5WE0

Structural Basis for Shelterin Bridge Assembly

External Resource: Annotation

Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e5we0A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e5we0D1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: F_UNCLASSIFIED	ECOD (1.6)
G	F_UNCLASSIFIED	e5we0G1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: F_UNCLASSIFIED	ECOD (1.6)
J	F_UNCLASSIFIED	e5we0J1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: F_UNCLASSIFIED	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D, G, J	Protection of telomeres protein poz1	DNA binding binding organic cyclic compound binding nucleic acid binding	telomere organization chromosome organization primary metabolic process DNA metabolic process nucleic acid metabolic process telomere maintenance cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization organic substance metabolic process telomere capping cellular process metabolic process telomere organization chromosome organization primary metabolic process DNA metabolic process nucleic acid metabolic process telomere maintenance cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization organic substance metabolic process telomere capping cellular process metabolic process cellular component organization or biogenesis macromolecule metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, telomeric repeat region chromosome chromosome, telomeric region chromosomal region non-membrane-bounded organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, telomeric repeat region chromosome chromosome, telomeric region chromosomal region non-membrane-bounded organelle membrane-bounded organelle protein-containing complex protein-DNA complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle telomere cap complex shelterin complex nuclear telomere cap complex
B, E, H, K	Protection of telomeres protein tpz1	sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding telomeric DNA binding	nuclear DNA replication telomere organization cell cycle DNA replication mitotic cell cycle telomere maintenance via semi-conservative replication nucleobase-containing compound metabolic process cellular component organization organic substance metabolic process mitotic telomere maintenance via semi-conservative replication cell cycle cellular component organization or biogenesis cell cycle process DNA-templated DNA replication chromosome organization nuclear DNA replication telomere organization cell cycle DNA replication mitotic cell cycle telomere maintenance via semi-conservative replication nucleobase-containing compound metabolic process cellular component organization organic substance metabolic process mitotic telomere maintenance via semi-conservative replication cell cycle cellular component organization or biogenesis cell cycle process DNA-templated DNA replication chromosome organization primary metabolic process DNA metabolic process nucleic acid metabolic process telomere maintenance organic cyclic compound metabolic process organelle organization mitotic cell cycle process DNA replication cellular process metabolic process macromolecule metabolic process protein-containing complex organization protein-DNA complex assembly cellular component biogenesis protein-DNA complex organization cellular component assembly telomere-telomerase complex assembly protein-containing complex assembly telomere capping cellular biosynthetic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening nucleic acid biosynthetic process organic substance biosynthetic process telomere maintenance via telomerase cellular metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process biosynthetic process organic cyclic compound biosynthetic process DNA biosynthetic process protein localization localization cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to chromosome, telomeric region	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome, telomeric repeat region chromosome chromosome, telomeric region cellular anatomical entity chromosomal region non-membrane-bounded organelle membrane-bounded organelle protein-containing complex protein-DNA complex nucleus intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome, telomeric repeat region chromosome chromosome, telomeric region cellular anatomical entity chromosomal region non-membrane-bounded organelle membrane-bounded organelle protein-containing complex protein-DNA complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle telomere cap complex shelterin complex nuclear telomere cap complex
C, F, I, L	DNA-binding protein rap1	sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding telomeric DNA binding	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process mitotic telomere clustering and tethering at nuclear periphery localization telomere localization telomere tethering at nuclear periphery chromosome localization organelle localization mitotic telomere tethering at nuclear periphery cellular response to stimulus telomere maintenance in response to DNA damage response to stimulus telomere organization cellular component organization cellular response to stress response to stress cellular component organization or biogenesis protection from non-homologous end joining at telomere chromosome organization DNA metabolic process telomere maintenance organelle organization telomere capping DNA damage response telomere maintenance via telomere lengthening establishment of organelle localization meiotic attachment of telomeric heterochromatin to spindle pole body meiotic chromosome segregation cellular localization sexual reproduction reproductive process meiotic cell cycle process meiosis I establishment of localization in cell meiotic nuclear division cell cycle chromosome segregation cell cycle process meiotic cell cycle organelle fission meiotic telomere clustering establishment of localization chromosome organization involved in meiotic cell cycle nuclear division chromosome localization to nuclear envelope involved in homologous chromosome segregation meiosis I cell cycle process nuclear chromosome segregation microtubule-based process homologous chromosome segregation establishment of chromosome localization	intracellular anatomical structure meiotic spindle pole body cellular anatomical entity intracellular organelle microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle spindle pole body microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle protein-containing complex protein-DNA complex intracellular anatomical structure meiotic spindle pole body cellular anatomical entity intracellular organelle microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle spindle pole body microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle protein-containing complex protein-DNA complex nucleus nuclear protein-containing complex chromosome intracellular membrane-bounded organelle chromosomal region telomere cap complex chromosome, telomeric repeat region chromosome, telomeric region shelterin complex nuclear telomere cap complex nucleus leading edge

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, E, H, K	IPR028631	Adrenocortical dysplasia protein	Family
C, F, I, L	IPR039595	TE2IP/Rap1	Family
C, F, I, L	IPR009057	Homeobox-like domain superfamily	Homologous Superfamily
C, F, I, L	IPR001357	BRCT domain	Domain
C, F, I, L	IPR015280	Rap1, DNA-binding domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.