5XE7

Crystal structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigJ

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08281	e5xe7A2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF08281	ECOD (1.6)
A	PF04542	e5xe7A1	A: alpha complex topology	X: Sigma2 domain-like	H: Sigma2 domain of RNA polymerase sigma factors (From Topology)	T: Sigma2 domain of RNA polymerase sigma factors	F: PF04542	ECOD (1.6)
A	PF12680	e5xe7A3	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: PF12680	ECOD (1.6)
B	PF08281	e5xe7B4	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF08281	ECOD (1.6)
B	PF04542	e5xe7B3	A: alpha complex topology	X: Sigma2 domain-like	H: Sigma2 domain of RNA polymerase sigma factors (From Topology)	T: Sigma2 domain of RNA polymerase sigma factors	F: PF04542	ECOD (1.6)
B	PF12680	e5xe7B2	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: PF12680	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF12680	SnoaL-like domain (SnoaL_2)	SnoaL-like domain	This family contains a large number of proteins that share the SnoaL fold.	Domain
A, B	PF08281	Sigma-70, region 4 (Sigma70_r4_2)	Sigma-70, region 4	Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	ECF RNA polymerase sigma factor SigJ	DNA binding binding organic cyclic compound binding nucleic acid binding transcription regulator activity DNA-binding transcription factor activity sigma factor activity	cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process organic substance metabolic process cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process organic substance metabolic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process cellular process macromolecule metabolic process response to hydrogen peroxide response to oxidative stress response to stimulus response to stress response to chemical response to oxygen-containing compound response to reactive oxygen species response to inorganic substance	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR007627	RNA polymerase sigma-70 region 2	Domain
A, B	IPR032710	NTF2-like domain superfamily	Homologous Superfamily
A, B	IPR013249	RNA polymerase sigma factor 70, region 4 type 2	Domain
A, B	IPR013325	RNA polymerase sigma factor, region 2	Homologous Superfamily
A, B	IPR013324	RNA polymerase sigma factor, region 3/4-like	Homologous Superfamily
A, B	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR037401	SnoaL-like domain	Domain
A, B	IPR014284	RNA polymerase sigma-70 like domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.