Annotations: 5XWS

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5xwsa_	Alpha and beta proteins (a/b)	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	L domain-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13855	e5xwsA1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat
A	PF13927	Immunoglobulin domain (Ig_3)	Immunoglobulin domain	This family contains immunoglobulin-like domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Leucine-rich repeat and fibronectin type-III domain-containing protein 5	-	cellular component organization cell adhesion cell junction organization cell-cell adhesion cellular process synaptic membrane adhesion synapse organization cellular component organization or biogenesis cell-cell adhesion via plasma-membrane adhesion molecules multicellular organismal process regulation of cellular component organization regulation of cellular process regulation of presynapse assembly cellular component biogenesis cellular component organization cell adhesion cell junction organization cell-cell adhesion cellular process synaptic membrane adhesion synapse organization cellular component organization or biogenesis cell-cell adhesion via plasma-membrane adhesion molecules multicellular organismal process regulation of cellular component organization regulation of cellular process regulation of presynapse assembly cellular component biogenesis multicellular organism development regulation of presynapse organization cellular component assembly cell junction assembly anatomical structure development regulation of synapse structure or activity regulation of biological quality regulation of synapse assembly system development developmental process regulation of biological process biological regulation presynapse organization nervous system development regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization synapse assembly presynapse assembly regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus negative regulation of biological process response to external stimulus regulation of inflammatory response regulation of response to stimulus response to stress negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response regulation of macrophage activation regulation of leukocyte activation cell activation regulation of cell activation myeloid leukocyte activation leukocyte activation negative regulation of cell activation macrophage activation negative regulation of immune system process immune system process negative regulation of cellular process regulation of multicellular organismal process regulation of immune system process negative regulation of multicellular organismal process negative regulation of leukocyte activation negative regulation of macrophage activation	postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region cell surface GABA-ergic synapse glutamatergic synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR003599	Immunoglobulin subtype	Domain
A	IPR003598	Immunoglobulin subtype 2	Domain
A	IPR001611	Leucine-rich repeat	Repeat
A	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR007110	Immunoglobulin-like domain	Domain
A	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q96NI6	adrenal cortex carcinoma atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor astrocytic tumor bipolar disorder invasive ductal breast carcinoma malignant glioma ovarian cancer pilocytic astrocytoma psoriasis atopic eczema adrenal cortex carcinoma atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor astrocytic tumor bipolar disorder invasive ductal breast carcinoma malignant glioma ovarian cancer pilocytic astrocytoma psoriasis atopic eczema endogenous depression large cell medulloblastoma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.