rhabdoid tumor chronic obstructive pulmonary disease hypertrophic pyloric stenosis medulloblastoma pancreatic ductal adenocarcinoma rheumatoid arthritis breast cancer glioblastoma large cell medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm spina bifida
C, D	Pharos: Q13188	Crohn disease malignant mesothelioma ovarian cancer pituitary cancer exocrine pancreatic carcinoma malignant pancreatic neoplasm Ovarian clear cell carcinoma psoriasis glioblastoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm subependymal giant cell astrocytoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
C, D	TPO	Parent Component: THR RESID: AA0038 PSI-MOD : O-phospho-L-threonine MOD:00047

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.