5W4T

Crystal Structure of Fish Cadherin-23 EC1-3

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth C]	SCOP2B Superfamily	Cadherin-like	8092024	3002049	SCOP2B (2022-06-29)
A [auth C]	SCOP2B Superfamily	Cadherin-like	8092023	3002049	SCOP2B (2022-06-29)
A [auth C]	SCOP2B Superfamily	Cadherin-like	8092025	3002049	SCOP2B (2022-06-29)
B [auth A]	SCOP2 Family	Cadherin	8088104	4007535	SCOP2 (2022-06-29)
B [auth A]	SCOP2 Family	Cadherin	8092021	4007535	SCOP2 (2022-06-29)
B [auth A]	SCOP2 Family	Cadherin	8092022	4007535	SCOP2 (2022-06-29)
B [auth A]	SCOP2 Superfamily	Cadherin-like	8092023	3002049	SCOP2 (2022-06-29)
B [auth A]	SCOP2 Superfamily	Cadherin-like	8092024	3002049	SCOP2 (2022-06-29)
B [auth A]	SCOP2 Superfamily	Cadherin-like	8092025	3002049	SCOP2 (2022-06-29)
C [auth B]	SCOP2B Superfamily	Cadherin-like	8092025	3002049	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Cadherin-like	8092023	3002049	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Cadherin-like	8092024	3002049	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cadherin-like	8092025	3002049	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cadherin-like	8092024	3002049	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cadherin-like	8092023	3002049	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	PF00028	e5w4tC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00028	ECOD (1.6)
B [auth A]	PF00028	e5w4tA3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00028	ECOD (1.6)
C [auth B]	PF00028	e5w4tB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00028	ECOD (1.6)
D	PF00028	e5w4tD3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00028	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth C]	2.60.40.60	Mainly Beta	Sandwich	Immunoglobulin-like	Cadherins	CATH (utative)
B [auth A]	2.60.40.60	Mainly Beta	Sandwich	Immunoglobulin-like	Cadherins	CATH (utative)
C [auth B]	2.60.40.60	Mainly Beta	Sandwich	Immunoglobulin-like	Cadherins	CATH (utative)
D	2.60.40.60	Mainly Beta	Sandwich	Immunoglobulin-like	Cadherins	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C], B [auth A], C [auth B], D	PF00028	Cadherin domain (Cadherin)	Cadherin domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth A], C [auth B], D	Cadherin 23	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding cell adhesion molecule binding cadherin binding protein binding transporter activity transmembrane transporter activity	cell adhesion cell-cell adhesion cellular process cell-cell adhesion via plasma-membrane adhesion molecules developmental process multicellular organismal process epithelium development epidermal cell differentiation cellular developmental process epidermis development nervous system development tissue development epithelial cell differentiation hair cell differentiation cell adhesion cell-cell adhesion cellular process cell-cell adhesion via plasma-membrane adhesion molecules developmental process multicellular organismal process epithelium development epidermal cell differentiation cellular developmental process epidermis development nervous system development tissue development epithelial cell differentiation hair cell differentiation generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development system development protein localization localization cellular localization protein localization to cilium protein localization to organelle cellular macromolecule localization macromolecule localization detection of external stimulus system process nervous system process response to stimulus detection of mechanical stimulus involved in sensory perception of sound response to mechanical stimulus response to external stimulus detection of mechanical stimulus involved in sensory perception sensory perception of mechanical stimulus detection of abiotic stimulus detection of stimulus sensory perception detection of mechanical stimulus response to abiotic stimulus detection of stimulus involved in sensory perception sensory perception of sound neuromuscular process equilibrioception neuromuscular process controlling balance inner ear receptor cell development cell projection organization sensory organ development cell development neuron projection development cellular component organization inner ear development cellular component organization or biogenesis mechanoreceptor differentiation plasma membrane bounded cell projection organization ear development animal organ development inner ear receptor cell differentiation neuron development inner ear receptor cell stereocilium organization import into cell transport endocytosis establishment of localization vesicle-mediated transport homophilic cell adhesion via plasma membrane adhesion molecules inner ear auditory receptor cell differentiation auditory receptor cell development lateral line development cell morphogenesis neuromast hair cell morphogenesis neuromast development sensory system development neuromast hair cell development cell morphogenesis involved in neuron differentiation lateral line system development anatomical structure morphogenesis neuromast hair cell differentiation	membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection membrane cell periphery protein-containing complex extrinsic component of plasma membrane catenin complex plasma membrane protein complex plasma membrane membrane protein complex membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection membrane cell periphery protein-containing complex extrinsic component of plasma membrane catenin complex plasma membrane protein complex plasma membrane membrane protein complex extrinsic component of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], B [auth A], C [auth B], D	IPR015919	Cadherin-like superfamily	Homologous Superfamily
A [auth C], B [auth A], C [auth B], D	IPR020894	Cadherin conserved site	Conserved Site
A [auth C], B [auth A], C [auth B], D	IPR002126	Cadherin-like	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.