Annotations: 5V1D

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e5v1dA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: PERK and Ire1 luminal domains	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth B]	F_UNCLASSIFIED	e5v1dB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: PERK and Ire1 luminal domains	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth C]	PF13360	e5v1dC1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: PERK and Ire1 luminal domains	F: PF13360	ECOD (1.6)
F [auth D]	PF13360	e5v1dD1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: PERK and Ire1 luminal domains	F: PF13360	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B], D [auth C], F [auth D]	eIF2AK3 protein	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity eukaryotic translation initiation factor 2alpha kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups identical protein binding protein binding protein phosphatase binding phosphatase binding enzyme binding	developmental process multicellular organism development multicellular organismal process pancreas development endocrine system development anatomical structure development animal organ development endocrine pancreas development system development regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process developmental process multicellular organism development multicellular organismal process pancreas development endocrine system development anatomical structure development animal organ development endocrine pancreas development system development regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process regulation of cytokine production organic substance biosynthetic process cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of vascular endothelial growth factor production regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression vascular endothelial growth factor production biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of vascular endothelial growth factor production regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development cellular response to stimulus response to stimulus signaling regulation of cellular response to stress regulation of response to endoplasmic reticulum stress regulation of signal transduction regulation of programmed cell death intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress regulation of intrinsic apoptotic signaling pathway intracellular signal transduction cell communication regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway cellular response to stress regulation of intracellular signal transduction regulation of response to stress response to stress signal transduction intrinsic apoptotic signaling pathway response to endoplasmic reticulum stress regulation of signaling regulation of apoptotic process cell death apoptotic signaling pathway regulation of response to stimulus regulation of cell communication apoptotic process programmed cell death regulation of apoptotic signaling pathway ossification cellular response to nutrient levels response to nutrient levels response to starvation cellular response to glucose starvation cellular response to starvation regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase I regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase I primary metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of transcription by RNA polymerase I regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process cellular response to cold response to abiotic stimulus response to cold response to temperature stimulus response to biotic stimulus cellular response to biotic stimulus ER overload response ER-nucleus signaling pathway cellular response to amino acid starvation response to amino acid starvation response to organic substance cellular response to topologically incorrect protein endoplasmic reticulum unfolded protein response cellular response to unfolded protein response to unfolded protein cellular response to chemical stimulus response to chemical response to topologically incorrect protein cellular response to organic substance protein phosphorylation organonitrogen compound metabolic process protein autophosphorylation phosphorylation macromolecule modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle organelle subcompartment membrane endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle organelle subcompartment membrane endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane
B [auth E], E [auth F], G	12-mer peptide	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B], D [auth C], F [auth D]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, C [auth B], D [auth C], F [auth D]	IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily	Homologous Superfamily
A, C [auth B], D [auth C], F [auth D]	IPR000719	Protein kinase domain	Domain
A, C [auth B], D [auth C], F [auth D]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A, C [auth B], D [auth C], F [auth D]	IPR008271	Serine/threonine-protein kinase, active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.