Annotations: 5XNP

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	I-set	e5xnpA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set	ECOD (1.6)
A	LRR_8_1	e5xnpA1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_1	ECOD (1.6)
B	I-set	e5xnpB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set	ECOD (1.6)
B	LRR_8_1	e5xnpB1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_1	ECOD (1.6)
C [auth D]	I-set	e5xnpD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set	ECOD (1.6)
C [auth D]	I-set_2	e5xnpD3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_2	ECOD (1.6)
D [auth E]	I-set	e5xnpE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set	ECOD (1.6)
D [auth E]	I-set_2	e5xnpE3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_2	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat
A, B	PF13927	Immunoglobulin domain (Ig_3)	Immunoglobulin domain	This family contains immunoglobulin-like domains.	Domain
C [auth D], D [auth E]	PF13927	Immunoglobulin domain (Ig_3)	Immunoglobulin domain	This family contains immunoglobulin-like domains.	Domain
C [auth D], D [auth E]	PF07679	Immunoglobulin I-set domain (I-set)	Immunoglobulin I-set domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Leucine-rich repeat and fibronectin type-III domain-containing protein 5	-	cellular component organization cell adhesion cell junction organization cell-cell adhesion cellular process synaptic membrane adhesion synapse organization cellular component organization or biogenesis cell-cell adhesion via plasma-membrane adhesion molecules multicellular organismal process regulation of cellular component organization regulation of cellular process regulation of presynapse assembly cellular component biogenesis cellular component organization cell adhesion cell junction organization cell-cell adhesion cellular process synaptic membrane adhesion synapse organization cellular component organization or biogenesis cell-cell adhesion via plasma-membrane adhesion molecules multicellular organismal process regulation of cellular component organization regulation of cellular process regulation of presynapse assembly cellular component biogenesis multicellular organism development regulation of presynapse organization cellular component assembly cell junction assembly anatomical structure development regulation of synapse structure or activity regulation of biological quality regulation of synapse assembly system development developmental process regulation of biological process biological regulation presynapse organization nervous system development regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization synapse assembly presynapse assembly regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus negative regulation of biological process response to external stimulus regulation of inflammatory response regulation of response to stimulus response to stress negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response regulation of macrophage activation regulation of leukocyte activation cell activation regulation of cell activation myeloid leukocyte activation leukocyte activation negative regulation of cell activation macrophage activation negative regulation of immune system process immune system process negative regulation of cellular process regulation of multicellular organismal process regulation of immune system process negative regulation of multicellular organismal process negative regulation of leukocyte activation negative regulation of macrophage activation	postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region cell surface GABA-ergic synapse glutamatergic synapse
C [auth D], D [auth E]	Receptor-type tyrosine-protein phosphatase delta	protein binding binding signaling receptor binding phosphoric ester hydrolase activity molecular transducer activity catalytic activity, acting on a protein phosphatase activity signaling receptor activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity transmembrane receptor protein phosphatase activity transmembrane signaling receptor activity protein binding binding signaling receptor binding phosphoric ester hydrolase activity molecular transducer activity catalytic activity, acting on a protein phosphatase activity signaling receptor activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity transmembrane receptor protein phosphatase activity transmembrane signaling receptor activity transmembrane receptor protein tyrosine phosphatase activity catalytic activity cell adhesion molecule binding	positive regulation of nervous system development multicellular organismal process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization regulation of developmental process positive regulation of biological process regulation of nervous system development positive regulation of developmental process cellular component organization cellular component biogenesis multicellular organism development cellular component assembly cell junction assembly anatomical structure development positive regulation of nervous system development multicellular organismal process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization regulation of developmental process positive regulation of biological process regulation of nervous system development positive regulation of developmental process cellular component organization cellular component biogenesis multicellular organism development cellular component assembly cell junction assembly anatomical structure development regulation of multicellular organismal process regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of synapse assembly regulation of biological quality positive regulation of cellular process system development developmental process regulation of multicellular organismal development regulation of biological process positive regulation of cellular component biogenesis biological regulation nervous system development regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly regulation of synapse organization cell junction organization positive regulation of multicellular organismal process cellular process synapse assembly positive regulation of synapse assembly membrane organization presynapse organization membrane biogenesis presynaptic membrane assembly membrane assembly presynaptic membrane organization presynapse assembly cell adhesion cell-cell adhesion synaptic membrane adhesion cell-cell adhesion via plasma-membrane adhesion molecules protein dephosphorylation organonitrogen compound metabolic process dephosphorylation cellular metabolic process primary metabolic process organic substance metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process response to stimulus regulation of response to stimulus immune response immune system process regulation of immune response regulation of immune system process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cellular developmental process generation of neurons neurogenesis neuron differentiation cell differentiation trans-synaptic signaling synaptic signaling trans-synaptic signaling by trans-synaptic complex signaling cell-cell signaling cell communication cellular response to stimulus cell surface receptor signaling pathway via STAT negative regulation of signaling negative regulation of biological process regulation of signal transduction negative regulation of cell communication negative regulation of cellular process regulation of receptor signaling pathway via JAK-STAT signal transduction negative regulation of receptor signaling pathway via JAK-STAT regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction regulation of cell communication negative regulation of receptor signaling pathway via STAT regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT modulation of chemical synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of postsynaptic specialization assembly regulation of excitatory synapse assembly postsynaptic density organization regulation of postsynaptic density organization postsynapse organization organelle assembly postsynaptic specialization assembly postsynapse assembly regulation of postsynapse organization regulation of organelle organization excitatory synapse assembly organelle organization regulation of organelle assembly postsynaptic specialization organization postsynaptic density assembly regulation of postsynaptic density assembly cell surface receptor protein tyrosine phosphatase signaling pathway enzyme-linked receptor protein signaling pathway cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell morphogenesis regulation of cell development cell projection morphogenesis neuron projection morphogenesis regulation of dendrite morphogenesis positive regulation of cell projection organization regulation of cell projection organization positive regulation of cell development positive regulation of cell morphogenesis regulation of dendrite development regulation of neuron projection development plasma membrane bounded cell projection morphogenesis cell development cell morphogenesis positive regulation of cell differentiation dendrite development positive regulation of neurogenesis regulation of anatomical structure morphogenesis plasma membrane bounded cell projection organization positive regulation of dendrite morphogenesis dendrite morphogenesis cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis neuron development regulation of plasma membrane bounded cell projection organization	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle cell periphery plasma membrane membrane presynapse extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle cell periphery plasma membrane membrane presynapse synapse cell junction presynaptic membrane plasma membrane region synaptic membrane glutamatergic synapse neuron to neuron synapse hippocampal mossy fiber to CA3 synapse Schaffer collateral - CA1 synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B	IPR003599	Immunoglobulin subtype	Domain
A, B	IPR003598	Immunoglobulin subtype 2	Domain
A, B	IPR001611	Leucine-rich repeat	Repeat
A, B	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A, B	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR007110	Immunoglobulin-like domain	Domain
A, B	IPR036116	Fibronectin type III superfamily	Homologous Superfamily
C [auth D], D [auth E]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
C [auth D], D [auth E]	IPR003599	Immunoglobulin subtype	Domain
C [auth D], D [auth E]	IPR003598	Immunoglobulin subtype 2	Domain
C [auth D], D [auth E]	IPR003595	Protein-tyrosine phosphatase, catalytic	Domain
C [auth D], D [auth E]	IPR013098	Immunoglobulin I-set	Domain
C [auth D], D [auth E]	IPR016130	Protein-tyrosine phosphatase, active site	Active Site
C [auth D], D [auth E]	IPR029021	Protein-tyrosine phosphatase-like	Homologous Superfamily
C [auth D], D [auth E]	IPR003961	Fibronectin type III	Domain
C [auth D], D [auth E]	IPR000242	Tyrosine-specific protein phosphatase, PTPase domain	Domain
C [auth D], D [auth E]	IPR000387	Tyrosine-specific protein phosphatases domain	Domain
C [auth D], D [auth E]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C [auth D], D [auth E]	IPR007110	Immunoglobulin-like domain	Domain
C [auth D], D [auth E]	IPR045905	Receptor-type tyrosine-protein phosphatase delta, PTPase domain, repeat 1	Domain
C [auth D], D [auth E]	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q96NI6	adrenal cortex carcinoma atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor astrocytic tumor bipolar disorder invasive ductal breast carcinoma malignant glioma ovarian cancer pilocytic astrocytoma psoriasis atopic eczema adrenal cortex carcinoma atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor astrocytic tumor bipolar disorder invasive ductal breast carcinoma malignant glioma ovarian cancer pilocytic astrocytoma psoriasis atopic eczema endogenous depression large cell medulloblastoma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer
C [auth D], D [auth E]	Pharos: P23468	restless legs syndrome breast carcinoma colorectal cancer breast cancer Liver Cirrhosis, Experimental malignant colon neoplasm malignant mesothelioma acute myeloid leukemia ovarian cancer attention deficit hyperactivity disorder, inattentive type psoriasis type 2 diabetes mellitus facioscapulohumeral muscular dystrophy interstitial cystitis lung adenocarcinoma restless legs syndrome breast carcinoma colorectal cancer breast cancer Liver Cirrhosis, Experimental malignant colon neoplasm malignant mesothelioma acute myeloid leukemia ovarian cancer attention deficit hyperactivity disorder, inattentive type psoriasis type 2 diabetes mellitus facioscapulohumeral muscular dystrophy interstitial cystitis lung adenocarcinoma malignant ependymoma maturity-onset diabetes of the young non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia atypical teratoid rhabdoid tumor ulcerative colitis Down syndrome glioblastoma large cell medulloblastoma lung cancer malignant glioma medulloblastoma osteosarcoma pituitary cancer subependymal giant cell astrocytoma colorectal carcinoma Emery-Dreifuss muscular dystrophy hydrolethalus syndrome