5WBK

Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human S6K1

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	KOG1517	e5wbkA3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: KOG1517	ECOD (1.6)
A	Raptor_N,Arm	e5wbkA2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Raptor_N,Arm	ECOD (1.6)
A	Raptor_N	e5wbkA4	A: a/b three-layered sandwiches	X: Caspase-like (From Topology)	H: Caspase-like (From Topology)	T: Caspase-like	F: Raptor_N	ECOD (1.6)
A	UNK_F_TYPE	e5wbkA1	A: extended segments	X: TOR1 N-terminal extended segment (From Topology)	H: TOR1 N-terminal extended segment (From Topology)	T: TOR1 N-terminal extended segment	F: UNK_F_TYPE	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF14538	Raptor N-terminal CASPase like domain (Raptor_N)	Raptor N-terminal CASPase like domain	This domain is found at the N-terminus of the Raptor protein. It has been identified to have a CASPase like structure [1]. It conserves the characteristic cys/his dyad of the caspases suggesting it may have a peptidase activity.	Domain
A	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Regulatory-associated protein of TOR 1	protein binding binding kinase binding enzyme binding	developmental process multicellular organismal process reproductive system development reproductive process embryo development developmental process involved in reproduction multicellular organism development fruit development embryo development ending in seed dormancy seed development anatomical structure development reproductive structure development post-embryonic development system development developmental process multicellular organismal process reproductive system development reproductive process embryo development developmental process involved in reproduction multicellular organism development fruit development embryo development ending in seed dormancy seed development anatomical structure development reproductive structure development post-embryonic development system development negative regulation of cellular catabolic process negative regulation of catabolic process regulation of biological process catabolic process regulation of cellular process cellular metabolic process negative regulation of metabolic process autophagy biological regulation negative regulation of biological process regulation of cellular metabolic process regulation of catabolic process regulation of autophagy negative regulation of cellular metabolic process cellular catabolic process negative regulation of autophagy regulation of cellular catabolic process negative regulation of cellular process cellular process metabolic process process utilizing autophagic mechanism regulation of metabolic process cellular response to stimulus TOR signaling response to stimulus signaling intracellular signal transduction cell communication signal transduction maintenance of shoot apical meristem identity meristem development meristem maintenance maintenance of cell number tissue development maintenance of meristem identity stem cell population maintenance	intracellular anatomical structure cytoplasm cellular anatomical entity protein-containing complex TORC1 complex TOR complex intracellular protein-containing complex cullin-RING ubiquitin ligase complex ubiquitin ligase complex catalytic complex Cul4-RING E3 ubiquitin ligase complex transferase complex
B [auth T]	Ribosomal protein S6 kinase beta-1	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups identical protein binding protein binding protein phosphatase binding phosphatase binding enzyme binding protein phosphatase 2A binding protein serine/threonine/tyrosine kinase activity PDZ domain binding protein domain specific binding protein serine kinase activity protein serine/threonine kinase activity peptide binding ribosomal protein S6 kinase activity	response to stimulus response to chemical response to xenobiotic stimulus cellular response to stimulus cellular response to nutrient levels response to nutrient levels cellular response to chemical stimulus response to nutrient cellular response to nutrient cellular process regulation of muscle tissue development regulation of growth regulation of developmental process developmental growth response to stimulus response to chemical response to xenobiotic stimulus cellular response to stimulus cellular response to nutrient levels response to nutrient levels cellular response to chemical stimulus response to nutrient cellular response to nutrient cellular process regulation of muscle tissue development regulation of growth regulation of developmental process developmental growth skeletal muscle tissue development positive regulation of skeletal muscle tissue development positive regulation of biological process regulation of skeletal muscle tissue development muscle structure development positive regulation of developmental process skeletal muscle organ development regulation of skeletal muscle tissue growth anatomical structure development positive regulation of skeletal muscle tissue growth muscle tissue development muscle organ development positive regulation of developmental growth developmental process regulation of biological process regulation of developmental growth animal organ development biological regulation growth tissue development positive regulation of growth positive regulation of muscle tissue development skeletal muscle tissue growth regulation of localization hexose transmembrane transport regulation of cellular process glucose import regulation of transport transport organic substance transport carbohydrate transport establishment of localization transmembrane transport regulation of glucose transmembrane transport localization regulation of transmembrane transport glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport regulation of glucose import response to organic substance response to ketone response to lipid response to oxygen-containing compound response to testosterone response to organic cyclic compound response to hormone response to endogenous stimulus response to organonitrogen compound response to peptide hormone response to nitrogen compound response to glucagon apoptotic process cell death programmed cell death response to acid chemical response to amino acid response to L-leucine response to toxic substance positive regulation of locomotion regulation of cell motility positive regulation of smooth muscle cell migration regulation of smooth muscle cell migration positive regulation of cell migration smooth muscle cell migration muscle cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion positive regulation of cellular process cellular response to endogenous stimulus response to steroid hormone cellular response to organic substance cellular response to ketone cellular response to steroid hormone stimulus cellular response to hormone stimulus cellular response to dexamethasone stimulus response to glucocorticoid cellular response to organic cyclic compound cellular response to glucocorticoid stimulus cellular response to oxygen-containing compound cellular response to corticosteroid stimulus response to corticosteroid cellular response to lipid response to dexamethasone cellular response to nitrogen compound negative regulation of signaling signaling negative regulation of biological process regulation of signal transduction insulin receptor signaling pathway regulation of cellular response to insulin stimulus negative regulation of cell communication cell surface receptor protein tyrosine kinase signaling pathway cell communication negative regulation of cellular process signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus regulation of insulin receptor signaling pathway cellular response to peptide hormone stimulus negative regulation of signal transduction negative regulation of cellular response to insulin stimulus cellular response to organonitrogen compound regulation of response to stimulus negative regulation of insulin receptor signaling pathway response to insulin regulation of cell communication cellular response to insulin stimulus intracellular signal transduction phosphatidylinositol-mediated signaling trans-synaptic signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling mitotic cell cycle process cell cycle phase transition cell cycle G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle mitotic cell cycle phase transition cell cycle process cell population proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation organonitrogen compound metabolic process protein phosphorylation phosphorylation cellular metabolic process primary metabolic process peptidyl-serine modification organic substance metabolic process peptidyl-serine phosphorylation macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process import into cell organic anion transport carboxylic acid transport lipid localization lipid transport organic acid transport monocarboxylic acid transport fatty acid transport lipid import into cell macromolecule localization long-chain fatty acid import into cell long-chain fatty acid transport TOR signaling regulation of programmed cell death extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of programmed cell death regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of apoptotic signaling pathway cellular biosynthetic process positive regulation of protein metabolic process organonitrogen compound biosynthetic process positive regulation of translation positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression positive regulation of metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process translational initiation regulation of biosynthetic process regulation of translational initiation regulation of protein metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of translation regulation of macromolecule biosynthetic process positive regulation of translational initiation regulation of metabolic process positive regulation of cellular biosynthetic process regulation of muscle adaptation response to electrical stimulus multicellular organismal process system process regulation of system process regulation of muscle system process muscle system process response to electrical stimulus involved in regulation of muscle adaptation response to stimulus involved in regulation of muscle adaptation muscle adaptation response to abiotic stimulus regulation of multicellular organismal process intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction sexual reproduction cellular developmental process reproductive process multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation cell differentiation germ cell development muscle atrophy striated muscle adaptation skeletal muscle atrophy skeletal muscle adaptation striated muscle atrophy multicellular organismal movement musculoskeletal movement nervous system process neuromuscular process skeletal muscle contraction muscle contraction striated muscle contraction response to hexose response to monosaccharide response to carbohydrate response to glucose response to alcohol response to ethanol behavior learning or memory long-term memory cognition memory positive regulation of cell communication positive regulation of signal transduction positive regulation of TORC1 signaling positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling regulation of TORC1 signaling regulation of TOR signaling positive regulation of intracellular signal transduction TORC1 signaling positive regulation of signaling response to mechanical stimulus response to external stimulus biological process involved in interspecies interaction between organisms response to type II interferon response to cytokine cellular response to type II interferon response to biotic stimulus response to stress innate immune response cellular response to cytokine stimulus response to external biotic stimulus immune response response to other organism defense response defense response to symbiont immune system process defense response to other organism cellular response to growth factor stimulus response to growth factor behavioral defense response fear response behavioral fear response multicellular organismal response to stress positive regulation of cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle regulation of cell cycle response to lipopolysaccharide response to bacterium response to molecule of bacterial origin response to tumor necrosis factor	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol synapse cell junction glutamatergic synapse cell projection neuron projection plasma membrane bounded cell projection perinuclear region of cytoplasm membrane-bounded organelle mitochondrial membrane mitochondrion intracellular anatomical structure cytoplasm cellular anatomical entity cytosol synapse cell junction glutamatergic synapse cell projection neuron projection plasma membrane bounded cell projection perinuclear region of cytoplasm membrane-bounded organelle mitochondrial membrane mitochondrion membrane organelle outer membrane intracellular membrane-bounded organelle intracellular organelle organelle envelope bounding membrane of organelle organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane postsynapse cell surface nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004083	Regulatory associated protein of TOR	Family
A	IPR029347	Raptor, N-terminal CASPase-like domain	Domain
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR001680	WD40 repeat	Repeat
A	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
B [auth T]	IPR000719	Protein kinase domain	Domain
B [auth T]	IPR017892	Protein kinase, C-terminal	Domain
B [auth T]	IPR016238	Ribosomal protein S6 kinase	Family
B [auth T]	IPR017441	Protein kinase, ATP binding site	Binding Site
B [auth T]	IPR000961	AGC-kinase, C-terminal	Domain
B [auth T]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B [auth T]	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth T]	Pharos: P23443	diffuse large B-cell lymphoma hypertensive disorder Ceroid lipofuscinosis, neuronal 1, infantile psoriasis breast disease colorectal cancer inborn carbohydrate metabolic disorder medulloblastoma Pick disease cancer Crohn disease inflammatory bowel disease osteosarcoma progressive supranuclear palsy B-cell chronic lymphocytic leukemia diffuse large B-cell lymphoma hypertensive disorder Ceroid lipofuscinosis, neuronal 1, infantile psoriasis breast disease colorectal cancer inborn carbohydrate metabolic disorder medulloblastoma Pick disease cancer Crohn disease inflammatory bowel disease osteosarcoma progressive supranuclear palsy B-cell chronic lymphocytic leukemia ovarian cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.