Annotations: 5X57

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02187	e5x57A1	A: a+b two layers	X: Type III secretory system chaperone-like	H: GAS2 domain (From Topology)	T: GAS2 domain	F: PF02187	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02187	Growth-Arrest-Specific Protein 2 Domain (GAS2)	Growth-Arrest-Specific Protein 2 Domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5	cytoskeletal protein binding microtubule binding protein binding binding microtubule minus-end binding tubulin binding cation binding ion binding calcium ion binding metal ion binding small molecule binding actin binding protein-containing complex binding actin filament binding cytoskeletal protein binding microtubule binding protein binding binding microtubule minus-end binding tubulin binding cation binding ion binding calcium ion binding metal ion binding small molecule binding actin binding protein-containing complex binding actin filament binding RNA binding organic cyclic compound binding nucleic acid binding cell adhesion molecule binding cadherin binding structural molecule activity	protein localization Golgi to plasma membrane transport establishment of protein localization cellular localization nitrogen compound transport post-Golgi vesicle-mediated transport transport establishment of protein localization to plasma membrane Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization protein localization to cell periphery establishment of protein localization to membrane protein localization Golgi to plasma membrane transport establishment of protein localization cellular localization nitrogen compound transport post-Golgi vesicle-mediated transport transport establishment of protein localization to plasma membrane Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization protein localization to cell periphery establishment of protein localization to membrane protein localization to plasma membrane organic substance transport localization within membrane protein localization to membrane establishment of localization vesicle-mediated transport to the plasma membrane protein transport macromolecule localization cellular process Golgi vesicle transport regulation of cellular process regulation of cellular component organization cell-substrate junction assembly cellular component organization cellular component biogenesis cell adhesion cellular component assembly cell junction assembly regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly regulation of biological process regulation of cell-substrate adhesion regulation of cell adhesion biological regulation cell-substrate adhesion regulation of cellular component biogenesis regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization regulation of focal adhesion assembly regulation of cell-substrate junction assembly multicellular organismal process regulation of developmental process cellular developmental process regulation of neuron projection arborization cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis regulation of cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development regulation of anatomical structure morphogenesis system development developmental process plasma membrane bounded cell projection organization regulation of cell projection organization nervous system development generation of neurons anatomical structure morphogenesis neuron projection arborization neuron development axon extension positive regulation of nervous system development regulation of growth axonogenesis regulation of cellular component size developmental growth regulation of cell differentiation regulation of neurogenesis regulation of cell development positive regulation of developmental process positive regulation of cell projection organization regulation of biological quality positive regulation of developmental growth positive regulation of cell development developmental growth involved in morphogenesis positive regulation of multicellular organismal process regulation of neuron projection development positive regulation of cellular component organization positive regulation of biological process cell growth regulation of axon extension regulation of nervous system development regulation of extent of cell growth positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process positive regulation of axon extension positive regulation of cellular process positive regulation of axonogenesis regulation of cell size neuron projection extension regulation of multicellular organismal development regulation of developmental growth developmental cell growth growth positive regulation of cell growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation positive regulation of growth regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size regulation of cell motility regulation of locomotion regulation of cell migration cell migration cell motility locomotion organelle organization microtubule cytoskeleton organization microtubule-based process cytoplasmic microtubule organization supramolecular fiber organization cytoskeleton organization cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of Wnt signaling pathway signal transduction Wnt signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling wound healing response to stress response to wounding intermediate filament-based process intermediate filament cytoskeleton organization epithelium migration tissue migration ameboidal-type cell migration epithelial cell migration regulation of epithelial cell migration regulation of microtubule-based process	membrane cellular anatomical entity anchoring junction hemidesmosome cell junction cell-substrate junction ruffle cell leading edge plasma membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane membrane cellular anatomical entity anchoring junction hemidesmosome cell junction cell-substrate junction ruffle cell leading edge plasma membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane plasma membrane region cell projection membrane polymeric cytoskeletal fiber intracellular anatomical structure intermediate filament cytoskeleton intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle intermediate filament supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle actin cytoskeleton cytoplasm membrane-bounded organelle Golgi apparatus intracellular membrane-bounded organelle endomembrane system microtubule microtubule cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR041615	Desmoplakin, SH3 domain	Domain
A	IPR043197	Plakin	Family
A	IPR001101	Plectin repeat	Repeat
A	IPR001715	Calponin homology domain	Domain
A	IPR002048	EF-hand domain	Domain
A	IPR011992	EF-hand domain pair	Homologous Superfamily
A	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A	IPR001589	Actinin-type actin-binding domain, conserved site	Conserved Site
A	IPR049538	Plectin-like, spectrin-like repeat	Repeat
A	IPR035915	Plakin repeat superfamily	Homologous Superfamily
A	IPR003108	GAR domain	Domain
A	IPR001452	SH3 domain	Domain
A	IPR036872	CH domain superfamily	Homologous Superfamily
A	IPR018159	Spectrin/alpha-actinin	Repeat
A	IPR041573	Desmoplakin, spectrin-like domain	Domain
A	IPR036534	GAR domain superfamily	Homologous Superfamily
A	IPR002017	Spectrin repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9UPN3	osteosarcoma pancreatic intraductal papillary-mucinous neoplasm Pick disease tuberculosis Alzheimer disease Duchenne muscular dystrophy juvenile dermatomyositis lung adenocarcinoma lymphoplasmacytic lymphoma Malignant neoplasm of breast non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia progressive supranuclear palsy ulcerative colitis osteosarcoma pancreatic intraductal papillary-mucinous neoplasm Pick disease tuberculosis Alzheimer disease Duchenne muscular dystrophy juvenile dermatomyositis lung adenocarcinoma lymphoplasmacytic lymphoma Malignant neoplasm of breast non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia progressive supranuclear palsy ulcerative colitis astrocytic tumor Emery-Dreifuss muscular dystrophy large cell medulloblastoma lung cancer malignant ependymoma metabolic syndrome X oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma peripheral arterial disease psoriasis B-cell chronic lymphocytic leukemia hereditary spastic paraplegia lissencephaly spectrum disorders lung carcinoma malignant mesothelioma myopathy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.