5YRP

Crystal structure of the EAL domain of Mycobacterium smegmatis DcpA

External Resource: Annotation


Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APF00563e5yrpA1 A: a/b barrelsX: TIM beta/alpha-barrelH: EAL domain (From Topology)T: EAL domainF: PF00563ECOD (1.6)
BPF00563e5yrpB1 A: a/b barrelsX: TIM beta/alpha-barrelH: EAL domain (From Topology)T: EAL domainF: PF00563ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.20.20.450 Alpha Beta Alpha-Beta Barrel TIM Barrel EAL domainCATH (utative)
B3.20.20.450 Alpha Beta Alpha-Beta Barrel TIM Barrel EAL domainCATH (utative)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF00563EAL domain (EAL)EAL domainThis domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function [1]. The domain contains many conserved acidic residues tha ...This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function [1]. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site [1].
Domain

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B
IPR000160GGDEF domainDomain
A, B
IPR003018GAF domainDomain
A, B
IPR029016GAF-like domain superfamilyHomologous Superfamily
A, B
IPR043128Reverse transcriptase/Diguanylate cyclase domainHomologous Superfamily
A, B
IPR001633EAL domainDomain
A, B
IPR035919EAL domain superfamilyHomologous Superfamily
A, B
IPR029787Nucleotide cyclaseHomologous Superfamily