5X2P

Crystal structure of the medaka fish taste receptor T1r2a-T1r3 ligand binding domains in complex with L-glutamate

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5x2pa_	Alpha and beta proteins (a/b)	Periplasmic binding protein-like I	Periplasmic binding protein-like I	automated matches	automated matches	Japanese rice fish (Oryzias latipes ) [TaxId: 8090 ],	SCOPe (2.08)
C	d5x2pc_	Alpha and beta proteins (a/b)	Periplasmic binding protein-like I	Periplasmic binding protein-like I	automated matches	automated matches	Japanese rice fish (Oryzias latipes ) [TaxId: 8090 ],	SCOPe (2.08)
B	d5x2pb_	Alpha and beta proteins (a/b)	Periplasmic binding protein-like I	Periplasmic binding protein-like I	automated matches	automated matches	Japanese rice fish (Oryzias latipes ) [TaxId: 8090 ],	SCOPe (2.08)
D	d5x2pd_	Alpha and beta proteins (a/b)	Periplasmic binding protein-like I	Periplasmic binding protein-like I	automated matches	automated matches	Japanese rice fish (Oryzias latipes ) [TaxId: 8090 ],	SCOPe (2.08)
E [auth H]	d5x2ph_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
G [auth J]	d5x2pj_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
H [auth K]	d5x2pk2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
H [auth K]	d5x2pk1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
F [auth L]	d5x2pl2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
F [auth L]	d5x2pl1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Type 1 solute binding protein-like	8078813	3000125	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Type 1 solute binding protein-like	8078813	3000125	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Type 1 solute binding protein-like	8078811	3000125	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Type 1 solute binding protein-like	8078811	3000125	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01094	e5x2pA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: PF01094	ECOD (1.6)
C	PF01094	e5x2pC2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: PF01094	ECOD (1.6)
B	PF01094	e5x2pB2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: PF01094	ECOD (1.6)
D	PF01094	e5x2pD2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: PF01094	ECOD (1.6)
E [auth H]	PF07654	e5x2pH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
E [auth H]	PF07686	e5x2pH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
G [auth J]	PF07654	e5x2pJ2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
G [auth J]	PF07686	e5x2pJ1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
H [auth K]	PF07654	e5x2pK1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
H [auth K]	PF07686	e5x2pK2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
F [auth L]	PF07654	e5x2pL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
F [auth L]	PF07686	e5x2pL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E [auth H]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
G [auth J]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
H [auth K]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
F [auth L]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
E [auth H], G [auth J]	Heavy Chain	IGHV1	-	taste receptor, type 1, member 2a \| taste receptor, type 1, member 3, taste receptor, type 1, member 2a	SAbDab (2024-04-26)
F [auth L], H [auth K]	Light Chain	IGKV3	Kappa	taste receptor, type 1, member 2a \| taste receptor, type 1, member 3, taste receptor, type 1, member 2a	SAbDab (2024-04-26)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF01094	Receptor family ligand binding region (ANF_receptor)	Receptor family ligand binding region	-	Family
B, D	PF01094	Receptor family ligand binding region (ANF_receptor)	Receptor family ligand binding region	-	Family
B, D	PF07562	Nine Cysteines Domain of family 3 GPCR (NCD3G)	Nine Cysteines Domain of family 3 GPCR	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Taste receptor, type 1, member 2a	molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity	-	cell periphery plasma membrane membrane cellular anatomical entity
B, D	Taste receptor, type 1, member 3	molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity	-	cell periphery plasma membrane membrane cellular anatomical entity
E [auth H], G [auth J]	Fab16A Heavy chain	-	-	-
F [auth L], H [auth K]	Fab16A Light chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR017978	GPCR family 3, C-terminal	Domain
A, C	IPR011500	GPCR, family 3, nine cysteines domain	Domain
A, C	IPR028082	Periplasmic binding protein-like I	Homologous Superfamily
A, C	IPR000337	GPCR, family 3	Family
A, C	IPR000068	GPCR, family 3, extracellular calcium-sensing receptor-related	Family
A, C	IPR038550	GPCR, family 3, nine cysteines domain superfamily	Homologous Superfamily
A, C	IPR001828	Receptor, ligand binding region	Domain
B, D	IPR017978	GPCR family 3, C-terminal	Domain
B, D	IPR011500	GPCR, family 3, nine cysteines domain	Domain
B, D	IPR028082	Periplasmic binding protein-like I	Homologous Superfamily
B, D	IPR000337	GPCR, family 3	Family
B, D	IPR000068	GPCR, family 3, extracellular calcium-sensing receptor-related	Family
B, D	IPR038550	GPCR, family 3, nine cysteines domain superfamily	Homologous Superfamily
B, D	IPR001828	Receptor, ligand binding region	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.