5WCL

NMR structure of the N-domain of troponin C bound to switch region of troponin I and 3-methyldiphenylamine (solvent exposed mode)

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13833	e5wclA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13833	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13833	EF-hand domain pair (EF-hand_8)	EF-hand domain pair	-	Domain
A	PF00992	Troponin (Troponin)	Troponin	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Troponin C, slow skeletal and cardiac muscles,Troponin I, cardiac muscle	protein binding binding protein domain specific binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding troponin C binding troponin T binding kinase binding enzyme binding protein kinase binding molecular function inhibitor activity channel regulator activity protein binding binding protein domain specific binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding troponin C binding troponin T binding kinase binding enzyme binding protein kinase binding molecular function inhibitor activity channel regulator activity transporter inhibitor activity calcium channel inhibitor activity ion channel inhibitor activity ion channel regulator activity molecular function regulator activity calcium channel regulator activity transporter regulator activity channel inhibitor activity calcium-dependent protein binding cation binding ion binding calcium ion binding metal ion binding small molecule binding identical protein binding protein homodimerization activity protein dimerization activity troponin I binding	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development negative regulation of ATP-dependent activity regulation of ATP-dependent activity regulation of molecular function biological regulation negative regulation of molecular function multicellular organismal movement developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development negative regulation of ATP-dependent activity regulation of ATP-dependent activity regulation of molecular function biological regulation negative regulation of molecular function multicellular organismal movement musculoskeletal movement system process nervous system process neuromuscular process skeletal muscle contraction muscle contraction muscle system process striated muscle contraction inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis regulation of biological process regulation of system process regulation of muscle system process smooth muscle contraction regulation of smooth muscle contraction regulation of muscle contraction regulation of multicellular organismal process heart process circulatory system process heart contraction blood circulation cellular developmental process blood vessel morphogenesis tube development vasculogenesis vasculature development anatomical structure morphogenesis tube morphogenesis cell differentiation cellular process blood vessel development regulation of systemic arterial blood pressure by ischemic conditions regulation of blood pressure regulation of systemic arterial blood pressure regulation of biological quality nervous system process involved in regulation of systemic arterial blood pressure cardiac muscle contraction ventricular cardiac muscle tissue morphogenesis heart morphogenesis striated muscle tissue development muscle structure development ventricular cardiac muscle tissue development cardiac chamber development animal organ morphogenesis muscle tissue development muscle organ development cardiac chamber morphogenesis cardiac muscle tissue development tissue development muscle tissue morphogenesis tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis cardiac ventricle development muscle organ morphogenesis cellular response to stimulus regulation of cellular process response to stimulus signaling regulation of heart contraction intracellular signal transduction cell communication intracellular signaling cassette signal transduction regulation of cardiac muscle contraction by calcium ion signaling regulation of cardiac muscle contraction regulation of blood circulation regulation of striated muscle contraction calcium-mediated signaling respiratory gaseous exchange by respiratory system diaphragm contraction respiratory system process involuntary skeletal muscle contraction regulation of muscle adaptation striated muscle adaptation transition between fast and slow fiber regulation of skeletal muscle adaptation muscle adaptation regulation of response to stimulus skeletal muscle adaptation response to metal ion response to chemical response to inorganic substance regulation of localization cellular localization regulation of actin filament-based process transport muscle filament sliding localization establishment of localization in cell actin filament-based process regulation of intracellular transport actin-myosin filament sliding regulation of transport regulation of muscle filament sliding speed intracellular transport actin filament-based movement establishment of localization regulation of cellular localization regulation of actin filament-based movement regulation of muscle filament sliding actin-mediated cell contraction	striated muscle thin filament protein-containing complex intracellular anatomical structure myofilament cellular anatomical entity actin cytoskeleton sarcomere intracellular organelle troponin complex cytoskeleton organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm striated muscle thin filament protein-containing complex intracellular anatomical structure myofilament cellular anatomical entity actin cytoskeleton sarcomere intracellular organelle troponin complex cytoskeleton organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle cytosol cardiac myofibril cardiac Troponin complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001978	Troponin	Family
A	IPR038077	Troponin domain superfamily	Homologous Superfamily
A	IPR021666	Troponin I residues 1-32	Family
A	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A	IPR002048	EF-hand domain	Domain
A	IPR011992	EF-hand domain pair	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P63316	dilated cardiomyopathy cardiomyopathy hypertrophic cardiomyopathy 7 cardiomyopathy, familial restrictive, 1 restrictive cardiomyopathy dilated cardiomyopathy 1FF dilated cardiomyopathy 2A hypertrophic cardiomyopathy heart disease acute coronary syndrome myocardial infarction medulloblastoma Obstructive asymmetric septal hypertrophy systemic lupus erythematosus Charcot-Marie-Tooth disease dilated cardiomyopathy cardiomyopathy hypertrophic cardiomyopathy 7 cardiomyopathy, familial restrictive, 1 restrictive cardiomyopathy dilated cardiomyopathy 1FF dilated cardiomyopathy 2A hypertrophic cardiomyopathy heart disease acute coronary syndrome myocardial infarction medulloblastoma Obstructive asymmetric septal hypertrophy systemic lupus erythematosus Charcot-Marie-Tooth disease familial hypertrophic cardiomyopathy hypertensive disorder dilated cardiomyopathy 1A facioscapulohumeral muscular dystrophy familial isolated dilated cardiomyopathy left ventricular noncompaction coronary artery disease familial dilated cardiomyopathy dilated cardiomyopathy 1Z hypertrophic cardiomyopathy 13 dilated cardiomyopathy cardiomyopathy pituitary cancer congestive heart failure endometriosis Hodgkins lymphoma interstitial cystitis lung carcinoma mood disorder psoriasis Charcot-Marie-Tooth disease familial dilated cardiomyopathy hypertrophic cardiomyopathy lung adenocarcinoma malignant colon neoplasm non-small cell lung carcinoma Conduction disorder of the heart familial isolated dilated cardiomyopathy lung cancer malignant mesothelioma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.