Annotations: 5V6P

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	ERAD-associated E3 ubiquitin-protein ligase HRD1	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity cation binding ion binding binding metal ion binding small molecule binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process cellular response to stimulus response to organic substance response to stimulus ERAD pathway cellular response to stress response to stress response to endoplasmic reticulum stress response to organonitrogen compound response to nitrogen compound proteasomal protein catabolic process response to chemical cellular process protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein K48-linked ubiquitination protein modification by small protein conjugation protein modification by small protein conjugation or removal fungal-type cell wall organization cellular component organization fungal-type cell wall organization or biogenesis cell wall organization or biogenesis cell wall organization cellular component organization or biogenesis external encapsulating structure organization protein autoubiquitination protein localization protein exit from endoplasmic reticulum cellular localization establishment of protein localization nitrogen compound transport transport localization establishment of localization in cell cellular macromolecule localization endoplasmic reticulum to cytosol transport organic substance transport intracellular transport establishment of localization protein transport retrograde protein transport, ER to cytosol macromolecule localization intracellular protein transport regulation of biological process regulation of cellular process cellular response to topologically incorrect protein signaling biological regulation endoplasmic reticulum unfolded protein response cellular response to unfolded protein response to unfolded protein cell communication cellular response to chemical stimulus response to topologically incorrect protein signal transduction cellular response to organic substance	membrane-bounded organelle protein-containing complex cytoplasmic ubiquitin ligase complex intracellular anatomical structure ubiquitin ligase complex membrane protein complex transferase complex endomembrane system ER ubiquitin ligase complex endoplasmic reticulum subcompartment intracellular organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane membrane-bounded organelle protein-containing complex cytoplasmic ubiquitin ligase complex intracellular anatomical structure ubiquitin ligase complex membrane protein complex transferase complex endomembrane system ER ubiquitin ligase complex endoplasmic reticulum subcompartment intracellular organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane catalytic complex organelle subcompartment membrane cellular anatomical entity intracellular membrane-bounded organelle organelle endoplasmic reticulum cytoplasm Hrd1p ubiquitin ligase complex organelle membrane intracellular protein-containing complex Hrd1p ubiquitin ligase ERAD-M complex Hrd1p ubiquitin ligase ERAD-L complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A, B	IPR001841	Zinc finger, RING-type	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	AAA-ATPase superfamily, transmembrane	ER retrotranslocon family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Sec, Translocase, and Insertase Proteins	ER-associated protein degradation (ERAD) protein. Hrd1 channel in complex with Hrd3

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.