Annotations: 6A59

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	zf-C2H2_18	e6a59A3	A: few secondary structure elements	X: beta-beta-alpha zinc fingers	H: beta-beta-alpha zinc fingers (From Topology)	T: beta-beta-alpha zinc fingers	F: zf-C2H2_18	ECOD (1.6)
A	zf-C2H2_17	e6a59A2	A: few secondary structure elements	X: beta-beta-alpha zinc fingers	H: beta-beta-alpha zinc fingers (From Topology)	T: beta-beta-alpha zinc fingers	F: zf-C2H2_17	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Lysine-specific demethylase REF6	sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding catalytic activity, acting on a protein protein demethylase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen histone demethylase activity demethylase activity dioxygenase activity oxidoreductase activity histone H3 demethylase activity histone modifying activity sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding catalytic activity, acting on a protein protein demethylase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen histone demethylase activity demethylase activity dioxygenase activity oxidoreductase activity histone H3 demethylase activity histone modifying activity histone H3K27me2/H3K27me3 demethylase activity catalytic activity 2-oxoglutarate-dependent dioxygenase activity cation binding ion binding metal ion binding small molecule binding	photoperiodism, flowering developmental process response to light stimulus multicellular organismal process regulation of biological process reproductive system development response to stimulus reproductive process biological regulation vegetative to reproductive phase transition of meristem developmental process involved in reproduction multicellular organism development photoperiodism regulation of response to stimulus anatomical structure development photoperiodism, flowering developmental process response to light stimulus multicellular organismal process regulation of biological process reproductive system development response to stimulus reproductive process biological regulation vegetative to reproductive phase transition of meristem developmental process involved in reproduction multicellular organism development photoperiodism regulation of response to stimulus anatomical structure development reproductive structure development post-embryonic development response to radiation response to abiotic stimulus regulation of photoperiodism, flowering system development heat acclimation response to stress response to heat response to temperature stimulus regulation of developmental process positive regulation of biological process post-embryonic root development positive regulation of developmental process regulation of lateral root development regulation of post-embryonic root development lateral root development regulation of multicellular organismal process regulation of root development root development regulation of multicellular organismal development plant organ development regulation of post-embryonic development positive regulation of multicellular organismal process post-embryonic plant organ development positive regulation of post-embryonic development positive regulation of lateral root development root system development response to organic substance response to lipid response to hormone response to brassinosteroid response to chemical response to endogenous stimulus response to oxygen-containing compound response to organic cyclic compound cellular response to stimulus regulation of cellular process signaling cellular response to oxygen-containing compound cell communication sugar mediated signaling pathway cellular response to carbohydrate stimulus cellular response to chemical stimulus response to carbohydrate cellular process cellular response to organic substance signal transduction carbohydrate mediated signaling cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process anatomical structure morphogenesis developmental growth unidimensional cell growth growth cell morphogenesis cell growth developmental growth involved in morphogenesis alcohol catabolic process catabolic process isoprenoid catabolic process oxoacid metabolic process organic hydroxy compound metabolic process alcohol metabolic process apocarotenoid catabolic process organic acid metabolic process organic acid catabolic process abscisic acid metabolic process cellular lipid catabolic process cellular catabolic process apocarotenoid metabolic process monocarboxylic acid catabolic process carboxylic acid catabolic process small molecule metabolic process tertiary alcohol metabolic process sesquiterpenoid catabolic process lipid catabolic process sesquiterpenoid metabolic process carboxylic acid metabolic process primary metabolic process terpenoid catabolic process abscisic acid catabolic process organic hydroxy compound catabolic process cellular lipid metabolic process olefinic compound catabolic process olefinic compound metabolic process monocarboxylic acid metabolic process small molecule catabolic process organic substance catabolic process terpenoid metabolic process isoprenoid metabolic process lipid metabolic process protein localization localization protein localization to chromatin cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to heterochromatin abscisic acid-activated signaling pathway hormone-mediated signaling pathway cellular response to endogenous stimulus cellular response to hormone stimulus cellular response to abscisic acid stimulus response to abscisic acid response to alcohol cellular response to alcohol cellular response to lipid protein-DNA complex organization cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis protein-containing complex organization epigenetic regulation of gene expression response to diterpene regulation of signal transduction intracellular signal transduction regulation of phosphorelay signal transduction system regulation of ethylene-activated signaling pathway regulation of intracellular signal transduction ethylene-activated signaling pathway response to ethylene regulation of signaling phosphorelay signal transduction system cellular response to ethylene stimulus regulation of cell communication response to mechanical stimulus response to external stimulus RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription leaf development shoot system development phyllome development multicellular organismal reproductive process developmental maturation seed dormancy process fruit development seed development release of seed from dormancy exit from dormancy dormancy process seed maturation cellular component biogenesis cellular component assembly protein complex oligomerization protein-containing complex assembly protein homooligomerization systemic acquired resistance biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to biotic stimulus defense response to other organism response to external biotic stimulus	membrane-bounded organelle ATPase complex protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular organelle lumen intracellular organelle SWI/SNF superfamily-type complex non-membrane-bounded organelle INO80-type complex membrane-bounded organelle ATPase complex protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular organelle lumen intracellular organelle SWI/SNF superfamily-type complex non-membrane-bounded organelle INO80-type complex catalytic complex protein-DNA complex chromatin intracellular membrane-bounded organelle cellular anatomical entity Ino80 complex organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013087	Zinc finger C2H2-type	Domain
A	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily
A	IPR003347	JmjC domain	Domain
A	IPR003349	JmjN domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.