5W7I

X-ray structure of ankyrin repeat domain of DHHC17 in complex with Snap25b peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ankyrin repeat	8067330	3000154	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ankyrin repeat	8067330	3000154	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ank_2	e5w7iA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: Ank_2	ECOD (1.6)
C	Ank_2	e5w7iC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: Ank_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.20	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Ankyrin repeat-containing domain	CATH (4.3.0)
C	1.25.40.20	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Ankyrin repeat-containing domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF12796	Ankyrin repeats (3 copies) (Ank_2)	Ankyrin repeats (3 copies)	-	Repeat
B, D	PF00835	SNAP-25 family (SNAP-25)	SNAP-25 family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Palmitoyltransferase ZDHHC17	protein binding binding signaling receptor binding protein-cysteine S-stearoyltransferase activity protein-cysteine S-acyltransferase activity catalytic activity, acting on a protein acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity S-acyltransferase activity catalytic activity protein-cysteine S-palmitoyltransferase activity palmitoyltransferase activity myristoyltransferase activity protein binding binding signaling receptor binding protein-cysteine S-stearoyltransferase activity protein-cysteine S-acyltransferase activity catalytic activity, acting on a protein acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity S-acyltransferase activity catalytic activity protein-cysteine S-palmitoyltransferase activity palmitoyltransferase activity myristoyltransferase activity protein-cysteine S-myristoyltransferase activity identical protein binding	protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport lipoprotein transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization cellular process lipoprotein localization protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport lipoprotein transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization cellular process lipoprotein localization cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of response to stimulus regulation of cell communication regulation of canonical NF-kappaB signal transduction positive regulation of signaling regulation of programmed cell death cell death programmed cell death organonitrogen compound metabolic process cellular biosynthetic process lipoprotein biosynthetic process cellular metabolic process lipoprotein metabolic process organonitrogen compound biosynthetic process primary metabolic process macromolecule biosynthetic process protein acylation protein lipidation organic substance metabolic process protein palmitoylation biosynthetic process macromolecule modification organic substance biosynthetic process metabolic process protein metabolic process macromolecule metabolic process protein modification process regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus neurotrophin signaling pathway enzyme-linked receptor protein signaling pathway cell surface receptor signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus neurotrophin TRK receptor signaling pathway regulation of neurotrophin TRK receptor signaling pathway response to growth factor multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development	membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system membrane intracellular vesicle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system membrane intracellular vesicle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle Golgi-associated vesicle membrane Golgi-associated vesicle vesicle organelle membrane Golgi membrane cell periphery presynapse synapse cell junction plasma membrane presynaptic membrane plasma membrane region synaptic membrane cell projection
B, D	Snap25b-111-120	SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity protein binding binding protein domain specific binding syntaxin-1 binding SNARE binding syntaxin binding transmembrane transporter binding lipid binding cytoskeletal protein binding myosin binding calcium-dependent protein binding	membrane organization protein-containing complex organization transport membrane fusion organelle membrane fusion establishment of localization vesicle-mediated transport cellular component organization cellular component biogenesis vesicle organization organelle fusion localization organelle organization cellular component assembly protein-containing complex assembly membrane organization protein-containing complex organization transport membrane fusion organelle membrane fusion establishment of localization vesicle-mediated transport cellular component organization cellular component biogenesis vesicle organization organelle fusion localization organelle organization cellular component assembly protein-containing complex assembly SNARE complex assembly cellular process cellular component organization or biogenesis vesicle fusion multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development developmental process plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development protein localization regulation of localization establishment of protein localization nitrogen compound transport regulation of cellular process cell communication cellular macromolecule localization regulation of biological quality regulation of peptide hormone secretion regulation of biological process regulation of hormone levels organic substance transport establishment of protein localization to extracellular region protein secretion regulation of protein secretion regulation of secretion cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion signaling hormone secretion protein localization to extracellular region peptide secretion secretion by cell regulation of secretion by cell amide transport signal release regulation of signaling secretion regulation of transport regulation of peptide transport biological regulation regulation of establishment of protein localization cell-cell signaling export from cell regulation of protein transport peptide transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization hormone transport regulation of cell communication insulin secretion establishment of localization in cell intracellular transport endosomal transport trans-synaptic signaling synaptic signaling anterograde trans-synaptic signaling chemical synaptic transmission regulation of cellular component organization cell junction assembly regulation of synapse structure or activity regulation of synapse assembly synapse organization regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization cell junction organization synapse assembly establishment of organelle localization regulated exocytosis synaptic vesicle cycle synaptic vesicle exocytosis vesicle-mediated transport in synapse dense core granule localization organelle localization presynaptic dense core vesicle exocytosis secretory granule localization calcium-ion regulated exocytosis vesicle localization calcium ion-regulated exocytosis of neurotransmitter neurotransmitter secretion establishment of vesicle localization neuronal dense core vesicle exocytosis dense core granule exocytosis neurotransmitter transport signal release from synapse exocytosis synaptic vesicle priming exocytic process membrane docking organelle localization by membrane tethering vesicle docking involved in exocytosis synaptic vesicle docking vesicle docking behavior locomotory behavior import into cell neurotransmitter uptake system process learning or memory long-term memory nervous system process cognition memory learning associative learning receptor internalization protein-containing complex localization neurotransmitter receptor internalization receptor-mediated endocytosis endocytosis endomembrane system organization vesicle fusion to plasma membrane synaptic vesicle fusion to presynaptic active zone membrane synaptic vesicle membrane organization positive regulation of cell communication positive regulation of establishment of protein localization positive regulation of insulin secretion positive regulation of peptide hormone secretion positive regulation of protein localization positive regulation of biological process positive regulation of secretion by cell positive regulation of protein transport positive regulation of hormone secretion positive regulation of secretion positive regulation of cellular process positive regulation of peptide secretion positive regulation of protein secretion positive regulation of transport positive regulation of signaling protein localization to synapse neurotransmitter receptor transport to postsynaptic membrane establishment of protein localization to postsynaptic membrane neurotransmitter receptor transport to plasma membrane protein localization to cell periphery protein localization to postsynaptic membrane neurotransmitter receptor transport establishment of protein localization to membrane localization within membrane protein localization to membrane exocytic insertion of neurotransmitter receptor to postsynaptic membrane vesicle-mediated transport to the plasma membrane regulation of postsynaptic membrane neurotransmitter receptor levels protein localization to postsynapse protein localization to cell junction receptor localization to synapse regulation of neuron projection development regulation of cell projection organization regulation of plasma membrane bounded cell projection organization modulation of chemical synaptic transmission long-term synaptic potentiation regulation of synaptic plasticity positive regulation of synaptic transmission regulation of trans-synaptic signaling	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system specific granule membrane intracellular organelle cytoplasmic vesicle membrane cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system specific granule membrane intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane specific granule photoreceptor inner segment cytoskeleton intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cytosol cell periphery presynapse synapse cell junction plasma membrane presynaptic membrane plasma membrane region synaptic membrane glutamatergic synapse neuron projection Golgi apparatus subcompartment Golgi apparatus organelle subcompartment trans-Golgi network SNARE complex protein-containing complex synaptobrevin 2-SNAP-25-syntaxin-1a complex membrane protein complex synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex perinuclear region of cytoplasm somatodendritic compartment cell body neuronal cell body synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex postsynapse transport vesicle synaptic vesicle exocytic vesicle actin-based cell projection filopodium tertiary granule membrane tertiary granule growth cone axon distal axon axonal growth cone site of polarized growth cell cortex ribbon synapse voltage-gated potassium channel complex plasma membrane protein complex potassium channel complex cation channel complex transporter complex transmembrane transporter complex monoatomic ion channel complex presynaptic active zone membrane presynaptic active zone endosome extrinsic component of plasma membrane extrinsic component of synaptic membrane extrinsic component of presynaptic membrane extrinsic component of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR002110	Ankyrin repeat	Repeat
A, C	IPR001594	Palmitoyltransferase, DHHC domain	Domain
A, C	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
B, D	IPR000727	Target SNARE coiled-coil homology domain	Domain
B, D	IPR039077	SNAP25, N-terminal SNARE motif, chordates	Domain
B, D	IPR000928	SNAP-25 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: Q8IUH5	astrocytic tumor large cell medulloblastoma oligodendroglioma atypical teratoid rhabdoid tumor malignant ependymoma osteosarcoma glioblastoma medulloblastoma ovarian cancer
B, D	Pharos: P60880	congenital myasthenic syndrome congenital myasthenic syndrome 18 melancholia bipolar disorder schizoaffective disorder Neuromuscular Manifestations endogenous depression type 2 diabetes mellitus primitive neuroectodermal tumor epilepsy interstitial cystitis lung carcinoma malignant glioma adrenal cortex carcinoma astrocytic tumor congenital myasthenic syndrome congenital myasthenic syndrome 18 melancholia bipolar disorder schizoaffective disorder Neuromuscular Manifestations endogenous depression type 2 diabetes mellitus primitive neuroectodermal tumor epilepsy interstitial cystitis lung carcinoma malignant glioma adrenal cortex carcinoma astrocytic tumor oligodendroglioma cystic fibrosis Parkinson disease depressive disorder Pick disease glioblastoma large cell medulloblastoma malignant colon neoplasm malignant mesothelioma maturity-onset diabetes of the young atypical teratoid rhabdoid tumor nasopharyngeal carcinoma botulism osteosarcoma peripheral nervous system disease pilocytic astrocytoma intellectual disability schizophreniform disorder subependymal giant cell astrocytoma malignant ependymoma Alzheimer disease medulloblastoma neurotic disorder overactive bladder peripheral neuropathy

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.