Annotations: 5Z5M

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF00576	e5z5mB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: PF00576	ECOD (1.6)
B	PF09349	e5z5mB1	A: alpha arrays	X: UraD-like (From Topology)	H: UraD-like (From Topology)	T: UraD-like	F: PF09349	ECOD (1.6)
C	PF00576	e5z5mC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: PF00576	ECOD (1.6)
C	PF09349	e5z5mC1	A: alpha arrays	X: UraD-like (From Topology)	H: UraD-like (From Topology)	T: UraD-like	F: PF09349	ECOD (1.6)
D	PF00576	e5z5mD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: PF00576	ECOD (1.6)
D	PF09349	e5z5mD1	A: alpha arrays	X: UraD-like (From Topology)	H: UraD-like (From Topology)	T: UraD-like	F: PF09349	ECOD (1.6)
A	PF00576	e5z5mA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: PF00576	ECOD (1.6)
A	PF09349	e5z5mA2	A: alpha arrays	X: UraD-like (From Topology)	H: UraD-like (From Topology)	T: UraD-like	F: PF09349	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.3330.10	Mainly Alpha	Orthogonal Bundle	UraD-like	Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	CATH (utative)
B	2.60.40.180	Mainly Beta	Sandwich	Immunoglobulin-like	Transthyretin/hydroxyisourate hydrolase domain	CATH (utative)
C	1.10.3330.10	Mainly Alpha	Orthogonal Bundle	UraD-like	Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	CATH (utative)
C	2.60.40.180	Mainly Beta	Sandwich	Immunoglobulin-like	Transthyretin/hydroxyisourate hydrolase domain	CATH (utative)
D	1.10.3330.10	Mainly Alpha	Orthogonal Bundle	UraD-like	Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	CATH (utative)
D	2.60.40.180	Mainly Beta	Sandwich	Immunoglobulin-like	Transthyretin/hydroxyisourate hydrolase domain	CATH (utative)
A	1.10.3330.10	Mainly Alpha	Orthogonal Bundle	UraD-like	Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	CATH (utative)
A	2.60.40.180	Mainly Beta	Sandwich	Immunoglobulin-like	Transthyretin/hydroxyisourate hydrolase domain	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF09349	OHCU decarboxylase (OHCU_decarbox)	OHCU decarboxylase	The proteins in this family are OHCU decarboxylase - enzymes of the purine catabolism that catalyse the conversion of OHCU into S(+)-allantoin [1]. This is the third step of the conversion of uric acid (a purine derivative) to allantoin. Step one is ...	The proteins in this family are OHCU decarboxylase - enzymes of the purine catabolism that catalyse the conversion of OHCU into S(+)-allantoin [1]. This is the third step of the conversion of uric acid (a purine derivative) to allantoin. Step one is catalysed by urate oxidase (Pfam:PF01014) and step two is catalysed by HIUases (Pfam:PF00576).	Domain
A, B, C, D	PF00576	HIUase/Transthyretin family (Transthyretin)	HIUase/Transthyretin family	This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of ...	This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyse the conversion of 5-hydroxyisourate (HIU) to OHCU [2,3]. HIU hydrolysis is the original function of the family and is conserved from bacteria to mammals; transthyretins arose by gene duplications in the vertebrate lineage [4]. HIUases are distinguished in the alignment from the conserved C-terminal YRGS sequence.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Predicted protein	hydrolase activity hydroxyisourate hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity carboxy-lyase activity lyase activity carbon-carbon lyase activity	organonitrogen compound metabolic process purine nucleobase metabolic process primary metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process nucleobase-containing small molecule metabolic process nucleobase metabolic process small molecule metabolic process metabolic process organonitrogen compound catabolic process catabolic process purine-containing compound catabolic process organonitrogen compound metabolic process purine nucleobase metabolic process primary metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process nucleobase-containing small molecule metabolic process nucleobase metabolic process small molecule metabolic process metabolic process organonitrogen compound catabolic process catabolic process purine-containing compound catabolic process organic cyclic compound catabolic process urate metabolic process urate catabolic process small molecule catabolic process organic substance catabolic process allantoin metabolic process amide metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR036817	Transthyretin/hydroxyisourate hydrolase domain superfamily	Homologous Superfamily
A, B, C, D	IPR023418	Transthyretin, thyroxine binding site	Binding Site
A, B, C, D	IPR023419	Transthyretin, conserved site	Conserved Site
A, B, C, D	IPR014306	Hydroxyisourate hydrolase	Family
A, B, C, D	IPR023416	Transthyretin/hydroxyisourate hydrolase domain	Domain
A, B, C, D	IPR036778	Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase superfamily	Homologous Superfamily
A, B, C, D	IPR017580	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase, type 1	Domain
A, B, C, D	IPR018020	Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.