Annotations: 5XMC

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	WW domain	8091384	4002695	SCOP2 (2022-06-29)
A	SCOP2 Family	WW domain	8091386	4002695	SCOP2 (2022-06-29)
A	SCOP2 Family	Hect E3 ligase catalytic domain	8091388	4002196	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	WW domain	8091385	3001621	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	WW domain	8091387	3001621	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Hect E3 ligase catalytic domain	8091389	3000934	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00397	e5xmcA3	A: beta meanders	X: WW domain-like	H: WW domain (From Topology)	T: WW domain	F: PF00397	ECOD (1.6)
A	PF00632	e5xmcA1	A: a+b complex topology	X: Hect, E3 ligase catalytic domain (From Topology)	H: Hect, E3 ligase catalytic domain (From Topology)	T: Hect, E3 ligase catalytic domain	F: PF00632	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00397	WW domain (WW)	WW domain	The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.	Domain
A	PF00632	HECT-domain (ubiquitin-transferase) (HECT)	HECT-domain (ubiquitin-transferase)	The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	E3 ubiquitin-protein ligase Itchy	protein binding binding arrestin family protein binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity ligase activity ribonucleoprotein complex binding protein binding binding arrestin family protein binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity ligase activity ribonucleoprotein complex binding protein-containing complex binding signaling receptor binding cytokine receptor binding CXCR chemokine receptor binding G protein-coupled receptor binding chemokine receptor binding ubiquitin-like protein ligase binding enzyme binding	localization import into cell receptor internalization transport cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport apoptotic process cell death programmed cell death biological process involved in interspecies interaction between organisms response to stimulus localization import into cell receptor internalization transport cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport apoptotic process cell death programmed cell death biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus organonitrogen compound metabolic process protein autoubiquitination primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal organonitrogen compound catabolic process catabolic process protein catabolic process macromolecule catabolic process organic substance catabolic process regulation of defense response regulation of response to biotic stimulus negative regulation of response to biotic stimulus regulation of response to external stimulus negative regulation of biological process regulation of defense response to virus regulation of response to stress response to virus regulation of biological process negative regulation of response to stimulus biological regulation defense response to virus regulation of response to stimulus negative regulation of response to external stimulus negative regulation of defense response negative regulation of defense response to virus receptor catabolic process regulation of cellular process positive regulation of biological process positive regulation of cellular metabolic process cellular catabolic process positive regulation of metabolic process receptor metabolic process positive regulation of macromolecule metabolic process positive regulation of receptor catabolic process positive regulation of cellular process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of catabolic process positive regulation of catabolic process regulation of receptor catabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process regulation of metabolic process immune system development multicellular organismal process regulation of T cell anergy lymphocyte anergy regulation of lymphocyte anergy positive regulation of lymphocyte anergy positive regulation of T cell tolerance induction multicellular organism development positive regulation of T cell anergy anatomical structure development regulation of immune system process regulation of multicellular organismal process regulation of T cell tolerance induction positive regulation of immune system process T cell anergy system development developmental process T cell tolerance induction positive regulation of multicellular organismal process regulation of tolerance induction positive regulation of tolerance induction tolerance induction proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process protein polyubiquitination protein K48-linked ubiquitination cellular response to stimulus positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway regulation of signal transduction cell communication immune response-activating signaling pathway positive regulation of immune response signal transduction innate immune response-activating signaling pathway regulation of innate immune response regulation of pattern recognition receptor signaling pathway positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway intracellular receptor signaling pathway signaling negative regulation of signaling negative regulation of cytoplasmic pattern recognition receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway negative regulation of cell communication positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway negative regulation of cellular process regulation of signaling positive regulation of innate immune response negative regulation of signal transduction negative regulation of immune system process regulation of cell communication protein deubiquitination regulation of protein modification process regulation of post-translational protein modification regulation of protein metabolic process regulation of primary metabolic process protein modification by small protein removal regulation of protein deubiquitination regulation of protein modification by small protein conjugation or removal protein monoubiquitination negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process protein K29-linked ubiquitination positive regulation of protein metabolic process positive regulation of protein catabolic process regulation of protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of intracellular signal transduction intracellular signal transduction negative regulation of JNK cascade regulation of intracellular signal transduction JNK cascade intracellular signaling cassette regulation of JNK cascade regulation of MAPK cascade MAPK cascade negative regulation of MAPK cascade cellular biosynthetic process negative regulation of DNA-binding transcription factor activity RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process negative regulation of NF-kappaB transcription factor activity nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process negative regulation of molecular function nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription protein K63-linked ubiquitination negative regulation of lymphocyte proliferation regulation of alpha-beta T cell activation regulation of leukocyte activation regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation alpha-beta T cell proliferation T cell activation lymphocyte proliferation alpha-beta T cell activation regulation of leukocyte proliferation cell population proliferation regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion mononuclear cell proliferation regulation of cell population proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process negative regulation of leukocyte activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation negative regulation of mononuclear cell proliferation regulation of alpha-beta T cell proliferation cell adhesion cell-cell adhesion CD4-positive, alpha-beta T cell activation regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation CD4-positive, alpha-beta T cell proliferation negative regulation of cell population proliferation regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation negative regulation of alpha-beta T cell proliferation regulation of CD4-positive, alpha-beta T cell activation negative regulation of CD4-positive, alpha-beta T cell proliferation regulation of mononuclear cell proliferation negative regulation of alpha-beta T cell activation regulation of lymphocyte activation	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol protein-containing complex ubiquitin ligase complex catalytic complex transferase complex intracellular protein-containing complex cell periphery cell cortex plasma membrane membrane-bounded organelle membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol protein-containing complex ubiquitin ligase complex catalytic complex transferase complex intracellular protein-containing complex cell periphery cell cortex plasma membrane membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen cytoplasmic vesicle intracellular vesicle vesicle endosome membrane early endosome endosome early endosome membrane endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR035983	HECT, E3 ligase catalytic domain	Homologous Superfamily
A	IPR036020	WW domain superfamily	Homologous Superfamily
A	IPR000008	C2 domain	Domain
A	IPR000569	HECT domain	Domain
A	IPR024928	E3 ubiquitin-protein ligase, SMURF1 type	Family
A	IPR035892	C2 domain superfamily	Homologous Superfamily
A	IPR001202	WW domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.