5YZD

Crystal structure of the prefusion form of measles virus fusion protein in complex with a fusion inhibitor peptide (FIP)

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00523	e5yzdA1	A: extended segments	X: Fusion glycoprotein F2 (From Topology)	H: Fusion glycoprotein F2 (From Topology)	T: Fusion glycoprotein F2	F: PF00523	ECOD (1.6)
B [auth C]	PF00523	e5yzdC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-like domain in paramyxoviruses fusion protein (From Topology)	T: Immunoglobulin-like domain in paramyxoviruses fusion protein	F: PF00523	ECOD (1.6)
B [auth C]	PF00523	e5yzdC1	A: a+b complex topology	X: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	H: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	T: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein	F: PF00523	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00523	Fusion glycoprotein F0 (Fusion_gly)	Fusion glycoprotein F0	-	Family
B [auth C]	PF00523	Fusion glycoprotein F0 (Fusion_gly)	Fusion glycoprotein F0	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	glycoprotein F2	-	membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane viral process cellular process cellular component organization or biogenesis membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction	virion component viral membrane viral envelope membrane cellular anatomical entity host cell plasma membrane host cellular component host cell part host cell membrane virion membrane
B [auth C]	glycoprotein F1,measles virus fusion protein	-	membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane viral process cellular process cellular component organization or biogenesis membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction	virion component viral membrane viral envelope membrane cellular anatomical entity host cell plasma membrane host cellular component host cell part host cell membrane virion membrane
C [auth B]	peptide CBZ-DPN-PHE-GLY	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000776	Precursor fusion glycoprotein F0, Paramyxoviridae	Family
B [auth C]	IPR000776	Precursor fusion glycoprotein F0, Paramyxoviridae	Family

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
C [auth B]	DPN	RESID: AA0194 PSI-MOD : D-phenylalanine MOD:00201
C [auth B]	PHQ	RESID: AA0194

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.