Annotations: 5X6O

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C]	PF08064	UME (NUC010) domain (UME)	UME (NUC010) domain	This domain is characteristic of UVSB PI-3 kinase, MEI-41 and ESR1 [1].	Domain
A [auth C]	PF02260	FATC domain (FATC)	FATC domain	-	Family
A [auth C]	PF00454	Phosphatidylinositol 3- and 4-kinase (PI3_PI4_kinase)	Phosphatidylinositol 3- and 4-kinase	-	Family
A [auth C]	PF02259	FAT domain (FAT)	FAT domain	-	Repeat
B [auth G]	PF09798	DNA damage checkpoint protein (LCD1)	DNA damage checkpoint protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C]	Serine/threonine-protein kinase MEC1	catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication cellular response to stress DNA damage response response to stress signal transduction in response to DNA damage cellular process signal transduction homologous recombination sexual reproduction reproductive process meiotic cell cycle process cellular component organization meiosis I meiotic nuclear division cell cycle cellular component organization or biogenesis reciprocal homologous recombination cell cycle process DNA recombination meiotic cell cycle organelle fission reciprocal meiotic recombination nuclear division organelle organization meiosis I cell cycle process mitotic recombination telomere organization chromosome organization telomere maintenance telomere maintenance via recombination positive regulation of DNA replication positive regulation of biological process regulation of primary metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process DNA-templated DNA replication positive regulation of nucleobase-containing compound metabolic process regulation of macromolecule metabolic process positive regulation of DNA metabolic process positive regulation of DNA-templated DNA replication regulation of DNA-templated DNA replication regulation of metabolic process regulation of DNA metabolic process regulation of DNA replication regulation of double-strand break repair regulation of cellular response to stress regulation of response to stress DNA repair double-strand break repair regulation of DNA repair regulation of response to stimulus phosphorylation cellular metabolic process phosphate-containing compound metabolic process phosphorus metabolic process DNA damage checkpoint signaling regulation of cell cycle phase transition negative regulation of biological process negative regulation of cell cycle cell cycle phase transition negative regulation of cellular process negative regulation of cell cycle phase transition regulation of cell cycle regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling protein-DNA complex organization protein-containing complex organization chromatin organization	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex nucleus nuclear protein-containing complex ATR-ATRIP complex
B [auth G]	DNA damage checkpoint protein LCD1	DNA binding binding organic cyclic compound binding damaged DNA binding nucleic acid binding	nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process primary metabolic process cellular biosynthetic process telomere organization RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening cellular component organization nucleic acid biosynthetic process organic substance biosynthetic process cellular component organization or biogenesis telomere maintenance via telomerase nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process primary metabolic process cellular biosynthetic process telomere organization RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening cellular component organization nucleic acid biosynthetic process organic substance biosynthetic process cellular component organization or biogenesis telomere maintenance via telomerase cellular metabolic process chromosome organization DNA metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process telomere maintenance organelle organization biosynthetic process organic cyclic compound biosynthetic process cellular process macromolecule metabolic process DNA biosynthetic process protein localization localization establishment of protein localization cellular localization cellular macromolecule localization macromolecule localization establishment of localization cellular response to stimulus response to stimulus cellular response to stress DNA damage response response to stress DNA repair regulation of cellular process regulation of double-strand break repair regulation of cellular response to stress regulation of primary metabolic process regulation of response to stress regulation of nucleobase-containing compound metabolic process double-strand break repair regulation of biological process biological regulation regulation of macromolecule metabolic process regulation of DNA repair regulation of response to stimulus regulation of metabolic process regulation of DNA metabolic process DNA damage checkpoint signaling regulation of cell cycle phase transition signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction cell communication negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle regulation of cell cycle cell cycle process regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling signal transduction in response to DNA damage protein-DNA complex organization protein-containing complex organization chromatin organization	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cytoplasm protein-containing complex nuclear protein-containing complex ATR-ATRIP complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C]	IPR016024	Armadillo-type fold	Homologous Superfamily
A [auth C]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A [auth C]	IPR003152	FATC domain	Domain
A [auth C]	IPR012993	UME domain	Domain
A [auth C]	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site	Conserved Site
A [auth C]	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain	Domain
A [auth C]	IPR003151	PIK-related kinase, FAT	Domain
A [auth C]	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily	Homologous Superfamily
A [auth C]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A [auth C]	IPR014009	PIK-related kinase	Domain
B [auth G]	IPR018622	DNA damage checkpoint protein, Lcd1	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.