Annotations: 5VBD

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF22900	e5vbdA1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF22900	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	USP9X	ubiquitin-like protein peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity K48-linked deubiquitinase activity catalytic activity deubiquitinase activity co-SMAD binding SMAD binding protein binding binding cysteine-type peptidase activity cysteine-type endopeptidase activity endopeptidase activity ubiquitin-like protein peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity K48-linked deubiquitinase activity catalytic activity deubiquitinase activity co-SMAD binding SMAD binding protein binding binding cysteine-type peptidase activity cysteine-type endopeptidase activity endopeptidase activity K63-linked deubiquitinase activity cysteine-type deubiquitinase activity K11-linked deubiquitinase activity molecular sequestering activity	organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cytosolic ciliogenesis cellular component biogenesis cellular component organization organelle organization cellular component assembly cilium assembly cellular process cellular component organization or biogenesis cilium organization cell projection assembly organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cytosolic ciliogenesis cellular component biogenesis cellular component organization organelle organization cellular component assembly cilium assembly cellular process cellular component organization or biogenesis cilium organization cell projection assembly regulation of protein stability biological regulation regulation of biological quality protein stabilization cellular response to stimulus cellular response to BMP stimulus regulation of biological process cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process cellular response to growth factor stimulus cell surface receptor signaling pathway response to stimulus signaling response to endogenous stimulus cell communication cellular response to endogenous stimulus response to BMP transforming growth factor beta receptor superfamily signaling pathway signal transduction response to growth factor BMP signaling pathway enzyme-linked receptor protein signaling pathway protein localization localization cellular localization cellular macromolecule localization macromolecule localization rhythmic process circadian rhythm regulation of circadian rhythm cell division cell cycle chromosome segregation cell cycle process organonitrogen compound metabolic process primary metabolic process amyloid fibril formation organic substance metabolic process metabolic process protein metabolic process macromolecule metabolic process supramolecular fiber organization positive regulation of DNA demethylation positive regulation of biological process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA modification regulation of DNA demethylation positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process organic cyclic compound metabolic process positive regulation of DNA metabolic process DNA demethylation DNA dealkylation macromolecule modification demethylation regulation of metabolic process regulation of DNA metabolic process protein ubiquitination post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal protein deubiquitination monoubiquitinated protein deubiquitination protein modification by small protein removal cell migration cell motility protein K63-linked deubiquitination catabolic process negative regulation of proteolysis negative regulation of proteolysis involved in protein catabolic process proteolysis involved in protein catabolic process negative regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process negative regulation of protein catabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis modification-dependent macromolecule catabolic process proteolysis negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process negative regulation of catabolic process negative regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of protein metabolic process negative regulation of metabolic process proteasomal protein catabolic process protein catabolic process regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process negative regulation of proteasomal protein catabolic process regulation of proteasomal protein catabolic process ubiquitin-dependent protein catabolic process organic substance catabolic process regulation of protein catabolic process protein deubiquitination involved in ubiquitin-dependent protein catabolic process sexual reproduction reproductive process multicellular organismal reproductive process female gamete generation gamete generation positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of TORC2 signaling regulation of intracellular signal transduction positive regulation of TOR signaling positive regulation of cellular process TOR signaling regulation of signaling regulation of TOR signaling regulation of TORC2 signaling positive regulation of intracellular signal transduction regulation of response to stimulus TORC2 signaling regulation of cell communication positive regulation of signaling establishment of protein localization protein localization to peroxisome nitrogen compound transport protein transmembrane import into intracellular organelle transport peroxisomal membrane transport peroxisome organization protein transmembrane transport establishment of localization in cell receptor metabolic process protein import into peroxisome matrix, receptor recycling establishment of protein localization to peroxisome intracellular protein transmembrane transport organic substance transport intracellular transport protein import into peroxisome matrix establishment of localization receptor recycling peroxisomal transport transmembrane transport establishment of protein localization to organelle protein transport protein localization to organelle intracellular protein transport axon extension multicellular organismal process axonogenesis cellular developmental process developmental growth plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell growth cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development developmental process neuron projection extension developmental cell growth growth nervous system development axon development cell morphogenesis involved in neuron differentiation developmental growth involved in morphogenesis generation of neurons anatomical structure morphogenesis neuron development neuron migration negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II cellular metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process negative regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process negative regulation of biosynthetic process regulation of protein binding positive regulation of molecular function regulation of molecular function positive regulation of protein binding regulation of binding positive regulation of binding cellular response to transforming growth factor beta stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway	membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection membrane intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection membrane intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol growth cone axon distal axon neuron projection site of polarized growth nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR028889	Ubiquitin specific protease domain	Domain
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR018200	Ubiquitin specific protease, conserved site	Conserved Site
A	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily
A	IPR021905	Ubiquitin C-terminal hydrolase-like, DUF3517	Domain
A	IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q93008	intellectual disability, X-linked 99 intellectual disability choanal atresia MENTAL RETARDATION, X-LINKED 99, SYNDROMIC, FEMALE-RESTRICTED polydactyly glioblastoma intellectual disability, X-linked 99, syndromic, female-restricted non-syndromic X-linked intellectual disability ovarian cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.