5VOZ

Yeast V-ATPase in complex with Legionella pneumophila effector SidK (rotational state 3)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: PDBTM

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
O	SCOP2B Superfamily	Vacuolar ATP synthase subunit C	8042806	3001744	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	ARM repeat-like	8033221	3000116	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02874	e5vozA2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02874	ECOD (1.6)
A	PF22919	e5vozA1	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: PF22919	ECOD (1.6)
A	PF16886	e5vozA4	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: PF16886	ECOD (1.6)
A	PF00006,PF16886	e5vozA3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00006,PF16886	ECOD (1.6)
C	PF02874	e5vozC2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02874	ECOD (1.6)
C	PF22919	e5vozC1	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: PF22919	ECOD (1.6)
C	PF16886	e5vozC4	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: PF16886	ECOD (1.6)
C	PF00006,PF16886	e5vozC3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00006,PF16886	ECOD (1.6)
E	PF02874	e5vozE3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02874	ECOD (1.6)
E	PF22919	e5vozE2	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: PF22919	ECOD (1.6)
E	PF16886	e5vozE4	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: PF16886	ECOD (1.6)
E	PF00006,PF16886	e5vozE1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00006,PF16886	ECOD (1.6)
S	PF00137	e5vozS2	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
U	PF00137	e5vozU2	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
W	PF00137	e5vozW2	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
Y	PF00137	e5vozY1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
Z	PF00137	e5vozZ1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
AA [auth a]	PF00137	e5voza2	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
T	PF00137	e5vozT2	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
V	PF00137	e5vozV2	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
X	PF00137	e5vozX1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: PF00137	ECOD (1.6)
FA [auth f]	F_UNCLASSIFIED	e5vozf1	A: alpha superhelices	X: Effector protein SidK (From Topology)	H: Effector protein SidK (From Topology)	T: Effector protein SidK	F: F_UNCLASSIFIED	ECOD (1.6)
EA [auth e]	F_UNCLASSIFIED	e5voze1	A: alpha superhelices	X: Effector protein SidK (From Topology)	H: Effector protein SidK (From Topology)	T: Effector protein SidK	F: F_UNCLASSIFIED	ECOD (1.6)
GA [auth g]	F_UNCLASSIFIED	e5vozg1	A: alpha superhelices	X: Effector protein SidK (From Topology)	H: Effector protein SidK (From Topology)	T: Effector protein SidK	F: F_UNCLASSIFIED	ECOD (1.6)
F	PF02874	e5vozF2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02874	ECOD (1.6)
F	PF22919	e5vozF1	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: PF22919	ECOD (1.6)
F	PF00006	e5vozF3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00006	ECOD (1.6)
B	PF02874	e5vozB3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02874	ECOD (1.6)
B	PF22919	e5vozB2	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: PF22919	ECOD (1.6)
B	PF00006	e5vozB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00006	ECOD (1.6)
D	PF02874	e5vozD3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02874	ECOD (1.6)
D	PF22919	e5vozD1	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: PF22919	ECOD (1.6)
D	PF00006	e5vozD2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00006	ECOD (1.6)
G	PF01991	e5vozG2	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: PF01991	ECOD (1.6)
G	PF01991	e5vozG1	A: extended segments	X: Helical region in V-type proton ATPase subunit E (From Topology)	H: Helical region in V-type proton ATPase subunit E (From Topology)	T: Helical region in V-type proton ATPase subunit E	F: PF01991	ECOD (1.6)
I	PF01991	e5vozI2	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: PF01991	ECOD (1.6)
I	PF01991	e5vozI1	A: extended segments	X: Helical region in V-type proton ATPase subunit E (From Topology)	H: Helical region in V-type proton ATPase subunit E (From Topology)	T: Helical region in V-type proton ATPase subunit E	F: PF01991	ECOD (1.6)
K	PF01991	e5vozK2	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: PF01991	ECOD (1.6)
K	PF01991	e5vozK1	A: extended segments	X: Helical region in V-type proton ATPase subunit E (From Topology)	H: Helical region in V-type proton ATPase subunit E (From Topology)	T: Helical region in V-type proton ATPase subunit E	F: PF01991	ECOD (1.6)
H	PF03179	e5vozH1	A: extended segments	X: V-type proton ATPase subunit G (From Topology)	H: V-type proton ATPase subunit G (From Topology)	T: V-type proton ATPase subunit G	F: PF03179	ECOD (1.6)
J	PF03179	e5vozJ1	A: extended segments	X: V-type proton ATPase subunit G (From Topology)	H: V-type proton ATPase subunit G (From Topology)	T: V-type proton ATPase subunit G	F: PF03179	ECOD (1.6)
L	PF03179	e5vozL1	A: extended segments	X: V-type proton ATPase subunit G (From Topology)	H: V-type proton ATPase subunit G (From Topology)	T: V-type proton ATPase subunit G	F: PF03179	ECOD (1.6)
M	PF01813	e5vozM1	A: alpha bundles	X: V-type proton ATPase subunit D (From Topology)	H: V-type proton ATPase subunit D (From Topology)	T: V-type proton ATPase subunit D	F: PF01813	ECOD (1.6)
N	PF01990	e5vozN1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: AtpF-like (From Topology)	T: AtpF-like	F: PF01990	ECOD (1.6)
O	PF03223	e5vozO1	A: alpha bundles	X: helical bundle domain in vacuolar ATP synthase subunit C (From Topology)	H: helical bundle domain in vacuolar ATP synthase subunit C (From Topology)	T: helical bundle domain in vacuolar ATP synthase subunit C	F: PF03223	ECOD (1.6)
O	PF03223	e5vozO2	A: a+b two layers	X: Alpha-beta plaits	H: ferredoxin-like domain in vacuolar ATP synthase subunit C (From Topology)	T: ferredoxin-like domain in vacuolar ATP synthase subunit C	F: PF03223	ECOD (1.6)
P	PF03224,PF11698	e5vozP1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF03224,PF11698	ECOD (1.6)
Q	PF01992	e5vozQ1	A: alpha bundles	X: V-type ATP synthase subunit C	H: V-type ATP synthase subunit C (From Topology)	T: V-type ATP synthase subunit C	F: PF01992	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E	PF16886	ATPsynthase alpha/beta subunit N-term extension (ATP-synt_ab_Xtn)	ATPsynthase alpha/beta subunit N-term extension	-	Family
A, C, E	PF02874	ATP synthase alpha/beta family, beta-barrel domain (ATP-synt_ab_N)	ATP synthase alpha/beta family, beta-barrel domain	This family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella.	Domain
R	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	-	Family
S	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	-	Family
AA [auth a], T, U, V, W, AA [auth a], T, U, V, W, X, Y, Z	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	-	Family
BA [auth b]	PF01496	V-type ATPase 116kDa subunit family (V_ATPase_I)	V-type ATPase 116kDa subunit family	-	Family
CA [auth c]	PF05493	ATP synthase subunit H (ATP_synt_H)	ATP synthase subunit H	-	Family
B, D, F	PF00006	ATP synthase alpha/beta family, nucleotide-binding domain (ATP-synt_ab)	ATP synthase alpha/beta family, nucleotide-binding domain	This entry includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.	Domain
B, D, F	PF02874	ATP synthase alpha/beta family, beta-barrel domain (ATP-synt_ab_N)	ATP synthase alpha/beta family, beta-barrel domain	This family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella.	Domain
G, I, K	PF01991	ATP synthase (E/31 kDa) subunit (vATP-synt_E)	ATP synthase (E/31 kDa) subunit	-	Family
H, J, L	PF03179	Vacuolar (H+)-ATPase G subunit (V-ATPase_G)	Vacuolar (H+)-ATPase G subunit	-	Coiled-coil
M	PF01813	ATP synthase subunit D (ATP-synt_D)	ATP synthase subunit D	-	Family
N	PF01990	ATP synthase (F/14-kDa) subunit (ATP-synt_F)	ATP synthase (F/14-kDa) subunit	-	Family
O	PF03223	V-ATPase subunit C (V-ATPase_C)	V-ATPase subunit C	-	Family
P	PF11698	V-ATPase subunit H (V-ATPase_H_C)	V-ATPase subunit H	-	Repeat
P	PF03224	V-ATPase subunit H (V-ATPase_H_N)	V-ATPase subunit H	-	Repeat
Q	PF01992	ATP synthase (C/AC39) subunit (vATP-synt_AC39)	ATP synthase (C/AC39) subunit	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E	V-type proton ATPase catalytic subunit A,V-type proton ATPase catalytic subunit A	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity channel activity catalytic activity ligase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding RNA binding mRNA binding endonuclease activity nuclease activity hydrolase activity, acting on ester bonds hydrolase activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport nucleobase-containing compound metabolic process organic cyclic compound metabolic process transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process DNA recombination metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process intron homing homeostatic process biological regulation intracellular pH reduction regulation of intracellular pH vesicle organization cellular component organization organelle organization cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis endosome organization intracellular chemical homeostasis cellular component organization or biogenesis regulation of biological quality endosomal lumen acidification monoatomic cation homeostasis endomembrane system organization regulation of cellular pH intracellular monoatomic ion homeostasis intein-mediated protein splicing organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis organic substance biosynthetic process protein processing protein metabolic process protein splicing Golgi lumen acidification vacuolar acidification	vacuolar membrane membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure catalytic complex membrane membrane protein complex proton-transporting V-type ATPase complex vacuole proton-transporting V-type ATPase, V1 domain cellular anatomical entity intracellular membrane-bounded organelle vacuolar proton-transporting V-type ATPase, V1 domain vacuolar membrane membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure catalytic complex membrane membrane protein complex proton-transporting V-type ATPase complex vacuole proton-transporting V-type ATPase, V1 domain cellular anatomical entity intracellular membrane-bounded organelle vacuolar proton-transporting V-type ATPase, V1 domain vacuolar proton-transporting V-type ATPase complex intracellular organelle bounding membrane of organelle proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain organelle cytoplasm organelle membrane storage vacuole lytic vacuole fungal-type vacuole lytic vacuole membrane fungal-type vacuole membrane Golgi membrane Golgi apparatus endomembrane system
R	V-type proton ATPase subunit c''	monoatomic cation transmembrane transporter activity P-type transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity ATPase-coupled monoatomic cation transmembrane transporter activity P-type proton-exporting transporter activity ATP-dependent activity P-type ion transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity P-type transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity ATPase-coupled monoatomic cation transmembrane transporter activity P-type proton-exporting transporter activity ATP-dependent activity P-type ion transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled ion transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle cytoplasm organelle membrane fungal-type vacuole membrane protein-containing complex ATPase complex proton-transporting two-sector ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex Golgi membrane Golgi apparatus endomembrane system vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V0 domain
S	V-type proton ATPase subunit c'	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuolar acidification	membrane-bounded organelle storage vacuole intracellular anatomical structure lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle organelle cytoplasm vacuolar membrane membrane lytic vacuole membrane membrane-bounded organelle storage vacuole intracellular anatomical structure lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle organelle cytoplasm vacuolar membrane membrane lytic vacuole membrane bounding membrane of organelle organelle membrane fungal-type vacuole membrane protein-containing complex ATPase complex proton-transporting two-sector ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex Golgi membrane Golgi apparatus endomembrane system vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V0 domain cell periphery
AA [auth a], T, U, V, W, AA [auth a], T, U, V, W, X, Y, Z	V-type proton ATPase subunit c	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport protein localization establishment of protein localization cellular localization nitrogen compound transport protein targeting organic substance transport establishment of protein localization to vacuole protein localization to vacuole intracellular transport establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell vacuolar transport protein targeting to vacuole intracellular protein transport intracellular copper ion homeostasis copper ion homeostasis import into cell endocytosis vesicle-mediated transport biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH regulation of pH regulation of biological quality regulation of cellular pH vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuole organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle cytoplasm organelle membrane fungal-type vacuole membrane protein-containing complex ATPase complex proton-transporting two-sector ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex Golgi membrane Golgi apparatus endomembrane system vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V0 domain
BA [auth b]	V-type proton ATPase subunit a, vacuolar isoform	phosphatidylinositol-3,5-bisphosphate binding binding ion binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity phosphatidylinositol-3,5-bisphosphate binding binding ion binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity ATPase binding protein binding enzyme binding	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular component organization cellular component biogenesis transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis cellular response to stimulus response to stimulus response to pH cellular response to pH response to alkaline pH response to abiotic stimulus cellular response to alkaline pH cellular response to abiotic stimulus cellular response to environmental stimulus response to osmotic stress cellular response to chemical stress cellular response to osmotic stress cellular response to chemical stimulus hyperosmotic response cellular hyperosmotic response cellular response to stress response to stress response to chemical organic substance metabolic process oxoacid metabolic process cellular metabolic process metabolic process small molecule metabolic process organic acid metabolic process phosphorus metabolic process polyphosphate metabolic process homeostatic process biological regulation intracellular pH reduction regulation of intracellular pH vacuolar acidification cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis	membrane-bounded organelle storage vacuole intracellular anatomical structure lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle organelle cytoplasm vacuolar membrane membrane lytic vacuole membrane membrane-bounded organelle storage vacuole intracellular anatomical structure lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle organelle cytoplasm vacuolar membrane membrane lytic vacuole membrane bounding membrane of organelle organelle membrane fungal-type vacuole membrane protein-containing complex ATPase complex catalytic complex vacuolar proton-transporting V-type ATPase, V0 domain membrane protein complex proton-transporting V-type ATPase complex proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex proton-transporting two-sector ATPase complex proton-transporting V-type ATPase, V0 domain
CA [auth c]	V-type proton ATPase subunit e	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular component organization cellular component biogenesis transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis mannoprotein biosynthetic process cell wall mannoprotein biosynthetic process cellular biosynthetic process cell wall organization or biogenesis organonitrogen compound biosynthetic process carbohydrate derivative metabolic process mannoprotein metabolic process organic substance metabolic process organic substance biosynthetic process protein metabolic process cell wall glycoprotein biosynthetic process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process cellular metabolic process glycoprotein biosynthetic process primary metabolic process glycoprotein metabolic process macromolecule biosynthetic process biosynthetic process metabolic process macromolecule metabolic process cell wall macromolecule metabolic process vesicle organization organelle organization endosome organization endosomal lumen acidification endomembrane system organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle cytoplasm organelle membrane fungal-type vacuole membrane protein-containing complex ATPase complex proton-transporting two-sector ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex Golgi membrane Golgi apparatus endomembrane system vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V0 domain
DA [auth d]	V-type proton ATPase subunit f	-	-	-
EA [auth e], FA [auth f], GA [auth g]	Uncharacterized protein	-	-	-
B, D, F	V-type proton ATPase subunit B	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport ribose phosphate metabolic process ATP metabolic process transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport ribose phosphate metabolic process ATP metabolic process carbohydrate derivative metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process organic substance metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process purine nucleoside triphosphate metabolic process organonitrogen compound metabolic process cellular metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process organic cyclic compound metabolic process organophosphate metabolic process metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process homeostatic process biological regulation intracellular pH reduction regulation of intracellular pH vesicle organization cellular component organization organelle organization cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis endosome organization intracellular chemical homeostasis cellular component organization or biogenesis regulation of biological quality endosomal lumen acidification monoatomic cation homeostasis endomembrane system organization regulation of cellular pH intracellular monoatomic ion homeostasis inorganic ion homeostasis intracellular calcium ion homeostasis calcium ion homeostasis cellular catabolic process autophagy of peroxisome catabolic process macroautophagy pexophagy autophagy process utilizing autophagic mechanism cellular component biogenesis cellular component assembly organelle assembly non-membrane-bounded organelle assembly proteasome storage granule assembly Golgi lumen acidification vacuolar acidification	organelle membrane contact site vacuole-mitochondrion membrane contact site organelle cellular anatomical entity intracellular anatomical structure cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular organelle intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle cytoplasmic stress granule vacuolar membrane organelle membrane contact site vacuole-mitochondrion membrane contact site organelle cellular anatomical entity intracellular anatomical structure cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular organelle intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle cytoplasmic stress granule vacuolar membrane membrane-bounded organelle protein-containing complex ATPase complex catalytic complex membrane membrane protein complex proton-transporting V-type ATPase complex vacuole proton-transporting V-type ATPase, V1 domain intracellular membrane-bounded organelle vacuolar proton-transporting V-type ATPase, V1 domain vacuolar proton-transporting V-type ATPase complex bounding membrane of organelle proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain organelle membrane storage vacuole lytic vacuole fungal-type vacuole lytic vacuole membrane fungal-type vacuole membrane Golgi membrane Golgi apparatus endomembrane system
G, I, K	V-type proton ATPase subunit E	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction regulation of intracellular pH vesicle organization cellular component organization organelle organization cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis endosome organization intracellular chemical homeostasis cellular component organization or biogenesis regulation of biological quality endosomal lumen acidification monoatomic cation homeostasis endomembrane system organization regulation of cellular pH intracellular monoatomic ion homeostasis Golgi lumen acidification vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle cytoplasm organelle membrane fungal-type vacuole membrane protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex vacuolar proton-transporting V-type ATPase complex proton-transporting two-sector ATPase complex proton-transporting V-type ATPase, V1 domain vacuolar proton-transporting V-type ATPase, V1 domain proton-transporting two-sector ATPase complex, catalytic domain Golgi membrane Golgi apparatus endomembrane system
H, J, L	V-type proton ATPase subunit G	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction regulation of intracellular pH vesicle organization cellular component organization organelle organization cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis endosome organization intracellular chemical homeostasis cellular component organization or biogenesis regulation of biological quality endosomal lumen acidification monoatomic cation homeostasis endomembrane system organization regulation of cellular pH intracellular monoatomic ion homeostasis Golgi lumen acidification vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle cytoplasm organelle membrane fungal-type vacuole membrane protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex vacuolar proton-transporting V-type ATPase complex proton-transporting two-sector ATPase complex proton-transporting V-type ATPase, V1 domain vacuolar proton-transporting V-type ATPase, V1 domain proton-transporting two-sector ATPase complex, catalytic domain Golgi membrane Golgi apparatus endomembrane system
M	V-type proton ATPase subunit D	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction regulation of intracellular pH vesicle organization cellular component organization organelle organization cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis endosome organization intracellular chemical homeostasis cellular component organization or biogenesis regulation of biological quality endosomal lumen acidification monoatomic cation homeostasis endomembrane system organization regulation of cellular pH intracellular monoatomic ion homeostasis Golgi lumen acidification vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle cytoplasm organelle membrane fungal-type vacuole membrane protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex vacuolar proton-transporting V-type ATPase complex proton-transporting two-sector ATPase complex proton-transporting V-type ATPase, V1 domain vacuolar proton-transporting V-type ATPase, V1 domain proton-transporting two-sector ATPase complex, catalytic domain Golgi membrane Golgi apparatus endomembrane system
N	V-type proton ATPase subunit F	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle cytoplasm organelle membrane fungal-type vacuole membrane protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V1 domain vacuolar proton-transporting V-type ATPase, V1 domain vacuolar proton-transporting V-type ATPase complex proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain Golgi membrane Golgi apparatus endomembrane system
O	V-type proton ATPase subunit C	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle cytoplasm organelle membrane fungal-type vacuole membrane protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V1 domain vacuolar proton-transporting V-type ATPase, V1 domain vacuolar proton-transporting V-type ATPase complex proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain Golgi membrane Golgi apparatus endomembrane system
P	V-type proton ATPase subunit H	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle cytoplasm organelle membrane fungal-type vacuole membrane protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V1 domain vacuolar proton-transporting V-type ATPase, V1 domain vacuolar proton-transporting V-type ATPase complex proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain Golgi membrane Golgi apparatus endomembrane system
Q	V-type proton ATPase subunit d	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular localization establishment of localization in cell transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular localization establishment of localization in cell vacuolar transport intracellular transport homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle cytoplasm organelle membrane fungal-type vacuole membrane protein-containing complex ATPase complex proton-transporting two-sector ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex Golgi membrane Golgi apparatus endomembrane system vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V0 domain

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E	IPR036844	Hint domain superfamily	Homologous Superfamily
A, C, E	IPR022878	V-type ATP synthase catalytic alpha chain	Family
A, C, E	IPR006142	Intein	Domain
A, C, E	IPR007868	Hom-end-associated Hint	Domain
A, C, E	IPR024034	ATPase, F1/V1 complex, beta/alpha subunit, C-terminal	Homologous Superfamily
A, C, E	IPR036121	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily	Homologous Superfamily
A, C, E	IPR006141	Intein N-terminal splicing region	PTM
A, C, E	IPR000194	ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain	Domain
A, C, E	IPR003586	Hint domain C-terminal	Domain
A, C, E	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, C, E	IPR004100	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain	Domain
A, C, E	IPR031686	ATPsynthase alpha/beta subunit, N-terminal extension	Domain
A, C, E	IPR004042	Intein DOD homing endonuclease	Domain
A, C, E	IPR027434	Homing endonuclease	Homologous Superfamily
A, C, E	IPR023366	ATP synthase subunit alpha, N-terminal domain-like superfamily	Homologous Superfamily
A, C, E	IPR020003	ATPase, alpha/beta subunit, nucleotide-binding domain, active site	Active Site
A, C, E	IPR003587	Hint domain N-terminal	Domain
A, C, E	IPR030934	Intein C-terminal splicing region	Domain
A, C, E	IPR007869	Homing endonuclease PI-Sce	Domain
R	IPR035921	F/V-ATP synthase subunit C superfamily	Homologous Superfamily
R	IPR002379	V-ATPase proteolipid subunit C-like domain	Domain
R	IPR000245	V-ATPase proteolipid subunit	Family
S	IPR035921	F/V-ATP synthase subunit C superfamily	Homologous Superfamily
S	IPR002379	V-ATPase proteolipid subunit C-like domain	Domain
S	IPR011555	V-ATPase proteolipid subunit C, eukaryotic	Family
S	IPR000245	V-ATPase proteolipid subunit	Family
AA [auth a], T, U, V, W, AA [auth a], T, U, V, W, X, Y, Z	IPR035921	F/V-ATP synthase subunit C superfamily	Homologous Superfamily
AA [auth a], T, U, V, W, AA [auth a], T, U, V, W, X, Y, Z	IPR002379	V-ATPase proteolipid subunit C-like domain	Domain
AA [auth a], T, U, V, W, AA [auth a], T, U, V, W, X, Y, Z	IPR011555	V-ATPase proteolipid subunit C, eukaryotic	Family
AA [auth a], T, U, V, W, AA [auth a], T, U, V, W, X, Y, Z	IPR000245	V-ATPase proteolipid subunit	Family
BA [auth b]	IPR026028	ATPase, V0 complex, subunit 116kDa, eukaryotic	Family
BA [auth b]	IPR002490	V-type ATPase, V0 complex, 116kDa subunit family	Family
CA [auth c]	IPR008389	ATPase, V0 complex, subunit e1/e2	Family
B, D, F	IPR000194	ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain	Domain
B, D, F	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B, D, F	IPR004100	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain	Domain
B, D, F	IPR005723	ATPase, V1 complex, subunit B	Family
B, D, F	IPR022879	V-type ATP synthase regulatory subunit B/beta	Family
B, D, F	IPR020003	ATPase, alpha/beta subunit, nucleotide-binding domain, active site	Active Site
G, I, K	IPR002842	V-type ATPase subunit E	Family
G, I, K	IPR038495	V-type ATPase subunit E, C-terminal domain superfamily	Homologous Superfamily
H, J, L	IPR005124	Vacuolar (H+)-ATPase G subunit	Family
M	IPR002699	ATPase, V1 complex, subunit D	Family
N	IPR036906	ATPase, V1 complex, subunit F superfamily	Homologous Superfamily
N	IPR005772	ATPase, V1 complex, subunit F, eukaryotic	Family
N	IPR008218	ATPase, V1 complex, subunit F	Family
O	IPR036132	Vacuolar ATP synthase subunit C superfamily	Homologous Superfamily
O	IPR004907	ATPase, V1 complex, subunit C	Family
P	IPR004908	ATPase, V1 complex, subunit H	Family
P	IPR016024	Armadillo-type fold	Homologous Superfamily
P	IPR011989	Armadillo-like helical	Homologous Superfamily
P	IPR038497	ATPase, V1 complex, subunit H, C-terminal domain superfamily	Homologous Superfamily
P	IPR011987	ATPase, V1 complex, subunit H, C-terminal	Domain
Q	IPR036079	V-type ATP synthase subunit c/d subunit superfamily	Homologous Superfamily
Q	IPR035067	V-type ATPase subunit C/d	Homologous Superfamily
Q	IPR044911	V-type ATP synthase c/d subunit, domain 3 superfamily	Homologous Superfamily
Q	IPR016727	ATPase, V0 complex, subunit d	Family
Q	IPR002843	ATPase, V0 complex, c/d subunit	Family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, AA [auth a], B, BA [auth b], C A, AA [auth a], B, BA [auth b], C, CA [auth c], D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z	PDBTM	Annotated as membrane protein by PDBTM