5WQL

Structure of a PDZ-protease bound to a substrate-binding adaptor

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth B]	d5wqlb_	All alpha proteins	alpha-alpha superhelix	TPR-like	Tetratricopeptide repeat (TPR)	Lipoprotein NlpI	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
B [auth A]	d5wqla1	All alpha proteins	alpha-alpha superhelix	TPR-like	Tetratricopeptide repeat (TPR)	Lipoprotein NlpI	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
B [auth A]	d5wqla2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2B Superfamily	TPR-like	8044044	3001345	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	TPR-like	8044044	3001345	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF07719	e5wqlB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF07719	ECOD (1.6)
B [auth A]	PF07719	e5wqlA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF07719	ECOD (1.6)
C	PF00595	e5wqlC2	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)
C	PF17804	e5wqlC1	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: PF17804	ECOD (1.6)
C	PF03572,PF11818	e5wqlC3	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: PF03572,PF11818	ECOD (1.6)
D	PF00595	e5wqlD2	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)
D	PF17804	e5wqlD1	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: PF17804	ECOD (1.6)
D	PF03572,PF11818	e5wqlD3	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: PF03572,PF11818	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)
B [auth A]	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C, D	PF17804	Tail specific protease N-terminal domain (TSP_NTD)	Tail specific protease N-terminal domain	The N-terminal domain of tail specific proteases has a novel fold composed of 10 alpha helices [1].	Domain
C, D	PF03572	Peptidase family S41 (Peptidase_S41)	Peptidase family S41	-	Family
C, D	PF11818	C-terminal domain of tail specific protease (DUF3340) (DUF3340)	C-terminal domain of tail specific protease (DUF3340)	-	Family
C, D	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	Lipoprotein NlpI	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity protein-macromolecule adaptor activity molecular adaptor activity	cellular process cell cycle organic substance metabolic process organonitrogen compound metabolic process glycosaminoglycan metabolic process aminoglycan metabolic process peptidoglycan metabolic process carbohydrate derivative metabolic process metabolic process macromolecule metabolic process cell division	cell periphery plasma membrane membrane cellular anatomical entity
C, D	Tail-specific protease	peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity endopeptidase activity serine hydrolase activity serine-type peptidase activity serine-type endopeptidase activity	response to stimulus response to chemical response to antibiotic organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process response to stimulus response to chemical response to antibiotic organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteolysis cellular response to stimulus regulation of biological process regulation of cellular process signaling biological regulation cellular process signal transduction cell communication	cell periphery plasma membrane membrane cellular anatomical entity outer membrane-bounded periplasmic space cell envelope periplasmic space
E [auth F], F [auth H]	ALA-ALA-ALA-ALA-ALA-ALA	-	-	-
G [auth E]	ALA-ALA-ALA-ALA	-	-	-
H [auth G]	LEU-SER-ARG-SER	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR019734	Tetratricopeptide repeat	Repeat
A [auth B], B [auth A]	IPR023605	Lipoprotein NlpI	Family
C, D	IPR040573	Tail specific protease, N-terminal domain	Domain
C, D	IPR029045	ClpP/crotonase-like domain superfamily	Homologous Superfamily
C, D	IPR020992	Tail specific protease, C-terminal	Domain
C, D	IPR036034	PDZ superfamily	Homologous Superfamily
C, D	IPR005151	Tail specific protease	Domain
C, D	IPR001478	PDZ domain	Domain
C, D	IPR004447	C-terminal-processing peptidase S41A	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.