6AHD

The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ribonuclease H-like	8041105	3000143	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	JAB1/MPN domain-like	8053277	3001105	SCOP2B (2022-06-29)
J [auth L]	SCOP2B Superfamily	Nop domain	8033305	3001551	SCOP2B (2022-06-29)
BB [auth V]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041748	3000419	SCOP2B (2022-06-29)
EA [auth j]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041748	3000419	SCOP2B (2022-06-29)
N [auth b]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041748	3000419	SCOP2B (2022-06-29)
O [auth c]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041749	3000419	SCOP2B (2022-06-29)
FA [auth k]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041749	3000419	SCOP2B (2022-06-29)
VA [auth P]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041749	3000419	SCOP2B (2022-06-29)
R [auth f]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063468	3000419	SCOP2B (2022-06-29)
IA [auth n]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063468	3000419	SCOP2B (2022-06-29)
YA [auth S]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063468	3000419	SCOP2B (2022-06-29)
CA [auth h]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041751	3000419	SCOP2B (2022-06-29)
S [auth g]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041751	3000419	SCOP2B (2022-06-29)
ZA [auth T]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041751	3000419	SCOP2B (2022-06-29)
V [auth W]	SCOP2B Superfamily	Cyclophilin-like	8042789	3000168	SCOP2B (2022-06-29)
W [auth A0]	SCOP2B Superfamily	Ubiquitin-like	8038047	3000157	SCOP2B (2022-06-29)
Y [auth Z]	SCOP2B Superfamily	PRP38-like	8055808	3002318	SCOP2B (2022-06-29)
JA [auth o]	SCOP2B Superfamily	L domain-like	8043993	3001010	SCOP2B (2022-06-29)
KA [auth p]	SCOP2B Superfamily	RNA-binding domain RBD	8035327	3000110	SCOP2B (2022-06-29)
PA [auth r]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063456	3000419	SCOP2B (2022-06-29)
QA [auth s]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063488	3000419	SCOP2B (2022-06-29)
RA [auth t]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063472	3000419	SCOP2B (2022-06-29)
SA [auth x]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063442	3000419	SCOP2B (2022-06-29)
TA [auth y]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063466	3000419	SCOP2B (2022-06-29)
UA [auth z]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063492	3000419	SCOP2B (2022-06-29)
EB [auth 3]	SCOP2B Superfamily	WD40 repeat-like	8052534	3001694	SCOP2B (2022-06-29)
EB [auth 3]	SCOP2B Superfamily	WD40 repeat-like	8052535	3001694	SCOP2B (2022-06-29)
EB [auth 3]	SCOP2B Superfamily	WD40 repeat-like	8051197	3001694	SCOP2B (2022-06-29)
EB [auth 3]	SCOP2B Superfamily	WD40 repeat-like	8052534	3001694	SCOP2B (2022-06-29)
FB [auth 5]	SCOP2B Superfamily	RNA-binding domain RBD	8040695	3000110	SCOP2B (2022-06-29)
GB [auth 6]	SCOP2B Superfamily	Triquetra zinc finger motif	8051848	3002040	SCOP2B (2022-06-29)
JB [auth 4]	SCOP2B Superfamily	RNA-binding domain RBD	8090834	3000110	SCOP2B (2022-06-29)
KB [auth D]	SCOP2B Superfamily	Brl domain-like	8036193	3000115	SCOP2B (2022-06-29)
KB [auth D]	SCOP2B Superfamily	E set domains	8055093	3000070	SCOP2B (2022-06-29)
F [auth O]	SCOP2B Superfamily	Thioredoxin-like	8044390	3000031	SCOP2B (2022-06-29)
I [auth M]	SCOP2B Superfamily	L30e-like	8043738	3001739	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF10596,PF10597	e6ahdA6	A: alpha bundles	X: helical bundle domain in reverse transcriptase-like polymerases (From Topology)	H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)	T: helical bundle domain in reverse transcriptase-like polymerases	F: PF10596,PF10597	ECOD (1.6)
A	PF08082,PF08083	e6ahdA3	A: alpha complex topology	X: Pre-mRNA-splicing factor 8 N-terminal domain (From Topology)	H: Pre-mRNA-splicing factor 8 N-terminal domain (From Topology)	T: Pre-mRNA-splicing factor 8 N-terminal domain	F: PF08082,PF08083	ECOD (1.6)
A	PF10598	e6ahdA5	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: PF10598	ECOD (1.6)
A	PF01398,PF08084	e6ahdA2	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: PF01398,PF08084	ECOD (1.6)
A	PF10596	e6ahdA4	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: PF10596	ECOD (1.6)
A	PF12134	e6ahdA1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF12134	ECOD (1.6)
J [auth L]	PF01798	e6ahdL2	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: Nop C-terminal domain	F: PF01798	ECOD (1.6)
J [auth L]	PF01798	e6ahdL1	A: alpha complex topology	X: Nop N-terminal domain (From Topology)	H: Nop N-terminal domain (From Topology)	T: Nop N-terminal domain	F: PF01798	ECOD (1.6)
J [auth L]	PF09785	e6ahdL3	A: extended segments	X: Pre-mRNA-processing factor 31 C-terminal region (From Topology)	H: Pre-mRNA-processing factor 31 C-terminal region (From Topology)	T: Pre-mRNA-processing factor 31 C-terminal region	F: PF09785	ECOD (1.6)
L [auth J]	PF06544	e6ahdJ1	A: a+b two layers	X: Alpha-beta plaits	H: Acylphosphatase-like (From Topology)	T: Acylphosphatase-like	F: PF06544	ECOD (1.6)
L [auth J]	PF08572	e6ahdJ2	A: extended segments	X: U4/U6 small nuclear ribonucleoprotein PRP3 N-terminal region (From Topology)	H: U4/U6 small nuclear ribonucleoprotein PRP3 N-terminal region (From Topology)	T: U4/U6 small nuclear ribonucleoprotein PRP3 N-terminal region	F: PF08572	ECOD (1.6)
AB [auth U]	PF01423	e6ahdU1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
DA [auth i]	PF01423	e6ahdi1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
M [auth a]	PF01423	e6ahda1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
BB [auth V]	PF01423	e6ahdV1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
EA [auth j]	PF01423	e6ahdj1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
N [auth b]	PF01423	e6ahdb1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
O [auth c]	PF01423	e6ahdc1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
FA [auth k]	PF01423	e6ahdk1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
VA [auth P]	PF01423	e6ahdP1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
P [auth d]	PF01423	e6ahdd1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
GA [auth l]	PF01423	e6ahdl1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
WA [auth Q]	PF01423	e6ahdQ1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
HA [auth m]	PF01423	e6ahdm1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
Q [auth e]	PF01423	e6ahde1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
XA [auth R]	PF01423	e6ahdR1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
R [auth f]	PF01423	e6ahdf1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
IA [auth n]	PF01423	e6ahdn1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
YA [auth S]	PF01423	e6ahdS1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
CA [auth h]	PF01423	e6ahdh1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
S [auth g]	PF01423	e6ahdg1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
ZA [auth T]	PF01423	e6ahdT1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
T [auth E]	PF00400	e6ahdE1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
U [auth X]	PF06220	e6ahdX1	A: few secondary structure elements	X: beta-beta-alpha zinc fingers	H: beta-beta-alpha zinc fingers (From Topology)	T: beta-beta-alpha zinc fingers	F: PF06220	ECOD (1.6)
V [auth W]	PF00160	e6ahdW1	A: beta barrels	X: Cyclophilin-like (From Topology)	H: Cyclophilin-like (From Topology)	T: Cyclophilin-like	F: PF00160	ECOD (1.6)
W [auth A0]	PF00240	e6ahdA01	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF00240	ECOD (1.6)
Y [auth Z]	PF03371	e6ahdZ1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Pre-mRNA-splicing factor 38A (From Topology)	T: Pre-mRNA-splicing factor 38A	F: PF03371	ECOD (1.6)
Z [auth 8]	PF12171	e6ahd81	A: few secondary structure elements	X: beta-beta-alpha zinc fingers	H: beta-beta-alpha zinc fingers (From Topology)	T: beta-beta-alpha zinc fingers	F: PF12171	ECOD (1.6)
AA [auth Y]	PF00400	e6ahdY1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
AA [auth Y]	PF08513	e6ahdY2	A: alpha duplicates or obligate multimers	X: Lis-homology dimerization domain (From Topology)	H: Lis-homology dimerization domain (From Topology)	T: Lis-homology dimerization domain	F: PF08513	ECOD (1.6)
JA [auth o]	PF14580	e6ahdo1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF14580	ECOD (1.6)
KA [auth p]	PF00076	e6ahdp1	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: PF00076	ECOD (1.6)
LA [auth u]	PF01805,PF12230	e6ahdu1	A: alpha bundles	X: Surp module (SWAP domain) (From Topology)	H: Surp module (SWAP domain) (From Topology)	T: Surp module (SWAP domain)	F: PF01805,PF12230	ECOD (1.6)
MA [auth v]	PF16835	e6ahdv1	A: beta sandwiches	X: HSP20-like	H: Pre-mRNA-splicing factor PRP11 C-terminal domain (From Topology)	T: Pre-mRNA-splicing factor PRP11 C-terminal domain	F: PF16835	ECOD (1.6)
OA [auth q]	PF01423	e6ahdq1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
PA [auth r]	PF01423	e6ahdr1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
QA [auth s]	PF01423	e6ahds1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
RA [auth t]	PF01423	e6ahdt1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
SA [auth x]	PF01423	e6ahdx1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
TA [auth y]	PF01423	e6ahdy1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
UA [auth z]	PF01423	e6ahdz1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
EB [auth 3]	PF03178,PF10433	e6ahd34	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF03178,PF10433	ECOD (1.6)
EB [auth 3]	PF10433	e6ahd33	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF10433	ECOD (1.6)
EB [auth 3]	PF03178	e6ahd31	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF03178	ECOD (1.6)
FB [auth 5]	PF00076	e6ahd51	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: PF00076	ECOD (1.6)
GB [auth 6]	PF03660	e6ahd61	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: PHD finger-like domain-containing protein 5A	F: PF03660	ECOD (1.6)
HB [auth 7]	PF07189	e6ahd71	A: alpha arrays	X: RDS3 complex subunit 10 (From Topology)	H: RDS3 complex subunit 10 (From Topology)	T: RDS3 complex subunit 10	F: PF07189	ECOD (1.6)
JB [auth 4]	PF00076	e6ahd41	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: PF00076	ECOD (1.6)
KB [auth D]	PF02889	e6ahdD3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02889	ECOD (1.6)
KB [auth D]	F_UNCLASSIFIED	e6ahdD5	A: alpha arrays	X: HTH	H: HTH	T: winged	F: F_UNCLASSIFIED	ECOD (1.6)
KB [auth D]	F_UNCLASSIFIED	e6ahdD1	A: alpha arrays	X: HhH/H2TH	H: SAM-like subdomain in Sec63-like proteins (From Topology)	T: SAM-like subdomain in Sec63-like proteins	F: F_UNCLASSIFIED	ECOD (1.6)
KB [auth D]	PF02889	e6ahdD12	A: alpha arrays	X: Sec63 N-terminal subdomain-like (From Topology)	H: Sec63 N-terminal subdomain-like (From Topology)	T: Sec63 N-terminal subdomain-like	F: PF02889	ECOD (1.6)
KB [auth D]	PF00270	e6ahdD11	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00270	ECOD (1.6)
KB [auth D]	PF00271	e6ahdD2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00271	ECOD (1.6)
F [auth O]	PF02966	e6ahdO1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF02966	ECOD (1.6)
G [auth C]	PF03144	e6ahdC2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF03144	ECOD (1.6)
G [auth C]	PF03764	e6ahdC5	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: PF03764	ECOD (1.6)
G [auth C]	PF00679	e6ahdC1	A: a+b two layers	X: Alpha-beta plaits	H: EF-G C-terminal domain-like (From Topology)	T: EF-G C-terminal domain-like	F: PF00679	ECOD (1.6)
G [auth C]	PF14492	e6ahdC4	A: a+b two layers	X: Alpha-beta plaits	H: EF-G C-terminal domain-like (From Topology)	T: EF-G C-terminal domain-like	F: PF14492	ECOD (1.6)
G [auth C]	PF00009	e6ahdC3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00009	ECOD (1.6)
I [auth M]	PF01248	e6ahdM1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: L30e-like (From Topology)	T: L30e-like	F: PF01248	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF10597	U5-snRNA binding site 2 of PrP8 (U5_2-snRNA_bdg)	U5-snRNA binding site 2 of PrP8	The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis [1]. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that ...	The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis [1]. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor [2].	Domain
A	PF10598	RNA recognition motif of the spliceosomal PrP8 (RRM_4)	RNA recognition motif of the spliceosomal PrP8	The large RNA-protein complex of the spliceosome catalyses pre-mRNA splicing. One of the most conserved core proteins is PrP8 which occupies a central position in the catalytic core of the spliceosome, and has been implicated in several crucial molec ...	The large RNA-protein complex of the spliceosome catalyses pre-mRNA splicing. One of the most conserved core proteins is PrP8 which occupies a central position in the catalytic core of the spliceosome, and has been implicated in several crucial molecular rearrangements that occur there, and has recently come under the spotlight for its role in the inherited human disease, Retinitis Pigmentosa [1]. The RNA-recognition motif of PrP8 is highly conserved and provides a possible RNA binding centre for the 5-prime SS, BP, or 3-prime SS of pre-mRNA which are known to contact with Prp8. The most conserved regions of an RRM are defined as the RNP1 and RNP2 sequences. Recognition of RNA targets can also be modulated by a number of other factors, most notably the two loops beta1-alpha1, beta2-beta3 and the amino acid residues C-terminal to the RNP2 domain [2].	Domain
A	PF10596	U6-snRNA interacting domain of PrP8 (U6-snRNA_bdg)	U6-snRNA interacting domain of PrP8	This domain incorporates the interacting site for the U6-snRNA as part of the U4/U6.U5 tri-snRNPs complex of the spliceosome, and is the prime candidate for the role of cofactor for the spliceosome's RNA core. The essential spliceosomal protein Prp8 ...	This domain incorporates the interacting site for the U6-snRNA as part of the U4/U6.U5 tri-snRNPs complex of the spliceosome, and is the prime candidate for the role of cofactor for the spliceosome's RNA core. The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor [1].	Domain
A	PF12134	PRP8 domain IV core (PRP8_domainIV)	PRP8 domain IV core	This domain is found in eukaryotes, and is about 20 amino acids in length. It is found associated with Pfam:PF10597, Pfam:PF10596, Pfam:PF10598, Pfam:PF08083, Pfam:PF08082, Pfam:PF01398, Pfam:PF08084. There is a conserved LILR sequence motif. The dom ...	This domain is found in eukaryotes, and is about 20 amino acids in length. It is found associated with Pfam:PF10597, Pfam:PF10596, Pfam:PF10598, Pfam:PF08083, Pfam:PF08082, Pfam:PF01398, Pfam:PF08084. There is a conserved LILR sequence motif. The domain is a selenomethionine domain in a subunit of the spliceosome. The function of PRP8 domain IV is believed to be interaction with the splicosomal core.	Domain
A	PF08082	PRO8NT (NUC069), PrP8 N-terminal domain (PRO8NT)	PRO8NT (NUC069), PrP8 N-terminal domain	The PRO8NT domain is found at the N-terminus of pre-mRNA splicing factors of PRO8 family [1]. The NLS or nuclear localisation signal for these spliceosome proteins begins at the start and runs for 60 residues. N-terminal to this domain is a highly va ...	The PRO8NT domain is found at the N-terminus of pre-mRNA splicing factors of PRO8 family [1]. The NLS or nuclear localisation signal for these spliceosome proteins begins at the start and runs for 60 residues. N-terminal to this domain is a highly variable proline-rich region [4].	Domain
A	PF08083	PROCN (NUC071) domain (PROCN)	PROCN (NUC071) domain	The PROCN domain is the central domain in pre-mRNA splicing factors of PRO8 family [1].	Domain
A	PF01398	JAB1/Mov34/MPN/PAD-1 ubiquitin protease (JAB)	JAB1/Mov34/MPN/PAD-1 ubiquitin protease	-	Family
A	PF08084	PROCT (NUC072) domain (PROCT)	PROCT (NUC072) domain	The PROCT domain is the C-terminal domain in pre-mRNA splicing factors of PRO8 family [1].	Domain
J [auth L]	PF09785	Prp31 C terminal domain (Prp31_C)	Prp31 C terminal domain	-	Family
J [auth L]	PF01798	snoRNA binding domain, fibrillarin (Nop)	snoRNA binding domain, fibrillarin	-	Family
K [auth 9]	PF03343	SART-1 family (SART-1)	SART-1 family	-	Family
L [auth J]	PF08572	pre-mRNA processing factor 3 domain (PRP3)	pre-mRNA processing factor 3 domain	This domain is found in U4/U6 and U4/U5/U6-small nuclear ribonucleoprotein Prp3, part of the tri-RNA complex that form the spliceosome. Prp3 plays a key role in the recognition of the snRNA duplex. The pre-mRNA processing factor 3 (PRP3) domain, resp ...	This domain is found in U4/U6 and U4/U5/U6-small nuclear ribonucleoprotein Prp3, part of the tri-RNA complex that form the spliceosome. Prp3 plays a key role in the recognition of the snRNA duplex. The pre-mRNA processing factor 3 (PRP3) domain, responsible for the binding to stem II of the snRNA duplex, is highly conserved among eukaryotes and is found N-terminal to Pfam:PF06544 [3,4]. The human PRP3 has been implicated in autosomal retinitis pigmentosa [2].	Domain
L [auth J]	PF06544	Small nuclear ribonucleoprotein Prp3, C-terminal domain (Prp3_C)	Small nuclear ribonucleoprotein Prp3, C-terminal domain	This domain is found at the C-terminal end of U4/U6 and U4/U5/U6- small nuclear ribonucleoprotein Prp3, part of the tri-RNA complex that form the spliceosome. Prp3 plays a key role in the recognition of the snRNA duplex. This binding domain, highly c ...	This domain is found at the C-terminal end of U4/U6 and U4/U5/U6- small nuclear ribonucleoprotein Prp3, part of the tri-RNA complex that form the spliceosome. Prp3 plays a key role in the recognition of the snRNA duplex. This binding domain, highly conserved among eukaryotes, interacts with the 3' end of U6 snRNA. It adopts a ferredoxin-like fold, showing a five-stranded mixed beta-sheet with three alpha-helices, two of them running parallel to the beta-strands on one side of the sheet and one on the other. This fold is extended with a long beta-hairpin, an extra beta-strand, an helix and a final loop at the C terminus. It is located C-terminal to Pfam:PF08572 [1-4].	Domain
BB [auth V], EA [auth j], N [auth b]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
FA [auth k], O [auth c], VA [auth P]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
IA [auth n], R [auth f], YA [auth S]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
CA [auth h], S [auth g], ZA [auth T]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
T [auth E]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
U [auth X]	PF06220	U1 zinc finger (zf-U1)	U1 zinc finger	This family consists of several U1 small nuclear ribonucleoprotein C (U1-C) proteins. The U1 small nuclear ribonucleoprotein (U1 snRNP) binds to the pre-mRNA 5' splice site (ss) at early stages of spliceosome assembly. Recruitment of U1 to a class o ...	This family consists of several U1 small nuclear ribonucleoprotein C (U1-C) proteins. The U1 small nuclear ribonucleoprotein (U1 snRNP) binds to the pre-mRNA 5' splice site (ss) at early stages of spliceosome assembly. Recruitment of U1 to a class of weak 5' ss is promoted by binding of the protein TIA-1 to uridine-rich sequences immediately downstream from the 5' ss. Binding of TIA-1 in the vicinity of a 5' ss helps to stabilise U1 snRNP recruitment, at least in part, via a direct interaction with U1-C, thus providing one molecular mechanism for the function of this splicing regulator [1]. This domain is probably a zinc-binding. It is found in multiple copies in some members of the family.	Domain
V [auth W]	PF00160	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (Pro_isomerase)	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerisation during which the peptide bond pr ...	The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilised in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function [1].	Domain
W [auth A0]	PF00240	Ubiquitin family (ubiquitin)	Ubiquitin family	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry ...	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites [5].	Domain
X [auth 0]	PF06991	Microfibril-associated/Pre-mRNA processing (MFAP1)	Microfibril-associated/Pre-mRNA processing	-	Family
Y [auth Z]	PF03371	PRP38 family (PRP38)	PRP38 family	-	Family
Z [auth 8]	PF12171	Zinc-finger double-stranded RNA-binding (zf-C2H2_jaz)	Zinc-finger double-stranded RNA-binding	-	Family
AA [auth Y]	PF17814	LisH-like dimerisation domain (LisH_TPL)	LisH-like dimerisation domain	TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif [1].	Domain
AA [auth Y]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
JA [auth o]	PF14580	Leucine-rich repeat (LRR_9)	Leucine-rich repeat	-	Repeat
KA [auth p]	PF00076	RNA recognition motif (RRM_1)	RNA recognition motif	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ...	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	Domain
LA [auth u]	PF01805	Surp module (Surp)	Surp module	-	Family
MA [auth v]	PF16835	Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) (SF3A2)	Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)	SF3A2 is one of the components of the SF3a splicing factor complex of the mature U2 snRNP (small nuclear ribonucleoprotein particle). In yeast, SF3a shows a bifurcated assembly structure of three subunits, Prp9 (subunit 3), Prp11 (subunit 2) and Prp2 ...	SF3A2 is one of the components of the SF3a splicing factor complex of the mature U2 snRNP (small nuclear ribonucleoprotein particle). In yeast, SF3a shows a bifurcated assembly structure of three subunits, Prp9 (subunit 3), Prp11 (subunit 2) and Prp21 (subunit 1). with Prp21 wrapping around Prp11 [1].	Domain
NA [auth w]	PF16837	Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 (SF3A3)	Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9	SF3A3 is one of the components of the SF3a splicing factor complex of the mature U2 snRNP (small nuclear ribonucleoprotein particle). In yeast, SF3a shows a bifurcated assembly structure of three subunits, Prp9 (subunit 3), Prp11 (subunit 2) and Prp2 ...	SF3A3 is one of the components of the SF3a splicing factor complex of the mature U2 snRNP (small nuclear ribonucleoprotein particle). In yeast, SF3a shows a bifurcated assembly structure of three subunits, Prp9 (subunit 3), Prp11 (subunit 2) and Prp21 (subunit 1). Prp9 and Prp21 were not thought to interact with each other but the alpha1 helix of Prp9 does make important contacts with the SURP2 domain of Prp21, thus the two do interact via a bidentate-binding mode. Prp9 harbours a major binding site for stem-loop IIa of U2 snRNA [1].	Domain
NA [auth w]	PF13297	Replication stress response SDE2 C-terminal (SDE2_2C)	Replication stress response SDE2 C-terminal	This domain represents the C-terminal region of the Replication stress response SDE2, a genome surveillance factor. It contains the DNA-binding SAP domain, frequently found in proteins involved in DNA repair. SDE2 C-terminal domain must be cleaved fr ...	This domain represents the C-terminal region of the Replication stress response SDE2, a genome surveillance factor. It contains the DNA-binding SAP domain, frequently found in proteins involved in DNA repair. SDE2 C-terminal domain must be cleaved from its N-terminal at a diglycine motif within the ubiquitin-like fold, after Proliferating cell nuclear antigen (PCNA) interaction. This generates a functional protein that negatively regulates damage-inducible PCNA monoubiquitination, which then is proteolytically degraded to allow S phase progression and replication fork recovery in response to DNA damage [1].	Domain
OA [auth q]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
PA [auth r]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
QA [auth s]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
RA [auth t]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
SA [auth x]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
TA [auth y]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
UA [auth z]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
CB [auth K]	PF08799	pre-mRNA processing factor 4 (PRP4) like (PRP4)	pre-mRNA processing factor 4 (PRP4) like	This small domain is found on PRP4 ribonuleoproteins. PRP4 is a U4/U6 small nuclear ribonucleoprotein that is involved in pre-mRNA processing.	Domain
CB [auth K]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
EB [auth 3]	PF10433	Mono-functional DNA-alkylating methyl methanesulfonate N-term (MMS1_N)	Mono-functional DNA-alkylating methyl methanesulfonate N-term	-	Repeat
EB [auth 3]	PF03178	CPSF A subunit region (CPSF_A)	CPSF A subunit region	-	Repeat
FB [auth 5]	PF00076	RNA recognition motif (RRM_1)	RNA recognition motif	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ...	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	Domain
GB [auth 6]	PF03660	PHF5-like protein (PHF5)	PHF5-like protein	-	Family
HB [auth 7]	PF07189	Splicing factor 3B subunit 10 (SF3b10) (SF3b10)	Splicing factor 3B subunit 10 (SF3b10)	-	Family
IB [auth 2]	PF04037	Domain of unknown function (DUF382) (DUF382)	Domain of unknown function (DUF382)	-	Family
IB [auth 2]	PF04046	PSP (PSP)	PSP	-	Family
JB [auth 4]	PF00076	RNA recognition motif (RRM_1)	RNA recognition motif	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ...	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	Domain
KB [auth D]	PF02889	Sec63 Brl domain (Sec63)	Sec63 Brl domain	-	Family
KB [auth D]	PF00270	DEAD/DEAH box helicase (DEAD)	DEAD/DEAH box helicase	Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome ...	Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.	Domain
KB [auth D]	PF00271	Helicase conserved C-terminal domain (Helicase_C)	Helicase conserved C-terminal domain	The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.	Domain
F [auth O]	PF02966	Mitosis protein DIM1 (DIM1)	Mitosis protein DIM1	-	Domain
G [auth C]	PF00679	Elongation factor G C-terminus (EFG_C)	Elongation factor G C-terminus	This domain includes the carboxyl terminal regions of Elongation factor G, elongation factor 2 and some tetracycline resistance proteins and adopt a ferredoxin-like fold.	Domain
G [auth C]	PF00009	Elongation factor Tu GTP binding domain (GTP_EFTU)	Elongation factor Tu GTP binding domain	This domain contains a P-loop motif, also found in several other families such as Pfam:PF00071, Pfam:PF00025 and Pfam:PF00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.	Domain
G [auth C]	PF14492	Elongation Factor G, domain III (EFG_III)	Elongation Factor G, domain III	This domain is found in Elongation Factor G. It shares a similar structure with domain V (Pfam:PF00679). Structural studies in drosophila indicate this is domain 3 [1].	Domain
G [auth C]	PF03144	Elongation factor Tu domain 2 (GTP_EFTU_D2)	Elongation factor Tu domain 2	Elongation factor Tu consists of three structural domains, this is the second domain. This domain adopts a beta barrel structure. This the second domain is involved in binding to charged tRNA [1]. This domain is also found in other proteins such as e ...	Elongation factor Tu consists of three structural domains, this is the second domain. This domain adopts a beta barrel structure. This the second domain is involved in binding to charged tRNA [1]. This domain is also found in other proteins such as elongation factor G and translation initiation factor IF-2. This domain is structurally related to Pfam:PF03143, and in fact has weak sequence matches to this domain.	Domain
G [auth C]	PF03764	Elongation factor G, domain IV (EFG_IV)	Elongation factor G, domain IV	This domain is found in elongation factor G, elongation factor 2 and some tetracycline resistance proteins and adopts a ribosomal protein S5 domain 2-like fold.	Domain
H [auth N]	PF14559	Tetratricopeptide repeat (TPR_19)	Tetratricopeptide repeat	-	Repeat
H [auth N]	PF13181	Tetratricopeptide repeat (TPR_8)	Tetratricopeptide repeat	-	Repeat
H [auth N]	PF06424	PRP1 splicing factor, N-terminal (PRP1_N)	PRP1 splicing factor, N-terminal	This domain is specific to the N-terminal part of the prp1 splicing factor, which is involved in mRNA splicing (and possibly also poly(A)+ RNA nuclear export and cell cycle progression). This domain is specific to the N terminus of the RNA splicing f ...	This domain is specific to the N-terminal part of the prp1 splicing factor, which is involved in mRNA splicing (and possibly also poly(A)+ RNA nuclear export and cell cycle progression). This domain is specific to the N terminus of the RNA splicing factor encoded by prp1 [1]. It is involved in mRNA splicing and possibly also poly(A)and RNA nuclear export and cell cycle progression.	Domain
I [auth M]	PF01248	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family (Ribosomal_L7Ae)	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family	This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD11 ...	This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118 [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Pre-mRNA-processing-splicing factor 8	RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U1 snRNA binding U6 snRNA binding polyubiquitin modification-dependent protein binding protein binding modification-dependent protein binding K63-linked polyubiquitin modification-dependent protein binding U5 snRNA binding U2 snRNA binding pre-mRNA binding RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U1 snRNA binding U6 snRNA binding polyubiquitin modification-dependent protein binding protein binding modification-dependent protein binding K63-linked polyubiquitin modification-dependent protein binding U5 snRNA binding U2 snRNA binding pre-mRNA binding pre-mRNA intronic binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process RNA splicing, via transesterification reactions biosynthetic process organic substance biosynthetic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process RNA splicing, via transesterification reactions biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process ribonucleoprotein complex biogenesis mRNA processing spliceosomal tri-snRNP complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization spliceosomal snRNP assembly mRNA metabolic process mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile cellular response to stimulus response to organic substance biological process involved in interspecies interaction between organisms response to stimulus response to lipid response to other organism cellular response to lipopolysaccharide response to oxygen-containing compound response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound response to biotic stimulus cellular response to biotic stimulus cellular response to chemical stimulus response to chemical response to bacterium cellular response to lipid cellular response to organic substance response to external biotic stimulus response to molecule of bacterial origin response to cytokine cellular response to tumor necrosis factor cellular response to cytokine stimulus response to tumor necrosis factor	membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen U2-type spliceosomal complex protein-containing complex catalytic complex nuclear protein-containing complex U2-type catalytic step 1 spliceosome spliceosomal complex ribonucleoprotein complex catalytic step 1 spliceosome catalytic step 2 spliceosome spliceosomal snRNP complex Sm-like protein family complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex U2-type precatalytic spliceosome precatalytic spliceosome U5 snRNP U2-type catalytic step 2 spliceosome
J [auth L]	U4/U6 small nuclear ribonucleoprotein Prp31	RNA binding snRNA binding U4atac snRNA binding binding organic cyclic compound binding nucleic acid binding U4 snRNA binding ribonucleoprotein complex binding protein-containing complex binding snRNP binding identical protein binding protein binding	localization cellular localization cellular process ribonucleoprotein complex localization ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing spliceosomal tri-snRNP complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization localization cellular localization cellular process ribonucleoprotein complex localization ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing spliceosomal tri-snRNP complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization spliceosomal snRNP assembly cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex spliceosomal complex precatalytic spliceosome membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U2-type spliceosomal complex Cajal body U2-type precatalytic spliceosome U4atac snRNP histone methyltransferase complex catalytic complex MLL1/2 complex transferase complex MLL1 complex methyltransferase complex
K [auth 9]	U4/U6.U5 tri-snRNP-associated protein 1	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing nucleobase-containing compound metabolic process cellular component biogenesis ribosome biogenesis organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process maturation of 5S rRNA cellular metabolic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing nucleobase-containing compound metabolic process cellular component biogenesis ribosome biogenesis organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process maturation of 5S rRNA cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process metabolic process cellular process macromolecule metabolic process mRNA processing RNA splicing mRNA metabolic process RNA splicing, via transesterification reactions mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile multicellular organismal process regulation of leukocyte differentiation regulation of cellular process regulation of leukocyte activation regulation of cell activation mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation positive regulation of T cell differentiation regulation of cell development positive regulation of developmental process multicellular organism development positive regulation of cell activation T cell activation cell differentiation anatomical structure development positive regulation of leukocyte activation T cell differentiation regulation of immune system process positive regulation of immune system process developmental process regulation of biological process positive regulation of T cell activation positive regulation of cell development regulation of leukocyte cell-cell adhesion positive regulation of multicellular organismal process leukocyte differentiation cellular developmental process regulation of developmental process positive regulation of biological process cell development positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation cell adhesion regulation of cytotoxic T cell differentiation cell-cell adhesion positive regulation of hemopoiesis positive regulation of cell differentiation regulation of multicellular organismal process regulation of cell-cell adhesion positive regulation of cellular process regulation of lymphocyte differentiation regulation of multicellular organismal development cytotoxic T cell differentiation hemopoiesis positive regulation of cell adhesion regulation of cell adhesion cell activation biological regulation regulation of T cell activation immune system process regulation of hemopoiesis positive regulation of cytotoxic T cell differentiation positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation regulation of lymphocyte activation protein-RNA complex assembly cellular component organization protein-RNA complex organization cellular component assembly protein-containing complex assembly protein-containing complex organization spliceosomal snRNP assembly	membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system nucleus membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system nucleus membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen Cajal body catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex U2-type spliceosomal complex U2-type precatalytic spliceosome precatalytic spliceosome cytosol spliceosomal snRNP complex Sm-like protein family complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex
L [auth J]	U4/U6 small nuclear ribonucleoprotein Prp3	RNA binding binding organic cyclic compound binding nucleic acid binding identical protein binding protein binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile ribonucleoprotein complex biogenesis spliceosomal tri-snRNP complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization spliceosomal snRNP assembly	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen Cajal body U2-type spliceosomal complex protein-containing complex nuclear protein-containing complex U2-type precatalytic spliceosome spliceosomal complex ribonucleoprotein complex precatalytic spliceosome cytoplasm cytosol spliceosomal snRNP complex Sm-like protein family complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex
AB [auth U], DA [auth i], M [auth a]	SmB	-	-	-
BB [auth V], EA [auth j], N [auth b]	Small nuclear ribonucleoprotein Sm D1	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm spliceosomal complex precatalytic spliceosome U2 snRNP catalytic step 2 spliceosome catalytic complex cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP commitment complex U2-type catalytic step 2 spliceosome
FA [auth k], O [auth c], VA [auth P]	Small nuclear ribonucleoprotein Sm D2	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm spliceosomal complex precatalytic spliceosome U2 snRNP catalytic step 2 spliceosome catalytic complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U2-type catalytic step 2 spliceosome
GA [auth l], P [auth d], WA [auth Q]	SmE	-	-	-
HA [auth m], Q [auth e], XA [auth R]	SmF	-	-	-
IA [auth n], R [auth f], YA [auth S]	Small nuclear ribonucleoprotein G	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex P granule cytoplasmic ribonucleoprotein granule germ plasm ribonucleoprotein granule pole plasm intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle spliceosomal complex precatalytic spliceosome U2 snRNP catalytic step 2 spliceosome catalytic complex cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U7 snRNP prespliceosome U2-type prespliceosome U2-type catalytic step 2 spliceosome
CA [auth h], S [auth g], ZA [auth T]	Small nuclear ribonucleoprotein Sm D3	RNA binding binding organic cyclic compound binding nucleic acid binding histone pre-mRNA DCP binding snRNA binding U7 snRNA binding telomerase RNA binding protein binding enzyme binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation organonitrogen compound metabolic process protein methylation protein alkylation protein metabolic process protein modification process	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm spliceosomal complex precatalytic spliceosome catalytic complex telomerase holoenzyme complex U2 snRNP catalytic step 2 spliceosome cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U7 snRNP commitment complex nuclear body U2-type catalytic step 2 spliceosome
B [auth I]	U4snRNA	-	-	-
T [auth E]	U5 small nuclear ribonucleoprotein 40 kDa protein	RNA binding binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex cytoplasm cytosol sno(s)RNA-containing ribonucleoprotein complex U5 snRNP spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
U [auth X]	WW domain-binding protein 4	protein binding binding proline-rich region binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding RNA binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen U2-type spliceosomal complex U2-type precatalytic spliceosome
V [auth W]	Peptidyl-prolyl cis-trans isomerase H	isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity amide binding binding cyclosporin A binding ribonucleoprotein complex binding protein-containing complex binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of biological process positive regulation of viral genome replication positive regulation of viral process biological regulation positive regulation of biological process viral life cycle regulation of viral process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of biological process positive regulation of viral genome replication positive regulation of viral process biological regulation positive regulation of biological process viral life cycle regulation of viral process regulation of viral life cycle viral genome replication viral process regulation of viral genome replication organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process protein metabolic process macromolecule metabolic process RNA splicing RNA metabolic process mRNA processing mRNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing macromolecule modification peptidyl-amino acid modification peptidyl-proline modification protein modification process protein peptidyl-prolyl isomerization	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex cytoplasm cytosol spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U4/U6 snRNP U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex
W [auth A0]	Ubiquitin-like protein 5	protein tag activity molecular tag activity	organic substance metabolic process organonitrogen compound metabolic process macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process gene expression mRNA processing organic substance metabolic process organonitrogen compound metabolic process macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing protein localization regulation of localization establishment of protein localization cellular localization regulation of cellular process regulation of protein localization protein targeting regulation of protein targeting to mitochondrion positive regulation of biological process positive regulation of establishment of protein localization localization cellular macromolecule localization positive regulation of protein targeting to mitochondrion positive regulation of cellular process regulation of biological process regulation of establishment of protein localization biological regulation establishment of localization regulation of establishment of protein localization to mitochondrion establishment of protein localization to organelle regulation of protein targeting regulation of cellular localization macromolecule localization protein localization to organelle protein localization to mitochondrion positive regulation of protein localization protein targeting to mitochondrion establishment of protein localization to mitochondrion positive regulation of establishment of protein localization to mitochondrion	membrane-bounded organelle Cajal body intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle Cajal body intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm
X [auth 0]	Microfibrillar-associated protein 1	RNA binding binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex cell periphery extracellular matrix membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex cell periphery extracellular matrix external encapsulating structure microfibril supramolecular fiber supramolecular polymer supramolecular complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type precatalytic spliceosome precatalytic spliceosome centrosome microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle
Y [auth Z]	Pre-mRNA-splicing factor 38A	RNA binding binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type spliceosomal complex U2-type precatalytic spliceosome
Z [auth 8]	Zinc finger matrin-type protein 2	DNA binding binding organic cyclic compound binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex organelle membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type spliceosomal complex U2-type precatalytic spliceosome spliceosomal complex precatalytic spliceosome
AA [auth Y]	WD40 repeat-containing protein SMU1	-	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile regulation of cellular process alternative mRNA splicing, via spliceosome regulation of mRNA splicing, via spliceosome regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of biosynthetic process regulation of mRNA processing regulation of biological process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of RNA splicing regulation of cellular biosynthetic process regulation of gene expression regulation of alternative mRNA splicing, via spliceosome regulation of macromolecule biosynthetic process regulation of mRNA metabolic process regulation of metabolic process	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen U2-type spliceosomal complex U2-type precatalytic spliceosome cytoplasm
BA [auth H]	U2snRNA	-	-	-
JA [auth o]	U2 small nuclear ribonucleoprotein A'	RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U2 snRNA binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen Sm-like protein family complex small nuclear ribonucleoprotein complex spliceosomal snRNP complex U2 snRNP catalytic step 2 spliceosome catalytic complex U2-type precatalytic spliceosome precatalytic spliceosome U2-type catalytic step 2 spliceosome
C [auth B]	U5snRNA	-	-	-
KA [auth p]	U2 small nuclear ribonucleoprotein B''	RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U1 snRNA binding ribonucleoprotein complex binding snRNP binding protein-containing complex binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle cytoplasmic ribonucleoprotein granule cellular anatomical entity cytoplasm supramolecular complex non-membrane-bounded organelle ribonucleoprotein granule membrane-bounded organelle U2-type spliceosomal complex protein-containing complex nucleus intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle cytoplasmic ribonucleoprotein granule cellular anatomical entity cytoplasm supramolecular complex non-membrane-bounded organelle ribonucleoprotein granule membrane-bounded organelle U2-type spliceosomal complex protein-containing complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle spliceosomal complex ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex U2-type precatalytic spliceosome precatalytic spliceosome nucleolus fibrillar center U1 snRNP U2-type catalytic step 2 spliceosome
LA [auth u]	Splicing factor 3A subunit 1	RNA binding binding organic cyclic compound binding nucleic acid binding	cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing RNA splicing cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing RNA splicing cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly mRNA splice site recognition mRNA 3'-splice site recognition	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex U2-type precatalytic spliceosome precatalytic spliceosome prespliceosome U2-type prespliceosome
MA [auth v]	Splicing factor 3A subunit 2	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding RNA binding organic cyclic compound binding nucleic acid binding	regulation of neuron projection development multicellular organismal process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization cellular developmental process cell projection organization positive regulation of biological process cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation positive regulation of neuron projection development regulation of neuron projection development multicellular organismal process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization cellular developmental process cell projection organization positive regulation of biological process cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation positive regulation of neuron projection development cell differentiation anatomical structure development positive regulation of cell projection organization cellular component organization or biogenesis positive regulation of cellular process system development developmental process regulation of biological process plasma membrane bounded cell projection organization regulation of cell projection organization biological regulation nervous system development generation of neurons neuron development cellular process regulation of plasma membrane bounded cell projection organization ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process U2-type prespliceosome assembly mRNA splice site recognition mRNA 3'-splice site recognition	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex U2-type precatalytic spliceosome precatalytic spliceosome prespliceosome U2-type prespliceosome
NA [auth w]	Splicing factor 3A subunit 3	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding RNA binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly mRNA splice site recognition mRNA 3'-splice site recognition	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex U2-type precatalytic spliceosome precatalytic spliceosome
OA [auth q]	U6 snRNA-associated Sm-like protein LSm2	small GTPase binding protein binding binding enzyme binding GTPase binding RNA binding U6 snRNA binding snRNA binding organic cyclic compound binding nucleic acid binding	regulation of cellular process catabolic process cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process macromolecule catabolic process nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process RNA catabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of cellular process catabolic process cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process macromolecule catabolic process nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process RNA catabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process mRNA catabolic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process mRNA metabolic process negative regulation of cellular biosynthetic process nucleic acid metabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process regulation of cellular biosynthetic process regulation of gene expression organic cyclic compound metabolic process negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process organic substance catabolic process RNA splicing mRNA processing RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing ribonucleoprotein complex biogenesis spliceosomal tri-snRNP complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization spliceosomal snRNP assembly	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome spliceosomal snRNP complex U6 snRNP membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome spliceosomal snRNP complex U6 snRNP Sm-like protein family complex small nuclear ribonucleoprotein complex catalytic step 2 spliceosome catalytic complex U2-type spliceosomal complex U2-type precatalytic spliceosome Lsm2-8 complex cytoplasm cytosol cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular non-membrane-bounded organelle supramolecular complex P-body non-membrane-bounded organelle Lsm1-7-Pat1 complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
PA [auth r]	U6 snRNA-associated Sm-like protein LSm3	RNA binding U6 snRNA binding snRNA binding U6 snRNA 3'-end binding binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing cellular component biogenesis cellular component organization organelle organization cellular component assembly organelle assembly P-body assembly non-membrane-bounded organelle assembly cellular component organization or biogenesis	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome spliceosomal snRNP complex U6 snRNP membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome spliceosomal snRNP complex U6 snRNP Sm-like protein family complex small nuclear ribonucleoprotein complex catalytic step 2 spliceosome catalytic complex U2-type spliceosomal complex U2-type precatalytic spliceosome Lsm2-8 complex cytoplasm cytosol cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular non-membrane-bounded organelle supramolecular complex P-body non-membrane-bounded organelle Lsm1-7-Pat1 complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
QA [auth s]	U6 snRNA-associated Sm-like protein LSm4	PH domain binding protein binding binding protein domain specific binding RNA binding U6 snRNA binding snRNA binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process regulation of cellular process catabolic process negative regulation of biological process negative regulation of cellular metabolic process macromolecule catabolic process negative regulation of cellular process RNA catabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process mRNA catabolic process nuclear-transcribed mRNA catabolic process regulation of biological process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process mRNA metabolic process negative regulation of cellular biosynthetic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process regulation of macromolecule biosynthetic process regulation of metabolic process organic substance catabolic process mRNA processing RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile cellular component biogenesis cellular component organization organelle organization cellular component assembly organelle assembly P-body assembly non-membrane-bounded organelle assembly cellular component organization or biogenesis ribonucleoprotein complex biogenesis protein-RNA complex assembly protein-RNA complex organization protein-containing complex assembly protein-containing complex organization spliceosomal snRNP assembly	membrane cellular anatomical entity membrane-bounded organelle spliceosomal snRNP complex protein-containing complex U6 snRNP intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle intracellular organelle small nuclear ribonucleoprotein complex organelle membrane cellular anatomical entity membrane-bounded organelle spliceosomal snRNP complex protein-containing complex U6 snRNP intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2-type spliceosomal complex U2-type precatalytic spliceosome spliceosomal complex precatalytic spliceosome Lsm2-8 complex cytoplasm cytosol spliceosomal tri-snRNP complex cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular non-membrane-bounded organelle supramolecular complex P-body non-membrane-bounded organelle U4/U6 x U5 tri-snRNP complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
RA [auth t]	U6 snRNA-associated Sm-like protein LSm5	protein heterodimerization activity protein binding binding protein dimerization activity RNA binding organic cyclic compound binding nucleic acid binding	regulation of cellular process catabolic process cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process macromolecule catabolic process nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process RNA catabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of cellular process catabolic process cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process macromolecule catabolic process nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process RNA catabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process mRNA catabolic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process mRNA metabolic process negative regulation of cellular biosynthetic process nucleic acid metabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process regulation of cellular biosynthetic process regulation of gene expression organic cyclic compound metabolic process negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process organic substance catabolic process RNA splicing mRNA processing RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex U6 snRNP intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex U6 snRNP intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2-type spliceosomal complex U2-type precatalytic spliceosome spliceosomal complex precatalytic spliceosome Lsm2-8 complex cytoplasm cytosol Lsm1-7-Pat1 complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
SA [auth x]	U6 snRNA-associated Sm-like protein LSm6	protein heterodimerization activity protein binding binding protein dimerization activity RNA binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process regulation of cellular process catabolic process negative regulation of biological process negative regulation of cellular metabolic process macromolecule catabolic process negative regulation of cellular process RNA catabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process mRNA catabolic process regulation of biological process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process mRNA metabolic process negative regulation of cellular biosynthetic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process regulation of macromolecule biosynthetic process regulation of metabolic process organic substance catabolic process mRNA processing RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile tRNA metabolic process tRNA processing ncRNA metabolic process ribonucleoprotein complex biogenesis rRNA processing cellular component biogenesis ribosome biogenesis maturation of SSU-rRNA cellular component organization or biogenesis rRNA metabolic process ribosomal small subunit biogenesis	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle spliceosomal snRNP complex protein-containing complex U6 snRNP nuclear protein-containing complex Sm-like protein family complex small nuclear ribonucleoprotein complex ribonucleoprotein complex U2-type spliceosomal complex U2-type precatalytic spliceosome spliceosomal complex precatalytic spliceosome Lsm2-8 complex cytoplasm cytosol sno(s)RNA-containing ribonucleoprotein complex cytoplasmic ribonucleoprotein granule ribonucleoprotein granule supramolecular complex P-body U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex nucleoplasm
TA [auth y]	U6 snRNA-associated Sm-like protein LSm7	RNA binding U6 snRNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding	regulation of cellular process catabolic process cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process macromolecule catabolic process nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process RNA catabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of cellular process catabolic process cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process macromolecule catabolic process nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process RNA catabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process mRNA catabolic process nuclear-transcribed mRNA catabolic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process mRNA metabolic process negative regulation of cellular biosynthetic process nucleic acid metabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process regulation of cellular biosynthetic process regulation of gene expression organic cyclic compound metabolic process negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process organic substance catabolic process RNA splicing mRNA processing RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex U6 snRNP intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex U6 snRNP intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex catalytic step 2 spliceosome catalytic complex spliceosomal complex U2-type spliceosomal complex U2-type precatalytic spliceosome precatalytic spliceosome Lsm2-8 complex cytoplasm cytosol U12-type spliceosomal complex spliceosomal tri-snRNP complex Lsm1-7-Pat1 complex U4/U6 x U5 tri-snRNP complex prespliceosome U2-type prespliceosome membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
D [auth F]	U6snRNA	-	-	-
UA [auth z]	U6 snRNA-associated Sm-like protein LSm8	RNA binding U6 snRNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome spliceosomal snRNP complex U6 snRNP membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome spliceosomal snRNP complex U6 snRNP Sm-like protein family complex small nuclear ribonucleoprotein complex U2-type spliceosomal complex U2-type precatalytic spliceosome Lsm2-8 complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
CB [auth K]	U4/U6 small nuclear ribonucleoprotein Prp4	RNA binding U6 snRNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U4 snRNA binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen Cajal body U2-type spliceosomal complex protein-containing complex nuclear protein-containing complex U2-type precatalytic spliceosome spliceosomal complex ribonucleoprotein complex precatalytic spliceosome spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U4/U6 snRNP U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex
DB [auth 1]	Splicing factor 3B subunit 1	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding splicing factor binding protein binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase I positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase I regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of transcription by RNA polymerase I positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of transcription by RNA polymerase III positive regulation of transcription by RNA polymerase III transcription by RNA polymerase III transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II protein-DNA complex organization chromatin organization chromatin remodeling	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle nuclear speck nuclear body nucleoplasm spliceosomal snRNP complex protein-containing complex nuclear protein-containing complex Sm-like protein family complex small nuclear ribonucleoprotein complex ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex spliceosomal complex U11/U12 snRNP U2-type spliceosomal complex U2-type precatalytic spliceosome precatalytic spliceosome U12-type spliceosomal complex ATPase complex B-WICH complex chromosome SWI/SNF superfamily-type complex protein-DNA complex chromatin prespliceosome U2-type prespliceosome
EB [auth 3]	Splicing factor 3B subunit 3	protein-containing complex binding binding RNA binding snRNA binding organic cyclic compound binding nucleic acid binding U2 snRNA binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly catabolic process negative regulation of biological process macromolecule catabolic process negative regulation of protein catabolic process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound catabolic process negative regulation of catabolic process organonitrogen compound metabolic process regulation of protein metabolic process negative regulation of metabolic process protein catabolic process regulation of catabolic process organic substance catabolic process regulation of protein catabolic process cellular response to stimulus response to stimulus regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress DNA repair DNA metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus regulation of DNA metabolic process regulation of RNA splicing	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle U2-type spliceosomal complex protein-containing complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex catalytic complex peptidase complex protein-DNA complex chromatin chromosome transferase complex histone acetyltransferase complex acetyltransferase complex protein acetyltransferase complex SAGA-type complex SAGA complex intracellular protein-containing complex spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome U2-type precatalytic spliceosome precatalytic spliceosome U12-type spliceosomal complex nucleoplasm
FB [auth 5]	SF3b14a, Splicing factor 3B subunit 6	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding	developmental process multicellular organismal process chordate embryonic development embryo development in utero embryonic development multicellular organism development anatomical structure morphogenesis blastocyst formation embryo development ending in birth or egg hatching anatomical structure development anatomical structure formation involved in morphogenesis blastocyst development RNA splicing cellular biosynthetic process developmental process multicellular organismal process chordate embryonic development embryo development in utero embryonic development multicellular organism development anatomical structure morphogenesis blastocyst formation embryo development ending in birth or egg hatching anatomical structure development anatomical structure formation involved in morphogenesis blastocyst development RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome spliceosomal snRNP complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex U12-type spliceosomal complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
GB [auth 6]	PHD finger-like domain-containing protein 5A	DNA binding binding organic cyclic compound binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding RNA binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly developmental process stem cell differentiation cellular developmental process cell differentiation	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix U2-type spliceosomal complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix U2-type spliceosomal complex protein-containing complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex precatalytic spliceosome nuclear speck nuclear body nucleoplasm spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP U2-type precatalytic spliceosome U12-type spliceosomal complex
HB [auth 7]	SF3b5, Splicing factor 3B subunit 5	splicing factor binding protein binding binding RNA binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly cellular response to stimulus response to stimulus regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress DNA repair DNA metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus regulation of DNA metabolic process regulation of RNA splicing	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic complex peptidase complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic complex peptidase complex protein-DNA complex chromatin chromosome transferase complex histone acetyltransferase complex acetyltransferase complex intracellular non-membrane-bounded organelle protein acetyltransferase complex SAGA-type complex SAGA complex intracellular protein-containing complex non-membrane-bounded organelle precatalytic spliceosome spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP U2-type precatalytic spliceosome U12-type spliceosomal complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
IB [auth 2]	SF3b145, Splicing factor 3B subunit 2	RNA binding binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome membrane-enclosed lumen membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex U2-type precatalytic spliceosome U12-type spliceosomal complex
JB [auth 4]	SF3b49, Splicing factor 3B subunit 4	splicing factor binding protein binding binding RNA binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly regulation of cellular process regulation of mRNA splicing, via spliceosome positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of mRNA metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression positive regulation of mRNA processing regulation of macromolecule biosynthetic process regulation of metabolic process positive regulation of mRNA splicing, via spliceosome positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process regulation of biosynthetic process regulation of mRNA processing biological regulation regulation of macromolecule metabolic process regulation of RNA splicing regulation of cellular biosynthetic process positive regulation of gene expression regulation of mRNA metabolic process positive regulation of RNA splicing positive regulation of cellular biosynthetic process	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex spliceosomal snRNP complex Sm-like protein family complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP U2-type precatalytic spliceosome precatalytic spliceosome U12-type spliceosomal complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
KB [auth D]	Brr2, U5 small nuclear ribonucleoprotein 200 kDa helicase	catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity RNA binding binding organic cyclic compound binding nucleic acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity RNA binding binding organic cyclic compound binding nucleic acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity, acting on RNA RNA helicase activity ATP-dependent activity, acting on RNA identical protein binding protein binding	developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) protein-containing complex organization cellular metabolic process spliceosomal conformational changes to generate catalytic conformation primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal complex assembly mRNA cis splicing, via spliceosome cis assembly of pre-catalytic spliceosome	membrane cellular anatomical entity membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle membrane cellular anatomical entity membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic step 1 spliceosome catalytic step 2 spliceosome spliceosomal snRNP complex Sm-like protein family complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type precatalytic spliceosome precatalytic spliceosome U5 snRNP
E [auth G]	pre-mRNA	-	-	-
F [auth O]	Thioredoxin-like protein 4A	-	cellular process cell cycle ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process cellular process cell cycle ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process cell division	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity U2-type precatalytic spliceosome intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity U2-type precatalytic spliceosome intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome cytoplasm cytosol U5 snRNP spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
G [auth C]	116 kDa U5 small nuclear ribonucleoprotein component	RNA binding binding organic cyclic compound binding nucleic acid binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding RNA binding binding organic cyclic compound binding nucleic acid binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding snRNA binding U5 snRNA binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing cellular response to stimulus cellular response to chemical stimulus response to stimulus response to chemical cellular response to xenobiotic stimulus response to xenobiotic stimulus response to organic substance response to organonitrogen compound response to oxygen-containing compound response to nitrogen compound response to organic cyclic compound response to cocaine response to alkaloid	membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex cytoplasm cytosol spliceosomal snRNP complex Sm-like protein family complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex Cajal body U2-type spliceosomal complex U2-type precatalytic spliceosome precatalytic spliceosome U2-type catalytic step 2 spliceosome
H [auth N]	Pre-mRNA-processing factor 6	ribonucleoprotein complex binding protein-containing complex binding binding RNA binding organic cyclic compound binding nucleic acid binding identical protein binding protein binding	localization macromolecule localization RNA localization RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process localization macromolecule localization RNA localization RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process ribonucleoprotein complex biogenesis mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile spliceosomal tri-snRNP complex assembly spliceosomal snRNP assembly regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process	membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex U2-type spliceosomal complex U2-type precatalytic spliceosome precatalytic spliceosome U5 snRNP spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex
I [auth M]	NHP2-like protein 1	RNA binding snRNA binding U4atac snRNA binding binding organic cyclic compound binding nucleic acid binding box C/D sno(s)RNA binding snoRNA binding U3 snoRNA binding U4 snRNA binding ATPase binding protein binding enzyme binding	sexual reproduction reproductive process fertilization single fertilization ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing cellular component biogenesis nucleobase-containing compound metabolic process ribosome biogenesis organic substance metabolic process maturation of SSU-rRNA organic substance biosynthetic process sexual reproduction reproductive process fertilization single fertilization ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing cellular component biogenesis nucleobase-containing compound metabolic process ribosome biogenesis organic substance metabolic process maturation of SSU-rRNA organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process ribosomal small subunit biogenesis nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process cellular process metabolic process macromolecule metabolic process ribosomal large subunit biogenesis maturation of LSU-rRNA protein-containing complex organization small nucleolar ribonucleoprotein complex assembly protein-RNA complex assembly cellular component organization protein-RNA complex organization cellular component assembly protein-containing complex assembly box C/D snoRNP assembly RNA splicing mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex precatalytic spliceosome spliceosomal snRNP complex Sm-like protein family complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex nucleoplasm box C/D methylation guide snoRNP complex sno(s)RNA-containing ribonucleoprotein complex box C/D RNP complex preribosome small-subunit processome dense fibrillar component U2-type spliceosomal complex U2-type precatalytic spliceosome ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome ribosome cytoplasm cytosol large ribosomal subunit U4atac snRNP

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR012984	PROCT domain	Domain
A	IPR012591	PRO8NT domain	Domain
A	IPR019580	Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding	Domain
A	IPR027652	Pre-mRNA-processing-splicing factor 8	Family
A	IPR043172	Prp8 RNase domain IV, palm region	Homologous Superfamily
A	IPR012592	PROCN domain	Domain
A	IPR012337	Ribonuclease H-like superfamily	Homologous Superfamily
A	IPR043173	Prp8 RNase domain IV, fingers region	Homologous Superfamily
A	IPR021983	PRP8 domain IV core	Domain
A	IPR019581	Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding	Domain
A	IPR037518	MPN domain	Domain
A	IPR019582	RNA recognition motif, spliceosomal PrP8	Domain
A	IPR042516	Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily	Homologous Superfamily
A	IPR000555	JAB1/MPN/MOV34 metalloenzyme domain	Domain
J [auth L]	IPR042239	Nop, C-terminal domain	Homologous Superfamily
J [auth L]	IPR019175	Prp31 C-terminal	Domain
J [auth L]	IPR002687	Nop domain	Domain
J [auth L]	IPR012976	NOSIC	Domain
J [auth L]	IPR027105	U4/U6 small nuclear ribonucleoprotein Prp31	Family
J [auth L]	IPR036070	Nop domain superfamily	Homologous Superfamily
K [auth 9]	IPR045347	HIND motif	Conserved Site
K [auth 9]	IPR005011	SNU66/SART1 family	Family
L [auth J]	IPR027104	U4/U6 small nuclear ribonucleoprotein Prp3	Family
L [auth J]	IPR002483	PWI domain	Domain
L [auth J]	IPR013881	Pre-mRNA-splicing factor 3 domain	Domain
L [auth J]	IPR036483	PWI domain superfamily	Homologous Superfamily
L [auth J]	IPR010541	Small nuclear ribonucleoprotein Prp3, C-terminal domain	Domain
BB [auth V], EA [auth j], N [auth b]	IPR027141	Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3	Family
BB [auth V], EA [auth j], N [auth b]	IPR034102	Small nuclear ribonucleoprotein D1	Domain
BB [auth V], EA [auth j], N [auth b]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
BB [auth V], EA [auth j], N [auth b]	IPR047575	Sm domain	Domain
BB [auth V], EA [auth j], N [auth b]	IPR010920	LSM domain superfamily	Homologous Superfamily
FA [auth k], O [auth c], VA [auth P]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
FA [auth k], O [auth c], VA [auth P]	IPR047575	Sm domain	Domain
FA [auth k], O [auth c], VA [auth P]	IPR027248	Small nuclear ribonucleoprotein Sm D2	Family
FA [auth k], O [auth c], VA [auth P]	IPR010920	LSM domain superfamily	Homologous Superfamily
IA [auth n], R [auth f], YA [auth S]	IPR044641	Sm-like protein Lsm7/SmG	Family
IA [auth n], R [auth f], YA [auth S]	IPR034098	Small nuclear ribonucleoprotein G	Family
IA [auth n], R [auth f], YA [auth S]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
IA [auth n], R [auth f], YA [auth S]	IPR047575	Sm domain	Domain
IA [auth n], R [auth f], YA [auth S]	IPR010920	LSM domain superfamily	Homologous Superfamily
CA [auth h], S [auth g], ZA [auth T]	IPR027141	Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3	Family
CA [auth h], S [auth g], ZA [auth T]	IPR034099	Small nuclear ribonucleoprotein Sm D3	Family
CA [auth h], S [auth g], ZA [auth T]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
CA [auth h], S [auth g], ZA [auth T]	IPR047575	Sm domain	Domain
CA [auth h], S [auth g], ZA [auth T]	IPR010920	LSM domain superfamily	Homologous Superfamily
T [auth E]	IPR019775	WD40 repeat, conserved site	Conserved Site
T [auth E]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
T [auth E]	IPR001680	WD40 repeat	Repeat
T [auth E]	IPR020472	G-protein beta WD-40 repeat	Repeat
T [auth E]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
U [auth X]	IPR003604	Matrin/U1-C-like, C2H2-type zinc finger	Domain
U [auth X]	IPR040023	WW domain-binding protein 4	Family
U [auth X]	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily
U [auth X]	IPR036020	WW domain superfamily	Homologous Superfamily
U [auth X]	IPR000690	Matrin/U1-C, C2H2-type zinc finger	Domain
U [auth X]	IPR001202	WW domain	Domain
U [auth X]	IPR013085	U1-C, C2H2-type zinc finger	Domain
V [auth W]	IPR029000	Cyclophilin-like domain superfamily	Homologous Superfamily
V [auth W]	IPR024936	Cyclophilin-type peptidyl-prolyl cis-trans isomerase	Family
V [auth W]	IPR002130	Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain	Domain
V [auth W]	IPR020892	Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site	Conserved Site
W [auth A0]	IPR039732	Ubiquitin-like modifier Hub1/Ubl5	Family
W [auth A0]	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
W [auth A0]	IPR000626	Ubiquitin-like domain	Domain
X [auth 0]	IPR033194	Microfibrillar-associated protein 1	Family
X [auth 0]	IPR009730	Micro-fibrillar-associated protein 1, C-terminal	Domain
Y [auth Z]	IPR024767	Pre-mRNA-splicing factor 38, C-terminal	Domain
Y [auth Z]	IPR005037	Pre-mRNA-splicing factor 38	Family
Z [auth 8]	IPR003604	Matrin/U1-C-like, C2H2-type zinc finger	Domain
Z [auth 8]	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily
Z [auth 8]	IPR040107	U4/U6.U5 small nuclear ribonucleoprotein component Snu23	Family
Z [auth 8]	IPR022755	Zinc finger, double-stranded RNA binding	Domain
AA [auth Y]	IPR019775	WD40 repeat, conserved site	Conserved Site
AA [auth Y]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
AA [auth Y]	IPR006595	CTLH, C-terminal LisH motif	Domain
AA [auth Y]	IPR045184	WD40 repeat-containing protein SMU1	Family
AA [auth Y]	IPR001680	WD40 repeat	Repeat
AA [auth Y]	IPR020472	G-protein beta WD-40 repeat	Repeat
AA [auth Y]	IPR006594	LIS1 homology motif	Conserved Site
AA [auth Y]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
JA [auth o]	IPR001611	Leucine-rich repeat	Repeat
JA [auth o]	IPR003603	U2A'/phosphoprotein 32 family A, C-terminal	Domain
JA [auth o]	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
KA [auth p]	IPR034562	U2 small nuclear ribonucleoprotein B'', RNA recognition motif 2	Domain
KA [auth p]	IPR000504	RNA recognition motif domain	Domain
KA [auth p]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
KA [auth p]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
KA [auth p]	IPR034564	U2 small nuclear ribonucleoprotein B'', RNA recognition motif 1	Domain
LA [auth u]	IPR045146	Splicing factor 3A subunit 1	Family
LA [auth u]	IPR035967	SWAP/Surp superfamily	Homologous Superfamily
LA [auth u]	IPR000061	SWAP/Surp	Domain
LA [auth u]	IPR000626	Ubiquitin-like domain	Domain
LA [auth u]	IPR035563	Splicing factor 3A subunit 1, ubiquitin domain	Domain
LA [auth u]	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
LA [auth u]	IPR022030	Splicing factor 3A subunit 1, conserved domain	Domain
MA [auth v]	IPR031781	SF3A2 domain	Domain
MA [auth v]	IPR003604	Matrin/U1-C-like, C2H2-type zinc finger	Domain
MA [auth v]	IPR013087	Zinc finger C2H2-type	Domain
MA [auth v]	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily
MA [auth v]	IPR000690	Matrin/U1-C, C2H2-type zinc finger	Domain
NA [auth w]	IPR021966	Splicing factor SF3a60 binding domain	Domain
NA [auth w]	IPR031774	SF3A3 domain	Domain
NA [auth w]	IPR024598	Splicing factor SF3a60 /Prp9 subunit, C-terminal	Domain
NA [auth w]	IPR000690	Matrin/U1-C, C2H2-type zinc finger	Domain
NA [auth w]	IPR025086	SDE2-like, C-terminal domain	Domain
OA [auth q]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
OA [auth q]	IPR047575	Sm domain	Domain
OA [auth q]	IPR010920	LSM domain superfamily	Homologous Superfamily
OA [auth q]	IPR016654	U6 snRNA-associated Sm-like protein LSm2	Family
PA [auth r]	IPR040002	U6 snRNA-associated Sm-like protein Lsm3	Family
PA [auth r]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
PA [auth r]	IPR047575	Sm domain	Domain
PA [auth r]	IPR010920	LSM domain superfamily	Homologous Superfamily
PA [auth r]	IPR034105	Sm-like protein Lsm3	Domain
QA [auth s]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
QA [auth s]	IPR027141	Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3	Family
QA [auth s]	IPR047575	Sm domain	Domain
QA [auth s]	IPR034101	Sm-like protein Lsm4	Domain
QA [auth s]	IPR010920	LSM domain superfamily	Homologous Superfamily
RA [auth t]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
RA [auth t]	IPR047575	Sm domain	Domain
RA [auth t]	IPR033871	Sm-like protein LSm5	Domain
RA [auth t]	IPR010920	LSM domain superfamily	Homologous Superfamily
SA [auth x]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
SA [auth x]	IPR047575	Sm domain	Domain
SA [auth x]	IPR016487	Sm-like protein Lsm6/SmF	Family
SA [auth x]	IPR010920	LSM domain superfamily	Homologous Superfamily
TA [auth y]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
TA [auth y]	IPR047575	Sm domain	Domain
TA [auth y]	IPR044641	Sm-like protein Lsm7/SmG	Family
TA [auth y]	IPR010920	LSM domain superfamily	Homologous Superfamily
TA [auth y]	IPR017132	Sm-like protein Lsm7	Family
UA [auth z]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
UA [auth z]	IPR047575	Sm domain	Domain
UA [auth z]	IPR034103	Sm-like protein Lsm8	Domain
UA [auth z]	IPR010920	LSM domain superfamily	Homologous Superfamily
UA [auth z]	IPR044642	U6 snRNA-associated Sm-like protein Lsm1/8	Family
CB [auth K]	IPR019775	WD40 repeat, conserved site	Conserved Site
CB [auth K]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
CB [auth K]	IPR036285	PRP4-like superfamily	Homologous Superfamily
CB [auth K]	IPR014906	Pre-mRNA processing factor 4 (PRP4)-like	Domain
CB [auth K]	IPR001680	WD40 repeat	Repeat
CB [auth K]	IPR020472	G-protein beta WD-40 repeat	Repeat
CB [auth K]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
DB [auth 1]	IPR016024	Armadillo-type fold	Homologous Superfamily
DB [auth 1]	IPR011989	Armadillo-like helical	Homologous Superfamily
DB [auth 1]	IPR015016	Splicing factor 3B subunit 1	Domain
DB [auth 1]	IPR038737	Splicing factor 3B subunit 1-like	Family
EB [auth 3]	IPR018846	Cleavage/polyadenylation specificity factor, A subunit, N-terminal	Domain
EB [auth 3]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
EB [auth 3]	IPR004871	Cleavage/polyadenylation specificity factor, A subunit, C-terminal	Domain
EB [auth 3]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
FB [auth 5]	IPR000504	RNA recognition motif domain	Domain
FB [auth 5]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
FB [auth 5]	IPR034150	SF3B6, RNA recognition motif	Domain
FB [auth 5]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
GB [auth 6]	IPR005345	PHF5-like	Family
HB [auth 7]	IPR017089	Splicing factor 3B, subunit 5	Family
HB [auth 7]	IPR009846	Splicing factor 3B subunit 5/RDS3 complex subunit 10	Family
IB [auth 2]	IPR006568	PSP, proline-rich	Domain
IB [auth 2]	IPR007180	Domain of unknown function DUF382	Domain
IB [auth 2]	IPR003034	SAP domain	Domain
JB [auth 4]	IPR034159	SF3B4, RNA recognition motif 2	Domain
JB [auth 4]	IPR000504	RNA recognition motif domain	Domain
JB [auth 4]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
JB [auth 4]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
JB [auth 4]	IPR034158	SF3B4, RNA recognition motif 1	Domain
KB [auth D]	IPR048863	Pre-mRNA-splicing helicase BRR2-like, plug domain	Domain
KB [auth D]	IPR041094	Brr2, N-terminal helicase PWI domain	Domain
KB [auth D]	IPR004179	Sec63 domain	Domain
KB [auth D]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
KB [auth D]	IPR011545	DEAD/DEAH box helicase domain	Domain
KB [auth D]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
KB [auth D]	IPR001650	Helicase, C-terminal domain-like	Domain
KB [auth D]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
KB [auth D]	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
KB [auth D]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
KB [auth D]	IPR035892	C2 domain superfamily	Homologous Superfamily
F [auth O]	IPR004123	Dim1 family	Family
F [auth O]	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily
G [auth C]	IPR005517	Translation elongation factor EFG/EF2, domain IV	Domain
G [auth C]	IPR000795	Translational (tr)-type GTP-binding domain	Domain
G [auth C]	IPR035647	EF-G domain III/V-like	Homologous Superfamily
G [auth C]	IPR035655	116kDa U5 small nuclear ribonucleoprotein component, C-terminal	Domain
G [auth C]	IPR041095	Elongation Factor G, domain II	Domain
G [auth C]	IPR004161	Translation elongation factor EFTu-like, domain 2	Domain
G [auth C]	IPR009000	Translation protein, beta-barrel domain superfamily	Homologous Superfamily
G [auth C]	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
G [auth C]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
G [auth C]	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup	Homologous Superfamily
G [auth C]	IPR031950	116kDa U5 small nuclear ribonucleoprotein component, N-terminal	Domain
G [auth C]	IPR000640	Elongation factor EFG, domain V-like	Domain
G [auth C]	IPR044121	Snu114, GTP-binding domain	Domain
G [auth C]	IPR005225	Small GTP-binding protein domain	Domain
H [auth N]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
H [auth N]	IPR010491	PRP1 splicing factor, N-terminal	Domain
H [auth N]	IPR003107	HAT (Half-A-TPR) repeat	Repeat
H [auth N]	IPR045075	Pre-mRNA-splicing factor Syf1-like	Family
H [auth N]	IPR019734	Tetratricopeptide repeat	Repeat
I [auth M]	IPR002415	H/ACA ribonucleoprotein complex, subunit Nhp2-like	Family
I [auth M]	IPR029064	Ribosomal protein eL30-like superfamily	Homologous Superfamily
I [auth M]	IPR018492	Ribosomal protein eL8/Nhp2 family	Family
I [auth M]	IPR004038	Ribosomal protein eL8/eL30/eS12/Gadd45	Domain
I [auth M]	IPR004037	Large ribosomal subunit protein eL8-like, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q6P2Q9	retinitis pigmentosa retinitis pigmentosa 13 HIV infectious disease Acute Cerebrovascular Accidents brain aneurysm cone-rod dystrophy malignant ependymoma pancreatic ductal adenocarcinoma acute myeloid leukemia diabetes mellitus oligodendroglioma retinal degeneration astrocytic tumor cerebrovascular disorder glioblastoma retinitis pigmentosa retinitis pigmentosa 13 HIV infectious disease Acute Cerebrovascular Accidents brain aneurysm cone-rod dystrophy malignant ependymoma pancreatic ductal adenocarcinoma acute myeloid leukemia diabetes mellitus oligodendroglioma retinal degeneration astrocytic tumor cerebrovascular disorder glioblastoma Hodgkins lymphoma ovarian cancer
J [auth L]	Pharos: Q8WWY3	retinitis pigmentosa retinitis pigmentosa 11 alcoholic liver cirrhosis malignant ependymoma ovarian cancer cone-rod dystrophy medulloblastoma psoriasis Gaucher disease night blindness retinal degeneration Takayasu arteritis
K [auth 9]	Pharos: O43290	acute myeloid leukemia Crohn disease inflammatory bowel disease ovarian cancer Sjogren syndrome astrocytic tumor diabetes mellitus malignant mesothelioma plasma cell myeloma skin basal cell carcinoma congestive heart failure glioblastoma osteosarcoma primary cutaneous T-cell non-Hodgkin lymphoma
L [auth J]	Pharos: O43395	retinitis pigmentosa retinitis pigmentosa 18 anorexia nervosa dermatomyositis oligodendroglioma ovarian cancer plasma cell myeloma atopic eczema malignant mesothelioma osteoarthritis pancreatic intraductal papillary-mucinous carcinoma psoriasis cone-rod dystrophy medulloblastoma osteosarcoma retinitis pigmentosa retinitis pigmentosa 18 anorexia nervosa dermatomyositis oligodendroglioma ovarian cancer plasma cell myeloma atopic eczema malignant mesothelioma osteoarthritis pancreatic intraductal papillary-mucinous carcinoma psoriasis cone-rod dystrophy medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia retinal degeneration
BB [auth V], EA [auth j], N [auth b]	Pharos: P62314	acute myeloid leukemia gastric carcinoma medulloblastoma plasma cell myeloma psoriasis atypical teratoid rhabdoid tumor large cell medulloblastoma non-small cell lung carcinoma pneumonia dermatomyositis lung cancer ovarian cancer polycystic ovary syndrome
FA [auth k], O [auth c], VA [auth P]	Pharos: P62316	chronic obstructive pulmonary disease lung cancer ovarian cancer diabetes mellitus lymphoplasmacytic lymphoma plasma cell myeloma heart disease medulloblastoma
IA [auth n], R [auth f], YA [auth S]	Pharos: P62308	Adenocarcinoma of Lung lung adenocarcinoma
CA [auth h], S [auth g], ZA [auth T]	Pharos: P62318	carcinoma Mammary Neoplasms, Experimental HIV infectious disease sarcomatoid carcinoma acne lymphoplasmacytic lymphoma ovarian cancer undifferentiated carcinoma medulloblastoma plasma cell myeloma dermatomyositis lung cancer mammary neoplasms, animal non-alcoholic fatty liver disease
T [auth E]	Pharos: Q96DI7	large cell medulloblastoma medulloblastoma subependymal giant cell astrocytoma lung cancer pituitary cancer malignant mesothelioma primitive neuroectodermal tumor
U [auth X]	Pharos: O75554	astrocytic tumor ductal breast carcinoma in situ invasive ductal breast carcinoma Malignant neoplasm of breast ovarian cancer systemic lupus erythematosus Crohn disease gastric carcinoma large cell medulloblastoma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia dermatomyositis glioblastoma malignant glioma osteosarcoma astrocytic tumor ductal breast carcinoma in situ invasive ductal breast carcinoma Malignant neoplasm of breast ovarian cancer systemic lupus erythematosus Crohn disease gastric carcinoma large cell medulloblastoma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia dermatomyositis glioblastoma malignant glioma osteosarcoma spina bifida
V [auth W]	Pharos: O43447	lung cancer medulloblastoma malignant ependymoma oligodendroglioma malignant mesothelioma ovarian cancer
W [auth A0]	Pharos: Q9BZL1	plasma cell myeloma psoriasis
X [auth 0]	Pharos: P55081	metabolic syndrome X ovarian cancer psoriasis
Y [auth Z]	Pharos: Q8NAV1	non-small cell lung carcinoma tuberculosis osteosarcoma ovarian cancer
Z [auth 8]	Pharos: Q96NC0	atypical teratoid rhabdoid tumor ovarian cancer glioblastoma large cell medulloblastoma
AA [auth Y]	Pharos: Q2TAY7	atypical teratoid rhabdoid tumor medulloblastoma psoriasis glioblastoma osteosarcoma large cell medulloblastoma ovarian cancer
KA [auth p]	Pharos: P08579	breast carcinoma medulloblastoma colorectal cancer lung cancer
LA [auth u]	Pharos: Q15459	astrocytic tumor heart disease oligodendroglioma psoriasis colorectal cancer large cell medulloblastoma osteosarcoma rheumatoid arthritis glioblastoma myopathy ovarian cancer subependymal giant cell astrocytoma
MA [auth v]	Pharos: Q15428	astrocytic tumor glioblastoma medulloblastoma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor large cell medulloblastoma myocardial infarction psoriasis Gaucher disease malignant mesothelioma ovarian cancer
NA [auth w]	Pharos: Q12874	HIV infectious disease astrocytic tumor diabetes mellitus HIV Coinfection ovarian cancer colorectal adenoma Hashimoto thyroiditis colorectal cancer heart disease malignant mesothelioma
OA [auth q]	Pharos: Q9Y333	atypical teratoid rhabdoid tumor chronic obstructive pulmonary disease heart disease lung cancer membranous glomerulonephritis systemic lupus erythematosus autism spectrum disorder diabetes mellitus hepatitis B virus infection lung carcinoma skin basal cell carcinoma vitiligo cervical cancer eosinophilic esophagitis hypertensive disorder atypical teratoid rhabdoid tumor chronic obstructive pulmonary disease heart disease lung cancer membranous glomerulonephritis systemic lupus erythematosus autism spectrum disorder diabetes mellitus hepatitis B virus infection lung carcinoma skin basal cell carcinoma vitiligo cervical cancer eosinophilic esophagitis hypertensive disorder medulloblastoma squamous cell lung carcinoma wet macular degeneration
PA [auth r]	Pharos: P62310	atypical teratoid rhabdoid tumor glioblastoma osteosarcoma breast carcinoma lung cancer ovarian cancer dilated cardiomyopathy medulloblastoma
QA [auth s]	Pharos: Q9Y4Z0	astrocytic tumor DOID:9357 hypertensive disorder lung adenocarcinoma medulloblastoma pancreatic ductal adenocarcinoma systemic lupus erythematosus breast carcinoma gastroesophageal reflux disease hypothyroidism lung cancer osteosarcoma pancreatic intraductal papillary-mucinous carcinoma tuberculosis dermatomyositis astrocytic tumor DOID:9357 hypertensive disorder lung adenocarcinoma medulloblastoma pancreatic ductal adenocarcinoma systemic lupus erythematosus breast carcinoma gastroesophageal reflux disease hypothyroidism lung cancer osteosarcoma pancreatic intraductal papillary-mucinous carcinoma tuberculosis dermatomyositis Hashimoto thyroiditis invasive ductal breast carcinoma malignant pancreatic neoplasm ovarian cancer rheumatoid arthritis
RA [auth t]	Pharos: Q9Y4Y9	polycystic ovary syndrome Sclerocystic Ovaries adenoma glioblastoma malignant ependymoma medulloblastoma ovarian cancer plasma cell myeloma primitive neuroectodermal tumor astrocytic tumor large cell medulloblastoma malignant glioma nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous neoplasm pneumonia polycystic ovary syndrome Sclerocystic Ovaries adenoma glioblastoma malignant ependymoma medulloblastoma ovarian cancer plasma cell myeloma primitive neuroectodermal tumor astrocytic tumor large cell medulloblastoma malignant glioma nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous neoplasm pneumonia psoriasis atypical teratoid rhabdoid tumor lung cancer malignant mesothelioma oligodendroglioma pilocytic astrocytoma
SA [auth x]	Pharos: P62312	acute myeloid leukemia malignant mesothelioma subependymal giant cell astrocytoma
TA [auth y]	Pharos: Q9UK45	diabetes mellitus lymphoplasmacytic lymphoma oligodendroglioma psoriasis glioblastoma medulloblastoma ovarian cancer X-linked mixed deafness with perilymphatic gusher lung cancer myopathy plasma cell myeloma
UA [auth z]	Pharos: O95777	adrenal cortex carcinoma atypical teratoid rhabdoid tumor glioblastoma medulloblastoma ovarian cancer psoriasis astrocytic tumor breast carcinoma lung cancer oligodendroglioma pituitary cancer attention deficit hyperactivity disorder, inattentive type endogenous depression malignant glioma osteosarcoma adrenal cortex carcinoma atypical teratoid rhabdoid tumor glioblastoma medulloblastoma ovarian cancer psoriasis astrocytic tumor breast carcinoma lung cancer oligodendroglioma pituitary cancer attention deficit hyperactivity disorder, inattentive type endogenous depression malignant glioma osteosarcoma primitive neuroectodermal tumor
CB [auth K]	Pharos: O43172	retinitis pigmentosa 70 retinitis pigmentosa substance-related disorder acute myeloid leukemia Drug abuse substance dependence aggressive systemic mastocytosis drug dependence malignant mesothelioma osteosarcoma retinal degeneration substance abuse cone-rod dystrophy mast cell leukemia ovarian cancer
DB [auth 1]	Pharos: O75533	B-cell chronic lymphocytic leukemia uveal melanoma myelodysplastic syndrome malignant mesothelioma prostate cancer ocular melanoma ovarian cancer primitive neuroectodermal tumor Prostatic Neoplasms abdominal aortic aneurysm thoracic aortic aneurysm anorexia nervosa autism spectrum disorder brain aneurysm malignant ependymoma B-cell chronic lymphocytic leukemia uveal melanoma myelodysplastic syndrome malignant mesothelioma prostate cancer ocular melanoma ovarian cancer primitive neuroectodermal tumor Prostatic Neoplasms abdominal aortic aneurysm thoracic aortic aneurysm anorexia nervosa autism spectrum disorder brain aneurysm malignant ependymoma medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma progressive supranuclear palsy psoriasis acute myeloid leukemia astrocytic tumor cancer Gaucher disease large cell medulloblastoma osteosarcoma Pick disease allergic rhinitis atypical teratoid rhabdoid tumor bipolar disorder congenital anemia glioblastoma malignant choroid melanoma
EB [auth 3]	Pharos: Q15393	astrocytic tumor Intractable Eczema lung cancer atopic eczema large cell medulloblastoma malignant colon neoplasm atypical teratoid rhabdoid tumor ovarian cancer
FB [auth 5]	Pharos: Q9Y3B4	breast cancer ovarian cancer endogenous depression medulloblastoma
GB [auth 6]	Pharos: Q7RTV0	allergic rhinitis vitiligo Crohn disease osteosarcoma
HB [auth 7]	Pharos: Q9BWJ5	diabetes mellitus pancreatic ductal adenocarcinoma glioblastoma Sjogren syndrome ovarian cancer
IB [auth 2]	Pharos: Q13435	astrocytic tumor ovarian cancer bipolar I disorder plasma cell myeloma obesity disorder
JB [auth 4]	Pharos: Q15427	Nager acrofacial dysostosis acrofacial dysostosis Rodriguez type breast carcinoma intellectual disability malignant glioma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm astrocytic tumor glioblastoma large cell medulloblastoma malignant mesothelioma ovarian cancer Radial club hand atypical teratoid rhabdoid tumor idiopathic scoliosis Nager acrofacial dysostosis acrofacial dysostosis Rodriguez type breast carcinoma intellectual disability malignant glioma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm astrocytic tumor glioblastoma large cell medulloblastoma malignant mesothelioma ovarian cancer Radial club hand atypical teratoid rhabdoid tumor idiopathic scoliosis malignant ependymoma pancreatic ductal adenocarcinoma
KB [auth D]	Pharos: O75643	retinitis pigmentosa retinitis pigmentosa 33 acute myeloid leukemia cone-rod dystrophy large cell medulloblastoma malignant pancreatic neoplasm osteosarcoma psoriasis astrocytic tumor dermatomyositis lung cancer medulloblastoma ovarian cancer retinal degeneration colorectal cancer retinitis pigmentosa retinitis pigmentosa 33 acute myeloid leukemia cone-rod dystrophy large cell medulloblastoma malignant pancreatic neoplasm osteosarcoma psoriasis astrocytic tumor dermatomyositis lung cancer medulloblastoma ovarian cancer retinal degeneration colorectal cancer diabetes mellitus malignant ependymoma oligodendroglioma primitive neuroectodermal tumor
F [auth O]	Pharos: P83876	Burn-Mckeown syndrome choanal atresia-hearing loss-cardiac defects-craniofacial dysmorphism syndrome astrocytic tumor choanal atresia glioblastoma malignant ependymoma ovarian cancer atypical teratoid rhabdoid tumor intellectual disability malignant glioma plasma cell myeloma diabetes mellitus lung cancer osteosarcoma psoriasis
G [auth C]	Pharos: Q15029	mandibulofacial dysostosis-microcephaly syndrome intellectual disability choanal atresia large cell medulloblastoma Nager acrofacial dysostosis diabetes mellitus ovarian cancer microcephaly Primary microcephaly
H [auth N]	Pharos: O94906	retinitis pigmentosa retinitis pigmentosa 60 cone-rod dystrophy heart disease medulloblastoma ovarian cancer retinal degeneration rheumatoid arthritis Gaucher disease large cell medulloblastoma metabolic syndrome X pituitary cancer glioblastoma malignant ependymoma oligodendroglioma retinitis pigmentosa retinitis pigmentosa 60 cone-rod dystrophy heart disease medulloblastoma ovarian cancer retinal degeneration rheumatoid arthritis Gaucher disease large cell medulloblastoma metabolic syndrome X pituitary cancer glioblastoma malignant ependymoma oligodendroglioma psoriasis
I [auth M]	Pharos: P55769	glioblastoma ovarian cancer lung cancer psoriasis osteosarcoma Sjogren syndrome