5WRW

Structure of human apo-SRP72

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF12895	e5wrwA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF12895	ECOD (1.6)
B	PF12895	e5wrwB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF12895	ECOD (1.6)
C	PF12895	e5wrwC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF12895	ECOD (1.6)
D	PF12895	e5wrwD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF12895	ECOD (1.6)
E	PF12895	e5wrwE1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF12895	ECOD (1.6)
F	PF12895	e5wrwF1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF12895	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF17004	Putative TPR-like repeat (SRP_TPR_like)	Putative TPR-like repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Signal recognition particle subunit SRP72	ribonucleoprotein complex binding protein-containing complex binding binding signal recognition particle binding RNA binding 7S RNA binding organic cyclic compound binding nucleic acid binding TPR domain binding protein binding protein domain specific binding	protein localization establishment of protein localization cellular localization establishment of protein localization to membrane protein targeting localization within membrane protein localization to membrane establishment of localization protein targeting to membrane localization SRP-dependent cotranslational protein targeting to membrane establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle protein localization establishment of protein localization cellular localization establishment of protein localization to membrane protein targeting localization within membrane protein localization to membrane establishment of localization protein targeting to membrane localization SRP-dependent cotranslational protein targeting to membrane establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle cotranslational protein targeting to membrane cellular process establishment of protein localization to endoplasmic reticulum protein localization to endoplasmic reticulum protein targeting to ER	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol signal recognition particle protein-containing complex ribonucleoprotein complex signal recognition particle, endoplasmic reticulum targeting membrane-bounded organelle intracellular organelle organelle endoplasmic reticulum intracellular membrane-bounded organelle endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR013699	Signal recognition particle, SRP72 subunit, RNA-binding	Domain
A, B, C, D, E A, B, C, D, E, F	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR031545	Signal recognition particle subunit SRP72, TPR-like repeat	Repeat
A, B, C, D, E A, B, C, D, E, F	IPR026270	Signal recognition particle, SRP72 subunit	Family
A, B, C, D, E A, B, C, D, E, F	IPR019734	Tetratricopeptide repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: O76094	autosomal dominant aplasia and myelodysplasia bone marrow failure syndrome cholestasis plasma cell myeloma ulcerative colitis Chemically-Induced Liver Toxicity drug-induced liver injury juvenile dermatomyositis lung cancer ovarian cancer psoriasis large cell medulloblastoma myopathy pancytopenia-developmental delay syndrome rheumatoid arthritis autosomal dominant aplasia and myelodysplasia bone marrow failure syndrome cholestasis plasma cell myeloma ulcerative colitis Chemically-Induced Liver Toxicity drug-induced liver injury juvenile dermatomyositis lung cancer ovarian cancer psoriasis large cell medulloblastoma myopathy pancytopenia-developmental delay syndrome rheumatoid arthritis congenital anemia lung adenocarcinoma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.