5Z57

Cryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstrom

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	JAB1/MPN domain-like	8053277	3001105	SCOP2B (2022-06-29)
J [auth f]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063452	3000419	SCOP2B (2022-06-29)
T [auth m]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063452	3000419	SCOP2B (2022-06-29)
K [auth e]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063476	3000419	SCOP2B (2022-06-29)
U [auth l]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063476	3000419	SCOP2B (2022-06-29)
L [auth g]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063468	3000419	SCOP2B (2022-06-29)
V [auth n]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063468	3000419	SCOP2B (2022-06-29)
W [auth o]	SCOP2B Superfamily	L domain-like	8043993	3001010	SCOP2B (2022-06-29)
X [auth p]	SCOP2B Superfamily	RNA-binding domain RBD	8035327	3000110	SCOP2B (2022-06-29)
DA [auth 3]	SCOP2B Superfamily	WD40 repeat-like	8051197	3001694	SCOP2B (2022-06-29)
DA [auth 3]	SCOP2B Superfamily	WD40 repeat-like	8052534	3001694	SCOP2B (2022-06-29)
DA [auth 3]	SCOP2B Superfamily	WD40 repeat-like	8052534	3001694	SCOP2B (2022-06-29)
DA [auth 3]	SCOP2B Superfamily	WD40 repeat-like	8052535	3001694	SCOP2B (2022-06-29)
EA [auth 4]	SCOP2B Superfamily	RNA-binding domain RBD	8090834	3000110	SCOP2B (2022-06-29)
FA [auth 5]	SCOP2B Superfamily	RNA-binding domain RBD	8040695	3000110	SCOP2B (2022-06-29)
GA [auth 6]	SCOP2B Superfamily	Triquetra zinc finger motif	8051848	3002040	SCOP2B (2022-06-29)
JA [auth L]	SCOP2B Superfamily	Homeodomain-like	8089608	3000001	SCOP2B (2022-06-29)
QA [auth Q]	SCOP2B Superfamily	ARM repeat-like	8090869	3000116	SCOP2B (2022-06-29)
QA [auth Q]	SCOP2B Superfamily	RecA-like P-loop NTPases	8090872	3002019	SCOP2B (2022-06-29)
QA [auth Q]	SCOP2B Superfamily	RecA-like P-loop NTPases	8090871	3002019	SCOP2B (2022-06-29)
QA [auth Q]	SCOP2B Superfamily	Upf1 beta-barrel domain-like	8090870	3002168	SCOP2B (2022-06-29)
SA [auth O]	SCOP2B Superfamily	RNA-binding domain RBD	8064957	3000110	SCOP2B (2022-06-29)
VA [auth S]	SCOP2B Superfamily	Cyclophilin-like	8033930	3000168	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Brl domain-like	8036193	3000115	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	E set domains	8055093	3000070	SCOP2B (2022-06-29)
BB [auth Y]	SCOP2B Superfamily	RNA-binding domain RBD	8061967	3000110	SCOP2B (2022-06-29)
EB [auth y]	SCOP2B Superfamily	Cyclophilin-like	8035984	3000168	SCOP2B (2022-06-29)
EB [auth y]	SCOP2B Superfamily	RNA-binding domain RBD	8039202	3000110	SCOP2B (2022-06-29)
P [auth h]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041751	3000419	SCOP2B (2022-06-29)
F [auth a]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041751	3000419	SCOP2B (2022-06-29)
G [auth b]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041747	3000419	SCOP2B (2022-06-29)
Q [auth i]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041747	3000419	SCOP2B (2022-06-29)
H [auth c]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041748	3000419	SCOP2B (2022-06-29)
R [auth j]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041748	3000419	SCOP2B (2022-06-29)
I [auth d]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041749	3000419	SCOP2B (2022-06-29)
S [auth k]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041749	3000419	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	U5_2-snRNA_bdg	e5z57A3	A: alpha bundles	X: helical bundle domain in reverse transcriptase-like polymerases (From Topology)	H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)	T: helical bundle domain in reverse transcriptase-like polymerases	F: U5_2-snRNA_bdg	ECOD (1.6)
A	PROCN_C,PROCN_N	e5z57A1	A: alpha complex topology	X: Pre-mRNA-splicing factor 8 N-terminal domain (From Topology)	H: Pre-mRNA-splicing factor 8 N-terminal domain (From Topology)	T: Pre-mRNA-splicing factor 8 N-terminal domain	F: PROCN_C,PROCN_N	ECOD (1.6)
A	RRM_4	e5z57A2	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: RRM_4	ECOD (1.6)
A	PROCT	e5z57A4	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: PROCT	ECOD (1.6)
A	U6-snRNA_bdg	e5z57A5	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: U6-snRNA_bdg	ECOD (1.6)
J [auth f]	LSM	e5z57f1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
T [auth m]	LSM	e5z57m1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
K [auth e]	LSM	e5z57e1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
U [auth l]	LSM	e5z57l1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
L [auth g]	LSM	e5z57g1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
V [auth n]	LSM	e5z57n1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
W [auth o]	LRR_9	e5z57o1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_9	ECOD (1.6)
X [auth p]	RRM_1_1	e5z57p2	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: RRM_1_1	ECOD (1.6)
X [auth p]	RRM_1_2	e5z57p1	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: RRM_1_2	ECOD (1.6)
Y [auth w]	PRP9_N	e5z57w1	A: alpha bundles	X: Pre-mRNA-splicing factor PRP9 (From Topology)	H: Pre-mRNA-splicing factor PRP9 (From Topology)	T: Pre-mRNA-splicing factor PRP9	F: PRP9_N	ECOD (1.6)
Z [auth u]	Surp	e5z57u1	A: alpha bundles	X: Surp module (SWAP domain) (From Topology)	H: Surp module (SWAP domain) (From Topology)	T: Surp module (SWAP domain)	F: Surp	ECOD (1.6)
AA [auth v]	SF3A2	e5z57v1	A: beta sandwiches	X: HSP20-like	H: Pre-mRNA-splicing factor PRP11 C-terminal domain (From Topology)	T: Pre-mRNA-splicing factor PRP11 C-terminal domain	F: SF3A2	ECOD (1.6)
AA [auth v]	zf-met_1	e5z57v2	A: few secondary structure elements	X: beta-beta-alpha zinc fingers	H: beta-beta-alpha zinc fingers (From Topology)	T: beta-beta-alpha zinc fingers	F: zf-met_1	ECOD (1.6)
BA [auth 1]	KOG0213	e5z5711	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: KOG0213	ECOD (1.6)
DA [auth 3]	CPSF_A_N	e5z5732	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: CPSF_A_N	ECOD (1.6)
DA [auth 3]	MMS1_N_C	e5z5734	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: MMS1_N_C	ECOD (1.6)
DA [auth 3]	MMS1_N_N	e5z5731	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: MMS1_N_N	ECOD (1.6)
DA [auth 3]	CPSF_A_C	e5z5733	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: CPSF_A_C	ECOD (1.6)
EA [auth 4]	RRM_1_1	e5z5741	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: RRM_1_1	ECOD (1.6)
FA [auth 5]	RRM_1_2	e5z5751	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: RRM_1_2	ECOD (1.6)
GA [auth 6]	PHF5	e5z5761	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: PHD finger-like domain-containing protein 5A	F: PHF5	ECOD (1.6)
HA [auth 7]	SF3b10	e5z5771	A: alpha arrays	X: RDS3 complex subunit 10 (From Topology)	H: RDS3 complex subunit 10 (From Topology)	T: RDS3 complex subunit 10	F: SF3b10	ECOD (1.6)
IA [auth J]	TPR_11_6	e5z57J1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_6	ECOD (1.6)
PA [auth I]	TPR_15	e5z57I1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_15	ECOD (1.6)
QA [auth Q]	Aquarius_N_2nd	e5z57Q5	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: Aquarius_N_2nd	ECOD (1.6)
QA [auth Q]	Aquarius_N_1st	e5z57Q4	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Aquarius_N_1st	ECOD (1.6)
QA [auth Q]	Aquarius_N_3rd	e5z57Q2	A: a+b two layers	X: Spliceosomal helicase Aquarius insert domain (From Topology)	H: Spliceosomal helicase Aquarius insert domain (From Topology)	T: Spliceosomal helicase Aquarius insert domain	F: Aquarius_N_3rd	ECOD (1.6)
QA [auth Q]	AAA_11_1	e5z57Q1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: AAA_11_1	ECOD (1.6)
QA [auth Q]	AAA_12	e5z57Q3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: AAA_12	ECOD (1.6)
RA [auth N]	G10	e5z57N1	A: few secondary structure elements	X: Pre-mRNA-splicing factor BUD31 (From Topology)	H: Pre-mRNA-splicing factor BUD31 (From Topology)	T: Pre-mRNA-splicing factor BUD31	F: G10	ECOD (1.6)
SA [auth O]	RRM_1_6	e5z57O1	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: RRM_1_6	ECOD (1.6)
SA [auth O]	KOG0153	e5z57O2	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: FYVE/PHD zinc finger	F: KOG0153	ECOD (1.6)
SA [auth O]	Torus	e5z57O3	A: few secondary structure elements	X: CCCH zinc finger	H: CCCH zinc finger (From Topology)	T: CCCH zinc finger	F: Torus	ECOD (1.6)
VA [auth S]	Pro_isomerase	e5z57S1	A: beta barrels	X: Cyclophilin-like (From Topology)	H: Cyclophilin-like (From Topology)	T: Cyclophilin-like	F: Pro_isomerase	ECOD (1.6)
WA [auth T]	ANAPC4_WD40_1	e5z57T1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_1	ECOD (1.6)
D	Sec63_3rd	e5z57D12	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Sec63_3rd	ECOD (1.6)
D	KOG0952	e5z57D6	A: alpha arrays	X: HTH	H: HTH	T: winged	F: KOG0952	ECOD (1.6)
D	Sec63_2nd_1	e5z57D8	A: alpha arrays	X: HhH/H2TH	H: SAM-like subdomain in Sec63-like proteins (From Topology)	T: SAM-like subdomain in Sec63-like proteins	F: Sec63_2nd_1	ECOD (1.6)
D	Sec63_2nd	e5z57D2	A: alpha arrays	X: HhH/H2TH	H: SAM-like subdomain in Sec63-like proteins (From Topology)	T: SAM-like subdomain in Sec63-like proteins	F: Sec63_2nd	ECOD (1.6)
D	Sec63_1st	e5z57D11	A: alpha arrays	X: Sec63 N-terminal subdomain-like (From Topology)	H: Sec63 N-terminal subdomain-like (From Topology)	T: Sec63 N-terminal subdomain-like	F: Sec63_1st	ECOD (1.6)
D	DEAD_1	e5z57D5	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: DEAD_1	ECOD (1.6)
D	Helicase_C_5	e5z57D1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Helicase_C_5	ECOD (1.6)
D	DEAD_1,KOG0951_2nd	e5z57D4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: DEAD_1,KOG0951_2nd	ECOD (1.6)
YA [auth V]	MIF4G	e5z57V2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: MIF4G	ECOD (1.6)
YA [auth V]	MA3	e5z57V1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: MA3	ECOD (1.6)
AB [auth X]	FHA	e5z57X1	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: FHA	ECOD (1.6)
BB [auth Y]	RRM_1_4	e5z57Y1	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: RRM_1_4	ECOD (1.6)
DB [auth x]	OB_NTP_bind	e5z57x3	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: OB_NTP_bind	ECOD (1.6)
DB [auth x]	HA2_N,HA2_C	e5z57x1	A: alpha arrays	X: Sec63 N-terminal subdomain-like (From Topology)	H: Sec63 N-terminal subdomain-like (From Topology)	T: Sec63 N-terminal subdomain-like	F: HA2_N,HA2_C	ECOD (1.6)
DB [auth x]	Helicase_C_7	e5z57x2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Helicase_C_7	ECOD (1.6)
DB [auth x]	DEAD_3	e5z57x4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: DEAD_3	ECOD (1.6)
EB [auth y]	Pro_isomerase	e5z57y1	A: beta barrels	X: Cyclophilin-like (From Topology)	H: Cyclophilin-like (From Topology)	T: Cyclophilin-like	F: Pro_isomerase	ECOD (1.6)
EB [auth y]	RRM_1_1	e5z57y2	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: RRM_1_1	ECOD (1.6)
E	ANAPC4_WD40_7	e5z57E1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_7	ECOD (1.6)
P [auth h]	LSM	e5z57h1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
F [auth a]	LSM	e5z57a1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
G [auth b]	LSM	e5z57b1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
Q [auth i]	LSM	e5z57i1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
H [auth c]	LSM	e5z57c1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
R [auth j]	LSM	e5z57j1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
I [auth d]	LSM	e5z57d1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)
S [auth k]	LSM	e5z57k1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF10597	U5-snRNA binding site 2 of PrP8 (U5_2-snRNA_bdg)	U5-snRNA binding site 2 of PrP8	The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis [1]. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that ...	The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis [1]. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor [2].	Domain
A	PF10598	RNA recognition motif of the spliceosomal PrP8 (RRM_4)	RNA recognition motif of the spliceosomal PrP8	The large RNA-protein complex of the spliceosome catalyses pre-mRNA splicing. One of the most conserved core proteins is PrP8 which occupies a central position in the catalytic core of the spliceosome, and has been implicated in several crucial molec ...	The large RNA-protein complex of the spliceosome catalyses pre-mRNA splicing. One of the most conserved core proteins is PrP8 which occupies a central position in the catalytic core of the spliceosome, and has been implicated in several crucial molecular rearrangements that occur there, and has recently come under the spotlight for its role in the inherited human disease, Retinitis Pigmentosa [1]. The RNA-recognition motif of PrP8 is highly conserved and provides a possible RNA binding centre for the 5-prime SS, BP, or 3-prime SS of pre-mRNA which are known to contact with Prp8. The most conserved regions of an RRM are defined as the RNP1 and RNP2 sequences. Recognition of RNA targets can also be modulated by a number of other factors, most notably the two loops beta1-alpha1, beta2-beta3 and the amino acid residues C-terminal to the RNP2 domain [2].	Domain
A	PF10596	U6-snRNA interacting domain of PrP8 (U6-snRNA_bdg)	U6-snRNA interacting domain of PrP8	This domain incorporates the interacting site for the U6-snRNA as part of the U4/U6.U5 tri-snRNPs complex of the spliceosome, and is the prime candidate for the role of cofactor for the spliceosome's RNA core. The essential spliceosomal protein Prp8 ...	This domain incorporates the interacting site for the U6-snRNA as part of the U4/U6.U5 tri-snRNPs complex of the spliceosome, and is the prime candidate for the role of cofactor for the spliceosome's RNA core. The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor [1].	Domain
A	PF08082	PRO8NT (NUC069), PrP8 N-terminal domain (PRO8NT)	PRO8NT (NUC069), PrP8 N-terminal domain	The PRO8NT domain is found at the N-terminus of pre-mRNA splicing factors of PRO8 family [1]. The NLS or nuclear localisation signal for these spliceosome proteins begins at the start and runs for 60 residues. N-terminal to this domain is a highly va ...	The PRO8NT domain is found at the N-terminus of pre-mRNA splicing factors of PRO8 family [1]. The NLS or nuclear localisation signal for these spliceosome proteins begins at the start and runs for 60 residues. N-terminal to this domain is a highly variable proline-rich region [4].	Domain
A	PF08083	PROCN (NUC071) domain (PROCN)	PROCN (NUC071) domain	The PROCN domain is the central domain in pre-mRNA splicing factors of PRO8 family [1].	Domain
A	PF01398	JAB1/Mov34/MPN/PAD-1 ubiquitin protease (JAB)	JAB1/Mov34/MPN/PAD-1 ubiquitin protease	-	Family
A	PF08084	PROCT (NUC072) domain (PROCT)	PROCT (NUC072) domain	The PROCT domain is the C-terminal domain in pre-mRNA splicing factors of PRO8 family [1].	Domain
J [auth f], T [auth m]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
K [auth e], U [auth l]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
L [auth g], V [auth n]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
W [auth o]	PF14580	Leucine-rich repeat (LRR_9)	Leucine-rich repeat	-	Repeat
X [auth p]	PF00076	RNA recognition motif (RRM_1)	RNA recognition motif	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ...	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	Domain
Y [auth w]	PF16837	Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 (SF3A3)	Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9	SF3A3 is one of the components of the SF3a splicing factor complex of the mature U2 snRNP (small nuclear ribonucleoprotein particle). In yeast, SF3a shows a bifurcated assembly structure of three subunits, Prp9 (subunit 3), Prp11 (subunit 2) and Prp2 ...	SF3A3 is one of the components of the SF3a splicing factor complex of the mature U2 snRNP (small nuclear ribonucleoprotein particle). In yeast, SF3a shows a bifurcated assembly structure of three subunits, Prp9 (subunit 3), Prp11 (subunit 2) and Prp21 (subunit 1). Prp9 and Prp21 were not thought to interact with each other but the alpha1 helix of Prp9 does make important contacts with the SURP2 domain of Prp21, thus the two do interact via a bidentate-binding mode. Prp9 harbours a major binding site for stem-loop IIa of U2 snRNA [1].	Domain
Y [auth w]	PF13297	Replication stress response SDE2 C-terminal (SDE2_2C)	Replication stress response SDE2 C-terminal	This domain represents the C-terminal region of the Replication stress response SDE2, a genome surveillance factor. It contains the DNA-binding SAP domain, frequently found in proteins involved in DNA repair. SDE2 C-terminal domain must be cleaved fr ...	This domain represents the C-terminal region of the Replication stress response SDE2, a genome surveillance factor. It contains the DNA-binding SAP domain, frequently found in proteins involved in DNA repair. SDE2 C-terminal domain must be cleaved from its N-terminal at a diglycine motif within the ubiquitin-like fold, after Proliferating cell nuclear antigen (PCNA) interaction. This generates a functional protein that negatively regulates damage-inducible PCNA monoubiquitination, which then is proteolytically degraded to allow S phase progression and replication fork recovery in response to DNA damage [1].	Domain
Z [auth u]	PF01805	Surp module (Surp)	Surp module	-	Family
AA [auth v]	PF12874	Zinc-finger of C2H2 type (zf-met)	Zinc-finger of C2H2 type	This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.	Domain
CA [auth 2]	PF04037	Domain of unknown function (DUF382) (DUF382)	Domain of unknown function (DUF382)	-	Family
CA [auth 2]	PF04046	PSP (PSP)	PSP	-	Family
DA [auth 3]	PF10433	Mono-functional DNA-alkylating methyl methanesulfonate N-term (MMS1_N)	Mono-functional DNA-alkylating methyl methanesulfonate N-term	-	Repeat
DA [auth 3]	PF03178	CPSF A subunit region (CPSF_A)	CPSF A subunit region	-	Repeat
EA [auth 4]	PF00076	RNA recognition motif (RRM_1)	RNA recognition motif	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ...	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	Domain
FA [auth 5]	PF00076	RNA recognition motif (RRM_1)	RNA recognition motif	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ...	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	Domain
GA [auth 6]	PF03660	PHF5-like protein (PHF5)	PHF5-like protein	-	Family
HA [auth 7]	PF07189	Splicing factor 3B subunit 10 (SF3b10) (SF3b10)	Splicing factor 3B subunit 10 (SF3b10)	-	Family
IA [auth J]	PF02184	HAT (Half-A-TPR) repeat (HAT)	HAT (Half-A-TPR) repeat	-	Repeat
JA [auth L]	PF13921	Myb-like DNA-binding domain (Myb_DNA-bind_6)	Myb-like DNA-binding domain	This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family [1].	Domain
C	PF00679	Elongation factor G C-terminus (EFG_C)	Elongation factor G C-terminus	This domain includes the carboxyl terminal regions of Elongation factor G, elongation factor 2 and some tetracycline resistance proteins and adopt a ferredoxin-like fold.	Domain
C	PF00009	Elongation factor Tu GTP binding domain (GTP_EFTU)	Elongation factor Tu GTP binding domain	This domain contains a P-loop motif, also found in several other families such as Pfam:PF00071, Pfam:PF00025 and Pfam:PF00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.	Domain
C	PF14492	Elongation Factor G, domain III (EFG_III)	Elongation Factor G, domain III	This domain is found in Elongation Factor G. It shares a similar structure with domain V (Pfam:PF00679). Structural studies in drosophila indicate this is domain 3 [1].	Domain
C	PF03144	Elongation factor Tu domain 2 (GTP_EFTU_D2)	Elongation factor Tu domain 2	Elongation factor Tu consists of three structural domains, this is the second domain. This domain adopts a beta barrel structure. This the second domain is involved in binding to charged tRNA [1]. This domain is also found in other proteins such as e ...	Elongation factor Tu consists of three structural domains, this is the second domain. This domain adopts a beta barrel structure. This the second domain is involved in binding to charged tRNA [1]. This domain is also found in other proteins such as elongation factor G and translation initiation factor IF-2. This domain is structurally related to Pfam:PF03143, and in fact has weak sequence matches to this domain.	Domain
C	PF03764	Elongation factor G, domain IV (EFG_IV)	Elongation factor G, domain IV	This domain is found in elongation factor G, elongation factor 2 and some tetracycline resistance proteins and adopts a ribosomal protein S5 domain 2-like fold.	Domain
KA [auth q], LA [auth r], MA [auth s], NA [auth t]	PF08606	Prp19/Pso4-like (Prp19)	Prp19/Pso4-like	This regions is found specifically in PRP19-like protein. The region represented by this family covers the sequence implicated in self-interaction and a coiled-coiled motif [1]. PRP19-like proteins form an oligomer that is necessary ...	This regions is found specifically in PRP19-like protein. The region represented by this family covers the sequence implicated in self-interaction and a coiled-coiled motif [1]. PRP19-like proteins form an oligomer that is necessary for spliceosome assembly [1].	Domain
KA [auth q], LA [auth r], MA [auth s], NA [auth t]	PF04564	U-box domain (U-box)	U-box domain	The U-box is a domain of ~70 amino acids that is present in proteins from yeast to human. It consists of the beta-beta-alpha-beta-alpha- fold typical of U-box and RING domains. The central alpha helix is flanked by two prominent surface-exposed loop ...	The U-box is a domain of ~70 amino acids that is present in proteins from yeast to human. It consists of the beta-beta-alpha-beta-alpha- fold typical of U-box and RING domains. The central alpha helix is flanked by two prominent surface-exposed loop regions. This domain is one class of E3 ligases, involved in the ubiquitination process [1-3]. This domain is related to the Ring finger Pfam:PF00097 but lacks the zinc binding residues [4].	Domain
OA [auth K]	PF05700	Breast carcinoma amplified sequence 2 (BCAS2) (BCAS2)	Breast carcinoma amplified sequence 2 (BCAS2)	-	Family
PA [auth I]	PF13181	Tetratricopeptide repeat (TPR_8)	Tetratricopeptide repeat	-	Repeat
QA [auth Q]	PF21144	Intron-binding protein aquarius insert domain (Aquarius_N_3rd)	Intron-binding protein aquarius insert domain	This entry represents the insert domain of intron-binding protein aquarius, a splicing factor which links excision of introns from pre-mRNA with snoRP assembly [1,2].	Domain
QA [auth Q]	PF13086	AAA domain (AAA_11)	AAA domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.	Domain
QA [auth Q]	PF21143	Intron-binding protein aquarius, beta-barrel (Aquarius_N_2nd)	Intron-binding protein aquarius, beta-barrel	This entry represents the beta-barrel domain found at the N-terminal of intron-binding protein aquarius, a splicing factor which links excision of introns from pre-mRNA with snoRP assembly [1,2].	Domain
QA [auth Q]	PF13087	AAA domain (AAA_12)	AAA domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.	Domain
QA [auth Q]	PF16399	Intron-binding protein aquarius N-terminal (Aquarius_N_1st)	Intron-binding protein aquarius N-terminal	-	Repeat
RA [auth N]	PF01125	Pre-mRNA-splicing factor BUD31 (BUD31)	Pre-mRNA-splicing factor BUD31	This entry includes Pre-mRNA-splicing factor BUD31, also known as G10 protein, and its homologues. BUD31 is involved in the pre-mRNA splicing process [1-3] and it is highly conserved in a wide range of eukaryotic species. Human BUD31 may play a role ...	This entry includes Pre-mRNA-splicing factor BUD31, also known as G10 protein, and its homologues. BUD31 is involved in the pre-mRNA splicing process [1-3] and it is highly conserved in a wide range of eukaryotic species. Human BUD31 may play a role as a regulator of androgen receptor (AR) transcriptional activity, probably increasing the AR transcriptional activity [4].	Domain
SA [auth O]	PF00076	RNA recognition motif (RRM_1)	RNA recognition motif	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ...	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	Domain
SA [auth O]	PF21369	STL11, N-terminal (STL11_N)	STL11, N-terminal	This entry represents the N-terminal domain of STL11 from yeast and its homologues [1-4], such as RBM22 from human. This domain comprises a zinc finger, FYVE/PHD type. Members of this entry are involved in pre-mRNA splicing.	Domain
TA [auth P]	PF04889	Cwf15/Cwc15 cell cycle control protein (Cwf_Cwc_15)	Cwf15/Cwc15 cell cycle control protein	-	Family
VA [auth S]	PF00160	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (Pro_isomerase)	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerisation during which the peptide bond pr ...	The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilised in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function [1].	Domain
WA [auth T]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
D	PF02889	Sec63 Brl domain (Sec63)	Sec63 Brl domain	-	Family
D	PF00270	DEAD/DEAH box helicase (DEAD)	DEAD/DEAH box helicase	Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome ...	Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.	Domain
D	PF00271	Helicase conserved C-terminal domain (Helicase_C)	Helicase conserved C-terminal domain	The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.	Domain
YA [auth V]	PF02854	MIF4G domain (MIF4G)	MIF4G domain	-	Repeat
ZA [auth W]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
BB [auth Y]	PF00076	RNA recognition motif (RRM_1)	RNA recognition motif	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ...	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	Domain
CB [auth Z]	PF09736	Pre-mRNA-splicing factor of RES complex (Bud13)	Pre-mRNA-splicing factor of RES complex	-	Family
DB [auth x]	PF04408	Helicase associated domain (HA2), winged-helix (HA2_N)	Helicase associated domain (HA2), winged-helix	The helicase associated domain (HA2) has an all alpha-helical fold and consists of a N-terminal winged-helix (WH) domain and a C-terminal degenerate helical-bundle domain, referred to as the ratchet-like domain [1,2,3]. These domains collaborate wit ...	The helicase associated domain (HA2) has an all alpha-helical fold and consists of a N-terminal winged-helix (WH) domain and a C-terminal degenerate helical-bundle domain, referred to as the ratchet-like domain [1,2,3]. These domains collaborate with RecA domains at the N-terminal in completing an RNA binding channel to allow the helicases to keep a stable grip on the RNA [3] and assure its correct function. This entry represents the WH domain, which connects the N- (RecA domains) and C-terminal domains (ratchet-like and OB-fold) of helicases.	Domain
DB [auth x]	PF07717	Oligonucleotide/oligosaccharide-binding (OB)-fold (OB_NTP_bind)	Oligonucleotide/oligosaccharide-binding (OB)-fold	This family is found towards the C-terminus of the DEAD-box helicases (Pfam:PF00270). In these helicases it is apparently always found in association with Pfam:PF04408. There do seem to be a couple of instances where it occurs by itself - e.g. Swiss: ...	This family is found towards the C-terminus of the DEAD-box helicases (Pfam:PF00270). In these helicases it is apparently always found in association with Pfam:PF04408. There do seem to be a couple of instances where it occurs by itself - e.g. Swiss:Q84VZ2. The structure PDB:3i4u adopts an OB-fold. helicases (Pfam:PF00270). In these helicases it is apparently always found in association with Pfam:PF04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins [1].	Domain
DB [auth x]	PF00270	DEAD/DEAH box helicase (DEAD)	DEAD/DEAH box helicase	Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome ...	Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.	Domain
DB [auth x]	PF00271	Helicase conserved C-terminal domain (Helicase_C)	Helicase conserved C-terminal domain	The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.	Domain
DB [auth x]	PF21010	Helicase associated domain (HA2), ratchet-like (HA2_C)	Helicase associated domain (HA2), ratchet-like	The helicase associated domain (HA2) has an all alpha-helical fold and consists of a N-terminal winged-helix (WH) domain (Pfam:PF04408) and a C-terminal degenerate helical-bundle domain, referred to as the ratchet-like domain [1,2,3]. These domains c ...	The helicase associated domain (HA2) has an all alpha-helical fold and consists of a N-terminal winged-helix (WH) domain (Pfam:PF04408) and a C-terminal degenerate helical-bundle domain, referred to as the ratchet-like domain [1,2,3]. These domains collaborate with the RecA domains at the N-terminal in completing an RNA binding channel to allow the helicases to keep a stable grip on the RNA [3]. This entry represents the ratchet-like domain, which may be important for RNA translocation [1,2].	Domain
EB [auth y]	PF00160	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (Pro_isomerase)	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerisation during which the peptide bond pr ...	The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilised in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function [1].	Domain
EB [auth y]	PF00076	RNA recognition motif (RRM_1)	RNA recognition motif	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ...	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	Domain
E	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
F [auth a], P [auth h]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
G [auth b], Q [auth i]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
H [auth c], R [auth j]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
I [auth d], S [auth k]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Pre-mRNA-processing-splicing factor 8	RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U1 snRNA binding U6 snRNA binding polyubiquitin modification-dependent protein binding protein binding modification-dependent protein binding K63-linked polyubiquitin modification-dependent protein binding U5 snRNA binding U2 snRNA binding pre-mRNA binding RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U1 snRNA binding U6 snRNA binding polyubiquitin modification-dependent protein binding protein binding modification-dependent protein binding K63-linked polyubiquitin modification-dependent protein binding U5 snRNA binding U2 snRNA binding pre-mRNA binding pre-mRNA intronic binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process RNA splicing, via transesterification reactions biosynthetic process organic substance biosynthetic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process RNA splicing, via transesterification reactions biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process ribonucleoprotein complex biogenesis mRNA processing spliceosomal tri-snRNP complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization spliceosomal snRNP assembly mRNA metabolic process mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile cellular response to stimulus response to organic substance biological process involved in interspecies interaction between organisms response to stimulus response to lipid response to other organism cellular response to lipopolysaccharide response to oxygen-containing compound response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound response to biotic stimulus cellular response to biotic stimulus cellular response to chemical stimulus response to chemical response to bacterium cellular response to lipid cellular response to organic substance response to external biotic stimulus response to molecule of bacterial origin response to cytokine cellular response to tumor necrosis factor cellular response to cytokine stimulus response to tumor necrosis factor	membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen U2-type spliceosomal complex protein-containing complex catalytic complex nuclear protein-containing complex U2-type catalytic step 1 spliceosome spliceosomal complex ribonucleoprotein complex catalytic step 1 spliceosome catalytic step 2 spliceosome spliceosomal snRNP complex Sm-like protein family complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex U2-type precatalytic spliceosome precatalytic spliceosome U5 snRNP U2-type catalytic step 2 spliceosome
J [auth f], T [auth m]	Small nuclear ribonucleoprotein F	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm U2 snRNP catalytic step 2 spliceosome catalytic complex spliceosomal complex cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U7 snRNP U2-type catalytic step 2 spliceosome
K [auth e], U [auth l]	Small nuclear ribonucleoprotein E	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm spliceosomal complex precatalytic spliceosome catalytic complex telomerase holoenzyme complex U2 snRNP catalytic step 2 spliceosome cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U7 snRNP U2-type catalytic step 2 spliceosome
L [auth g], V [auth n]	Small nuclear ribonucleoprotein G	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex P granule cytoplasmic ribonucleoprotein granule germ plasm ribonucleoprotein granule pole plasm intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle spliceosomal complex precatalytic spliceosome U2 snRNP catalytic step 2 spliceosome catalytic complex cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U7 snRNP prespliceosome U2-type prespliceosome U2-type catalytic step 2 spliceosome
M [auth F]	U6 snRNA	-	-	-
N [auth G]	pre-mRNA	-	-	-
O [auth H]	U2 snRNA	-	-	-
W [auth o]	U2 small nuclear ribonucleoprotein A'	RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U2 snRNA binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen Sm-like protein family complex small nuclear ribonucleoprotein complex spliceosomal snRNP complex U2 snRNP catalytic step 2 spliceosome catalytic complex U2-type precatalytic spliceosome precatalytic spliceosome U2-type catalytic step 2 spliceosome
X [auth p]	U2 small nuclear ribonucleoprotein B''	RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U1 snRNA binding ribonucleoprotein complex binding snRNP binding protein-containing complex binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle cytoplasmic ribonucleoprotein granule cellular anatomical entity cytoplasm supramolecular complex non-membrane-bounded organelle ribonucleoprotein granule membrane-bounded organelle U2-type spliceosomal complex protein-containing complex nucleus intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle cytoplasmic ribonucleoprotein granule cellular anatomical entity cytoplasm supramolecular complex non-membrane-bounded organelle ribonucleoprotein granule membrane-bounded organelle U2-type spliceosomal complex protein-containing complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle spliceosomal complex ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex U2-type precatalytic spliceosome precatalytic spliceosome nucleolus fibrillar center U1 snRNP U2-type catalytic step 2 spliceosome
Y [auth w]	Splicing factor 3A subunit 3	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding RNA binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly mRNA splice site recognition mRNA 3'-splice site recognition	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex U2-type precatalytic spliceosome precatalytic spliceosome
Z [auth u]	Splicing factor 3A subunit 1	RNA binding binding organic cyclic compound binding nucleic acid binding	cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing RNA splicing cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing RNA splicing cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly mRNA splice site recognition mRNA 3'-splice site recognition	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex U2-type precatalytic spliceosome precatalytic spliceosome prespliceosome U2-type prespliceosome
B	U5 snRNA	-	-	-
AA [auth v]	Splicing factor 3A subunit 2	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding RNA binding organic cyclic compound binding nucleic acid binding	regulation of neuron projection development multicellular organismal process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization cellular developmental process cell projection organization positive regulation of biological process cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation positive regulation of neuron projection development regulation of neuron projection development multicellular organismal process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization cellular developmental process cell projection organization positive regulation of biological process cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation positive regulation of neuron projection development cell differentiation anatomical structure development positive regulation of cell projection organization cellular component organization or biogenesis positive regulation of cellular process system development developmental process regulation of biological process plasma membrane bounded cell projection organization regulation of cell projection organization biological regulation nervous system development generation of neurons neuron development cellular process regulation of plasma membrane bounded cell projection organization ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process U2-type prespliceosome assembly mRNA splice site recognition mRNA 3'-splice site recognition	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex U2-type precatalytic spliceosome precatalytic spliceosome prespliceosome U2-type prespliceosome
BA [auth 1]	Splicing factor 3B subunit 1	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding splicing factor binding protein binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase I positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase I regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of transcription by RNA polymerase I positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of transcription by RNA polymerase III positive regulation of transcription by RNA polymerase III transcription by RNA polymerase III transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II protein-DNA complex organization chromatin organization chromatin remodeling	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle nuclear speck nuclear body nucleoplasm spliceosomal snRNP complex protein-containing complex nuclear protein-containing complex Sm-like protein family complex small nuclear ribonucleoprotein complex ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex spliceosomal complex U11/U12 snRNP U2-type spliceosomal complex U2-type precatalytic spliceosome precatalytic spliceosome U12-type spliceosomal complex ATPase complex B-WICH complex chromosome SWI/SNF superfamily-type complex protein-DNA complex chromatin prespliceosome U2-type prespliceosome
CA [auth 2]	Splicing factor 3B subunit 2	RNA binding binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome membrane-enclosed lumen membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex U2-type precatalytic spliceosome U12-type spliceosomal complex
DA [auth 3]	Splicing factor 3B subunit 3	protein-containing complex binding binding RNA binding snRNA binding organic cyclic compound binding nucleic acid binding U2 snRNA binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly catabolic process negative regulation of biological process macromolecule catabolic process negative regulation of protein catabolic process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound catabolic process negative regulation of catabolic process organonitrogen compound metabolic process regulation of protein metabolic process negative regulation of metabolic process protein catabolic process regulation of catabolic process organic substance catabolic process regulation of protein catabolic process cellular response to stimulus response to stimulus regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress DNA repair DNA metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus regulation of DNA metabolic process regulation of RNA splicing	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle U2-type spliceosomal complex protein-containing complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex catalytic complex peptidase complex protein-DNA complex chromatin chromosome transferase complex histone acetyltransferase complex acetyltransferase complex protein acetyltransferase complex SAGA-type complex SAGA complex intracellular protein-containing complex spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome U2-type precatalytic spliceosome precatalytic spliceosome U12-type spliceosomal complex nucleoplasm
EA [auth 4]	Splicing factor 3B subunit 4	splicing factor binding protein binding binding RNA binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly regulation of cellular process regulation of mRNA splicing, via spliceosome positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of mRNA metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression positive regulation of mRNA processing regulation of macromolecule biosynthetic process regulation of metabolic process positive regulation of mRNA splicing, via spliceosome positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process regulation of biosynthetic process regulation of mRNA processing biological regulation regulation of macromolecule metabolic process regulation of RNA splicing regulation of cellular biosynthetic process positive regulation of gene expression regulation of mRNA metabolic process positive regulation of RNA splicing positive regulation of cellular biosynthetic process	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex spliceosomal snRNP complex Sm-like protein family complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP U2-type precatalytic spliceosome precatalytic spliceosome U12-type spliceosomal complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
FA [auth 5]	Splicing factor 3B subunit 6	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding	developmental process multicellular organismal process chordate embryonic development embryo development in utero embryonic development multicellular organism development anatomical structure morphogenesis blastocyst formation embryo development ending in birth or egg hatching anatomical structure development anatomical structure formation involved in morphogenesis blastocyst development RNA splicing cellular biosynthetic process developmental process multicellular organismal process chordate embryonic development embryo development in utero embryonic development multicellular organism development anatomical structure morphogenesis blastocyst formation embryo development ending in birth or egg hatching anatomical structure development anatomical structure formation involved in morphogenesis blastocyst development RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome spliceosomal snRNP complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex U12-type spliceosomal complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
GA [auth 6]	PHD finger-like domain-containing protein 5A	DNA binding binding organic cyclic compound binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding RNA binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly developmental process stem cell differentiation cellular developmental process cell differentiation	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix U2-type spliceosomal complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix U2-type spliceosomal complex protein-containing complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex precatalytic spliceosome nuclear speck nuclear body nucleoplasm spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP U2-type precatalytic spliceosome U12-type spliceosomal complex
HA [auth 7]	Splicing factor 3B subunit 5	splicing factor binding protein binding binding RNA binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly cellular response to stimulus response to stimulus regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress DNA repair DNA metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus regulation of DNA metabolic process regulation of RNA splicing	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic complex peptidase complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic complex peptidase complex protein-DNA complex chromatin chromosome transferase complex histone acetyltransferase complex acetyltransferase complex intracellular non-membrane-bounded organelle protein acetyltransferase complex SAGA-type complex SAGA complex intracellular protein-containing complex non-membrane-bounded organelle precatalytic spliceosome spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP U2-type precatalytic spliceosome U12-type spliceosomal complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
IA [auth J]	Crooked neck-like protein 1	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex Prp19 complex post-mRNA release spliceosomal complex U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
JA [auth L]	Cell division cycle 5-like protein	RNA binding binding organic cyclic compound binding nucleic acid binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription regulatory region nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity RNA binding binding organic cyclic compound binding nucleic acid binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription regulatory region nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity WD40-repeat domain binding protein binding protein domain specific binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity identical protein binding	cellular process cell cycle cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process cell cycle cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process macromolecule metabolic process DNA repair RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing regulation of cellular process regulation of primary metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process regulation of biological process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process DNA damage checkpoint signaling regulation of cell cycle phase transition signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction cell communication negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction regulation of cell cycle cell cycle process regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling signal transduction in response to DNA damage	membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex Prp19 complex cytoplasm U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
C	116 kDa U5 small nuclear ribonucleoprotein component	RNA binding binding organic cyclic compound binding nucleic acid binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding RNA binding binding organic cyclic compound binding nucleic acid binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding snRNA binding U5 snRNA binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing cellular response to stimulus cellular response to chemical stimulus response to stimulus response to chemical cellular response to xenobiotic stimulus response to xenobiotic stimulus response to organic substance response to organonitrogen compound response to oxygen-containing compound response to nitrogen compound response to organic cyclic compound response to cocaine response to alkaloid	membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex cytoplasm cytosol spliceosomal snRNP complex Sm-like protein family complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex Cajal body U2-type spliceosomal complex U2-type precatalytic spliceosome precatalytic spliceosome U2-type catalytic step 2 spliceosome
KA [auth q], LA [auth r], MA [auth s], NA [auth t]	Pre-mRNA-processing factor 19	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-ubiquitin ligase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity identical protein binding protein binding binding	protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process organic substance metabolic process biosynthetic process organic substance biosynthetic process lipid biosynthetic process primary metabolic process metabolic process lipid metabolic process organonitrogen compound catabolic process protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process organic substance metabolic process biosynthetic process organic substance biosynthetic process lipid biosynthetic process primary metabolic process metabolic process lipid metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process macromolecule catabolic process proteolysis protein metabolic process macromolecule metabolic process organic substance catabolic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing spliceosomal tri-snRNP complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization spliceosomal snRNP assembly cellular metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile spliceosomal complex assembly protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal protein K63-linked ubiquitination cellular response to stimulus DNA damage checkpoint signaling regulation of cellular process regulation of cell cycle phase transition response to stimulus signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction cell communication cellular response to stress response to stress negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle regulation of cell cycle cell cycle process regulation of biological process regulation of cell cycle process biological regulation DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling DNA damage response signal transduction in response to DNA damage regulation of mRNA splicing, via spliceosome positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of mRNA metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression positive regulation of mRNA processing regulation of macromolecule biosynthetic process regulation of metabolic process positive regulation of mRNA splicing, via spliceosome positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process regulation of biosynthetic process regulation of mRNA processing regulation of macromolecule metabolic process regulation of RNA splicing regulation of cellular biosynthetic process positive regulation of gene expression regulation of mRNA metabolic process positive regulation of RNA splicing positive regulation of cellular biosynthetic process double-strand break repair double-strand break repair via nonhomologous end joining DNA metabolic process DNA repair	membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen U2-type spliceosomal complex protein-containing complex catalytic complex nuclear protein-containing complex U2-type catalytic step 1 spliceosome spliceosomal complex ribonucleoprotein complex catalytic step 1 spliceosome catalytic step 2 spliceosome Prp19 complex cytoplasm lipid droplet intracellular non-membrane-bounded organelle non-membrane-bounded organelle cytoskeleton spindle microtubule cytoskeleton site of double-strand break site of DNA damage chromosome U2-type catalytic step 2 spliceosome
OA [auth K]	Pre-mRNA-splicing factor SPF27	-	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle nuclear speck nuclear body nucleoplasm catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton Prp19 complex U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
PA [auth I]	Pre-mRNA-splicing factor SYF1	-	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing generation of catalytic spliceosome for first transesterification step protein-containing complex organization cellular metabolic process spliceosomal conformational changes to generate catalytic conformation primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development blastocyst development cellular response to stimulus response to stimulus transcription-coupled nucleotide-excision repair DNA metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress DNA repair nucleobase-containing compound biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process organic cyclic compound biosynthetic process	membrane cellular anatomical entity membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane cellular anatomical entity membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex Prp19 complex post-mRNA release spliceosomal complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
QA [auth Q]	Intron-binding protein aquarius	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding RNA binding nucleic acid binding mRNA binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity single-stranded RNA binding catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid helicase activity 3'-5' RNA helicase activity RNA helicase activity ATP-dependent activity, acting on RNA	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing	membrane cellular anatomical entity membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane cellular anatomical entity membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
RA [auth N]	Protein BUD31 homolog	transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding binding DNA-binding transcription factor binding transcription coactivator activity transcription regulator activity transcription coregulator activity nuclear receptor coactivator activity protein-macromolecule adaptor activity molecular adaptor activity	cellular response to stimulus regulation of cellular process response to stimulus regulation of signal transduction cell communication regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process signal transduction regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II cellular response to stimulus regulation of cellular process response to stimulus regulation of signal transduction cell communication regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process signal transduction regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of signaling receptor activity cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of molecular function organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of response to stimulus regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process positive regulation of androgen receptor activity positive regulation of DNA-binding transcription factor activity signaling cellular biosynthetic process regulation of signaling receptor activity RNA metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process organic substance metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of signaling biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of cell communication cellular process RNA splicing mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex protein-DNA complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle U2-type spliceosomal complex catalytic step 2 spliceosome catalytic complex nuclear protein-containing complex U2-type catalytic step 2 spliceosome spliceosomal complex ribonucleoprotein complex
SA [auth O]	Pre-mRNA-splicing factor RBM22	pre-mRNA binding RNA binding binding organic cyclic compound binding nucleic acid binding U6 snRNA binding snRNA binding calcium-dependent protein binding protein binding cation binding ion binding metal ion binding small molecule binding	cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing RNA splicing cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing RNA splicing cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process protein localization regulation of localization establishment of protein localization regulation of cellular process nitrogen compound transport nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization localization import into nucleus cellular macromolecule localization establishment of localization in cell regulation of intracellular transport regulation of biological process positive regulation of protein localization to nucleus organic substance transport positive regulation of protein import into nucleus intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus establishment of localization establishment of protein localization to organelle positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport cellular localization regulation of protein localization transport positive regulation of nucleocytoplasmic transport positive regulation of biological process regulation of protein localization to nucleus positive regulation of protein transport regulation of protein import into nucleus protein import into nucleus positive regulation of intracellular transport positive regulation of cellular process regulation of transport biological regulation regulation of establishment of protein localization regulation of protein transport positive regulation of transport regulation of cellular localization protein transport macromolecule localization protein localization to organelle positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of RNA splicing positive regulation of RNA metabolic process regulation of cellular biosynthetic process regulation of gene expression positive regulation of gene expression regulation of macromolecule biosynthetic process positive regulation of RNA splicing regulation of metabolic process positive regulation of cellular biosynthetic process nuclear export regulation of protein export from nucleus protein export from nucleus positive regulation of protein export from nucleus cellular response to stimulus cellular response to chemical stimulus response to stimulus response to chemical cellular response to xenobiotic stimulus response to xenobiotic stimulus	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic step 1 spliceosome catalytic step 2 spliceosome Prp19 complex cytoplasm membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type catalytic step 2 spliceosome
TA [auth P]	Spliceosome-associated protein CWC15 homolog	RNA binding binding organic cyclic compound binding nucleic acid binding	cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing RNA splicing cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing RNA splicing cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex U2-type spliceosomal complex U2-type catalytic step 2 spliceosome Prp19 complex
UA [auth R]	Skip	-	-	-
VA [auth S]	Peptidyl-prolyl cis-trans isomerase-like 1	isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity amide binding binding cyclosporin A binding disordered domain specific binding protein binding protein domain specific binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process RNA splicing RNA metabolic process mRNA processing mRNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing macromolecule modification peptidyl-amino acid modification peptidyl-proline modification protein modification process protein peptidyl-prolyl isomerization developmental process multicellular organism development multicellular organismal process embryonic brain development anatomical structure development animal organ development embryonic organ development embryo development	membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
WA [auth T]	Pleiotropic regulator 1	-	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing regulation of cell cycle phase transition regulation of cellular process positive regulation of biological process cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle regulation of cell cycle positive regulation of cellular process cell cycle process positive regulation of G1/S transition of mitotic cell cycle regulation of biological process regulation of cell cycle process biological regulation positive regulation of cell cycle regulation of mitotic cell cycle phase transition positive regulation of cell cycle G1/S phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle positive regulation of cell cycle phase transition G1/S transition of mitotic cell cycle mitotic cell cycle phase transition protein localization localization cellular localization protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to nucleus	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen nuclear membrane membrane endomembrane system organelle envelope nuclear envelope organelle membrane catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex Prp19 complex nucleolus fibrillar center intracellular non-membrane-bounded organelle non-membrane-bounded organelle U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
D	U5 small nuclear ribonucleoprotein 200 kDa helicase	catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity RNA binding binding organic cyclic compound binding nucleic acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity RNA binding binding organic cyclic compound binding nucleic acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity, acting on RNA RNA helicase activity ATP-dependent activity, acting on RNA identical protein binding protein binding	developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) protein-containing complex organization cellular metabolic process spliceosomal conformational changes to generate catalytic conformation primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal complex assembly mRNA cis splicing, via spliceosome cis assembly of pre-catalytic spliceosome	membrane cellular anatomical entity membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle membrane cellular anatomical entity membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic step 1 spliceosome catalytic step 2 spliceosome spliceosomal snRNP complex Sm-like protein family complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type precatalytic spliceosome precatalytic spliceosome U5 snRNP
XA [auth U]	Serine/arginine repetitive matrix protein 2	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding protein binding C2H2 zinc finger domain binding protein domain specific binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen Cajal body catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex U2-type spliceosomal complex U2-type precatalytic spliceosome precatalytic spliceosome U2-type catalytic step 2 spliceosome
YA [auth V]	Pre-mRNA-splicing factor CWC22 homolog	RNA binding binding organic cyclic compound binding nucleic acid binding	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of mRNA splicing, via spliceosome mRNA processing regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process RNA processing regulation of biosynthetic process regulation of mRNA processing regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of mRNA splicing, via spliceosome mRNA processing regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process RNA processing regulation of biosynthetic process regulation of mRNA processing regulation of biological process RNA splicing cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression regulation of RNA splicing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome metabolic process cellular process regulation of macromolecule biosynthetic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process regulation of mRNA metabolic process regulation of metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen U2-type spliceosomal complex protein-containing complex catalytic complex nuclear protein-containing complex U2-type catalytic step 1 spliceosome spliceosomal complex ribonucleoprotein complex catalytic step 1 spliceosome catalytic step 2 spliceosome U2-type precatalytic spliceosome precatalytic spliceosome cytoplasm cytosol U2-type catalytic step 2 spliceosome
ZA [auth W]	Pre-mRNA-processing factor 17	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing developmental process multicellular organism development multicellular organismal process embryonic brain development anatomical structure development animal organ development embryonic organ development embryo development	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
AB [auth X]	Smad nuclear-interacting protein 1	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding molecular function inhibitor activity molecular function regulator activity transcription regulator inhibitor activity	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process negative regulation of canonical NF-kappaB signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette negative regulation of cellular process signal transduction regulation of biological process regulation of signaling negative regulation of response to stimulus biological regulation negative regulation of signal transduction canonical NF-kappaB signal transduction regulation of response to stimulus regulation of cell communication regulation of canonical NF-kappaB signal transduction ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly negative regulation of cellular metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process negative regulation of cellular biosynthetic process regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process miRNA processing regulation of macromolecule biosynthetic process regulation of metabolic process	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2 snRNP membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2 snRNP U2-type spliceosomal complex U2-type precatalytic spliceosome spliceosomal complex precatalytic spliceosome cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
BB [auth Y]	RNA-binding motif protein, X-linked 2	RNA binding binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex precatalytic spliceosome nuclear membrane membrane endomembrane system organelle envelope nuclear envelope organelle membrane spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP U2-type spliceosomal complex U2-type precatalytic spliceosome nucleoplasm endoplasmic reticulum cytoplasm
CB [auth Z]	BUD13 homolog	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex RES complex spliceosomal snRNP complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex RES complex spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type precatalytic spliceosome precatalytic spliceosome
DB [auth x]	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides molecular adaptor activity catalytic activity, acting on RNA RNA helicase activity ATP-dependent activity, acting on RNA protein binding ubiquitin binding ubiquitin-like protein binding molecular transducer activity pattern recognition receptor activity signaling receptor activity RNA binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus immune system process defense response to other organism response to stress innate immune response antiviral innate immune response response to external biotic stimulus response to virus mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity U2-type precatalytic spliceosome intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity U2-type precatalytic spliceosome intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome cytoplasm membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
EB [auth y]	Peptidyl-prolyl cis-trans isomerase E	isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding poly(A) binding poly-purine tract binding single-stranded RNA binding amide binding isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding poly(A) binding poly-purine tract binding single-stranded RNA binding amide binding cyclosporin A binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process macromolecule modification peptidyl-amino acid modification peptidyl-proline modification protein modification process protein peptidyl-prolyl isomerization regulation of cellular process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of viral genome replication positive regulation of viral process positive regulation of biological process viral life cycle regulation of viral process regulation of viral life cycle viral genome replication viral process regulation of viral genome replication RNA splicing mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex cytoplasm cytosol intracellular vesicle ficolin-1-rich granule endomembrane system cytoplasmic vesicle ficolin-1-rich granule lumen secretory granule secretory vesicle vesicle extracellular region vesicle lumen cytoplasmic vesicle lumen secretory granule lumen U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
E	U5 small nuclear ribonucleoprotein 40 kDa protein	RNA binding binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex cytoplasm cytosol sno(s)RNA-containing ribonucleoprotein complex U5 snRNP spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
F [auth a], P [auth h]	Small nuclear ribonucleoprotein Sm D3	RNA binding binding organic cyclic compound binding nucleic acid binding histone pre-mRNA DCP binding snRNA binding U7 snRNA binding telomerase RNA binding protein binding enzyme binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation organonitrogen compound metabolic process protein methylation protein alkylation protein metabolic process protein modification process	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm spliceosomal complex precatalytic spliceosome catalytic complex telomerase holoenzyme complex U2 snRNP catalytic step 2 spliceosome cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U7 snRNP commitment complex nuclear body U2-type catalytic step 2 spliceosome
G [auth b], Q [auth i]	Small nuclear ribonucleoprotein-associated proteins B and B'	RNA binding binding organic cyclic compound binding nucleic acid binding histone pre-mRNA DCP binding U1 snRNP binding ribonucleoprotein complex binding snRNP binding protein-containing complex binding telomerase RNA binding U2 snRNP binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation organonitrogen compound metabolic process protein methylation protein alkylation protein metabolic process protein modification process	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex catalytic complex telomerase holoenzyme complex U2 snRNP catalytic step 2 spliceosome spliceosomal complex histone pre-mRNA 3'end processing complex cytoplasm cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U7 snRNP prespliceosome U2-type prespliceosome U2-type catalytic step 2 spliceosome
H [auth c], R [auth j]	Small nuclear ribonucleoprotein Sm D1	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm spliceosomal complex precatalytic spliceosome U2 snRNP catalytic step 2 spliceosome catalytic complex cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP commitment complex U2-type catalytic step 2 spliceosome
I [auth d], S [auth k]	Small nuclear ribonucleoprotein Sm D2	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm spliceosomal complex precatalytic spliceosome U2 snRNP catalytic step 2 spliceosome catalytic complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U2-type catalytic step 2 spliceosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR012984	PROCT domain	Domain
A	IPR012591	PRO8NT domain	Domain
A	IPR019580	Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding	Domain
A	IPR027652	Pre-mRNA-processing-splicing factor 8	Family
A	IPR043172	Prp8 RNase domain IV, palm region	Homologous Superfamily
A	IPR012592	PROCN domain	Domain
A	IPR012337	Ribonuclease H-like superfamily	Homologous Superfamily
A	IPR043173	Prp8 RNase domain IV, fingers region	Homologous Superfamily
A	IPR021983	PRP8 domain IV core	Domain
A	IPR019581	Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding	Domain
A	IPR037518	MPN domain	Domain
A	IPR019582	RNA recognition motif, spliceosomal PrP8	Domain
A	IPR042516	Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily	Homologous Superfamily
A	IPR000555	JAB1/MPN/MOV34 metalloenzyme domain	Domain
J [auth f], T [auth m]	IPR016487	Sm-like protein Lsm6/SmF	Family
J [auth f], T [auth m]	IPR034100	Small nuclear ribonucleoprotein F	Family
J [auth f], T [auth m]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
J [auth f], T [auth m]	IPR047575	Sm domain	Domain
J [auth f], T [auth m]	IPR010920	LSM domain superfamily	Homologous Superfamily
K [auth e], U [auth l]	IPR027078	Small nuclear ribonucleoprotein E	Family
K [auth e], U [auth l]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
K [auth e], U [auth l]	IPR047575	Sm domain	Domain
K [auth e], U [auth l]	IPR010920	LSM domain superfamily	Homologous Superfamily
L [auth g], V [auth n]	IPR044641	Sm-like protein Lsm7/SmG	Family
L [auth g], V [auth n]	IPR034098	Small nuclear ribonucleoprotein G	Family
L [auth g], V [auth n]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
L [auth g], V [auth n]	IPR047575	Sm domain	Domain
L [auth g], V [auth n]	IPR010920	LSM domain superfamily	Homologous Superfamily
W [auth o]	IPR001611	Leucine-rich repeat	Repeat
W [auth o]	IPR003603	U2A'/phosphoprotein 32 family A, C-terminal	Domain
W [auth o]	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
X [auth p]	IPR034562	U2 small nuclear ribonucleoprotein B'', RNA recognition motif 2	Domain
X [auth p]	IPR000504	RNA recognition motif domain	Domain
X [auth p]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
X [auth p]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
X [auth p]	IPR034564	U2 small nuclear ribonucleoprotein B'', RNA recognition motif 1	Domain
Y [auth w]	IPR021966	Splicing factor SF3a60 binding domain	Domain
Y [auth w]	IPR031774	SF3A3 domain	Domain
Y [auth w]	IPR024598	Splicing factor SF3a60 /Prp9 subunit, C-terminal	Domain
Y [auth w]	IPR000690	Matrin/U1-C, C2H2-type zinc finger	Domain
Y [auth w]	IPR025086	SDE2-like, C-terminal domain	Domain
Z [auth u]	IPR045146	Splicing factor 3A subunit 1	Family
Z [auth u]	IPR035967	SWAP/Surp superfamily	Homologous Superfamily
Z [auth u]	IPR000061	SWAP/Surp	Domain
Z [auth u]	IPR000626	Ubiquitin-like domain	Domain
Z [auth u]	IPR035563	Splicing factor 3A subunit 1, ubiquitin domain	Domain
Z [auth u]	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
Z [auth u]	IPR022030	Splicing factor 3A subunit 1, conserved domain	Domain
AA [auth v]	IPR031781	SF3A2 domain	Domain
AA [auth v]	IPR003604	Matrin/U1-C-like, C2H2-type zinc finger	Domain
AA [auth v]	IPR013087	Zinc finger C2H2-type	Domain
AA [auth v]	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily
AA [auth v]	IPR000690	Matrin/U1-C, C2H2-type zinc finger	Domain
BA [auth 1]	IPR016024	Armadillo-type fold	Homologous Superfamily
BA [auth 1]	IPR011989	Armadillo-like helical	Homologous Superfamily
BA [auth 1]	IPR015016	Splicing factor 3B subunit 1	Domain
BA [auth 1]	IPR038737	Splicing factor 3B subunit 1-like	Family
CA [auth 2]	IPR006568	PSP, proline-rich	Domain
CA [auth 2]	IPR007180	Domain of unknown function DUF382	Domain
CA [auth 2]	IPR003034	SAP domain	Domain
DA [auth 3]	IPR018846	Cleavage/polyadenylation specificity factor, A subunit, N-terminal	Domain
DA [auth 3]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
DA [auth 3]	IPR004871	Cleavage/polyadenylation specificity factor, A subunit, C-terminal	Domain
DA [auth 3]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
EA [auth 4]	IPR034159	SF3B4, RNA recognition motif 2	Domain
EA [auth 4]	IPR000504	RNA recognition motif domain	Domain
EA [auth 4]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
EA [auth 4]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
EA [auth 4]	IPR034158	SF3B4, RNA recognition motif 1	Domain
FA [auth 5]	IPR000504	RNA recognition motif domain	Domain
FA [auth 5]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
FA [auth 5]	IPR034150	SF3B6, RNA recognition motif	Domain
FA [auth 5]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
GA [auth 6]	IPR005345	PHF5-like	Family
HA [auth 7]	IPR017089	Splicing factor 3B, subunit 5	Family
HA [auth 7]	IPR009846	Splicing factor 3B subunit 5/RDS3 complex subunit 10	Family
IA [auth J]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
IA [auth J]	IPR003107	HAT (Half-A-TPR) repeat	Repeat
IA [auth J]	IPR045075	Pre-mRNA-splicing factor Syf1-like	Family
JA [auth L]	IPR047240	Pre-mRNA splicing factor component CDC5L/Cef1, second SANT/myb-like domain	Domain
JA [auth L]	IPR017930	Myb domain	Domain
JA [auth L]	IPR009057	Homeobox-like domain superfamily	Homologous Superfamily
JA [auth L]	IPR047242	Pre-mRNA splicing factor component CDC5L/Cef1	Family
JA [auth L]	IPR001005	SANT/Myb domain	Domain
JA [auth L]	IPR021786	Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal	Domain
C	IPR005517	Translation elongation factor EFG/EF2, domain IV	Domain
C	IPR000795	Translational (tr)-type GTP-binding domain	Domain
C	IPR035647	EF-G domain III/V-like	Homologous Superfamily
C	IPR035655	116kDa U5 small nuclear ribonucleoprotein component, C-terminal	Domain
C	IPR041095	Elongation Factor G, domain II	Domain
C	IPR004161	Translation elongation factor EFTu-like, domain 2	Domain
C	IPR009000	Translation protein, beta-barrel domain superfamily	Homologous Superfamily
C	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
C	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup	Homologous Superfamily
C	IPR031950	116kDa U5 small nuclear ribonucleoprotein component, N-terminal	Domain
C	IPR000640	Elongation factor EFG, domain V-like	Domain
C	IPR044121	Snu114, GTP-binding domain	Domain
C	IPR005225	Small GTP-binding protein domain	Domain
KA [auth q], LA [auth r], MA [auth s], NA [auth t]	IPR013915	Pre-mRNA-splicing factor 19	Domain
KA [auth q], LA [auth r], MA [auth s], NA [auth t]	IPR019775	WD40 repeat, conserved site	Conserved Site
KA [auth q], LA [auth r], MA [auth s], NA [auth t]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
KA [auth q], LA [auth r], MA [auth s], NA [auth t]	IPR038959	Pre-mRNA-processing factor 19	Family
KA [auth q], LA [auth r], MA [auth s], NA [auth t]	IPR003613	U-box domain	Domain
KA [auth q], LA [auth r], MA [auth s], NA [auth t]	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
KA [auth q], LA [auth r], MA [auth s], NA [auth t]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
KA [auth q], LA [auth r], MA [auth s], NA [auth t]	IPR001680	WD40 repeat	Repeat
KA [auth q], LA [auth r], MA [auth s], NA [auth t]	IPR020472	G-protein beta WD-40 repeat	Repeat
OA [auth K]	IPR008409	Pre-mRNA-splicing factor SPF27	Family
PA [auth I]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
PA [auth I]	IPR003107	HAT (Half-A-TPR) repeat	Repeat
PA [auth I]	IPR045075	Pre-mRNA-splicing factor Syf1-like	Family
PA [auth I]	IPR019734	Tetratricopeptide repeat	Repeat
QA [auth Q]	IPR048966	RNA helicase aquarius, beta-barrel	Domain
QA [auth Q]	IPR048967	RNA helicase aquarius, insertion domain	Domain
QA [auth Q]	IPR041677	DNA2/NAM7 helicase, helicase domain	Domain
QA [auth Q]	IPR026300	CWF11 family	Family
QA [auth Q]	IPR045055	DNA2/NAM7-like helicase	Family
QA [auth Q]	IPR032174	RNA helicase aquarius, N-terminal domain	Domain
QA [auth Q]	IPR041679	DNA2/NAM7 helicase-like, C-terminal	Domain
QA [auth Q]	IPR047187	Upf1-like, C-terminal helicase domain	Domain
QA [auth Q]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
RA [auth N]	IPR001748	Pre-mRNA-splicing factor BUD31	Family
RA [auth N]	IPR018230	BUD31/G10-related, conserved site	Conserved Site
SA [auth O]	IPR036855	Zinc finger, CCCH-type superfamily	Homologous Superfamily
SA [auth O]	IPR039171	Pre-mRNA-splicing factor Cwc2/Slt11	Family
SA [auth O]	IPR000504	RNA recognition motif domain	Domain
SA [auth O]	IPR000571	Zinc finger, CCCH-type	Domain
SA [auth O]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
SA [auth O]	IPR048995	STL11/RBM22-like, N-terminal domain	Domain
SA [auth O]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
TA [auth P]	IPR006973	Pre-mRNA-splicing factor Cwf15/Cwc15	Family
VA [auth S]	IPR029000	Cyclophilin-like domain superfamily	Homologous Superfamily
VA [auth S]	IPR024936	Cyclophilin-type peptidyl-prolyl cis-trans isomerase	Family
VA [auth S]	IPR002130	Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain	Domain
VA [auth S]	IPR044666	Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like	Family
VA [auth S]	IPR020892	Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site	Conserved Site
WA [auth T]	IPR019775	WD40 repeat, conserved site	Conserved Site
WA [auth T]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
WA [auth T]	IPR045241	WD repeat Prp46/PLRG1-like	Family
WA [auth T]	IPR001680	WD40 repeat	Repeat
WA [auth T]	IPR020472	G-protein beta WD-40 repeat	Repeat
WA [auth T]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
D	IPR048863	Pre-mRNA-splicing helicase BRR2-like, plug domain	Domain
D	IPR041094	Brr2, N-terminal helicase PWI domain	Domain
D	IPR004179	Sec63 domain	Domain
D	IPR014756	Immunoglobulin E-set	Homologous Superfamily
D	IPR011545	DEAD/DEAH box helicase domain	Domain
D	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
D	IPR001650	Helicase, C-terminal domain-like	Domain
D	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
D	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
D	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
D	IPR035892	C2 domain superfamily	Homologous Superfamily
XA [auth U]	IPR047490	Serine/arginine repetitive matrix protein 2, cwf21 domain	Domain
XA [auth U]	IPR013170	mRNA splicing factor Cwf21 domain	Domain
XA [auth U]	IPR024945	Spt5 C-terminal domain	Domain
YA [auth V]	IPR016024	Armadillo-type fold	Homologous Superfamily
YA [auth V]	IPR003891	Initiation factor eIF-4 gamma, MA3	Domain
YA [auth V]	IPR003890	MIF4G-like, type 3	Domain
ZA [auth W]	IPR019775	WD40 repeat, conserved site	Conserved Site
ZA [auth W]	IPR032847	Pre-mRNA-processing factor 17	Family
ZA [auth W]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
ZA [auth W]	IPR001680	WD40 repeat	Repeat
ZA [auth W]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
AB [auth X]	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
AB [auth X]	IPR000253	Forkhead-associated (FHA) domain	Domain
BB [auth Y]	IPR000504	RNA recognition motif domain	Domain
BB [auth Y]	IPR045844	Ist3-like, RNA recognition motif	Domain
BB [auth Y]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
BB [auth Y]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
CB [auth Z]	IPR018609	Bud13	Family
DB [auth x]	IPR011709	DEAD-box helicase, OB fold	Domain
DB [auth x]	IPR001650	Helicase, C-terminal domain-like	Domain
DB [auth x]	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
DB [auth x]	IPR048333	Helicase associated domain (HA2), winged-helix domain	Domain
DB [auth x]	IPR002464	DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site	Conserved Site
DB [auth x]	IPR007502	Helicase-associated domain	Domain
DB [auth x]	IPR011545	DEAD/DEAH box helicase domain	Domain
DB [auth x]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
EB [auth y]	IPR029000	Cyclophilin-like domain superfamily	Homologous Superfamily
EB [auth y]	IPR002130	Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain	Domain
EB [auth y]	IPR034168	Peptidyl-prolyl cis-trans isomerase E, RNA recognition motif	Domain
EB [auth y]	IPR016304	Peptidyl-prolyl cis-trans isomerase E	Family
EB [auth y]	IPR020892	Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site	Conserved Site
EB [auth y]	IPR000504	RNA recognition motif domain	Domain
EB [auth y]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
EB [auth y]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
E	IPR019775	WD40 repeat, conserved site	Conserved Site
E	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
E	IPR001680	WD40 repeat	Repeat
E	IPR020472	G-protein beta WD-40 repeat	Repeat
E	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
F [auth a], P [auth h]	IPR027141	Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3	Family
F [auth a], P [auth h]	IPR034099	Small nuclear ribonucleoprotein Sm D3	Family
F [auth a], P [auth h]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
F [auth a], P [auth h]	IPR047575	Sm domain	Domain
F [auth a], P [auth h]	IPR010920	LSM domain superfamily	Homologous Superfamily
G [auth b], Q [auth i]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
G [auth b], Q [auth i]	IPR017131	Small ribonucleoprotein associated, SmB/SmN	Family
G [auth b], Q [auth i]	IPR047575	Sm domain	Domain
G [auth b], Q [auth i]	IPR010920	LSM domain superfamily	Homologous Superfamily
H [auth c], R [auth j]	IPR027141	Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3	Family
H [auth c], R [auth j]	IPR034102	Small nuclear ribonucleoprotein D1	Domain
H [auth c], R [auth j]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
H [auth c], R [auth j]	IPR047575	Sm domain	Domain
H [auth c], R [auth j]	IPR010920	LSM domain superfamily	Homologous Superfamily
I [auth d], S [auth k]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
I [auth d], S [auth k]	IPR047575	Sm domain	Domain
I [auth d], S [auth k]	IPR027248	Small nuclear ribonucleoprotein Sm D2	Family
I [auth d], S [auth k]	IPR010920	LSM domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q6P2Q9	retinitis pigmentosa retinitis pigmentosa 13 HIV infectious disease Acute Cerebrovascular Accidents brain aneurysm cone-rod dystrophy malignant ependymoma pancreatic ductal adenocarcinoma acute myeloid leukemia diabetes mellitus oligodendroglioma retinal degeneration astrocytic tumor cerebrovascular disorder glioblastoma retinitis pigmentosa retinitis pigmentosa 13 HIV infectious disease Acute Cerebrovascular Accidents brain aneurysm cone-rod dystrophy malignant ependymoma pancreatic ductal adenocarcinoma acute myeloid leukemia diabetes mellitus oligodendroglioma retinal degeneration astrocytic tumor cerebrovascular disorder glioblastoma Hodgkins lymphoma ovarian cancer
J [auth f], T [auth m]	Pharos: P62306	atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma primitive neuroectodermal tumor chronic obstructive pulmonary disease large cell medulloblastoma malignant glioma squamous cell carcinoma cutaneous melanoma lung cancer medulloblastoma
K [auth e], U [auth l]	Pharos: P62304	hypotrichosis hypotrichosis 11 hypotrichosis simplex breast carcinoma
L [auth g], V [auth n]	Pharos: P62308	Adenocarcinoma of Lung lung adenocarcinoma
X [auth p]	Pharos: P08579	breast carcinoma medulloblastoma colorectal cancer lung cancer
Y [auth w]	Pharos: Q12874	HIV infectious disease astrocytic tumor diabetes mellitus HIV Coinfection ovarian cancer colorectal adenoma Hashimoto thyroiditis colorectal cancer heart disease malignant mesothelioma
Z [auth u]	Pharos: Q15459	astrocytic tumor heart disease oligodendroglioma psoriasis colorectal cancer large cell medulloblastoma osteosarcoma rheumatoid arthritis glioblastoma myopathy ovarian cancer subependymal giant cell astrocytoma
AA [auth v]	Pharos: Q15428	astrocytic tumor glioblastoma medulloblastoma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor large cell medulloblastoma myocardial infarction psoriasis Gaucher disease malignant mesothelioma ovarian cancer
BA [auth 1]	Pharos: O75533	B-cell chronic lymphocytic leukemia uveal melanoma myelodysplastic syndrome malignant mesothelioma prostate cancer ocular melanoma ovarian cancer primitive neuroectodermal tumor Prostatic Neoplasms abdominal aortic aneurysm thoracic aortic aneurysm anorexia nervosa autism spectrum disorder brain aneurysm malignant ependymoma B-cell chronic lymphocytic leukemia uveal melanoma myelodysplastic syndrome malignant mesothelioma prostate cancer ocular melanoma ovarian cancer primitive neuroectodermal tumor Prostatic Neoplasms abdominal aortic aneurysm thoracic aortic aneurysm anorexia nervosa autism spectrum disorder brain aneurysm malignant ependymoma medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma progressive supranuclear palsy psoriasis acute myeloid leukemia astrocytic tumor cancer Gaucher disease large cell medulloblastoma osteosarcoma Pick disease allergic rhinitis atypical teratoid rhabdoid tumor bipolar disorder congenital anemia glioblastoma malignant choroid melanoma
CA [auth 2]	Pharos: Q13435	astrocytic tumor ovarian cancer bipolar I disorder plasma cell myeloma obesity disorder
DA [auth 3]	Pharos: Q15393	astrocytic tumor Intractable Eczema lung cancer atopic eczema large cell medulloblastoma malignant colon neoplasm atypical teratoid rhabdoid tumor ovarian cancer
EA [auth 4]	Pharos: Q15427	Nager acrofacial dysostosis acrofacial dysostosis Rodriguez type breast carcinoma intellectual disability malignant glioma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm astrocytic tumor glioblastoma large cell medulloblastoma malignant mesothelioma ovarian cancer Radial club hand atypical teratoid rhabdoid tumor idiopathic scoliosis Nager acrofacial dysostosis acrofacial dysostosis Rodriguez type breast carcinoma intellectual disability malignant glioma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm astrocytic tumor glioblastoma large cell medulloblastoma malignant mesothelioma ovarian cancer Radial club hand atypical teratoid rhabdoid tumor idiopathic scoliosis malignant ependymoma pancreatic ductal adenocarcinoma
FA [auth 5]	Pharos: Q9Y3B4	breast cancer ovarian cancer endogenous depression medulloblastoma
GA [auth 6]	Pharos: Q7RTV0	allergic rhinitis vitiligo Crohn disease osteosarcoma
HA [auth 7]	Pharos: Q9BWJ5	diabetes mellitus pancreatic ductal adenocarcinoma glioblastoma Sjogren syndrome ovarian cancer
IA [auth J]	Pharos: Q9BZJ0	exocrine pancreatic carcinoma malignant pancreatic neoplasm tuberculosis hepatocellular carcinoma myopathy invasive ductal breast carcinoma ovarian cancer
JA [auth L]	Pharos: Q99459	breast cancer ossification of the posterior longitudinal ligament of the spine psoriasis dermatomyositis osteosarcoma lymphoplasmacytic lymphoma plasma cell myeloma
C	Pharos: Q15029	mandibulofacial dysostosis-microcephaly syndrome intellectual disability choanal atresia large cell medulloblastoma Nager acrofacial dysostosis diabetes mellitus ovarian cancer microcephaly Primary microcephaly
KA [auth q], LA [auth r], MA [auth s], NA [auth t]	Pharos: Q9UMS4	Disease Exacerbation gastric neoplasm malignant mesothelioma psoriasis hereditary diffuse gastric adenocarcinoma gastric cancer lung cancer osteosarcoma
OA [auth K]	Pharos: O75934	colorectal cancer oligodendroglioma plasma cell myeloma
PA [auth I]	Pharos: Q9HCS7	diabetes mellitus osteosarcoma psoriasis
QA [auth Q]	Pharos: O60306	atypical teratoid rhabdoid tumor hepatocellular carcinoma medulloblastoma psoriasis gastric cancer large cell medulloblastoma oligodendroglioma gastric carcinoma malignant mesothelioma ovarian cancer
RA [auth N]	Pharos: P41223	attention deficit hyperactivity disorder, inattentive type plasma cell myeloma glioblastoma ovarian cancer
SA [auth O]	Pharos: Q9NW64	astrocytic tumor oligodendroglioma plasma cell myeloma malignant mesothelioma osteosarcoma subependymal giant cell astrocytoma medulloblastoma ovarian cancer
TA [auth P]	Pharos: Q9P013	ovarian cancer
VA [auth S]	Pharos: Q9Y3C6	breast cancer exocrine pancreatic carcinoma hepatocellular carcinoma non-small cell lung carcinoma tuberculosis ductal breast carcinoma in situ gastric cancer invasive ductal breast carcinoma ovarian cancer ulcerative colitis endogenous depression gastric carcinoma malignant pancreatic neoplasm psoriasis
WA [auth T]	Pharos: O43660	juvenile dermatomyositis vascular disease myopathy ovarian cancer
D	Pharos: O75643	retinitis pigmentosa retinitis pigmentosa 33 acute myeloid leukemia cone-rod dystrophy large cell medulloblastoma malignant pancreatic neoplasm osteosarcoma psoriasis astrocytic tumor dermatomyositis lung cancer medulloblastoma ovarian cancer retinal degeneration colorectal cancer retinitis pigmentosa retinitis pigmentosa 33 acute myeloid leukemia cone-rod dystrophy large cell medulloblastoma malignant pancreatic neoplasm osteosarcoma psoriasis astrocytic tumor dermatomyositis lung cancer medulloblastoma ovarian cancer retinal degeneration colorectal cancer diabetes mellitus malignant ependymoma oligodendroglioma primitive neuroectodermal tumor
XA [auth U]	Pharos: Q9UQ35	acute myeloid leukemia atypical teratoid rhabdoid tumor Duchenne muscular dystrophy juvenile dermatomyositis ovarian cancer Pick disease rheumatoid arthritis Alzheimer disease Becker muscular dystrophy Emery-Dreifuss muscular dystrophy lymphoplasmacytic lymphoma pancreatic ductal adenocarcinoma primitive neuroectodermal tumor Sjogren syndrome astrocytic tumor acute myeloid leukemia atypical teratoid rhabdoid tumor Duchenne muscular dystrophy juvenile dermatomyositis ovarian cancer Pick disease rheumatoid arthritis Alzheimer disease Becker muscular dystrophy Emery-Dreifuss muscular dystrophy lymphoplasmacytic lymphoma pancreatic ductal adenocarcinoma primitive neuroectodermal tumor Sjogren syndrome astrocytic tumor dermatomyositis hereditary spastic paraplegia osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis
YA [auth V]	Pharos: Q9HCG8	osteosarcoma ovarian cancer
ZA [auth W]	Pharos: O60508	adenoma glioblastoma ovarian cancer atypical teratoid rhabdoid tumor large cell medulloblastoma psoriasis Gaucher disease malignant ependymoma tuberculosis
AB [auth X]	Pharos: Q8TAD8	psychomotor retardation, epilepsy, and craniofacial dysmorphism endometrial carcinoma oligodendroglioma psoriasis epilepsy osteosarcoma intellectual disability ovarian carcinoma tuberculosis
CB [auth Z]	Pharos: Q9BRD0	metabolic syndrome X abdominal aortic aneurysm medulloblastoma non-alcoholic fatty liver disease heart disease metabolic disease hypertrophic pyloric stenosis
DB [auth x]	Pharos: O60231	autism spectrum disorder endogenous depression medulloblastoma prostate carcinoma cervical cancer Graves disease ovarian cancer psoriatic arthritis chronic obstructive pulmonary disease lung carcinoma peripheral neuropathy swine influenza
EB [auth y]	Pharos: Q9UNP9	attention deficit hyperactivity disorder, inattentive type chronic obstructive pulmonary disease ovarian cancer
E	Pharos: Q96DI7	large cell medulloblastoma medulloblastoma subependymal giant cell astrocytoma lung cancer pituitary cancer malignant mesothelioma primitive neuroectodermal tumor
F [auth a], P [auth h]	Pharos: P62318	carcinoma Mammary Neoplasms, Experimental HIV infectious disease sarcomatoid carcinoma acne lymphoplasmacytic lymphoma ovarian cancer undifferentiated carcinoma medulloblastoma plasma cell myeloma dermatomyositis lung cancer mammary neoplasms, animal non-alcoholic fatty liver disease
G [auth b], Q [auth i]	Pharos: P14678	cerebrocostomandibular syndrome intellectual disability ovarian cancer atypical teratoid rhabdoid tumor dermatomyositis Disease Progression glioblastoma invasive ductal breast carcinoma malignant glioma medulloblastoma plasma cell myeloma diabetes mellitus gastric cancer hereditary diffuse gastric adenocarcinoma large cell medulloblastoma cerebrocostomandibular syndrome intellectual disability ovarian cancer atypical teratoid rhabdoid tumor dermatomyositis Disease Progression glioblastoma invasive ductal breast carcinoma malignant glioma medulloblastoma plasma cell myeloma diabetes mellitus gastric cancer hereditary diffuse gastric adenocarcinoma large cell medulloblastoma malignant mesothelioma osteosarcoma psoriasis gastric neoplasm lymphoplasmacytic lymphoma
H [auth c], R [auth j]	Pharos: P62314	acute myeloid leukemia gastric carcinoma medulloblastoma plasma cell myeloma psoriasis atypical teratoid rhabdoid tumor large cell medulloblastoma non-small cell lung carcinoma pneumonia dermatomyositis lung cancer ovarian cancer polycystic ovary syndrome
I [auth d], S [auth k]	Pharos: P62316	chronic obstructive pulmonary disease lung cancer ovarian cancer diabetes mellitus lymphoplasmacytic lymphoma plasma cell myeloma heart disease medulloblastoma