Annotations: 5W3S

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08016	e5w3sA1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF08016	ECOD (1.6)
A	PF21381	e5w3sA2	A: a+b two layers	X: Polycystin-mucolipin domain (From Topology)	H: Polycystin-mucolipin domain (From Topology)	T: Polycystin-mucolipin domain	F: PF21381	ECOD (1.6)
B	PF08016	e5w3sB1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF08016	ECOD (1.6)
B	PF21381	e5w3sB2	A: a+b two layers	X: Polycystin-mucolipin domain (From Topology)	H: Polycystin-mucolipin domain (From Topology)	T: Polycystin-mucolipin domain	F: PF21381	ECOD (1.6)
C	PF08016	e5w3sC1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF08016	ECOD (1.6)
C	PF21381	e5w3sC2	A: a+b two layers	X: Polycystin-mucolipin domain (From Topology)	H: Polycystin-mucolipin domain (From Topology)	T: Polycystin-mucolipin domain	F: PF21381	ECOD (1.6)
D	PF08016	e5w3sD1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF08016	ECOD (1.6)
D	PF21381	e5w3sD2	A: a+b two layers	X: Polycystin-mucolipin domain (From Topology)	H: Polycystin-mucolipin domain (From Topology)	T: Polycystin-mucolipin domain	F: PF21381	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF08016	Polycystin cation channel (PKD_channel)	Polycystin cation channel	-	Family
A, B, C, D	PF21381	Mucolipin, extracytosolic domain (MCLN_ECD)	Mucolipin, extracytosolic domain	Mucolipins 1-3 are ion channel proteins that belong to the transient receptor potential (TRP) superfamily of cation channels and are the major Ca2+-permeable channels on late endosomes and lysosomes (LEL). This entry represents the extracytosolic dom ...	Mucolipins 1-3 are ion channel proteins that belong to the transient receptor potential (TRP) superfamily of cation channels and are the major Ca2+-permeable channels on late endosomes and lysosomes (LEL). This entry represents the extracytosolic domain (ECD) which consists of two beta sheets and two extracytosolic helices that tetramerize into a ring that caps the extracytosolic side of the channel [1-5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Mucolipin-3 isoform 1	monoatomic cation transmembrane transporter activity intracellularly ligand-gated monoatomic ion channel activity gated channel activity monoatomic ion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity channel activity intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity monoatomic ion transmembrane transporter activity transporter activity ligand-gated monoatomic cation channel activity transmembrane transporter activity monoatomic cation transmembrane transporter activity intracellularly ligand-gated monoatomic ion channel activity gated channel activity monoatomic ion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity channel activity intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity monoatomic ion transmembrane transporter activity transporter activity ligand-gated monoatomic cation channel activity transmembrane transporter activity phosphatidylinositol-3,5-bisphosphate binding binding ion binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding identical protein binding protein binding	monoatomic cation transmembrane transport transmembrane transport localization transport monoatomic ion transmembrane transport monoatomic ion transport cellular process monoatomic cation transport establishment of localization protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly monoatomic cation transmembrane transport transmembrane transport localization transport monoatomic ion transmembrane transport monoatomic ion transport cellular process monoatomic cation transport establishment of localization protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis	vacuolar membrane membrane-bounded organelle autophagosome membrane intracellular anatomical structure membrane vacuole cellular anatomical entity intracellular membrane-bounded organelle autophagosome intracellular organelle bounding membrane of organelle organelle cytoplasm organelle membrane vacuolar membrane membrane-bounded organelle autophagosome membrane intracellular anatomical structure membrane vacuole cellular anatomical entity intracellular membrane-bounded organelle autophagosome intracellular organelle bounding membrane of organelle organelle cytoplasm organelle membrane lytic vacuole lytic vacuole membrane lysosomal membrane lysosome endosome membrane early endosome endosome intracellular vesicle early endosome membrane endomembrane system cytoplasmic vesicle membrane cytoplasmic vesicle vesicle membrane vesicle cell leading edge plasma membrane stereocilium bundle neuron projection leading edge membrane cluster of actin-based cell projections plasma membrane bounded cell projection neuron projection membrane cell periphery cell projection stereocilium actin-based cell projection plasma membrane region stereocilium membrane cell projection membrane late endosome membrane late endosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR039031	Mucolipin	Family
A, B, C, D	IPR049134	Mucolipin, extracytosolic domain	Domain
A, B, C, D	IPR047317	Mucolipin-3, extracytosolic/lumenal domain	Domain
A, B, C, D	IPR013122	Polycystin cation channel, PKD1/PKD2	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D	OPM	Transmembrane	Alpha-helical polytopic	Ion channel (VIC) superfamily	Polycystin cation channel

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Transient Receptor Potential (TRP)	TRPML3 ion channel

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.