Annotations: 5W78

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SapB_2	e5w78A1	A: alpha arrays	X: Saposin-like	H: Saposin-like (From Topology)	T: Saposin-like	F: SapB_2	ECOD (1.6)
B	Lipase_GDSL_2_1	e5w78B1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: SGNH hydrolase (From Topology)	T: SGNH hydrolase	F: Lipase_GDSL_2_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF20825	Saposin-like domain (Saposin)	Saposin-like domain	-	Family
B	PF00657	GDSL-like Lipase/Acylhydrolase (Lipase_GDSL)	GDSL-like Lipase/Acylhydrolase	-	Family
B	PF20825	Saposin-like domain (Saposin)	Saposin-like domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Acyloxyacyl hydrolase	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity acyloxyacyl hydrolase activity catalytic activity	fatty acid metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process organic substance metabolic process cellular lipid metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process regulation of defense response fatty acid metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process organic substance metabolic process cellular lipid metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process regulation of defense response regulation of biological process response to stimulus regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus biological regulation negative regulation of biological process response to external stimulus regulation of inflammatory response regulation of response to stimulus response to stress negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response carbohydrate derivative catabolic process catabolic process lipid catabolic process liposaccharide metabolic process carbohydrate derivative metabolic process macromolecule catabolic process lipopolysaccharide metabolic process lipopolysaccharide catabolic process macromolecule metabolic process organic substance catabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoplasmic vesicle organelle intracellular vesicle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle vesicle extracellular region
B	Acyloxyacyl hydrolase	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity acyloxyacyl hydrolase activity catalytic activity	fatty acid metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process organic substance metabolic process cellular lipid metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process regulation of defense response fatty acid metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process organic substance metabolic process cellular lipid metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process regulation of defense response regulation of biological process response to stimulus regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus biological regulation negative regulation of biological process response to external stimulus regulation of inflammatory response regulation of response to stimulus response to stress negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response carbohydrate derivative catabolic process catabolic process lipid catabolic process liposaccharide metabolic process carbohydrate derivative metabolic process macromolecule catabolic process lipopolysaccharide metabolic process lipopolysaccharide catabolic process macromolecule metabolic process organic substance catabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoplasmic vesicle organelle intracellular vesicle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle vesicle extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR039676	Acyloxyacyl hydrolase	Family
A	IPR001087	GDSL lipase/esterase	Family
A	IPR011001	Saposin-like	Homologous Superfamily
A	IPR036514	SGNH hydrolase superfamily	Homologous Superfamily
A	IPR048593	Acyloxyacyl hydrolase, N-terminal domain	Domain
A	IPR008139	Saposin B type domain	Domain
B	IPR039676	Acyloxyacyl hydrolase	Family
B	IPR001087	GDSL lipase/esterase	Family
B	IPR011001	Saposin-like	Homologous Superfamily
B	IPR036514	SGNH hydrolase superfamily	Homologous Superfamily
B	IPR048593	Acyloxyacyl hydrolase, N-terminal domain	Domain
B	IPR008139	Saposin B type domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P28039	amphetamine abuse acute myeloid leukemia Amphetamine-Related Disorders cutaneous lupus erythematosus interstitial cystitis osteosarcoma atopic eczema head and neck cancer lung carcinoma tuberculosis chronic obstructive pulmonary disease IgA glomerulonephritis MALT lymphoma
B	Pharos: P28039	amphetamine abuse acute myeloid leukemia Amphetamine-Related Disorders cutaneous lupus erythematosus interstitial cystitis osteosarcoma atopic eczema head and neck cancer lung carcinoma tuberculosis chronic obstructive pulmonary disease IgA glomerulonephritis MALT lymphoma

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Monotopic/peripheral	Alpha/Beta monotopic/peripheral	SGNH hydrolase superfamily	GDSL-like lipase, family 1

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.