5XTW

Crystal structure of the CysR-CTLD2 fragment of human MR at acidic pH

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00652	e5xtwA3	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: PF00652	ECOD (1.6)
A	PF00059	e5xtwA4	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)
A	PF00040	e5xtwA2	A: few secondary structure elements	X: Kringle-like (From Topology)	H: Kringle-like (From Topology)	T: Kringle-like	F: PF00040	ECOD (1.6)
B	PF00652	e5xtwB3	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: PF00652	ECOD (1.6)
B	PF00059	e5xtwB1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)
B	PF00040	e5xtwB4	A: few secondary structure elements	X: Kringle-like (From Topology)	H: Kringle-like (From Topology)	T: Kringle-like	F: PF00040	ECOD (1.6)
C	PF00652	e5xtwC4	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: PF00652	ECOD (1.6)
C	PF00059	e5xtwC3	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)
C	PF00040	e5xtwC1	A: few secondary structure elements	X: Kringle-like (From Topology)	H: Kringle-like (From Topology)	T: Kringle-like	F: PF00040	ECOD (1.6)
D	PF00652	e5xtwD4	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: PF00652	ECOD (1.6)
D	PF00059	e5xtwD1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)
D	PF00040	e5xtwD2	A: few secondary structure elements	X: Kringle-like (From Topology)	H: Kringle-like (From Topology)	T: Kringle-like	F: PF00040	ECOD (1.6)
E	PF00652	e5xtwE2	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: PF00652	ECOD (1.6)
E	PF00059	e5xtwE4	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)
E	PF00040	e5xtwE1	A: few secondary structure elements	X: Kringle-like (From Topology)	H: Kringle-like (From Topology)	T: Kringle-like	F: PF00040	ECOD (1.6)
F	PF00652	e5xtwF1	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: PF00652	ECOD (1.6)
F	PF00059	e5xtwF2	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)
F	PF00040	e5xtwF4	A: few secondary structure elements	X: Kringle-like (From Topology)	H: Kringle-like (From Topology)	T: Kringle-like	F: PF00040	ECOD (1.6)
G	PF00652	e5xtwG4	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: PF00652	ECOD (1.6)
G	PF00059	e5xtwG2	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)
G	PF00040	e5xtwG1	A: few secondary structure elements	X: Kringle-like (From Topology)	H: Kringle-like (From Topology)	T: Kringle-like	F: PF00040	ECOD (1.6)
H	PF00652	e5xtwH4	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: PF00652	ECOD (1.6)
H	PF00059	e5xtwH2	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)
H	PF00040	e5xtwH3	A: few secondary structure elements	X: Kringle-like (From Topology)	H: Kringle-like (From Topology)	T: Kringle-like	F: PF00040	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00040	Fibronectin type II domain (fn2)	Fibronectin type II domain	-	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	PF00652	Ricin-type beta-trefoil lectin domain (Ricin_B_lectin)	Ricin-type beta-trefoil lectin domain	-	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	PF00059	Lectin C-type domain (Lectin_C)	Lectin C-type domain	This family includes both long and short form C-type	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Macrophage mannose receptor 1	binding mannose binding monosaccharide binding carbohydrate binding small molecule binding protein binding virus receptor activity exogenous protein binding molecular transducer activity signaling receptor activity cargo receptor activity transmembrane signaling receptor activity	cellular response to stimulus response to organic substance biological process involved in interspecies interaction between organisms response to stimulus response to type II interferon response to cytokine cellular response to type II interferon response to biotic stimulus response to stress innate immune response cellular response to cytokine stimulus response to external biotic stimulus cellular response to organic substance immune response cellular response to stimulus response to organic substance biological process involved in interspecies interaction between organisms response to stimulus response to type II interferon response to cytokine cellular response to type II interferon response to biotic stimulus response to stress innate immune response cellular response to cytokine stimulus response to external biotic stimulus cellular response to organic substance immune response response to other organism defense response defense response to symbiont response to external stimulus cellular response to chemical stimulus response to chemical immune system process defense response to other organism cellular process response to interleukin-4 cellular response to interleukin-4 response to lipid cellular response to lipopolysaccharide response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to biotic stimulus response to bacterium cellular response to lipid response to molecule of bacterial origin localization import into cell transport receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport	cell surface cellular anatomical entity endosome membrane membrane-bounded organelle intracellular anatomical structure membrane endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cell surface cellular anatomical entity endosome membrane membrane-bounded organelle intracellular anatomical structure membrane endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle cytoplasm vesicle organelle membrane cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR013806	Kringle-like fold	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036943	Fibronectin type II domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR016187	C-type lectin fold	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR001304	C-type lectin-like	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR018378	C-type lectin, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR035992	Ricin B-like lectins	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000562	Fibronectin type II domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000772	Ricin B, lectin domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H	Pharos: P22897	allergic contact dermatitis lung carcinoma myopathy non-small cell lung carcinoma pancreatic ductal adenocarcinoma adrenal cortex carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast carcinoma dermatomyositis ductal breast carcinoma in situ head and neck cancer juvenile dermatomyositis lung adenocarcinoma malignant colon neoplasm nephrosclerosis allergic contact dermatitis lung carcinoma myopathy non-small cell lung carcinoma pancreatic ductal adenocarcinoma adrenal cortex carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast carcinoma dermatomyositis ductal breast carcinoma in situ head and neck cancer juvenile dermatomyositis lung adenocarcinoma malignant colon neoplasm nephrosclerosis osteosarcoma pancreatic intraductal papillary-mucinous carcinoma Sjogren syndrome breast fibroadenoma diabetes mellitus Emery-Dreifuss muscular dystrophy interstitial cystitis large cell medulloblastoma lung cancer medulloblastoma non-alcoholic fatty liver disease ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Becker muscular dystrophy ulcerative colitis chronic obstructive pulmonary disease Duchenne muscular dystrophy facioscapulohumeral muscular dystrophy invasive ductal breast carcinoma limb-girdle muscular dystrophy