5ZR1

Saccharomyces Cerevisiae Origin Recognition Complex Bound to a 72-bp Origin DNA containing ACS and B1 element

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Winged helix DNA-binding domain	8090224	3000034	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	RecA-like P-loop NTPases	8090226	3002019	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21312	e5zr1A2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF21312	ECOD (1.6)
A	PF17872	e5zr1A3	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17872	ECOD (1.6)
A	PF00004	e5zr1A1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
C	PF18137	e5zr1C3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF18137	ECOD (1.6)
C	PF07034	e5zr1C1	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF07034	ECOD (1.6)
C	PF07034	e5zr1C2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF07034	ECOD (1.6)
D	PF14629	e5zr1D1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF14629	ECOD (1.6)
D	PF14629	e5zr1D3	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF14629	ECOD (1.6)
D	F_UNCLASSIFIED	e5zr1D2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF21312	Origin recognition complex subunit 1 C-terminal winged HTH domain (ORC1_wHTH)	Origin recognition complex subunit 1 C-terminal winged HTH domain	This entry represents the C-terminal winged helix-turn-helix domain found in the Origin recognition complex subunit 1 protein [1].	Domain
A	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
B	PF04084	Origin recognition complex subunit 2 (ORC2)	Origin recognition complex subunit 2	-	Family
C	PF18137	Origin recognition complex winged helix C-terminal (ORC_WH_C)	Origin recognition complex winged helix C-terminal	This is the C-terminal winged-helix (WH) DNA-binding domain of the origin recognition complex present in Drosophila melanogaster. The WH domain is responsible for recognizing origin sequences [1].	Domain
D	PF14629	Origin recognition complex (ORC) subunit 4 C-terminus (ORC4_C)	Origin recognition complex (ORC) subunit 4 C-terminus	-	Family
E	PF13191	AAA ATPase domain (AAA_16)	AAA ATPase domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	Domain
E	PF14630	Origin recognition complex (ORC) subunit 5 C-terminus (ORC5_C)	Origin recognition complex (ORC) subunit 5 C-terminus	This entry represents the C-terminus of origin recognition complex subunit 5 [1,2], which consists of a winged helix domain (WHD).	Domain
E	PF21639	ORC5, lid domain (ORC5_lid)	ORC5, lid domain	ORC5 is a component of the origin recognition complex (ORC) that binds origins of replication. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. This is the lid domain, which with the N-terminal RecA-fold ...	ORC5 is a component of the origin recognition complex (ORC) that binds origins of replication. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. This is the lid domain, which with the N-terminal RecA-fold domain, constitutes the well-known AAA+ domain [1].	Domain
F	PF05460	Origin recognition complex subunit 6 (ORC6) (ORC6)	Origin recognition complex subunit 6 (ORC6)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Origin recognition complex subunit 1	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding nucleic acid binding DNA replication origin binding protein-containing complex binding chromatin binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity cation binding metal ion binding nucleosome binding	cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition response to stimulus signaling G2/M transition of mitotic cell cycle negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle cell communication mitotic G2/M transition checkpoint regulation of mitotic cell cycle cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition response to stimulus signaling G2/M transition of mitotic cell cycle negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle cell communication mitotic G2/M transition checkpoint regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle DNA replication checkpoint signaling regulation of cell cycle cell cycle process cell cycle G2/M phase transition regulation of biological process mitotic DNA replication checkpoint signaling negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process biological regulation DNA integrity checkpoint signaling regulation of cell cycle G2/M phase transition negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic cell cycle process negative regulation of cell cycle G2/M phase transition cellular process negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process chromosome organization maintenance of DNA repeat elements cellular component organization maintenance of rDNA organelle organization cellular component organization or biogenesis pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly cellular biosynthetic process negative regulation of cellular metabolic process chromatin organization organic substance biosynthetic process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen pre-replicative complex nuclear pre-replicative complex nuclear origin of replication recognition complex nuclear chromosome chromosome origin recognition complex intracellular non-membrane-bounded organelle non-membrane-bounded organelle
B	Origin recognition complex subunit 2	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein-containing complex binding chromatin binding	DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process subtelomeric heterochromatin formation regulation of cellular process cellular biosynthetic process DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process subtelomeric heterochromatin formation regulation of cellular process cellular biosynthetic process negative regulation of biological process telomere organization negative regulation of cellular metabolic process cellular component organization protein-DNA complex organization chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation chromosome organization regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organelle organization negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process cellular process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication cellular component biogenesis cellular component assembly protein-containing complex assembly cell cycle cell cycle process pre-replicative complex assembly involved in nuclear cell cycle DNA replication pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly silent mating-type cassette heterochromatin formation	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region chromosomal region non-membrane-bounded organelle pre-replicative complex nuclear pre-replicative complex nuclear origin of replication recognition complex nuclear chromosome origin recognition complex
C	Origin recognition complex subunit 3	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein-containing complex binding chromatin binding	DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cell cycle cellular component organization or biogenesis cell cycle process pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly cellular process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen pre-replicative complex nuclear pre-replicative complex nuclear origin of replication recognition complex nuclear chromosome chromosome origin recognition complex intracellular non-membrane-bounded organelle non-membrane-bounded organelle
D	Origin recognition complex subunit 4	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding	pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication nucleobase-containing compound metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization organic substance metabolic process cellular component assembly protein-containing complex assembly cell cycle cellular component organization or biogenesis cell cycle process pre-replicative complex assembly involved in nuclear cell cycle DNA replication pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication nucleobase-containing compound metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization organic substance metabolic process cellular component assembly protein-containing complex assembly cell cycle cellular component organization or biogenesis cell cycle process pre-replicative complex assembly involved in nuclear cell cycle DNA replication DNA-templated DNA replication protein-containing complex organization primary metabolic process pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly DNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process DNA replication metabolic process cellular process macromolecule metabolic process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process DNA replication initiation	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen pre-replicative complex nuclear pre-replicative complex nuclear origin of replication recognition complex nuclear chromosome chromosome origin recognition complex intracellular non-membrane-bounded organelle non-membrane-bounded organelle
E	Origin recognition complex subunit 5	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding nucleic acid binding DNA replication origin binding	DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process regulation of biological process biological regulation regulation of macromolecule metabolic process DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process regulation of biological process biological regulation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cell cycle cellular component organization or biogenesis cell cycle process pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly cellular process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen pre-replicative complex nuclear pre-replicative complex Cul8-RING ubiquitin ligase complex cullin-RING ubiquitin ligase complex ubiquitin ligase complex catalytic complex transferase complex intracellular protein-containing complex nuclear origin of replication recognition complex nuclear chromosome chromosome origin recognition complex intracellular non-membrane-bounded organelle non-membrane-bounded organelle
F	Origin recognition complex subunit 6	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding	pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication nucleobase-containing compound metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization organic substance metabolic process cellular component assembly protein-containing complex assembly cell cycle cellular component organization or biogenesis cell cycle process pre-replicative complex assembly involved in nuclear cell cycle DNA replication pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication nucleobase-containing compound metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization organic substance metabolic process cellular component assembly protein-containing complex assembly cell cycle cellular component organization or biogenesis cell cycle process pre-replicative complex assembly involved in nuclear cell cycle DNA replication DNA-templated DNA replication protein-containing complex organization primary metabolic process pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly DNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process DNA replication metabolic process cellular process macromolecule metabolic process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process DNA replication initiation	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen pre-replicative complex nuclear pre-replicative complex nuclear origin of replication recognition complex nuclear chromosome chromosome origin recognition complex intracellular non-membrane-bounded organelle non-membrane-bounded organelle
G	72bp-oring DNA, ACS305, T-rich	-	-	-
H	72bp-oring DNA, ACS305, A-rich	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR041083	AAA lid domain	Domain
A	IPR043151	Bromo adjacent homology (BAH) domain superfamily	Homologous Superfamily
A	IPR048867	Origin recognition complex subunit 1, C-terminal winged HTH domain	Domain
A	IPR001025	Bromo adjacent homology (BAH) domain	Domain
A	IPR003593	AAA+ ATPase domain	Domain
A	IPR003959	ATPase, AAA-type, core	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B	IPR007220	Origin recognition complex, subunit 2	Family
C	IPR020795	Origin recognition complex, subunit 3	Family
C	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
C	IPR040855	Origin recognition complex subunit 3, winged helix C-terminal	Domain
D	IPR032705	Origin recognition complex subunit 4, C-terminal	Domain
D	IPR016527	Origin recognition complex subunit 4	Family
D	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
E	IPR048866	ORC5, lid domain	Domain
E	IPR047088	Origin recognition complex subunit 5, C-terminal	Domain
E	IPR041664	Orc1-like, AAA ATPase domain	Domain
E	IPR020796	Origin recognition complex, subunit 5	Family
E	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
F	IPR016811	Origin recognition complex, subunit 6, fungi	Family
F	IPR008721	Origin recognition complex, subunit 6	Family