5YQ8

Crystal structure of retroviral protease-like domain of Ddi1 from Leishmania major

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Acid proteases	8086231	3001059	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Acid proteases	8086231	3001059	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Acid proteases	8086231	3001059	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Acid proteases	8086231	3001059	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF09668	e5yq8A1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF09668	ECOD (1.6)
B	PF09668	e5yq8B1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF09668	ECOD (1.6)
C	PF09668	e5yq8C1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF09668	ECOD (1.6)
D	PF09668	e5yq8D1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF09668	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)
B	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)
C	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)
D	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF09668	Aspartyl protease (Asp_protease)	Aspartyl protease	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	DNA-damage inducible protein DDI1-like protein	aspartic-type peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity aspartic-type endopeptidase activity catalytic activity endopeptidase activity	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR021109	Aspartic peptidase domain superfamily	Homologous Superfamily
A, B, C, D	IPR019103	Aspartic peptidase, DDI1-type	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.