Annotations: 6AHV

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08584	e6ahvA1	A: a+b complex topology	X: Ribonuclease P protein subunit p40 (From Topology)	H: Ribonuclease P protein subunit p40 (From Topology)	T: Ribonuclease P protein subunit p40	F: PF08584	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08584	Ribonuclease P 40kDa (Rpp40) subunit (Ribonuc_P_40)	Ribonuclease P 40kDa (Rpp40) subunit	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Ribonuclease P protein subunit p40	tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding ribonuclease P RNA binding	cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process tRNA processing organic substance biosynthetic process nucleic acid catabolic process cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process tRNA processing organic substance biosynthetic process nucleic acid catabolic process RNA 5'-end processing metabolic process cellular process macromolecule metabolic process RNA processing tRNA 5'-leader removal tRNA 5'-end processing ribonucleoprotein complex biogenesis rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cellular component biogenesis ribosome biogenesis maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cellular component organization or biogenesis rRNA metabolic process endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of 5.8S rRNA ribosomal small subunit biogenesis maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	membrane-bounded organelle protein-containing complex intracellular anatomical structure ribonuclease P complex multimeric ribonuclease P complex nucleus membrane-enclosed lumen nuclear protein-containing complex endonuclease complex intracellular organelle lumen intracellular organelle nucleolar ribonuclease P complex non-membrane-bounded organelle catalytic complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ribonuclease P complex multimeric ribonuclease P complex nucleus membrane-enclosed lumen nuclear protein-containing complex endonuclease complex intracellular organelle lumen intracellular organelle nucleolar ribonuclease P complex non-membrane-bounded organelle catalytic complex intracellular membrane-bounded organelle cellular anatomical entity nucleolus endoribonuclease complex organelle lumen organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle intracellular protein-containing complex nuclear lumen sno(s)RNA-containing ribonucleoprotein complex ribonuclease MRP complex nucleoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013893	Ribonuclease P protein subunit Rpp40	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O75818	acute myeloid leukemia malignant colon neoplasm oligodendroglioma psoriasis subependymal giant cell astrocytoma astrocytic tumor MALT lymphoma osteosarcoma skin basal cell carcinoma lung cancer non-small cell lung carcinoma ovarian cancer squamous cell carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.