Annotations: 5XQI

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF10259	e5xqiA1	A: alpha bundles	X: Bromodomain-like	H: Rogdi (From Topology)	T: Rogdi	F: PF10259	ECOD (1.6)
B	PF10259	e5xqiB1	A: alpha bundles	X: Bromodomain-like	H: Rogdi (From Topology)	T: Rogdi	F: PF10259	ECOD (1.6)
C	PF10259	e5xqiC1	A: alpha bundles	X: Bromodomain-like	H: Rogdi (From Topology)	T: Rogdi	F: PF10259	ECOD (1.6)
D	PF10259	e5xqiD1	A: alpha bundles	X: Bromodomain-like	H: Rogdi (From Topology)	T: Rogdi	F: PF10259	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF10259	Rogdi leucine zipper containing protein (Rogdi_lz)	Rogdi leucine zipper containing protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Protein rogdi homolog	-	regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process developmental process multicellular organism development multicellular organismal process head development central nervous system development regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development neurogenesis cellular developmental process cell differentiation anatomical structure morphogenesis odontogenesis of dentin-containing tooth odontogenesis animal organ morphogenesis hemopoiesis cell development	neuron to neuron synapse synapse cell junction hippocampal mossy fiber to CA3 synapse cellular anatomical entity somatodendritic compartment cell body perikaryon neuronal cell body protein-containing complex intracellular anatomical structure cytoplasm RAVE complex membrane-bounded organelle neuron to neuron synapse synapse cell junction hippocampal mossy fiber to CA3 synapse cellular anatomical entity somatodendritic compartment cell body perikaryon neuronal cell body protein-containing complex intracellular anatomical structure cytoplasm RAVE complex membrane-bounded organelle intracellular organelle organelle envelope organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system axon cell projection neuron projection plasma membrane bounded cell projection dendrite dendritic tree transport vesicle intracellular vesicle presynapse cytoplasmic vesicle synaptic vesicle secretory vesicle vesicle exocytic vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR028241	RAVE subunit 2/Rogdi	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q9GZN7	amelocerebrohypohidrotic syndrome amelogenesis imperfecta tuberculosis atypical teratoid rhabdoid tumor Epileptic encephalopathy invasive ductal breast carcinoma malignant glioma osteosarcoma primitive neuroectodermal tumor ductal breast carcinoma in situ glioblastoma large cell medulloblastoma medulloblastoma Pick disease subependymal giant cell astrocytoma amelocerebrohypohidrotic syndrome amelogenesis imperfecta tuberculosis atypical teratoid rhabdoid tumor Epileptic encephalopathy invasive ductal breast carcinoma malignant glioma osteosarcoma primitive neuroectodermal tumor ductal breast carcinoma in situ glioblastoma large cell medulloblastoma medulloblastoma Pick disease subependymal giant cell astrocytoma astrocytic tumor epilepsy intellectual disability malignant ependymoma oligodendroglioma pilocytic astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.