5ZYX

Solution NMR structure of K30 peptide in 10 mM dioctanoyl phosphatidylglycerol (D8PG)

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e5zyxA1	A: a+b two layers	X: Alpha-beta plaits	H: Ribosomal protein L10-like (From Topology)	T: Ribosomal protein L10-like	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08614	Autophagy protein 16 (ATG16) (ATG16)	Autophagy protein 16 (ATG16)	-	Coiled-coil

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ARG-TRP-LYS-ARG-HIS-ILE-SER-GLU-GLN-LEU-ARG-ARG-ARG-ASP-ARG-LEU-GLN-ARG-GLN-ALA	protein binding binding enzyme binding GTPase binding protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity identical protein binding	developmental process corpus callosum development multicellular organismal process head development forebrain development animal organ development brain development nervous system development multicellular organism development central nervous system development anatomical structure development telencephalon development system development pallium development developmental process corpus callosum development multicellular organismal process head development forebrain development animal organ development brain development nervous system development multicellular organism development central nervous system development anatomical structure development telencephalon development system development pallium development hippocampus development limbic system development autophagosome assembly catabolic process organelle assembly vacuole organization macroautophagy cellular metabolic process autophagy autophagosome organization cellular component biogenesis cellular component organization cellular catabolic process organelle organization cellular component assembly cellular process metabolic process cellular component organization or biogenesis process utilizing autophagic mechanism protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response xenophagy response to external stimulus response to biotic stimulus defense response to other organism response to stress response to external biotic stimulus microautophagy defense response to symbiont defense response to virus response to virus cellular biosynthetic process RNA metabolic process viral life cycle RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process organic substance metabolic process viral RNA genome replication viral process organic substance biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process negative stranded viral RNA replication viral genome replication biosynthetic process organic cyclic compound biosynthetic process macromolecule metabolic process positive regulation of autophagy regulation of biological process regulation of cellular process biological regulation positive regulation of biological process regulation of cellular metabolic process positive regulation of cellular metabolic process regulation of catabolic process regulation of autophagy positive regulation of catabolic process positive regulation of metabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process regulation of metabolic process positive regulation of cellular process C-terminal protein amino acid modification organonitrogen compound metabolic process lipoprotein biosynthetic process lipoprotein metabolic process organonitrogen compound biosynthetic process protein lipidation macromolecule modification protein metabolic process protein modification process post-translational protein modification C-terminal protein lipidation protein localization to phagophore assembly site	organelle membrane contact site organelle vacuole-isolation membrane contact site cellular anatomical entity membrane-bounded organelle intracellular anatomical structure axoneme ciliary plasm cilium cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection intracellular organelle cell projection organelle membrane contact site organelle vacuole-isolation membrane contact site cellular anatomical entity membrane-bounded organelle intracellular anatomical structure axoneme ciliary plasm cilium cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection intracellular organelle cell projection cytoskeleton intracellular non-membrane-bounded organelle cytoplasm non-membrane-bounded organelle endosome membrane endolysosome membrane intracellular vesicle lytic vacuole endomembrane system bounding membrane of organelle endolysosome vesicle membrane cytoplasmic vesicle vesicle lysosome vacuolar membrane membrane endosome vacuole intracellular membrane-bounded organelle lytic vacuole membrane cytoplasmic vesicle membrane lysosomal membrane organelle membrane cytosol phagophore assembly site membrane phagophore assembly site sperm midpiece 9+2 motile cilium sperm flagellum motile cilium protein-containing complex catalytic complex Atg12-Atg5-Atg16 complex transferase complex autophagosome autophagosome membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR045160	Autophagy-related protein 16	Family
A	IPR019775	WD40 repeat, conserved site	Conserved Site
A	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A	IPR013923	Autophagy-related protein 16 domain	Domain
A	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A	IPR001680	WD40 repeat	Repeat
A	IPR020472	G-protein beta WD-40 repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q676U5	Crohn disease inflammatory bowel disease inflammatory bowel disease 10 ulcerative colitis allergic rhinitis colitis Crohn's colitis ileocolitis intestinal disease osteosarcoma rheumatoid arthritis atopic eczema common variable immunodeficiency Crohn's disease of large bowel nephrolithiasis Crohn disease inflammatory bowel disease inflammatory bowel disease 10 ulcerative colitis allergic rhinitis colitis Crohn's colitis ileocolitis intestinal disease osteosarcoma rheumatoid arthritis atopic eczema common variable immunodeficiency Crohn's disease of large bowel nephrolithiasis Pick disease tuberculosis bowel dysfunction open-angle glaucoma

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Peptides	Alpha-helical peptides	Designed alpha-helical peptides	Basic amphiphilic peptides

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.