5VFW

An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Annexin A1	cell adhesion molecule binding cadherin binding involved in cell-cell adhesion cadherin binding protein binding binding cell adhesion mediator activity cell-cell adhesion mediator activity phospholipid binding lipid binding calcium-dependent phospholipid binding cation binding ion binding calcium ion binding metal ion binding cell adhesion molecule binding cadherin binding involved in cell-cell adhesion cadherin binding protein binding binding cell adhesion mediator activity cell-cell adhesion mediator activity phospholipid binding lipid binding calcium-dependent phospholipid binding cation binding ion binding calcium ion binding metal ion binding small molecule binding signaling receptor binding calcium-dependent protein binding enzyme regulator activity molecular function inhibitor activity phospholipase inhibitor activity phospholipase A2 inhibitor activity molecular function regulator activity enzyme inhibitor activity lipase inhibitor activity	regulation of localization regulation of cellular process transport negative regulation of biological process negative regulation of transport vesicle-mediated transport localization negative regulation of secretion regulation of secretion by cell secretion by cell negative regulation of exocytosis negative regulation of cellular process negative regulation of secretion by cell regulation of biological process regulation of localization regulation of cellular process transport negative regulation of biological process negative regulation of transport vesicle-mediated transport localization negative regulation of secretion regulation of secretion by cell secretion by cell negative regulation of exocytosis negative regulation of cellular process negative regulation of secretion by cell regulation of biological process regulation of transport secretion biological regulation export from cell regulation of vesicle-mediated transport establishment of localization regulation of secretion exocytosis regulation of exocytosis cellular process protein localization establishment of protein localization cellular localization nitrogen compound transport signaling hormone secretion cell communication protein localization to extracellular region peptide secretion amide transport signal release cellular macromolecule localization regulation of biological quality regulation of hormone levels organic substance transport prolactin secretion establishment of protein localization to extracellular region cell-cell signaling protein secretion peptide transport protein transport peptide hormone secretion macromolecule localization hormone transport multicellular organismal process homeostatic process leukocyte apoptotic process positive regulation of biological process regulation of programmed cell death regulation of neutrophil apoptotic process positive regulation of myeloid cell apoptotic process positive regulation of neutrophil apoptotic process regulation of immune system process myeloid cell homeostasis positive regulation of leukocyte apoptotic process positive regulation of immune system process positive regulation of cellular process regulation of leukocyte apoptotic process myeloid cell apoptotic process positive regulation of programmed cell death regulation of apoptotic process cell death positive regulation of apoptotic process neutrophil homeostasis neutrophil apoptotic process multicellular organismal-level homeostasis leukocyte homeostasis immune system process inflammatory cell apoptotic process homeostasis of number of cells apoptotic process programmed cell death regulation of myeloid cell apoptotic process response to stimulus immune response adaptive immune response positive regulation of response to wounding wound healing regulation of response to wounding positive regulation of response to stimulus positive regulation of wound healing regulation of response to stimulus response to stress regulation of response to stress regulation of wound healing response to wounding developmental process reproductive system development prostate gland development reproductive process gland development animal organ development urogenital system development developmental process involved in reproduction multicellular organism development anatomical structure development reproductive structure development system development import into cell phagocytosis endocytosis response to X-ray response to ionizing radiation response to radiation response to abiotic stimulus biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism innate immune response response to external biotic stimulus regulation of alpha-beta T cell activation regulation of leukocyte activation regulation of cell activation alpha-beta T cell differentiation involved in immune response regulation of cell development negative regulation of cell adhesion negative regulation of T cell differentiation type 2 immune response T cell activation cell differentiation regulation of T-helper cell differentiation regulation of type 2 immune response alpha-beta T cell activation T-helper cell differentiation negative regulation of leukocyte differentiation negative regulation of immune effector process immune effector process negative regulation of type 2 immune response negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process regulation of developmental process cell development CD4-positive, alpha-beta T cell differentiation negative regulation of T-helper 2 cell differentiation regulation of T cell differentiation alpha-beta T cell differentiation T cell activation involved in immune response leukocyte activation involved in immune response regulation of T-helper 2 cell differentiation regulation of cell-cell adhesion negative regulation of cell differentiation hemopoiesis negative regulation of developmental process regulation of cell adhesion cell activation negative regulation of cell development regulation of CD4-positive, alpha-beta T cell activation negative regulation of alpha-beta T cell activation regulation of lymphocyte activation regulation of immune effector process regulation of leukocyte differentiation mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation cell activation involved in immune response CD4-positive, alpha-beta T cell differentiation involved in immune response T cell differentiation negative regulation of hemopoiesis negative regulation of immune response negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of lymphocyte differentiation regulation of immune response negative regulation of CD4-positive, alpha-beta T cell differentiation negative regulation of leukocyte activation leukocyte differentiation cellular developmental process regulation of CD4-positive, alpha-beta T cell differentiation regulation of alpha-beta T cell differentiation lymphocyte activation negative regulation of alpha-beta T cell differentiation negative regulation of lymphocyte activation leukocyte cell-cell adhesion leukocyte activation cell adhesion cell-cell adhesion alpha-beta T cell activation involved in immune response CD4-positive, alpha-beta T cell activation T-helper 2 cell differentiation regulation of multicellular organismal process lymphocyte activation involved in immune response regulation of lymphocyte differentiation regulation of multicellular organismal development negative regulation of response to stimulus regulation of T cell activation T cell differentiation involved in immune response negative regulation of T-helper cell differentiation negative regulation of cell activation negative regulation of immune system process regulation of hemopoiesis cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization membrane fusion organelle membrane fusion regulation of vesicle fusion vesicle organization membrane organization regulation of organelle organization organelle fusion positive regulation of transport positive regulation of vesicle fusion vesicle fusion DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change regulation of cell cycle phase transition cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle regulation of cell cycle cell cycle process positive regulation of G1/S transition of mitotic cell cycle regulation of cell cycle process positive regulation of cell cycle regulation of mitotic cell cycle phase transition positive regulation of cell cycle G1/S phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle positive regulation of cell cycle phase transition G1/S transition of mitotic cell cycle mitotic cell cycle phase transition prostaglandin metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process regulation of lipid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process regulation of primary metabolic process positive regulation of metabolic process cellular ketone metabolic process regulation of small molecule metabolic process organic substance biosynthetic process positive regulation of lipid metabolic process positive regulation of prostaglandin biosynthetic process small molecule metabolic process prostaglandin biosynthetic process regulation of cellular ketone metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process biosynthetic process cellular lipid metabolic process regulation of fatty acid metabolic process regulation of fatty acid biosynthetic process metabolic process monocarboxylic acid metabolic process positive regulation of unsaturated fatty acid biosynthetic process regulation of metabolic process regulation of prostaglandin biosynthetic process icosanoid metabolic process cellular biosynthetic process regulation of unsaturated fatty acid biosynthetic process lipid biosynthetic process positive regulation of cellular metabolic process positive regulation of fatty acid biosynthetic process organic substance metabolic process prostanoid metabolic process positive regulation of biosynthetic process icosanoid biosynthetic process prostanoid biosynthetic process positive regulation of fatty acid metabolic process regulation of biosynthetic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process carboxylic acid metabolic process fatty acid biosynthetic process regulation of cellular biosynthetic process unsaturated fatty acid biosynthetic process positive regulation of lipid biosynthetic process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process positive regulation of cellular biosynthetic process lipid metabolic process nervous system development neurogenesis gliogenesis epithelium development tissue development liver development epithelial cell differentiation hepaticobiliary system development hepatocyte differentiation interleukin-1 production regulation of cytokine production cytokine production regulation of interleukin-1 production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression regulation of macromolecule biosynthetic process macromolecule metabolic process negative regulation of cellular metabolic process negative regulation of interleukin-8 production negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cytokine production interleukin-8 production negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of interleukin-8 production positive regulation of cell population proliferation positive regulation of cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of leukocyte proliferation cell population proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation regulation of cell population proliferation mononuclear cell proliferation positive regulation of leukocyte proliferation positive regulation of multicellular organismal process positive regulation of leukocyte cell-cell adhesion leukocyte proliferation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of mononuclear cell proliferation T cell proliferation regulation of lymphocyte proliferation positive regulation of cell adhesion regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of cell motility regulation of leukocyte migration leukocyte migration regulation of locomotion regulation of cell migration cell migration cell motility locomotion cellular response to endogenous stimulus cellular response to growth factor stimulus response to endogenous stimulus cellular response to vascular endothelial growth factor stimulus response to growth factor insulin secretion positive regulation of locomotion cell migration involved in sprouting angiogenesis regulation of blood vessel endothelial cell migration endothelial cell migration angiogenesis positive regulation of cell migration positive regulation of epithelial cell migration tube morphogenesis tissue migration ameboidal-type cell migration positive regulation of cell motility blood vessel endothelial cell migration regulation of endothelial cell migration epithelial cell migration positive regulation of cell migration involved in sprouting angiogenesis regulation of epithelial cell migration blood vessel development blood vessel morphogenesis tube development regulation of cell migration involved in sprouting angiogenesis sprouting angiogenesis vasculature development circulatory system development positive regulation of blood vessel endothelial cell migration anatomical structure morphogenesis epithelium migration positive regulation of endothelial cell migration anatomical structure formation involved in morphogenesis cellular response to stimulus G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger G protein-coupled receptor signaling pathway signal transduction tissue regeneration skeletal muscle tissue regeneration developmental growth growth regeneration myoblast migration involved in skeletal muscle regeneration muscle cell migration myoblast migration epidermal cell differentiation epidermis development skin development keratinocyte differentiation response to organic substance response to hormone response to chemical response to organonitrogen compound response to peptide hormone response to oxygen-containing compound response to nitrogen compound negative regulation of programmed cell death negative regulation of apoptotic process cell chemotaxis chemotaxis granulocyte migration cellular response to chemical stimulus taxis granulocyte chemotaxis myeloid leukocyte migration leukocyte chemotaxis neutrophil activation myeloid leukocyte activation granulocyte activation response to cytokine response to interleukin-1 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of T cell differentiation positive regulation of immune response positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of cell development T-helper 1 type immune response regulation of T-helper 1 type immune response regulation of T-helper 1 cell differentiation positive regulation of alpha-beta T cell differentiation positive regulation of T-helper cell differentiation positive regulation of cell differentiation positive regulation of immune effector process positive regulation of T-helper 1 cell differentiation positive regulation of developmental process regulation of adaptive immune response positive regulation of alpha-beta T cell activation positive regulation of CD4-positive, alpha-beta T cell activation regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of hemopoiesis T-helper 1 cell differentiation positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation organic anion transport carboxylic acid transport arachidonate transport lipid localization lipid transport organic acid transport monocarboxylic acid transport fatty acid transport icosanoid transport icosanoid secretion long-chain fatty acid transport arachidonic acid secretion regulation of cell shape cell morphogenesis regulation of cell morphogenesis regulation of anatomical structure morphogenesis cellular response to oxidative stress cellular response to chemical stress cellular response to oxygen-containing compound cellular response to hydrogen peroxide response to reactive oxygen species response to inorganic substance response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species cellular response to stress pancreas development endocrine system development endocrine pancreas development regulation of hormone secretion regulation of signaling regulation of cell communication cell surface receptor signaling pathway regulation of defense response regulation of response to external stimulus regulation of inflammatory response inflammatory response monocyte chemotaxis mononuclear cell migration positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process regulation of interleukin-2 production interleukin-2 production positive regulation of interleukin-2 production positive regulation of gene expression positive regulation of cytokine production response to lipid response to glucocorticoid cellular response to organic cyclic compound cellular response to glucocorticoid stimulus cellular response to corticosteroid stimulus response to corticosteroid response to steroid hormone cellular response to lipid cellular response to organic substance cellular response to steroid hormone stimulus response to organic cyclic compound cellular response to hormone stimulus neutrophil clearance apoptotic cell clearance response to estradiol organonitrogen compound metabolic process peptide cross-linking macromolecule modification protein metabolic process protein modification process	cell periphery plasma membrane membrane cellular anatomical entity cornified envelope extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery plasma membrane membrane cellular anatomical entity cornified envelope extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm cytosol sarcolemma basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane cell-cell junction adherens junction anchoring junction cell junction phagocytic cup focal adhesion cell-substrate junction apical part of cell apical plasma membrane cell surface cell projection cilium motile cilium plasma membrane bounded cell projection nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen endosome intracellular vesicle endomembrane system cytoplasmic vesicle endosome membrane early endosome early endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane lateral plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR018252	Annexin repeat, conserved site	Conserved Site
A	IPR037104	Annexin superfamily	Homologous Superfamily
A	IPR018502	Annexin repeat	Repeat
A	IPR001464	Annexin	Family
A	IPR002388	Annexin A1	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P04083	esophageal squamous cell carcinoma squamous cell carcinoma hypertensive disorder sarcomatoid carcinoma kidney disease stomach disease Liver Cirrhosis, Experimental prostate cancer carcinoma facioscapulohumeral muscular dystrophy pituitary cancer undifferentiated carcinoma lung carcinoma malignant ependymoma B-cell chronic lymphocytic leukemia esophageal squamous cell carcinoma squamous cell carcinoma hypertensive disorder sarcomatoid carcinoma kidney disease stomach disease Liver Cirrhosis, Experimental prostate cancer carcinoma facioscapulohumeral muscular dystrophy pituitary cancer undifferentiated carcinoma lung carcinoma malignant ependymoma B-cell chronic lymphocytic leukemia malignant pancreatic neoplasm breast carcinoma myopathy Duchenne muscular dystrophy esophageal adenocarcinoma pancreatic ductal adenocarcinoma gastric carcinoma invasive ductal breast carcinoma spina bifida large cell medulloblastoma subependymal giant cell astrocytoma lung adenocarcinoma amyotrophic lateral sclerosis astrocytic tumor malignant glioma Becker muscular dystrophy breast fibroadenoma medulloblastoma nasopharyngeal carcinoma ductal breast carcinoma in situ oral cavity neoplasm pilocytic astrocytoma glioblastoma juvenile dermatomyositis limb-girdle muscular dystrophy ulcerative colitis lung cancer lymphoplasmacytic lymphoma atypical teratoid rhabdoid tumor breast cancer mammary neoplasms, animal dermatomyositis Emery-Dreifuss muscular dystrophy ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.