5VOO

Methionine synthase folate-binding domain with methyltetrahydrofolate from Thermus thermophilus HB8

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Dihydropteroate synthetase-like	8085433	3000643	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Dihydropteroate synthetase-like	8085433	3000643	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Dihydropteroate synthetase-like	8085433	3000643	SCOP2B (2022-06-29)
D	SCOP2 Family	Methyltetrahydrofolate-utiluzing methyltransferases	8085432	4003343	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	Dihydropteroate synthetase-like	8085433	3000643	SCOP2 (2022-06-29)
E	SCOP2B Superfamily	Dihydropteroate synthetase-like	8085433	3000643	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Dihydropteroate synthetase-like	8085433	3000643	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00809	e5vooA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00809	ECOD (1.6)
B	PF00809	e5vooB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00809	ECOD (1.6)
C	PF00809	e5vooC1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00809	ECOD (1.6)
D	PF00809	e5vooD1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00809	ECOD (1.6)
E	PF00809	e5vooE1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00809	ECOD (1.6)
F	PF00809	e5vooF1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00809	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00809	Pterin binding enzyme (Pterin_bind)	Pterin binding enzyme	This family includes a variety of pterin binding enzymes that all adopt a TIM barrel fold. The family includes dihydropteroate synthase EC:2.5.1.15 as well as a group methyltransferase enzymes including methyltetrahydrofolate, corrinoid iron-sulfur p ...	This family includes a variety of pterin binding enzymes that all adopt a TIM barrel fold. The family includes dihydropteroate synthase EC:2.5.1.15 as well as a group methyltransferase enzymes including methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) Swiss:Q46389 that catalyses a key step in the Wood-Ljungdahl pathway of carbon dioxide fixation. It transfers the N5-methyl group from methyltetrahydrofolate (CH3-H4folate) to a cob(I)amide centre in another protein, the corrinoid iron-sulfur protein. MeTr is a member of a family of proteins that includes methionine synthase and methanogenic enzymes that activate the methyl group of methyltetra-hydromethano(or -sarcino)pterin [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	5-methyltetrahydrofolate homocysteine S-methyltransferase	vitamin binding binding cobalamin binding organic cyclic compound binding tetrapyrrole binding heterocyclic compound binding small molecule binding methionine synthase activity 5-methyltetrahydrofolate-dependent methyltransferase activity transferase activity, transferring one-carbon groups S-methyltransferase activity transferase activity methyltransferase activity catalytic activity vitamin binding binding cobalamin binding organic cyclic compound binding tetrapyrrole binding heterocyclic compound binding small molecule binding methionine synthase activity 5-methyltetrahydrofolate-dependent methyltransferase activity transferase activity, transferring one-carbon groups S-methyltransferase activity transferase activity methyltransferase activity catalytic activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding	methylation metabolic process organic cyclic compound metabolic process organic substance metabolic process organonitrogen compound metabolic process pteridine-containing compound metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR003759	Cobalamin (vitamin B12)-binding module, cap domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR011005	Dihydropteroate synthase-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR033706	Methionine synthase, B12-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR006158	Cobalamin (vitamin B12)-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR003726	Homocysteine-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR004223	Vitamin B12-dependent methionine synthase, activation domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR036589	Homocysteine-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR000489	Pterin-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR036724	Cobalamin-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR011822	Cobalamin-dependent methionine synthase	Family
A, B, C, D, E A, B, C, D, E, F	IPR036594	Methionine synthase domain	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR037010	Vitamin B12-dependent methionine synthase, activation domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.