5VFP

Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S Proteasome

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth H]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064014	3000131	SCOP2B (2022-06-29)
Z [auth h]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064014	3000131	SCOP2B (2022-06-29)
DA [auth l]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064060	3000131	SCOP2B (2022-06-29)
F [auth L]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064060	3000131	SCOP2B (2022-06-29)
EA [auth m]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064054	3000131	SCOP2B (2022-06-29)
G [auth M]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064054	3000131	SCOP2B (2022-06-29)
FA [auth n]	SCOP2B Superfamily	Class II glutamine amidotransferases	8079175	3000131	SCOP2B (2022-06-29)
H [auth N]	SCOP2B Superfamily	Class II glutamine amidotransferases	8079175	3000131	SCOP2B (2022-06-29)
GA [auth o]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064074	3000131	SCOP2B (2022-06-29)
I [auth O]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064074	3000131	SCOP2B (2022-06-29)
JA [auth r]	SCOP2B Superfamily	Class II glutamine amidotransferases	8079492	3000131	SCOP2B (2022-06-29)
L [auth R]	SCOP2B Superfamily	Class II glutamine amidotransferases	8079492	3000131	SCOP2B (2022-06-29)
MA [auth X]	SCOP2B Superfamily	Winged helix DNA-binding domain	8067905	3000034	SCOP2B (2022-06-29)
R [auth Y]	SCOP2B Superfamily	Winged helix DNA-binding domain	8057047	3000034	SCOP2B (2022-06-29)
R [auth Y]	SCOP2B Superfamily	TPR-like	8057045	3001345	SCOP2B (2022-06-29)
S [auth Z]	SCOP2B Superfamily	JAB1/MPN domain-like	8053252	3001105	SCOP2B (2022-06-29)
S [auth Z]	SCOP2B Superfamily	EIF3 subunit F C-terminal domain-like	8053251	3002167	SCOP2B (2022-06-29)
V [auth c]	SCOP2B Superfamily	EIF3 subunit F C-terminal domain-like	8053254	3002167	SCOP2B (2022-06-29)
V [auth c]	SCOP2B Superfamily	JAB1/MPN domain-like	8053255	3001105	SCOP2B (2022-06-29)
AA [auth i]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064036	3000131	SCOP2B (2022-06-29)
C [auth I]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064036	3000131	SCOP2B (2022-06-29)
BA [auth j]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064004	3000131	SCOP2B (2022-06-29)
D [auth J]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064004	3000131	SCOP2B (2022-06-29)
CA [auth k]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064022	3000131	SCOP2B (2022-06-29)
E [auth K]	SCOP2B Superfamily	Class II glutamine amidotransferases	8064022	3000131	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth H]	PF00227,PF10584	e5vfpH1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
Z [auth h]	PF00227,PF10584	e5vfph1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
DA [auth l]	PF00227,PF10584	e5vfpl1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
F [auth L]	PF00227,PF10584	e5vfpL1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
EA [auth m]	PF00227,PF10584	e5vfpm1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
G [auth M]	PF00227,PF10584	e5vfpM1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
FA [auth n]	PF00227	e5vfpn1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
H [auth N]	PF00227	e5vfpN1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
GA [auth o]	PF00227,PF12465	e5vfpo1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF12465	ECOD (1.6)
I [auth O]	PF00227,PF12465	e5vfpO1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF12465	ECOD (1.6)
HA [auth p]	PF00227	e5vfpp1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
J [auth P]	PF00227	e5vfpP1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
JA [auth r]	PF00227	e5vfpr1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
L [auth R]	PF00227	e5vfpR1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
KA [auth s]	PF00227	e5vfps1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
M [auth S]	PF00227	e5vfpS1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
LA [auth t]	PF00227	e5vfpt1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
N [auth T]	PF00227	e5vfpT1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
T [auth a]	PF01399	e5vfpa1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
T [auth a]	PF22037	e5vfpa2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF22037	ECOD (1.6)
T [auth a]	F_UNCLASSIFIED	e5vfpa3	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN9 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN9 C-terminal helix	F: F_UNCLASSIFIED	ECOD (1.6)
W [auth d]	PF10075	e5vfpd2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF10075	ECOD (1.6)
W [auth d]	PF10075	e5vfpd1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF10075	ECOD (1.6)
MA [auth X]	PF01399	e5vfpX2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
MA [auth X]	PF18055	e5vfpX3	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF18055	ECOD (1.6)
MA [auth X]	PF18503	e5vfpX1	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN6 C-termial helix (From Topology)	T: 26S proteasome regulatory subunit RPN6 C-termial helix	F: PF18503	ECOD (1.6)
OA [auth B]	PF16450	e5vfpB2	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF16450	ECOD (1.6)
OA [auth B]	PF17862	e5vfpB3	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
OA [auth B]	PF00004	e5vfpB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
A [auth G]	PF00227,PF10584	e5vfpG1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
Y [auth g]	PF00227,PF10584	e5vfpg1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
IA [auth q]	PF00227	e5vfpq1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
K [auth Q]	PF00227	e5vfpQ1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
O [auth U]	PF18004	e5vfpU1	A: beta sandwiches	X: 26S proteasome subunit Rpn2 C-terminal domain (From Topology)	H: 26S proteasome subunit Rpn2 C-terminal domain (From Topology)	T: 26S proteasome subunit Rpn2 C-terminal domain	F: PF18004	ECOD (1.6)
O [auth U]	PF21505	e5vfpU3	A: alpha superhelices	X: Repetitive alpha hairpins	H: 26S proteasome subunit Rpn2 N-terminal domain (From Topology)	T: 26S proteasome subunit Rpn2 N-terminal domain	F: PF21505	ECOD (1.6)
O [auth U]	PF01851	e5vfpU2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Proteasome/cyclosome (PC) repeat (From Topology)	T: Proteasome/cyclosome (PC) repeat	F: PF01851	ECOD (1.6)
P [auth V]	PF01399	e5vfpV3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
P [auth V]	F_UNCLASSIFIED	e5vfpV2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: F_UNCLASSIFIED	ECOD (1.6)
P [auth V]	PF08375	e5vfpV1	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN3 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN3 C-terminal helix	F: PF08375	ECOD (1.6)
Q [auth W]	PF01399	e5vfpW1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
Q [auth W]	PF22241	e5vfpW2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF22241	ECOD (1.6)
Q [auth W]	PF18098	e5vfpW3	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN5 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN5 C-terminal helix	F: PF18098	ECOD (1.6)
R [auth Y]	PF01399	e5vfpY2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01399	ECOD (1.6)
R [auth Y]	PF10602	e5vfpY1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF10602	ECOD (1.6)
R [auth Y]	PF21154	e5vfpY3	A: extended segments	X: 26S proteasome regulatory subunits C-terminal helices	H: 26S proteasome regulatory subunit RPN7 C-terminal helix (From Topology)	T: 26S proteasome regulatory subunit RPN7 C-terminal helix	F: PF21154	ECOD (1.6)
S [auth Z]	PF01398	e5vfpZ2	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: PF01398	ECOD (1.6)
S [auth Z]	PF13012	e5vfpZ1	A: extended segments	X: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	H: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	T: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain	F: PF13012	ECOD (1.6)
U [auth b]	PF13519	e5vfpb1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: PF13519	ECOD (1.6)
V [auth c]	PF01398	e5vfpc1	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: PF01398	ECOD (1.6)
V [auth c]	F_UNCLASSIFIED	e5vfpc2	A: extended segments	X: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	H: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology)	T: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)
NA [auth A]	PF17862	e5vfpA1	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
NA [auth A]	PF00004	e5vfpA3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
QA [auth D]	PF16450	e5vfpD2	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF16450	ECOD (1.6)
QA [auth D]	PF17862	e5vfpD3	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
QA [auth D]	PF00004	e5vfpD1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
AA [auth i]	PF00227,PF10584	e5vfpi1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
C [auth I]	PF00227,PF10584	e5vfpI1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
RA [auth E]	PF16450	e5vfpE1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF16450	ECOD (1.6)
RA [auth E]	PF17862	e5vfpE2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
RA [auth E]	PF00004	e5vfpE3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
SA [auth F]	PF16450	e5vfpF1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF16450	ECOD (1.6)
SA [auth F]	PF17862	e5vfpF3	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
SA [auth F]	PF00004	e5vfpF2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
TA [auth f]	PF17781	e5vfpf2	A: alpha superhelices	X: Repetitive alpha hairpins	H: 26S proteasome subunit Rpn2 N-terminal domain (From Topology)	T: 26S proteasome subunit Rpn2 N-terminal domain	F: PF17781	ECOD (1.6)
TA [auth f]	PF01851	e5vfpf3	A: alpha superhelices	X: Repetitive alpha hairpins	H: Proteasome/cyclosome (PC) repeat (From Topology)	T: Proteasome/cyclosome (PC) repeat	F: PF01851	ECOD (1.6)
BA [auth j]	PF00227,PF10584	e5vfpj1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
D [auth J]	PF00227,PF10584	e5vfpJ1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
CA [auth k]	PF00227,PF10584	e5vfpk1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
E [auth K]	PF00227,PF10584	e5vfpK1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth H], Z [auth h]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
B [auth H], Z [auth h]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
DA [auth l], F [auth L]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
DA [auth l], F [auth L]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
EA [auth m], G [auth M]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
EA [auth m], G [auth M]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
FA [auth n], H [auth N]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
GA [auth o], I [auth O]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
GA [auth o], I [auth O]	PF12465	Proteasome beta subunits C terminal (Pr_beta_C)	Proteasome beta subunits C terminal	-	Family
HA [auth p], J [auth P]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
JA [auth r], L [auth R]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
KA [auth s], M [auth S]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
LA [auth t], N [auth T]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
T [auth a]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
W [auth d]	PF10075	CSN8/PSMD8/EIF3K family (CSN8_PSD8_EIF3K)	CSN8/PSMD8/EIF3K family	-	Family
MA [auth X]	PF18055	26S proteasome regulatory subunit RPN6 N-terminal domain (RPN6_N)	26S proteasome regulatory subunit RPN6 N-terminal domain	-	Repeat
MA [auth X]	PF18503	26S proteasome subunit RPN6 C-terminal helix domain (RPN6_C_helix)	26S proteasome subunit RPN6 C-terminal helix domain	This is the C-terminal helix domain found in RPN6, a component of the 26S proteasome. The C-terminal helices are essential for lid assembly [1, 2].	Domain
MA [auth X]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
OA [auth B]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
OA [auth B]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
OA [auth B]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
PA [auth C]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
PA [auth C]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
PA [auth C]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
A [auth G], Y [auth g]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
A [auth G], Y [auth g]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
IA [auth q], K [auth Q]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
O [auth U]	PF13646	HEAT repeats (HEAT_2)	HEAT repeats	-	Repeat
O [auth U]	PF18004	26S proteasome regulatory subunit RPN2 C-terminal domain (RPN2_C)	26S proteasome regulatory subunit RPN2 C-terminal domain	This is the C-terminal domain found in S. cerevisiae Rpn2 (26S proteasome regulatory subunit RPN2) as well as other eukaryotic species. A study revealed that the C-terminal 52 residues of the Rpn2 C-terminal domain are responsible for mediating inter ...	This is the C-terminal domain found in S. cerevisiae Rpn2 (26S proteasome regulatory subunit RPN2) as well as other eukaryotic species. A study revealed that the C-terminal 52 residues of the Rpn2 C-terminal domain are responsible for mediating interactions with the ubiquitin-binding subunit Rpn13. Futhermore, the extreme C-terminal 20 or 21 residues of Rpn2 (926-945 or 925-945) of S. cerevisiae, were shown to be equally effective at binding Rpn13. Multiple sequence alignments indicate that Rpn2 orthologs are highly conserved in this C-terminal region and share characteristic acidic, aromatic, and proline residues, suggesting a common function. In the structure of Rpn2 from S. cerevisiae , this region is exposed and disordered, and is thus accessible for associating with Rpn13. The Rpn2 binding surface of human Rpn13 has been mapped by nuclear magnetic resonance titration to one surface of its Pru domain [1].	Domain
O [auth U]	PF01851	Proteasome/cyclosome repeat (PC_rep)	Proteasome/cyclosome repeat	-	Repeat
P [auth V]	PF08375	Proteasome regulatory subunit C-terminal (Rpn3_C)	Proteasome regulatory subunit C-terminal	-	Family
P [auth V]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
Q [auth W]	PF18098	26S proteasome regulatory subunit RPN5 C-terminal domain (RPN5_C)	26S proteasome regulatory subunit RPN5 C-terminal domain	This is the C-terminal domain of the 26S proteasome regulatory subunit RPN5 proteins.This helical domain can be found adjacent to Pfam:PF01399. The 26S proteasome is the major ATP-dependent protease in eukaryotes. Three subcomplexes form this degrada ...	This is the C-terminal domain of the 26S proteasome regulatory subunit RPN5 proteins.This helical domain can be found adjacent to Pfam:PF01399. The 26S proteasome is the major ATP-dependent protease in eukaryotes. Three subcomplexes form this degradation machine: the lid, the base, and the core. The helices found at the C terminus of each lid subunit form a helical bundle that directs the ordered self-assembly of the lid subcomplex. This domain which comprises the tail of RPN5 along with the tail of Rpn9, are important for Rpn12 binding to the lid [1].	Domain
Q [auth W]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
R [auth Y]	PF21154	26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix (RPN7_PSMD6_C)	26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix	RPN7/PSDM6 are regulatory subunits from the 26S proteasome. This entry represents the C-terminal helix.	Domain
R [auth Y]	PF10602	26S proteasome subunit RPN7 (RPN7)	26S proteasome subunit RPN7	-	Repeat
R [auth Y]	PF01399	PCI domain (PCI)	PCI domain	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	Domain
S [auth Z]	PF13012	Maintenance of mitochondrial structure and function (MitMem_reg)	Maintenance of mitochondrial structure and function	-	Family
S [auth Z]	PF01398	JAB1/Mov34/MPN/PAD-1 ubiquitin protease (JAB)	JAB1/Mov34/MPN/PAD-1 ubiquitin protease	-	Family
U [auth b]	PF13519	von Willebrand factor type A domain (VWA_2)	von Willebrand factor type A domain	-	Domain
V [auth c]	PF01398	JAB1/Mov34/MPN/PAD-1 ubiquitin protease (JAB)	JAB1/Mov34/MPN/PAD-1 ubiquitin protease	-	Family
NA [auth A]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
NA [auth A]	PF21236	26S proteasome regulatory subunit 7, OB domain (PRS7_OB)	26S proteasome regulatory subunit 7, OB domain	This is the OB domain from 26S proteasome regulatory subunit 7 (PRS7, also known as PSMC2, Rpt1 or MSS1), a component of the 19S proteasome cap [1-5]. These are one of six ATPases of the regulatory particle that form a heterohexameric ring. This doma ...	This is the OB domain from 26S proteasome regulatory subunit 7 (PRS7, also known as PSMC2, Rpt1 or MSS1), a component of the 19S proteasome cap [1-5]. These are one of six ATPases of the regulatory particle that form a heterohexameric ring. This domain mediates interactions with USP14 or Ubp6 [2,4].	Domain
NA [auth A]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
QA [auth D]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
QA [auth D]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
QA [auth D]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
AA [auth i], C [auth I]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
AA [auth i], C [auth I]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
RA [auth E]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
RA [auth E]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
RA [auth E]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
SA [auth F]	PF16450	Proteasomal ATPase OB C-terminal domain (Prot_ATP_ID_OB_C)	Proteasomal ATPase OB C-terminal domain	This is the C-terminal interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase [1-2]	Domain
SA [auth F]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
SA [auth F]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
TA [auth f]	PF01851	Proteasome/cyclosome repeat (PC_rep)	Proteasome/cyclosome repeat	-	Repeat
BA [auth j], D [auth J]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
BA [auth j], D [auth J]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
CA [auth k], E [auth K]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
CA [auth k], E [auth K]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth H], Z [auth h]	Proteasome subunit alpha type-2	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region cellular anatomical entity intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region cellular anatomical entity intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular non-membrane-bounded organelle supramolecular complex P-body non-membrane-bounded organelle ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
DA [auth l], F [auth L]	Proteasome subunit alpha type-1	binding lipid binding lipopolysaccharide binding carbohydrate derivative binding	immune system process regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process inflammatory response to antigenic stimulus response to stress regulation of response to stress regulation of immune system process negative regulation of inflammatory response to antigenic stimulus regulation of biological process defense response immune response immune system process regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process inflammatory response to antigenic stimulus response to stress regulation of response to stress regulation of immune system process negative regulation of inflammatory response to antigenic stimulus regulation of biological process defense response immune response negative regulation of response to stimulus negative regulation of immune response regulation of inflammatory response to antigenic stimulus biological regulation response to external stimulus regulation of inflammatory response regulation of response to stimulus negative regulation of immune system process negative regulation of response to external stimulus negative regulation of defense response regulation of immune response inflammatory response organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle centrosome microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
EA [auth m], G [auth M]	Proteasome subunit alpha type-3	ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process regulation of biological process regulation of catalytic activity regulation of protein metabolic process regulation of peptidase activity biological regulation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of molecular function regulation of proteolysis regulation of hydrolase activity regulation of endopeptidase activity regulation of metabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle synapse cell junction cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
FA [auth n], H [auth N]	Proteasome subunit beta type-6	cell adhesion molecule binding cadherin binding protein binding binding peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity threonine-type endopeptidase activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
GA [auth o], I [auth O]	Proteasome subunit beta type-7	peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity threonine-type endopeptidase activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region cellular anatomical entity membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region cellular anatomical entity membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle cytoplasm vesicle cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus nuclear body nucleoplasm nuclear lumen ficolin-1-rich granule ficolin-1-rich granule lumen
HA [auth p], J [auth P]	Proteasome subunit beta type-3	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
JA [auth r], L [auth R]	Proteasome subunit beta type-5	peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity threonine-type endopeptidase activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process response to oxidative stress response to stimulus response to stress proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
KA [auth s], M [auth S]	Proteasome subunit beta type-1	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol proteasome core complex proteasome core complex, beta-subunit complex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
LA [auth t], N [auth T]	Proteasome subunit beta type-4	binding lipid binding lipopolysaccharide binding carbohydrate derivative binding	regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process inflammatory response to antigenic stimulus response to stress regulation of response to stress regulation of immune system process negative regulation of inflammatory response to antigenic stimulus regulation of biological process defense response immune response negative regulation of response to stimulus regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process inflammatory response to antigenic stimulus response to stress regulation of response to stress regulation of immune system process negative regulation of inflammatory response to antigenic stimulus regulation of biological process defense response immune response negative regulation of response to stimulus negative regulation of immune response regulation of inflammatory response to antigenic stimulus biological regulation response to external stimulus regulation of inflammatory response regulation of response to stimulus negative regulation of immune system process immune system process negative regulation of response to external stimulus negative regulation of defense response regulation of immune response inflammatory response organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen cilium plasma membrane bounded cell projection ciliary basal body cell projection microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle
T [auth a]	26S proteasome non-ATPase regulatory subunit 13	structural molecule activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process sexual reproduction reproductive process meiotic cell cycle organelle fission meiotic cell cycle process cellular component organization nuclear division organelle organization meiosis I meiosis I cell cycle process cellular process meiotic nuclear division cell cycle cellular component organization or biogenesis cell cycle process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle extracellular region membrane-bounded organelle vesicle lumen proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle cytoplasm vesicle cytosol proteasome regulatory particle, lid subcomplex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
W [auth d]	26S proteasome non-ATPase regulatory subunit 8	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol proteasome accessory complex protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, lid subcomplex membrane-bounded organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol proteasome accessory complex protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, lid subcomplex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
X [auth e]	sem1	-	-	-
MA [auth X]	26S proteasome non-ATPase regulatory subunit 11	structural molecule activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis developmental process stem cell differentiation cellular developmental process cell differentiation proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle cytoplasm vesicle cytosol proteasome regulatory particle proteasome regulatory particle, lid subcomplex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
OA [auth B]	26S proteasome regulatory subunit 4	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity RNA binding nucleic acid binding proteasome-activating activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
PA [auth C]	26S proteasome regulatory subunit 8	transcription factor binding protein binding binding general transcription initiation factor binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding transcription factor binding protein binding binding general transcription initiation factor binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA-binding transcription factor binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity peptide hormone receptor binding signaling receptor binding G protein-coupled receptor binding thyrotropin-releasing hormone receptor binding hormone receptor binding proteasome-activating activity	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process positive regulation of metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process regulation of protein metabolic process proteasomal protein catabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process organic substance catabolic process regulation of protein catabolic process negative regulation of programmed cell death regulation of programmed cell death cell death programmed cell death proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process positive regulation of macromolecule biosynthetic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex extracellular exosome membrane-bounded organelle proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen cytoplasmic vesicle intracellular vesicle blood microparticle
A [auth G], Y [auth g]	Proteasome subunit alpha type-6	transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding NF-kappaB binding RNA binding organic cyclic compound binding nucleic acid binding peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity endopeptidase activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding NF-kappaB binding RNA binding organic cyclic compound binding nucleic acid binding peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity endopeptidase activity purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding anion binding heterocyclic compound binding small molecule binding	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process positive regulation of DNA-binding transcription factor activity regulation of cellular process cellular biosynthetic process positive regulation of NF-kappaB transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription regulation of metabolic process regulation of defense response response to stimulus regulation of response to external stimulus defense response regulation of inflammatory response response to external stimulus regulation of response to stimulus response to stress regulation of response to stress inflammatory response	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix protein-containing complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix protein-containing complex proteasome core complex, alpha-subunit complex catalytic complex peptidase complex proteasome complex endopeptidase complex proteasome core complex intracellular protein-containing complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleoplasm intracellular non-membrane-bounded organelle ribosome non-membrane-bounded organelle sarcomere contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex cytoplasmic ribonucleoprotein granule ribonucleoprotein granule P-body
IA [auth q], K [auth Q]	Proteasome subunit beta type-2	-	response to organic substance response to stimulus response to organonitrogen compound response to chemical response to nitrogen compound organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process response to organic substance response to stimulus response to organonitrogen compound response to chemical response to nitrogen compound organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process response to organic cyclic compound proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
O [auth U]	26S proteasome non-ATPase regulatory subunit 1	ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding enzyme regulator activity molecular function regulator activity	organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process catabolic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process organic substance metabolic process metabolic process organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process catabolic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process organic substance metabolic process metabolic process protein metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle extracellular region proteasome regulatory particle, base subcomplex cytoplasm proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle extracellular region proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle lytic vacuole intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen vacuolar lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle vesicle lysosome vesicle lumen azurophil granule vacuole intracellular membrane-bounded organelle secretory granule lumen azurophil granule lumen organelle lumen organelle secretory granule primary lysosome secretory vesicle intracellular non-membrane-bounded organelle proteasome storage granule non-membrane-bounded organelle nucleus nucleoplasm nuclear lumen
P [auth V]	26S proteasome non-ATPase regulatory subunit 3	enzyme regulator activity molecular function regulator activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process regulation of biological process regulation of protein metabolic process biological regulation regulation of macromolecule metabolic process regulation of catabolic process regulation of primary metabolic process regulation of metabolic process regulation of protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol proteasome regulatory particle proteasome regulatory particle, lid subcomplex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
Q [auth W]	26S proteasome non-ATPase regulatory subunit 12	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle extracellular region extracellular exosome membrane-bounded organelle proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol proteasome regulatory particle, lid subcomplex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
R [auth Y]	26S proteasome non-ATPase regulatory subunit 6	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex proteasome regulatory particle extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex proteasome regulatory particle extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle cytoplasm vesicle cytosol ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
S [auth Z]	26S proteasome non-ATPase regulatory subunit 7	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane cellular anatomical entity proteasome accessory complex intracellular anatomical structure proteasome regulatory particle extracellular region extracellular exosome membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane cellular anatomical entity proteasome accessory complex intracellular anatomical structure proteasome regulatory particle extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
U [auth b]	26S proteasome non-ATPase regulatory subunit 4	polyubiquitin modification-dependent protein binding protein binding binding modification-dependent protein binding molecular adaptor activity RNA binding organic cyclic compound binding nucleic acid binding identical protein binding	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
V [auth c]	26S proteasome non-ATPase regulatory subunit 14	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity ubiquitin-like protein peptidase activity metal-dependent deubiquitinase activity deubiquitinase activity K63-linked deubiquitinase activity protein-containing complex binding binding proteasome binding endopeptidase activator activity enzyme regulator activity peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity ubiquitin-like protein peptidase activity metal-dependent deubiquitinase activity deubiquitinase activity K63-linked deubiquitinase activity protein-containing complex binding binding proteasome binding endopeptidase activator activity enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity peptidase activator activity endopeptidase regulator activity cation binding ion binding metal ion binding small molecule binding	protein deubiquitination organonitrogen compound metabolic process protein K63-linked deubiquitination primary metabolic process organic substance metabolic process protein modification by small protein removal macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal organonitrogen compound catabolic process protein deubiquitination organonitrogen compound metabolic process protein K63-linked deubiquitination primary metabolic process organic substance metabolic process protein modification by small protein removal macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organic substance catabolic process response to organic substance response to stimulus response to alcohol response to chemical response to oxygen-containing compound response to ethanol cellular response to stimulus double-strand break repair DNA recombination DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process cellular response to stress DNA damage response response to stress recombinational repair cellular process double-strand break repair via homologous recombination DNA repair regulation of primary metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis regulation of biological process regulation of protein metabolic process biological regulation regulation of macromolecule metabolic process regulation of catabolic process regulation of proteasomal protein catabolic process regulation of metabolic process regulation of protein catabolic process double-strand break repair via nonhomologous end joining	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex cytoplasm cytosol proteasome regulatory particle proteasome regulatory particle, lid subcomplex membrane-bounded organelle proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex cytoplasm cytosol proteasome regulatory particle proteasome regulatory particle, lid subcomplex membrane-bounded organelle membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen organelle secretory granule secretory vesicle vesicle nucleus nucleoplasm nuclear lumen cytosolic proteasome complex extracellular region vesicle lumen cytoplasmic vesicle lumen secretory granule lumen
NA [auth A]	26S proteasome regulatory subunit 7	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity proteasome-activating activity	developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process biological regulation primary metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen organelle secretory granule secretory vesicle vesicle nucleus nucleoplasm nuclear lumen intracellular non-membrane-bounded organelle cytoplasmic ribonucleoprotein granule supramolecular complex non-membrane-bounded organelle ribonucleoprotein granule extracellular region vesicle lumen cytoplasmic vesicle lumen secretory granule lumen P-body
QA [auth D]	26S proteasome regulatory subunit 6B	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity proteasome-activating activity	developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development blastocyst development organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development blastocyst development organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process organic substance catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
AA [auth i], C [auth I]	Proteasome subunit alpha type-4	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol intracellular organelle intracellular membrane-bounded organelle cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular non-membrane-bounded organelle supramolecular complex P-body non-membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
RA [auth E]	26S proteasome regulatory subunit 10B	protein-macromolecule adaptor activity molecular adaptor activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding protein-macromolecule adaptor activity molecular adaptor activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity identical protein binding protein binding proteasome-activating activity	positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process biological regulation primary metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization positive regulation of cellular component biogenesis regulation of inclusion body assembly inclusion body assembly regulation of cellular component biogenesis cellular component organization cellular component biogenesis cellular component assembly positive regulation of inclusion body assembly cellular process cellular component organization or biogenesis positive regulation of cellular process transcription preinitiation complex assembly positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process cellular metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process RNA polymerase II preinitiation complex assembly regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of RNA polymerase II transcription preinitiation complex assembly cellular biosynthetic process positive regulation of DNA-templated transcription RNA metabolic process positive regulation of cellular metabolic process protein-DNA complex organization RNA biosynthetic process nucleic acid biosynthetic process regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of biosynthetic process protein-containing complex assembly regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of RNA polymerase II transcription preinitiation complex assembly protein-containing complex organization positive regulation of transcription initiation by RNA polymerase II protein-DNA complex assembly nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II positive regulation of cellular biosynthetic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex extracellular exosome membrane-bounded organelle proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol inclusion body nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen cytosolic proteasome complex
SA [auth F]	26S proteasome regulatory subunit 6A	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity identical protein binding protein binding proteasome-activating activity	viral gene expression biological process involved in interspecies interaction between organisms negative regulation by host of viral transcription modulation by host of symbiont process negative regulation by host of viral process biological process involved in symbiotic interaction modulation by host of viral transcription modulation by host of viral process viral process biological process involved in interaction with symbiont viral transcription positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process viral gene expression biological process involved in interspecies interaction between organisms negative regulation by host of viral transcription modulation by host of symbiont process negative regulation by host of viral process biological process involved in symbiotic interaction modulation by host of viral transcription modulation by host of viral process viral process biological process involved in interaction with symbiont viral transcription positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process biological regulation primary metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of cellular process positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process cellular metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription cellular biosynthetic process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process cellular process positive regulation of cellular biosynthetic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen organelle secretory granule secretory vesicle vesicle nucleus nucleoplasm nuclear lumen extracellular region vesicle lumen cytoplasmic vesicle lumen secretory granule lumen cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular non-membrane-bounded organelle supramolecular complex P-body non-membrane-bounded organelle
TA [auth f]	26S proteasome non-ATPase regulatory subunit 2	enzyme regulator activity molecular function regulator activity	organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process catabolic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process organic substance metabolic process metabolic process organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process catabolic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process organic substance metabolic process metabolic process protein metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle extracellular region proteasome regulatory particle, base subcomplex extracellular exosome proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex membrane proteasome regulatory particle extracellular region proteasome regulatory particle, base subcomplex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol intracellular non-membrane-bounded organelle proteasome storage granule non-membrane-bounded organelle ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
BA [auth j], D [auth J]	Proteasome subunit alpha type-7	identical protein binding protein binding binding	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol postsynapse synapse cell junction nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
CA [auth k], E [auth K]	Proteasome subunit alpha type-5	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region cellular anatomical entity intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region cellular anatomical entity intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth H], Z [auth h]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
B [auth H], Z [auth h]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
B [auth H], Z [auth h]	IPR023332	Proteasome alpha-type subunit	Family
B [auth H], Z [auth h]	IPR001353	Proteasome, subunit alpha/beta	Family
DA [auth l], F [auth L]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
DA [auth l], F [auth L]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
DA [auth l], F [auth L]	IPR035144	Proteasome subunit alpha 1	Family
DA [auth l], F [auth L]	IPR023332	Proteasome alpha-type subunit	Family
DA [auth l], F [auth L]	IPR001353	Proteasome, subunit alpha/beta	Family
EA [auth m], G [auth M]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
EA [auth m], G [auth M]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
EA [auth m], G [auth M]	IPR023332	Proteasome alpha-type subunit	Family
EA [auth m], G [auth M]	IPR001353	Proteasome, subunit alpha/beta	Family
FA [auth n], H [auth N]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
FA [auth n], H [auth N]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
FA [auth n], H [auth N]	IPR023333	Proteasome B-type subunit	Family
FA [auth n], H [auth N]	IPR001353	Proteasome, subunit alpha/beta	Family
FA [auth n], H [auth N]	IPR000243	Peptidase T1A, proteasome beta-subunit	Family
GA [auth o], I [auth O]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
GA [auth o], I [auth O]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
GA [auth o], I [auth O]	IPR024689	Proteasome beta subunit, C-terminal	Domain
GA [auth o], I [auth O]	IPR023333	Proteasome B-type subunit	Family
GA [auth o], I [auth O]	IPR001353	Proteasome, subunit alpha/beta	Family
GA [auth o], I [auth O]	IPR000243	Peptidase T1A, proteasome beta-subunit	Family
HA [auth p], J [auth P]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
HA [auth p], J [auth P]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
HA [auth p], J [auth P]	IPR023333	Proteasome B-type subunit	Family
HA [auth p], J [auth P]	IPR001353	Proteasome, subunit alpha/beta	Family
HA [auth p], J [auth P]	IPR033811	Proteasome beta 3 subunit	Family
JA [auth r], L [auth R]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
JA [auth r], L [auth R]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
JA [auth r], L [auth R]	IPR023333	Proteasome B-type subunit	Family
JA [auth r], L [auth R]	IPR001353	Proteasome, subunit alpha/beta	Family
JA [auth r], L [auth R]	IPR000243	Peptidase T1A, proteasome beta-subunit	Family
KA [auth s], M [auth S]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
KA [auth s], M [auth S]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
KA [auth s], M [auth S]	IPR023333	Proteasome B-type subunit	Family
KA [auth s], M [auth S]	IPR001353	Proteasome, subunit alpha/beta	Family
LA [auth t], N [auth T]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
LA [auth t], N [auth T]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
LA [auth t], N [auth T]	IPR023333	Proteasome B-type subunit	Family
LA [auth t], N [auth T]	IPR016295	Proteasome subunit beta 4	Family
LA [auth t], N [auth T]	IPR001353	Proteasome, subunit alpha/beta	Family
T [auth a]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
T [auth a]	IPR035298	26S Proteasome non-ATPase regulatory subunit 13	Family
T [auth a]	IPR000717	Proteasome component (PCI) domain	Domain
W [auth d]	IPR000717	Proteasome component (PCI) domain	Domain
W [auth d]	IPR006746	26S proteasome non-ATPase regulatory subunit Rpn12	Family
W [auth d]	IPR033464	CSN8/PSMD8/EIF3K	Domain
MA [auth X]	IPR040780	6S proteasome subunit Rpn6, C-terminal helix domain	Domain
MA [auth X]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
MA [auth X]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
MA [auth X]	IPR040773	26S proteasome regulatory subunit Rpn6, N-terminal	Domain
MA [auth X]	IPR000717	Proteasome component (PCI) domain	Domain
OA [auth B]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
OA [auth B]	IPR032501	Proteasomal ATPase, second OB domain	Domain
OA [auth B]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
OA [auth B]	IPR003593	AAA+ ATPase domain	Domain
OA [auth B]	IPR003959	ATPase, AAA-type, core	Domain
OA [auth B]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
OA [auth B]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
PA [auth C]	IPR003593	AAA+ ATPase domain	Domain
PA [auth C]	IPR003959	ATPase, AAA-type, core	Domain
PA [auth C]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
PA [auth C]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
PA [auth C]	IPR032501	Proteasomal ATPase, second OB domain	Domain
PA [auth C]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
PA [auth C]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
A [auth G], Y [auth g]	IPR034642	Proteasome subunit alpha6	Family
A [auth G], Y [auth g]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
A [auth G], Y [auth g]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
A [auth G], Y [auth g]	IPR023332	Proteasome alpha-type subunit	Family
A [auth G], Y [auth g]	IPR001353	Proteasome, subunit alpha/beta	Family
IA [auth q], K [auth Q]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
IA [auth q], K [auth Q]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
IA [auth q], K [auth Q]	IPR023333	Proteasome B-type subunit	Family
IA [auth q], K [auth Q]	IPR001353	Proteasome, subunit alpha/beta	Family
IA [auth q], K [auth Q]	IPR035206	Proteasome subunit beta 2	Family
O [auth U]	IPR040623	26S proteasome regulatory subunit RPN2, C-terminal	Domain
O [auth U]	IPR016024	Armadillo-type fold	Homologous Superfamily
O [auth U]	IPR002015	Proteasome/cyclosome repeat	Repeat
O [auth U]	IPR011989	Armadillo-like helical	Homologous Superfamily
O [auth U]	IPR048570	26S proteasome non-ATPase regulatory subunit 1/RPN2, N-terminal domain	Domain
O [auth U]	IPR016642	26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit	Family
P [auth V]	IPR013586	26S proteasome regulatory subunit, C-terminal	Domain
P [auth V]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
P [auth V]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
P [auth V]	IPR000717	Proteasome component (PCI) domain	Domain
Q [auth W]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
Q [auth W]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
Q [auth W]	IPR000717	Proteasome component (PCI) domain	Domain
Q [auth W]	IPR040896	26S proteasome regulatory subunit RPN5, C-terminal domain	Domain
Q [auth W]	IPR040134	26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4	Family
R [auth Y]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
R [auth Y]	IPR019585	26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1	Family
R [auth Y]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
R [auth Y]	IPR049549	26S proteasome regulatory subunit RPN7/PSMD6, C-terminal helix	Domain
R [auth Y]	IPR000717	Proteasome component (PCI) domain	Domain
R [auth Y]	IPR045135	26S proteasome regulatory subunit Rpn7, N-terminal	Domain
S [auth Z]	IPR033858	26S Proteasome non-ATPase regulatory subunit 7/8	Family
S [auth Z]	IPR024969	EIF3F/CSN6-like, C-terminal	Domain
S [auth Z]	IPR037518	MPN domain	Domain
S [auth Z]	IPR000555	JAB1/MPN/MOV34 metalloenzyme domain	Domain
U [auth b]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
U [auth b]	IPR002035	von Willebrand factor, type A	Domain
U [auth b]	IPR003903	Ubiquitin interacting motif	Conserved Site
U [auth b]	IPR049590	PSMD4, RAZUL domain	Domain
V [auth c]	IPR037518	MPN domain	Domain
V [auth c]	IPR000555	JAB1/MPN/MOV34 metalloenzyme domain	Domain
NA [auth A]	IPR003593	AAA+ ATPase domain	Domain
NA [auth A]	IPR003959	ATPase, AAA-type, core	Domain
NA [auth A]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
NA [auth A]	IPR048723	26S proteasome regulatory subunit 7-like, OB domain	Domain
NA [auth A]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
NA [auth A]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
NA [auth A]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
QA [auth D]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
QA [auth D]	IPR032501	Proteasomal ATPase, second OB domain	Domain
QA [auth D]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
QA [auth D]	IPR003593	AAA+ ATPase domain	Domain
QA [auth D]	IPR003959	ATPase, AAA-type, core	Domain
QA [auth D]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
QA [auth D]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
AA [auth i], C [auth I]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
AA [auth i], C [auth I]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
AA [auth i], C [auth I]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
AA [auth i], C [auth I]	IPR023332	Proteasome alpha-type subunit	Family
AA [auth i], C [auth I]	IPR001353	Proteasome, subunit alpha/beta	Family
RA [auth E]	IPR003593	AAA+ ATPase domain	Domain
RA [auth E]	IPR003959	ATPase, AAA-type, core	Domain
RA [auth E]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
RA [auth E]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
RA [auth E]	IPR032501	Proteasomal ATPase, second OB domain	Domain
RA [auth E]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
RA [auth E]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
SA [auth F]	IPR003593	AAA+ ATPase domain	Domain
SA [auth F]	IPR003959	ATPase, AAA-type, core	Domain
SA [auth F]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
SA [auth F]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
SA [auth F]	IPR032501	Proteasomal ATPase, second OB domain	Domain
SA [auth F]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
SA [auth F]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
TA [auth f]	IPR041433	26S proteasome non-ATPase regulatory subunit RPN1, C-terminal	Domain
TA [auth f]	IPR016024	Armadillo-type fold	Homologous Superfamily
TA [auth f]	IPR002015	Proteasome/cyclosome repeat	Repeat
TA [auth f]	IPR016643	26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit	Family
TA [auth f]	IPR011989	Armadillo-like helical	Homologous Superfamily
TA [auth f]	IPR040892	RPN1, N-terminal	Domain
BA [auth j], D [auth J]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
BA [auth j], D [auth J]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
BA [auth j], D [auth J]	IPR023332	Proteasome alpha-type subunit	Family
BA [auth j], D [auth J]	IPR001353	Proteasome, subunit alpha/beta	Family
CA [auth k], E [auth K]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
CA [auth k], E [auth K]	IPR033812	Proteasome subunit alpha5	Family
CA [auth k], E [auth K]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
CA [auth k], E [auth K]	IPR023332	Proteasome alpha-type subunit	Family
CA [auth k], E [auth K]	IPR001353	Proteasome, subunit alpha/beta	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth H], Z [auth h]	Pharos: P25787	osteoporosis heart disease breast cancer malignant mesothelioma Osteoporosis, Senile psoriasis colorectal cancer ovarian cancer
DA [auth l], F [auth L]	Pharos: P25786	mantle cell lymphoma plasma cell myeloma Systemic AL amyloidosis
EA [auth m], G [auth M]	Pharos: P25788	attention deficit hyperactivity disorder, inattentive type lymphoplasmacytic lymphoma pancreatic ductal adenocarcinoma Sjogren syndrome dermatomyositis osteosarcoma plasma cell myeloma heart disease ovarian cancer psoriasis
FA [auth n], H [auth N]	Pharos: P28072	attention deficit hyperactivity disorder, inattentive type ovarian cancer psoriasis brain aneurysm pancreatic ductal adenocarcinoma Sjogren syndrome lung cancer plasma cell myeloma systemic lupus erythematosus
GA [auth o], I [auth O]	Pharos: Q99436	atrial fibrillation allergic rhinitis hepatocellular carcinoma malignant ependymoma pancreatic intraductal papillary-mucinous carcinoma peripheral nervous system disease plasma cell myeloma astrocytic tumor hypothyroidism oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm peripheral neuropathy vitiligo lymphoplasmacytic lymphoma ovarian cancer atrial fibrillation allergic rhinitis hepatocellular carcinoma malignant ependymoma pancreatic intraductal papillary-mucinous carcinoma peripheral nervous system disease plasma cell myeloma astrocytic tumor hypothyroidism oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm peripheral neuropathy vitiligo lymphoplasmacytic lymphoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Pick disease
HA [auth p], J [auth P]	Pharos: P49720	chronic obstructive pulmonary disease lymphoplasmacytic lymphoma diabetes mellitus ovarian cancer glioblastoma plasma cell myeloma
JA [auth r], L [auth R]	Pharos: P28074	plasma cell myeloma acute lymphoblastic leukemia diabetes mellitus mantle cell lymphoma ovarian cancer Relapse multiple myeloma B-cell acute lymphoblastic leukemia hypertensive disorder medulloblastoma coronary artery disease lung cancer myocardial ischemia psoriasis
KA [auth s], M [auth S]	Pharos: P20618	acute coronary syndrome peripheral neuropathy plasma cell myeloma peripheral nervous system disease lymphoplasmacytic lymphoma osteoarthritis ovarian cancer dermatomyositis malignant colon neoplasm osteoarthritis susceptibility 1 pancreatic ductal adenocarcinoma glioblastoma mantle cell lymphoma Osteoarthrosis Deformans
LA [auth t], N [auth T]	Pharos: P28070	HIV infectious disease HIV Coinfection lymphoplasmacytic lymphoma plasma cell myeloma Sjogren syndrome major depressive disorder proteasome-associated autoinflammatory syndrome 3 lung cancer ovarian cancer psoriasis
T [auth a]	Pharos: Q9UNM6	HIV infectious disease benign prostatic hyperplasia heart disease osteosarcoma psoriasis brain aneurysm HIV Coinfection ovarian cancer uterine corpus leiomyoma Hashimoto thyroiditis plasma cell myeloma
W [auth d]	Pharos: P48556	HIV infectious disease glioblastoma ovarian cancer Sjogren syndrome HIV Coinfection pancreatic ductal adenocarcinoma plasma cell myeloma
MA [auth X]	Pharos: O00231	attention deficit hyperactivity disorder, inattentive type glioblastoma malignant ependymoma osteosarcoma plasma cell myeloma atypical teratoid rhabdoid tumor lung adenocarcinoma malignant glioma ovarian cancer subependymal giant cell astrocytoma breast cancer lung cancer malignant mesothelioma Pick disease tuberculosis
PA [auth C]	Pharos: P62195	Stevens-Johnson syndrome HIV infectious disease colorectal cancer plasma cell myeloma toxic epidermal necrolysis Drug-Induced Stevens Johnson Syndrome ovarian cancer
A [auth G], Y [auth g]	Pharos: P60900	HIV infectious disease myocardial infarction HIV Coinfection psoriasis
IA [auth q], K [auth Q]	Pharos: P49721	urinary bladder cancer atypical teratoid rhabdoid tumor glioblastoma lung carcinoma osteosarcoma Sjogren syndrome breast cancer invasive ductal breast carcinoma malignant mesothelioma ovarian cancer Systemic AL amyloidosis urinary bladder neoplasm diabetes mellitus large cell medulloblastoma mantle cell lymphoma urinary bladder cancer atypical teratoid rhabdoid tumor glioblastoma lung carcinoma osteosarcoma Sjogren syndrome breast cancer invasive ductal breast carcinoma malignant mesothelioma ovarian cancer Systemic AL amyloidosis urinary bladder neoplasm diabetes mellitus large cell medulloblastoma mantle cell lymphoma plasma cell myeloma systemic lupus erythematosus
O [auth U]	Pharos: Q99460	dermatomyositis osteosarcoma psoriasis lung adenocarcinoma ovarian cancer lung cancer pancreatic intraductal papillary-mucinous neoplasm
P [auth V]	Pharos: O43242	HIV infectious disease acute lymphoblastic leukemia cervical cancer dermatomyositis lung adenocarcinoma ulcerative colitis allergic rhinitis chronic obstructive pulmonary disease HIV Coinfection rheumatoid arthritis breast carcinoma Crohn disease systemic sclerosis
Q [auth W]	Pharos: O00232	contact dermatitis atypical teratoid rhabdoid tumor intellectual disability non-small cell lung carcinoma pancreatic ductal adenocarcinoma psoriasis invasive ductal breast carcinoma osteosarcoma Parkinson disease Stankiewicz-Isidor syndrome Contact hypersensitivity lung cancer ovarian cancer plasma cell myeloma
R [auth Y]	Pharos: Q15008	HIV infectious disease type 2 diabetes mellitus breast carcinoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma plasma cell myeloma Diabetes Mellitus, Non-Insulin-Dependent malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm maturity-onset diabetes of the young pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia
S [auth Z]	Pharos: P51665	lung cancer psoriasis ovarian cancer pancreatic intraductal papillary-mucinous neoplasm
U [auth b]	Pharos: P55036	heart disease ovarian cancer lung cancer plasma cell myeloma myocardial infarction
V [auth c]	Pharos: O00487	breast cancer lung cancer ovarian cancer endogenous depression lymphoplasmacytic lymphoma pancreatic intraductal papillary-mucinous neoplasm invasive ductal breast carcinoma medulloblastoma plasma cell myeloma
NA [auth A]	Pharos: P35998	dermatomyositis osteosarcoma plasma cell myeloma lung cancer ovarian cancer psoriasis malignant mesothelioma pancreatic ductal adenocarcinoma
QA [auth D]	Pharos: P43686	astrocytic tumor Hodgkins lymphoma diabetes mellitus osteosarcoma glioblastoma ovarian cancer
AA [auth i], C [auth I]	Pharos: P25789	Mammary Neoplasms, Experimental sarcomatoid carcinoma adult acute respiratory distress syndrome carcinoma HIV infectious disease liver cancer lung carcinoma mammary neoplasms, animal ovarian cancer polycystic ovary syndrome small cell lung carcinoma abdominal aortic aneurysm bipolar disorder bronchitis chronic obstructive pulmonary disease Mammary Neoplasms, Experimental sarcomatoid carcinoma adult acute respiratory distress syndrome carcinoma HIV infectious disease liver cancer lung carcinoma mammary neoplasms, animal ovarian cancer polycystic ovary syndrome small cell lung carcinoma abdominal aortic aneurysm bipolar disorder bronchitis chronic obstructive pulmonary disease liver neoplasm lymphoplasmacytic lymphoma peripheral arterial disease squamous cell lung carcinoma anorexia nervosa brain aneurysm dental caries lung adenocarcinoma nicotine dependence plasma cell myeloma Sjogren syndrome undifferentiated carcinoma autism spectrum disorder breast cancer dermatomyositis
SA [auth F]	Pharos: P17980	HIV infectious disease cataract HIV Coinfection lung cancer ovarian cancer prostate carcinoma cerebrovascular disorder metabolic syndrome X peripheral neuropathy subependymal giant cell astrocytoma endogenous depression hypertensive disorder open-angle glaucoma plasma cell myeloma
TA [auth f]	Pharos: Q13200	breast cancer ovarian cancer lung cancer psoriasis non-small cell lung carcinoma
BA [auth j], D [auth J]	Pharos: O14818	breast cancer lung cancer pancreatic intraductal papillary-mucinous carcinoma glioblastoma medulloblastoma plasma cell myeloma intellectual disability ovarian cancer Sjogren syndrome
CA [auth k], E [auth K]	Pharos: P28066	HIV infectious disease osteoporosis non-small cell lung carcinoma Osteoporosis, Age-Related ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma Alzheimer disease primitive neuroectodermal tumor cystic fibrosis tuberculosis fatty liver disease glioblastoma lung cancer malignant glioma HIV infectious disease osteoporosis non-small cell lung carcinoma Osteoporosis, Age-Related ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma Alzheimer disease primitive neuroectodermal tumor cystic fibrosis tuberculosis fatty liver disease glioblastoma lung cancer malignant glioma oligodendroglioma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pituitary cancer astrocytic tumor psoriasis diabetes mellitus gastric cancer hepatocellular carcinoma invasive ductal breast carcinoma lymphoplasmacytic lymphoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma Pick disease atypical teratoid rhabdoid tumor gastric carcinoma large cell medulloblastoma malignant ependymoma