6AHZ

The NMR Structure of the Polysialyltranseferase Domain (PSTD) in Polysialyltransferase ST8siaIV

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00777	Glycosyltransferase family 29 (sialyltransferase) (Glyco_transf_29)	Glycosyltransferase family 29 (sialyltransferase)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase	sialic acid binding organic acid binding binding ion binding anion binding carboxylic acid binding carbohydrate derivative binding small molecule binding glycosyltransferase activity sialyltransferase activity transferase activity catalytic activity alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	carbohydrate derivative biosynthetic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein glycosylation macromolecule biosynthetic process organic substance metabolic process biosynthetic process glycosylation macromolecule modification carbohydrate derivative biosynthetic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein glycosylation macromolecule biosynthetic process organic substance metabolic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process carbohydrate metabolic process oligosaccharide metabolic process developmental process multicellular organism development multicellular organismal process anatomical structure development nervous system development system development sphingolipid biosynthetic process glycolipid metabolic process lipid biosynthetic process ganglioside biosynthetic process amide metabolic process ceramide metabolic process membrane lipid metabolic process glycosphingolipid metabolic process liposaccharide metabolic process amide biosynthetic process sphingolipid metabolic process glycolipid biosynthetic process ceramide biosynthetic process cellular lipid metabolic process glycosphingolipid biosynthetic process membrane lipid biosynthetic process ganglioside metabolic process lipid metabolic process N-glycan processing sialylation	membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system Golgi membrane membrane bounding membrane of organelle organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR012163	Sialyltransferase	Family
A	IPR001675	Glycosyl transferase family 29	Family
A	IPR038578	GT29-like superfamiliy	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q92187	periodontitis sarcoidosis subependymal giant cell astrocytoma ulcerative colitis asthma colorectal cancer gastric carcinoma interstitial cystitis malignant ependymoma medulloblastoma ovarian cancer pilocytic astrocytoma schizophrenia systemic lupus erythematosus astrocytic tumor periodontitis sarcoidosis subependymal giant cell astrocytoma ulcerative colitis asthma colorectal cancer gastric carcinoma interstitial cystitis malignant ependymoma medulloblastoma ovarian cancer pilocytic astrocytoma schizophrenia systemic lupus erythematosus astrocytic tumor exocrine pancreatic carcinoma glioblastoma invasive ductal breast carcinoma malignant glioma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma primary biliary cholangitis Sjogren syndrome tuberculosis atypical teratoid rhabdoid tumor gastric cancer hepatocellular carcinoma lung cancer malignant pancreatic neoplasm osteosarcoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.