Annotations: 5VRF

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF01545	e5vrfB2	A: alpha bundles	X: Cation efflux protein transmembrane domain-like (From Topology)	H: Cation efflux protein transmembrane domain-like (From Topology)	T: Cation efflux protein transmembrane domain-like	F: PF01545	ECOD (1.6)
A [auth B]	PF16916	e5vrfB1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Cation efflux protein cytoplasmic domain-like (From Topology)	T: Cation efflux protein cytoplasmic domain-like	F: PF16916	ECOD (1.6)
B [auth A]	PF01545	e5vrfA2	A: alpha bundles	X: Cation efflux protein transmembrane domain-like (From Topology)	H: Cation efflux protein transmembrane domain-like (From Topology)	T: Cation efflux protein transmembrane domain-like	F: PF01545	ECOD (1.6)
B [auth A]	PF16916	e5vrfA1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Cation efflux protein cytoplasmic domain-like (From Topology)	T: Cation efflux protein cytoplasmic domain-like	F: PF16916	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF16916	Dimerisation domain of Zinc Transporter (ZT_dimer)	Dimerisation domain of Zinc Transporter	ZT_dimer is the dimerisation region of the whole molecule of zinc transporters since the full-length members form a homodimer during activity. The domain lies within the cytoplasm and exhibits an overall structural similarity with the copper metalloc ...	ZT_dimer is the dimerisation region of the whole molecule of zinc transporters since the full-length members form a homodimer during activity. The domain lies within the cytoplasm and exhibits an overall structural similarity with the copper metallochaperone Hah1 UniProtKB:O00244, exhibiting an open alpha-beta domain with two alpha helices (H1 and H2) aligned on one side and a three-stranded mixed beta-sheet (S1 to S3) on the other side. The N-terminal part of the members is the Cation_efflux family, Pfam:PF01545 [1].	Domain
A [auth B], B [auth A]	PF01545	Cation efflux family (Cation_efflux)	Cation efflux family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	Cadmium and zinc efflux pump FieF	monoatomic cation transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transition metal ion transmembrane transporter activity metal ion transmembrane transporter activity cadmium ion transmembrane transporter activity transmembrane transporter activity iron ion transmembrane transporter activity ferrous iron transmembrane transporter activity zinc ion transmembrane transporter activity zinc efflux active transmembrane transporter activity efflux transmembrane transporter activity monoatomic cation transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transition metal ion transmembrane transporter activity metal ion transmembrane transporter activity cadmium ion transmembrane transporter activity transmembrane transporter activity iron ion transmembrane transporter activity ferrous iron transmembrane transporter activity zinc ion transmembrane transporter activity zinc efflux active transmembrane transporter activity efflux transmembrane transporter activity monoatomic cation efflux transmembrane transporter activity secondary active transmembrane transporter activity active monoatomic ion transmembrane transporter activity zinc efflux transmembrane transporter activity active transmembrane transporter activity cation binding ion binding binding metal ion binding small molecule binding	inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis intracellular zinc ion homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR002524	Cation efflux protein	Family
A [auth B], B [auth A]	IPR027470	Cation efflux protein, cytoplasmic domain	Domain
A [auth B], B [auth A]	IPR036837	Cation efflux protein, cytoplasmic domain superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR027469	Cation efflux transmembrane domain superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth B], B [auth A]	OPM	Transmembrane	Alpha-helical polytopic	Cation diffusion facilitator	Bacterial zinc transporters

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth B], B [auth A]	PDBTM	Annotated as membrane protein by PDBTM

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.