5V5W

Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13927	e5v5wA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF13927	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13927	Immunoglobulin domain (Ig_3)	Immunoglobulin domain	This family contains immunoglobulin-like domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	MAM domain-containing glycosylphosphatidylinositol anchor protein 1	-	developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development spinal cord association neuron differentiation cellular developmental process dorsal spinal cord development cell differentiation in spinal cord developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development spinal cord association neuron differentiation cellular developmental process dorsal spinal cord development cell differentiation in spinal cord generation of neurons central nervous system neuron differentiation neurogenesis spinal cord development neuron differentiation cell differentiation cellular process regulation of biological process regulation of cellular component organization regulation of cellular process regulation of cell adhesion biological regulation regulation of synaptic membrane adhesion cellular component organization regulation of synapse organization cell adhesion cell junction organization cell-cell adhesion regulation of synapse structure or activity regulation of cell-cell adhesion synapse organization cellular component organization or biogenesis regulation of biological quality synaptic membrane adhesion cell-cell adhesion via plasma-membrane adhesion molecules regulation of presynapse assembly cellular component biogenesis regulation of presynapse organization cellular component assembly cell junction assembly regulation of synapse assembly presynapse organization regulation of cellular component biogenesis regulation of cell junction assembly synapse assembly presynapse assembly neuron migration cell migration cell motility cerebral cortex cell migration forebrain development cerebral cortex radially oriented cell migration pallium development cerebral cortex development telencephalon cell migration forebrain cell migration telencephalon development	membrane cellular anatomical entity side of membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system extracellular region cell periphery plasma membrane membrane cellular anatomical entity side of membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system extracellular region cell periphery plasma membrane extracellular space GABA-ergic synapse synapse cell junction

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR003599	Immunoglobulin subtype	Domain
A	IPR003598	Immunoglobulin subtype 2	Domain
A	IPR003961	Fibronectin type III	Domain
A	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR000998	MAM domain	Domain
A	IPR007110	Immunoglobulin-like domain	Domain
A	IPR013098	Immunoglobulin I-set	Domain
A	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8NFP4	bipolar disorder schizophrenia major depressive disorder Unipolar Depression ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.