Annotations: 5UMR

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF17292	e5umrA1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF17292	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF17292	POB3-like N-terminal PH domain (POB3_N)	POB3-like N-terminal PH domain	This domain is found at the N-terminus of POB3 and related proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	FACT complex subunit SSRP1	DNA binding binding organic cyclic compound binding nucleic acid binding protein binding histone binding RNA binding protein-containing complex binding chromatin binding nucleosome binding	protein-containing complex organization protein-DNA complex assembly protein-DNA complex organization cellular component organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization nucleobase-containing compound metabolic process protein-containing complex organization protein-DNA complex assembly protein-DNA complex organization cellular component organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular response to stimulus response to stimulus cellular response to stress DNA damage response response to stress DNA repair cellular component disassembly protein-DNA complex disassembly protein-containing complex disassembly nucleosome disassembly regulation of biological process regulation of chromatin organization regulation of cellular component organization regulation of cellular process biological regulation	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex transcription elongation factor complex protein-DNA complex nuclear protein-containing complex chromatin chromosome FACT complex nucleoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR038167	SSRP1 domain superfamily	Homologous Superfamily
A	IPR048985	FACT complex subunit SSRP1, C-terminal domain	Domain
A	IPR035417	FACT complex subunit SSRP1/POB3, N-terminal PH domain	Domain
A	IPR000969	FACT complex subunit SSRP1/POB3	Family
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR013719	Histone chaperone RTT106/FACT complex subunit SPT16-like, middle domain	Domain
A	IPR048993	FACT complex subunit SSRP1-like, first PH domain	Domain
A	IPR024954	SSRP1, dimerization domain	Domain
A	IPR009071	High mobility group box domain	Domain
A	IPR036910	High mobility group box domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q08945	astrocytic tumor diabetes mellitus lung adenocarcinoma malignant ependymoma medulloblastoma osteosarcoma atypical teratoid rhabdoid tumor glioblastoma lung cancer malignant glioma myopathy primitive neuroectodermal tumor Crohn disease large cell medulloblastoma malignant colon neoplasm astrocytic tumor diabetes mellitus lung adenocarcinoma malignant ependymoma medulloblastoma osteosarcoma atypical teratoid rhabdoid tumor glioblastoma lung cancer malignant glioma myopathy primitive neuroectodermal tumor Crohn disease large cell medulloblastoma malignant colon neoplasm malignant mesothelioma oligodendroglioma psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.