Annotations: 6APD

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00523	e6apdA1	A: a+b complex topology	X: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	H: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	T: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein	F: PF00523	ECOD (1.6)
B	PF00523	e6apdB1	A: a+b complex topology	X: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	H: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	T: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein	F: PF00523	ECOD (1.6)
C	PF00523	e6apdC1	A: a+b complex topology	X: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	H: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	T: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein	F: PF00523	ECOD (1.6)
D	PF07654	e6apdD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
D	PF07686	e6apdD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
F	PF07654	e6apdF2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
F	PF07686	e6apdF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
H	PF07654	e6apdH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
H	PF07686	e6apdH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
G	PF07654	e6apdG1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
G	PF07686	e6apdG2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
I	PF07654	e6apdI1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
I	PF07686	e6apdI2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
E	PF07654	e6apdE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
E	PF07686	e6apdE2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
J	PF07654	e6apdJ2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
J	PF07686	e6apdJ1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
K	PF07654	e6apdK1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
K	PF07686	e6apdK2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
N	PF07654	e6apdN1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
N	PF07686	e6apdN2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
O	PF07654	e6apdO2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
O	PF07686	e6apdO1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
L	PF07654	e6apdL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
L	PF07686	e6apdL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
M	PF07654	e6apdM1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
M	PF07686	e6apdM2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
D, F, H	Fab AM22	VH-CH1	Homo sapiens (human)	IGHV1-2401, IGHJ401, IGHJ402, IGHJ403, IGHG101, IGHG102, IGHG104, IGHG105	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-1_KAPPA	IMGT (202416-0)
E, G, I	Fab AM22	L-KAPPA	Homo sapiens (human)	IGKV3-1101, IGKV3D-1103, IGKJ301, IGKC01	V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA	IG	FAB-GAMMA-1_KAPPA	IMGT (202416-0)
J, K, N	Fab ADI-19425	VH-CH1	Homo sapiens (human)	IGHV3-2101, IGHV3-2102, IGHV3-2104, IGHV3-2103, IGHJ401, IGHJ402, IGHJ403, IGHG101, IGHG102, IGHG104, IGHG1*05	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-1_LAMBDA	IMGT (202416-0)
L, M, O	Fab ADI-19425	L-LAMBDA	Homo sapiens (human)	IGLV1-4001, IGLJ101, IGLC201, IGLC202, IGLC3*04	V-DOMAIN V-LAMBDA, C-DOMAIN C-LAMBDA	IG	FAB-GAMMA-1_LAMBDA	IMGT (202416-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
D, F, H	Heavy Chain	IGHV1	-	fusion glycoprotein f0,envelope glycoprotein	SAbDab (2024-04-26)
E, G, I	Light Chain	IGKV3	Kappa	fusion glycoprotein f0,envelope glycoprotein	SAbDab (2024-04-26)
J, K, N	Heavy Chain	IGHV3	-	fusion glycoprotein f0,envelope glycoprotein	SAbDab (2024-04-26)
L, M, O	Light Chain	IGLV1	Lambda	fusion glycoprotein f0,envelope glycoprotein	SAbDab (2024-04-26)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00523	Fusion glycoprotein F0 (Fusion_gly)	Fusion glycoprotein F0	-	Family
D, F, H	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain
D, F, H	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
E, G, I	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain
E, G, I	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
J, K, N	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain
J, K, N	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
L, M, O	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain
L, M, O	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Fusion glycoprotein F0,Envelope glycoprotein	identical protein binding protein binding binding	membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane viral process cellular process cellular component organization or biogenesis membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane viral process cellular process cellular component organization or biogenesis membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction virion attachment to host cell receptor-mediated virion attachment to host cell adhesion of symbiont to host cell entry receptor-mediated virion attachment to host cell adhesion of symbiont to host symbiont-mediated perturbation of host cellular process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization regulation of syncytium formation by plasma membrane fusion regulation of developmental process positive regulation of biological process cell-cell fusion modulation by virus of host process modulation by virus of syncytium formation via plasma membrane fusion positive regulation of developmental process anatomical structure development positive regulation of syncytium formation by virus syncytium formation induction by virus of host cell-cell fusion modulation of process of another organism positive regulation of cellular process modulation by virus of host cellular process developmental process regulation of biological process biological regulation positive regulation of syncytium formation by plasma membrane fusion syncytium formation by plasma membrane fusion anatomical structure morphogenesis modulation by symbiont of host process anatomical structure formation involved in morphogenesis	virion component viral membrane viral envelope membrane cellular anatomical entity host cell plasma membrane host cellular component host cell part host cell membrane virion membrane host intracellular part host cell Golgi membrane host cell Golgi apparatus host cell cytoplasm part virion component viral membrane viral envelope membrane cellular anatomical entity host cell plasma membrane host cellular component host cell part host cell membrane virion membrane host intracellular part host cell Golgi membrane host cell Golgi apparatus host cell cytoplasm part host cell cytoplasm host cell endomembrane system host intracellular region
D, F, H	AM22 Fab Heavy Chain,IGH@ protein	-	-	cell periphery plasma membrane membrane cellular anatomical entity protein-containing complex immunoglobulin complex
E, G, I	AM22 Fab Light Chain,Uncharacterized protein	-	-	extracellular region cellular anatomical entity
J, K, N	Immunoglobulin heavy variable 3-21,Immunoglobulin gamma-1 heavy chain	binding antigen binding	response to stimulus immune response immune system process adaptive immune response adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity B cell mediated immunity leukocyte mediated immunity immunoglobulin mediated immune response immune effector process	cell periphery plasma membrane membrane cellular anatomical entity protein-containing complex immunoglobulin complex extracellular region
L, M, O	IGL@ protein	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR012473	Fibritin C-terminal	Domain
A, B, C	IPR000776	Precursor fusion glycoprotein F0, Paramyxoviridae	Family
D, F, H	IPR003597	Immunoglobulin C1-set	Domain
D, F, H	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
D, F, H	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
D, F, H	IPR003599	Immunoglobulin subtype	Domain
D, F, H	IPR013106	Immunoglobulin V-set domain	Domain
D, F, H	IPR007110	Immunoglobulin-like domain	Domain
D, F, H	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
E, G, I	IPR003597	Immunoglobulin C1-set	Domain
E, G, I	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
E, G, I	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
E, G, I	IPR003599	Immunoglobulin subtype	Domain
E, G, I	IPR013106	Immunoglobulin V-set domain	Domain
E, G, I	IPR007110	Immunoglobulin-like domain	Domain
E, G, I	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
J, K, N	IPR003597	Immunoglobulin C1-set	Domain
J, K, N	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
J, K, N	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
J, K, N	IPR003599	Immunoglobulin subtype	Domain
J, K, N	IPR013106	Immunoglobulin V-set domain	Domain
J, K, N	IPR007110	Immunoglobulin-like domain	Domain
J, K, N	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
J, K, N	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
J, K, N	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
J, K, N	IPR013106	Immunoglobulin V-set domain	Domain
J, K, N	IPR007110	Immunoglobulin-like domain	Domain
L, M, O	IPR003597	Immunoglobulin C1-set	Domain
L, M, O	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
L, M, O	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
L, M, O	IPR003599	Immunoglobulin subtype	Domain
L, M, O	IPR013106	Immunoglobulin V-set domain	Domain
L, M, O	IPR007110	Immunoglobulin-like domain	Domain
L, M, O	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
J, K, N	Pharos: A0A0B4J1V1	B-cell chronic lymphocytic leukemia interstitial cystitis malignant colon neoplasm osteosarcoma plasma cell myeloma ulcerative colitis B-CELL MALIGNANCY, LOW-GRADE lung adenocarcinoma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma sinusitis cystic fibrosis lung cancer non-small cell lung carcinoma periodontitis B-cell chronic lymphocytic leukemia interstitial cystitis malignant colon neoplasm osteosarcoma plasma cell myeloma ulcerative colitis B-CELL MALIGNANCY, LOW-GRADE lung adenocarcinoma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma sinusitis cystic fibrosis lung cancer non-small cell lung carcinoma periodontitis tuberculosis