Annotations: 5V6B

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00595	e5v6bA2	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)
A	F_UNCLASSIFIED	e5v6bA3	A: alpha arrays	X: PWI domain-like	H: GIPC1 GH2 domain (From Topology)	T: GIPC1 GH2 domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e5v6bA1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00595	e5v6bB2	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)
B	F_UNCLASSIFIED	e5v6bB3	A: alpha arrays	X: PWI domain-like	H: GIPC1 GH2 domain (From Topology)	T: GIPC1 GH2 domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e5v6bB1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	PDZ domain-containing protein GIPC1	protein binding binding signaling receptor binding PDZ domain binding protein domain specific binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity cytoskeletal protein binding actin binding protein binding binding signaling receptor binding PDZ domain binding protein domain specific binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity cytoskeletal protein binding actin binding myosin binding identical protein binding	regulation of cytokinesis regulation of biological process regulation of cellular process positive regulation of cell division regulation of cell cycle process biological regulation positive regulation of biological process cytokinesis positive regulation of cell cycle regulation of cell division positive regulation of cytokinesis positive regulation of cell cycle process cellular process cell division regulation of cytokinesis regulation of biological process regulation of cellular process positive regulation of cell division regulation of cell cycle process biological regulation positive regulation of biological process cytokinesis positive regulation of cell cycle regulation of cell division positive regulation of cytokinesis positive regulation of cell cycle process cellular process cell division cell cycle regulation of cell cycle positive regulation of cellular process cell cycle process trans-synaptic signaling regulation of signaling modulation of chemical synaptic transmission signaling cell-cell signaling presynaptic modulation of chemical synaptic transmission chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication organic anion transport nitrogen compound transport carboxylic acid transport transport secretion organic substance transport export from cell establishment of localization organic acid transport amino acid transport localization acidic amino acid transport secretion by cell dicarboxylic acid transport glutamate secretion cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway positive regulation of signal transduction cellular response to growth factor stimulus response to stimulus cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction regulation of transforming growth factor beta receptor signaling pathway positive regulation of response to stimulus cellular response to endogenous stimulus signal transduction enzyme-linked receptor protein signaling pathway cell surface receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus positive regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to growth factor stimulus positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of cellular response to transforming growth factor beta stimulus response to transforming growth factor beta regulation of response to stimulus transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway positive regulation of signaling epithelium migration multicellular organismal process tissue migration endothelial cell migration ameboidal-type cell migration epithelial cell migration cell migration cell motility pigment metabolic process regulation of melanin biosynthetic process organic hydroxy compound metabolic process pigment biosynthetic process melanin metabolic process secondary metabolic process positive regulation of secondary metabolite biosynthetic process positive regulation of metabolic process organic substance metabolic process secondary metabolite biosynthetic process positive regulation of biosynthetic process organic substance biosynthetic process regulation of biosynthetic process positive regulation of melanin biosynthetic process regulation of secondary metabolite biosynthetic process organic cyclic compound metabolic process regulation of secondary metabolic process biosynthetic process organic hydroxy compound biosynthetic process phenol-containing compound metabolic process organic cyclic compound biosynthetic process phenol-containing compound biosynthetic process metabolic process melanin biosynthetic process regulation of metabolic process catabolic process negative regulation of proteolysis negative regulation of proteolysis involved in protein catabolic process proteolysis involved in protein catabolic process negative regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process negative regulation of protein catabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis modification-dependent macromolecule catabolic process proteolysis protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process negative regulation of catabolic process negative regulation of proteasomal ubiquitin-dependent protein catabolic process organonitrogen compound metabolic process regulation of protein metabolic process negative regulation of metabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process regulation of macromolecule metabolic process regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process negative regulation of proteasomal protein catabolic process regulation of proteasomal protein catabolic process ubiquitin-dependent protein catabolic process macromolecule metabolic process organic substance catabolic process regulation of protein catabolic process regulation of protein stability regulation of biological quality protein localization establishment of protein localization cellular localization protein targeting cellular macromolecule localization macromolecule localization regulation of synaptic plasticity G protein-coupled receptor signaling pathway response to organic substance response to cytokine response to interleukin-7 cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to interleukin-7 cellular response to organic substance	membrane cellular anatomical entity cell periphery cell cortex intracellular anatomical structure cytoplasm cytosol cluster of actin-based cell projections brush border presynapse synapse cell junction membrane-bounded organelle intracellular vesicle membrane cellular anatomical entity cell periphery cell cortex intracellular anatomical structure cytoplasm cytosol cluster of actin-based cell projections brush border presynapse synapse cell junction membrane-bounded organelle intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle vesicle endocytic vesicle vesicle membrane organelle membrane glutamatergic synapse somatodendritic compartment cell projection dendrite dendritic tree neuron projection dendritic shaft plasma membrane bounded cell projection neuron spine dendritic spine postsynapse Schaffer collateral - CA1 synapse transport vesicle endomembrane system synaptic vesicle secretory vesicle exocytic vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR017379	PDZ domain-containing protein GIPC1/2/3	Family
A, B	IPR036034	PDZ superfamily	Homologous Superfamily
A, B	IPR001478	PDZ domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.