5YYZ

Crystal structure of the MEK1 FHA domain in complex with the HOP1 pThr318 peptide.

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	FHA domain	8078536	4002605	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SMAD/FHA domain-like	8078537	3000137	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FHA	e5yyzA1	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: FHA	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00498	FHA domain (FHA)	FHA domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Meiosis-specific protein HOP1	DNA secondary structure binding DNA binding binding organic cyclic compound binding four-way junction DNA binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding	cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition regulation of cellular component organization response to stimulus sexual reproduction signaling regulation of reproductive process reproductive process meiotic recombination checkpoint signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition meiotic cell cycle process intracellular signal transduction cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition regulation of cellular component organization response to stimulus sexual reproduction signaling regulation of reproductive process reproductive process meiotic recombination checkpoint signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition meiotic cell cycle process intracellular signal transduction cell communication cellular component organization negative regulation of cellular process negative regulation of cell cycle phase transition meiotic nuclear division signal transduction cell cycle cellular component organization or biogenesis regulation of cell cycle negative regulation of meiotic nuclear division cell cycle process regulation of biological process regulation of meiotic cell cycle negative regulation of cellular component organization regulation of cell cycle process meiotic cell cycle organelle fission biological regulation negative regulation of cell cycle process meiotic cell cycle checkpoint signaling regulation of organelle organization cell cycle checkpoint signaling regulation of meiotic nuclear division organelle organization nuclear division negative regulation of nuclear division negative regulation of organelle organization negative regulation of reproductive process regulation of nuclear division cellular process negative regulation of meiotic cell cycle homologous recombination nucleobase-containing compound metabolic process organic substance metabolic process meiosis I reciprocal homologous recombination DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process reciprocal meiotic recombination organic cyclic compound metabolic process meiosis I cell cycle process metabolic process macromolecule metabolic process meiotic chromosome segregation synaptonemal complex assembly cellular component biogenesis cellular component assembly synaptonemal complex organization chromosome segregation chromosome organization chromosome organization involved in meiotic cell cycle homologous chromosome pairing at meiosis nuclear chromosome segregation homologous chromosome segregation	membrane-bounded organelle condensed nuclear chromosome intracellular anatomical structure nucleus membrane-enclosed lumen nuclear chromosome chromosome cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle membrane-bounded organelle condensed nuclear chromosome intracellular anatomical structure nucleus membrane-enclosed lumen nuclear chromosome chromosome cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle condensed chromosome non-membrane-bounded organelle nuclear lumen synaptonemal structure synaptonemal complex lateral element
A	Meiosis-specific serine/threonine-protein kinase MEK1	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein serine/threonine kinase activity protein serine kinase activity	cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition regulation of cellular component organization response to stimulus sexual reproduction signaling regulation of reproductive process reproductive process meiotic recombination checkpoint signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition meiotic cell cycle process intracellular signal transduction cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition regulation of cellular component organization response to stimulus sexual reproduction signaling regulation of reproductive process reproductive process meiotic recombination checkpoint signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition meiotic cell cycle process intracellular signal transduction cell communication cellular component organization negative regulation of cellular process negative regulation of cell cycle phase transition meiotic nuclear division signal transduction cell cycle cellular component organization or biogenesis regulation of cell cycle negative regulation of meiotic nuclear division cell cycle process regulation of biological process regulation of meiotic cell cycle negative regulation of cellular component organization regulation of cell cycle process meiotic cell cycle organelle fission biological regulation negative regulation of cell cycle process meiotic cell cycle checkpoint signaling regulation of organelle organization cell cycle checkpoint signaling regulation of meiotic nuclear division organelle organization nuclear division negative regulation of nuclear division negative regulation of organelle organization negative regulation of reproductive process regulation of nuclear division cellular process negative regulation of meiotic cell cycle phosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process phosphorus metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR016573	Meiosis-specific protein Hop1	Family
B	IPR036570	HORMA domain superfamily	Homologous Superfamily
B	IPR003511	HORMA domain	Domain
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
A	IPR000253	Forkhead-associated (FHA) domain	Domain
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR000719	Protein kinase domain	Domain
A	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B	TPO	Parent Component: THR RESID: AA0038 PSI-MOD : O-phospho-L-threonine MOD:00047

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.