Annotations: 6AHR

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
K	PF04032	e6ahrK1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF04032	ECOD (1.6)
L	PF08584	e6ahrL1	A: a+b complex topology	X: Ribonuclease P protein subunit p40 (From Topology)	H: Ribonuclease P protein subunit p40 (From Topology)	T: Ribonuclease P protein subunit p40	F: PF08584	ECOD (1.6)
D	PF01868	e6ahrD1	A: beta barrels	X: SH3	H: RNase P subunit p29 (From Topology)	T: RNase P subunit p29	F: PF01868	ECOD (1.6)
E	PF01900	e6ahrE1	A: a+b two layers	X: Alpha-beta plaits	H: Rpp14/Pop5-like (From Topology)	T: Rpp14/Pop5-like	F: PF01900	ECOD (1.6)
F	PF01918	e6ahrF1	A: a+b two layers	X: IF3-like	H: AlbA-like (From Topology)	T: AlbA-like	F: PF01918	ECOD (1.6)
G	PF12328	e6ahrG1	A: a+b two layers	X: IF3-like	H: AlbA-like (From Topology)	T: AlbA-like	F: PF12328	ECOD (1.6)
H	PF01900	e6ahrH1	A: a+b two layers	X: Alpha-beta plaits	H: Rpp14/Pop5-like (From Topology)	T: Rpp14/Pop5-like	F: PF01900	ECOD (1.6)
I	PF01876	e6ahrI1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF01876	ECOD (1.6)
J	PF01876	e6ahrJ1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF01876	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
K	PF04032	RNAse P Rpr2/Rpp21/SNM1 subunit domain (Rpr2)	RNAse P Rpr2/Rpp21/SNM1 subunit domain	-	Family
L	PF08584	Ribonuclease P 40kDa (Rpp40) subunit (Ribonuc_P_40)	Ribonuclease P 40kDa (Rpp40) subunit	-	Family
B	PF08170	POPLD (NUC188) domain (POPLD)	POPLD (NUC188) domain	This domain is found in POP1-like nucleolar proteins [1].	Domain
B	PF06978	Ribonucleases P/MRP protein subunit POP1, N-terminal (POP1_N)	Ribonucleases P/MRP protein subunit POP1, N-terminal	This entry represents a conserved region approximately 150 residues long located towards the N-terminus of the POP1 subunit that is common to both the RNase MRP and RNase P ribonucleoproteins (EC:3.1.26.5) [1]. These RNA-containing enzymes generate m ...	This entry represents a conserved region approximately 150 residues long located towards the N-terminus of the POP1 subunit that is common to both the RNase MRP and RNase P ribonucleoproteins (EC:3.1.26.5) [1]. These RNA-containing enzymes generate mature tRNA molecules by cleaving their 5' ends. This is a short N-terminal domain consisting of a small helical core and a long alpha-helix [2], which is enriched with positively charged residues involved in pre-tRNA substrate recognition [2].	Domain
D	PF01868	Ribonuclease P/MRP, subunit p29 (RNase_P-MRP_p29)	Ribonuclease P/MRP, subunit p29	-	Family
E	PF01900	Rpp14/Pop5 family (RNase_P_Rpp14)	Rpp14/Pop5 family	-	Family
F	PF01918	Alba (Alba)	Alba	-	Family
G	PF12328	Rpp20 subunit of nuclear RNase MRP and P (Rpp20)	Rpp20 subunit of nuclear RNase MRP and P	-	Family
H	PF01900	Rpp14/Pop5 family (RNase_P_Rpp14)	Rpp14/Pop5 family	-	Family
I, J	PF01876	RNase P subunit p30 (RNase_P_p30)	RNase P subunit p30	This protein is part of the RNase P complex that is involved in tRNA maturation [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	H1 RNA	-	-	-
K	Ribonuclease P protein subunit p21	tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding ribonuclease P RNA binding cation binding ion binding metal ion binding small molecule binding	response to stimulus response to chemical response to xenobiotic stimulus cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing tRNA 5'-end processing cellular metabolic process primary metabolic process gene expression response to stimulus response to chemical response to xenobiotic stimulus cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing tRNA 5'-end processing cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process RNA 5'-end processing metabolic process cellular process macromolecule metabolic process tRNA 5'-leader removal	membrane-bounded organelle protein-containing complex intracellular anatomical structure ribonuclease P complex multimeric ribonuclease P complex nucleus membrane-enclosed lumen nuclear protein-containing complex endonuclease complex intracellular organelle lumen intracellular organelle nucleolar ribonuclease P complex non-membrane-bounded organelle catalytic complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ribonuclease P complex multimeric ribonuclease P complex nucleus membrane-enclosed lumen nuclear protein-containing complex endonuclease complex intracellular organelle lumen intracellular organelle nucleolar ribonuclease P complex non-membrane-bounded organelle catalytic complex intracellular membrane-bounded organelle cellular anatomical entity nucleolus endoribonuclease complex organelle lumen organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle intracellular protein-containing complex nuclear lumen nucleoplasm
L	Ribonuclease P protein subunit p40	tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding ribonuclease P RNA binding	cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing tRNA 5'-end processing cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing tRNA 5'-end processing cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process RNA 5'-end processing metabolic process cellular process macromolecule metabolic process tRNA 5'-leader removal ribonucleoprotein complex biogenesis rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cellular component biogenesis ribosome biogenesis maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cellular component organization or biogenesis rRNA metabolic process endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of 5.8S rRNA ribosomal small subunit biogenesis maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	membrane-bounded organelle protein-containing complex intracellular anatomical structure ribonuclease P complex multimeric ribonuclease P complex nucleus membrane-enclosed lumen nuclear protein-containing complex endonuclease complex intracellular organelle lumen intracellular organelle nucleolar ribonuclease P complex non-membrane-bounded organelle catalytic complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ribonuclease P complex multimeric ribonuclease P complex nucleus membrane-enclosed lumen nuclear protein-containing complex endonuclease complex intracellular organelle lumen intracellular organelle nucleolar ribonuclease P complex non-membrane-bounded organelle catalytic complex intracellular membrane-bounded organelle cellular anatomical entity nucleolus endoribonuclease complex organelle lumen organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle intracellular protein-containing complex nuclear lumen sno(s)RNA-containing ribonucleoprotein complex ribonuclease MRP complex nucleoplasm
B	Ribonucleases P/MRP protein subunit POP1	RNA binding binding organic cyclic compound binding nucleic acid binding ribonuclease P RNA binding tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity RNA binding binding organic cyclic compound binding nucleic acid binding ribonuclease P RNA binding tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity	cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing tRNA 5'-end processing cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing tRNA 5'-end processing cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process RNA 5'-end processing metabolic process cellular process macromolecule metabolic process tRNA 5'-leader removal catabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process tRNA decay organic substance catabolic process RNA catabolic process	membrane-bounded organelle protein-containing complex intracellular anatomical structure ribonuclease P complex multimeric ribonuclease P complex nucleus membrane-enclosed lumen nuclear protein-containing complex endonuclease complex intracellular organelle lumen intracellular organelle nucleolar ribonuclease P complex non-membrane-bounded organelle catalytic complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ribonuclease P complex multimeric ribonuclease P complex nucleus membrane-enclosed lumen nuclear protein-containing complex endonuclease complex intracellular organelle lumen intracellular organelle nucleolar ribonuclease P complex non-membrane-bounded organelle catalytic complex intracellular membrane-bounded organelle cellular anatomical entity nucleolus endoribonuclease complex organelle lumen organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle intracellular protein-containing complex nuclear lumen sno(s)RNA-containing ribonucleoprotein complex ribonuclease MRP complex extracellular region extracellular space nucleoplasm
C	Ribonuclease P protein subunit p38	RNA binding binding organic cyclic compound binding nucleic acid binding ribonuclease P RNA binding tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity RNA binding binding organic cyclic compound binding nucleic acid binding ribonuclease P RNA binding tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity	cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing tRNA 5'-end processing cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing tRNA 5'-end processing cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process RNA 5'-end processing metabolic process cellular process macromolecule metabolic process tRNA 5'-leader removal ribonucleoprotein complex biogenesis rRNA processing cellular component biogenesis ribosome biogenesis cellular component organization or biogenesis rRNA metabolic process	membrane-bounded organelle protein-containing complex intracellular anatomical structure ribonuclease P complex multimeric ribonuclease P complex nucleus membrane-enclosed lumen nuclear protein-containing complex endonuclease complex intracellular organelle lumen intracellular organelle nucleolar ribonuclease P complex non-membrane-bounded organelle catalytic complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ribonuclease P complex multimeric ribonuclease P complex nucleus membrane-enclosed lumen nuclear protein-containing complex endonuclease complex intracellular organelle lumen intracellular organelle nucleolar ribonuclease P complex non-membrane-bounded organelle catalytic complex intracellular membrane-bounded organelle cellular anatomical entity nucleolus endoribonuclease complex organelle lumen organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle intracellular protein-containing complex nuclear lumen fibrillar center sno(s)RNA-containing ribonucleoprotein complex ribonuclease MRP complex nucleoplasm
D	Ribonuclease P protein subunit p29	RNA binding binding organic cyclic compound binding nucleic acid binding ribonuclease P RNA binding tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity RNA binding binding organic cyclic compound binding nucleic acid binding ribonuclease P RNA binding tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity	cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing tRNA 5'-end processing cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing tRNA 5'-end processing cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process RNA 5'-end processing metabolic process cellular process macromolecule metabolic process tRNA 5'-leader removal ribonucleoprotein complex biogenesis rRNA processing cellular component biogenesis ribosome biogenesis cellular component organization or biogenesis rRNA metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex endoribonuclease complex catalytic complex sno(s)RNA-containing ribonucleoprotein complex ribonuclease MRP complex ribonucleoprotein complex intracellular protein-containing complex endonuclease complex nucleoplasm ribonuclease P complex multimeric ribonuclease P complex
E	Ribonuclease P/MRP protein subunit POP5	tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding ribonuclease P RNA binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing nucleobase-containing compound metabolic process cellular component biogenesis ribosome biogenesis organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process cellular metabolic process primary metabolic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing nucleobase-containing compound metabolic process cellular component biogenesis ribosome biogenesis organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process metabolic process cellular process macromolecule metabolic process tRNA processing tRNA 5'-end processing tRNA metabolic process RNA 5'-end processing tRNA 5'-leader removal	membrane-bounded organelle protein-containing complex intracellular anatomical structure ribonuclease P complex multimeric ribonuclease P complex nucleus membrane-enclosed lumen nuclear protein-containing complex endonuclease complex intracellular organelle lumen intracellular organelle nucleolar ribonuclease P complex non-membrane-bounded organelle catalytic complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ribonuclease P complex multimeric ribonuclease P complex nucleus membrane-enclosed lumen nuclear protein-containing complex endonuclease complex intracellular organelle lumen intracellular organelle nucleolar ribonuclease P complex non-membrane-bounded organelle catalytic complex intracellular membrane-bounded organelle cellular anatomical entity nucleolus endoribonuclease complex organelle lumen organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle intracellular protein-containing complex nuclear lumen sno(s)RNA-containing ribonucleoprotein complex ribonuclease MRP complex nucleoplasm
F	Ribonuclease P protein subunit p25	tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding ribonuclease P RNA binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing nucleobase-containing compound metabolic process cellular component biogenesis ribosome biogenesis organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process cellular metabolic process primary metabolic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing nucleobase-containing compound metabolic process cellular component biogenesis ribosome biogenesis organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process metabolic process cellular process macromolecule metabolic process tRNA processing tRNA 5'-end processing tRNA metabolic process RNA 5'-end processing tRNA 5'-leader removal	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex endoribonuclease complex catalytic complex sno(s)RNA-containing ribonucleoprotein complex ribonuclease MRP complex ribonucleoprotein complex intracellular protein-containing complex endonuclease complex nucleoplasm centrosome microtubule organizing center cytoskeleton centriolar satellite microtubule cytoskeleton ribonuclease P complex multimeric ribonuclease P complex
G	Ribonuclease P protein subunit p20	RNA binding binding organic cyclic compound binding nucleic acid binding ribonuclease P RNA binding tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity RNA binding binding organic cyclic compound binding nucleic acid binding ribonuclease P RNA binding tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity	cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing tRNA 5'-end processing cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing tRNA 5'-end processing cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process RNA 5'-end processing metabolic process cellular process macromolecule metabolic process tRNA 5'-leader removal ribonucleoprotein complex biogenesis rRNA processing cellular component biogenesis ribosome biogenesis cellular component organization or biogenesis rRNA metabolic process	membrane-bounded organelle protein-containing complex intracellular anatomical structure ribonuclease P complex multimeric ribonuclease P complex nucleus membrane-enclosed lumen nuclear protein-containing complex endonuclease complex intracellular organelle lumen intracellular organelle nucleolar ribonuclease P complex non-membrane-bounded organelle catalytic complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ribonuclease P complex multimeric ribonuclease P complex nucleus membrane-enclosed lumen nuclear protein-containing complex endonuclease complex intracellular organelle lumen intracellular organelle nucleolar ribonuclease P complex non-membrane-bounded organelle catalytic complex intracellular membrane-bounded organelle cellular anatomical entity nucleolus endoribonuclease complex organelle lumen organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle intracellular protein-containing complex nuclear lumen sno(s)RNA-containing ribonucleoprotein complex ribonuclease MRP complex cytoplasm nucleoplasm
H	Ribonuclease P protein subunit p14	tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding ribonuclease P RNA binding	cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing tRNA 5'-end processing cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing tRNA 5'-end processing cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process RNA 5'-end processing metabolic process cellular process macromolecule metabolic process tRNA 5'-leader removal	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle nucleoplasm protein-containing complex endoribonuclease complex catalytic complex ribonuclease P complex multimeric ribonuclease P complex ribonucleoprotein complex intracellular protein-containing complex endonuclease complex
I, J	Ribonuclease P protein subunit p30	RNA binding binding organic cyclic compound binding nucleic acid binding ribonuclease P RNA binding tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity RNA binding binding organic cyclic compound binding nucleic acid binding ribonuclease P RNA binding tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity	cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing tRNA 5'-end processing cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing tRNA 5'-end processing cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process RNA 5'-end processing metabolic process cellular process macromolecule metabolic process tRNA 5'-leader removal ribonucleoprotein complex biogenesis rRNA processing cellular component biogenesis ribosome biogenesis cellular component organization or biogenesis rRNA metabolic process	membrane-bounded organelle protein-containing complex intracellular anatomical structure ribonuclease P complex multimeric ribonuclease P complex nucleus membrane-enclosed lumen nuclear protein-containing complex endonuclease complex intracellular organelle lumen intracellular organelle nucleolar ribonuclease P complex non-membrane-bounded organelle catalytic complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ribonuclease P complex multimeric ribonuclease P complex nucleus membrane-enclosed lumen nuclear protein-containing complex endonuclease complex intracellular organelle lumen intracellular organelle nucleolar ribonuclease P complex non-membrane-bounded organelle catalytic complex intracellular membrane-bounded organelle cellular anatomical entity nucleolus endoribonuclease complex organelle lumen organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle intracellular protein-containing complex nuclear lumen sno(s)RNA-containing ribonucleoprotein complex ribonuclease MRP complex nucleoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
K	IPR007175	Ribonuclease P subunit, Rpr2/Snm1/Rpp21	Family
L	IPR013893	Ribonuclease P protein subunit Rpp40	Family
B	IPR039182	Ribonucleases P/MRP protein subunit Pop1	Family
B	IPR009723	Pop1, N-terminal	Domain
B	IPR012590	POPLD domain	Domain
C	IPR004038	Ribosomal protein eL8/eL30/eS12/Gadd45	Domain
C	IPR042848	Ribonuclease P protein subunit Rpp38	Family
C	IPR029064	Ribosomal protein eL30-like superfamily	Homologous Superfamily
D	IPR036980	Ribonuclease P/MRP subunit Rpp29 superfamily	Homologous Superfamily
D	IPR002730	Ribonuclease P protein subunit Rpp29/RNP1	Family
D	IPR023534	Rof/RNase P-like	Homologous Superfamily
D	IPR016848	Ribonuclease P/MRP subunit Rpp29	Family
E	IPR002759	RNase P subunit Pop5/Rpp14/Rnp2-like	Family
E	IPR016819	Ribonuclease P/MRP protein subunit Pop5	Family
E	IPR038085	RNase P subunit Pop5/Rpp14/Rnp2-like domain superfamily	Homologous Superfamily
F	IPR036882	Alba-like domain superfamily	Homologous Superfamily
F	IPR002775	DNA/RNA-binding protein Alba-like	Domain
G	IPR036882	Alba-like domain superfamily	Homologous Superfamily
G	IPR014612	Ribonucleases P/MRP protein subunit Rpp20/Pop7	Family
H	IPR002759	RNase P subunit Pop5/Rpp14/Rnp2-like	Family
H	IPR038085	RNase P subunit Pop5/Rpp14/Rnp2-like domain superfamily	Homologous Superfamily
I, J	IPR016195	Polymerase/histidinol phosphatase-like	Homologous Superfamily
I, J	IPR002738	RNase P subunit p30	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
K	Pharos: Q9H633	attention deficit hyperactivity disorder, inattentive type endogenous depression psoriatic arthritis autism spectrum disorder Hashimoto thyroiditis squamous cell lung carcinoma cutaneous lupus erythematosus lung carcinoma
L	Pharos: O75818	acute myeloid leukemia malignant colon neoplasm oligodendroglioma psoriasis subependymal giant cell astrocytoma astrocytic tumor MALT lymphoma osteosarcoma skin basal cell carcinoma lung cancer non-small cell lung carcinoma ovarian cancer squamous cell carcinoma
B	Pharos: Q99575	anauxetic dysplasia anauxetic dysplasia 2 breast cancer malignant colon neoplasm Mitochondrial Diseases anauxetic dysplasia 1 large cell medulloblastoma osteosarcoma lung cancer medulloblastoma
C	Pharos: P78345	melanoma chronic kidney disease lung cancer cutaneous melanoma malignant ependymoma invasive ductal breast carcinoma
D	Pharos: O95707	ovarian cancer Malignant neoplasm of ovary ovarian neoplasm oligodendroglioma plasma cell myeloma
E	Pharos: Q969H6	attention deficit hyperactivity disorder, inattentive type medulloblastoma tuberculosis glioblastoma osteosarcoma lung cancer ovarian cancer
F	Pharos: Q9BUL9	astrocytic tumor hypertensive disorder malignant glioma rheumatoid arthritis atypical teratoid rhabdoid tumor lung cancer malignant mesothelioma systemic lupus erythematosus chronic obstructive pulmonary disease malignant ependymoma oligodendroglioma
G	Pharos: O75817	Hashimoto thyroiditis non-small cell lung carcinoma inflammatory bowel disease ovarian cancer lung cancer Sjogren syndrome
H	Pharos: O95059	rheumatoid arthritis osteosarcoma systemic sclerosis systemic lupus erythematosus
I, J	Pharos: P78346	atypical teratoid rhabdoid tumor malignant ependymoma osteosarcoma pituitary cancer glioblastoma malignant glioma ovarian cancer primitive neuroectodermal tumor large cell medulloblastoma medulloblastoma pilocytic astrocytoma tuberculosis