Annotations: 5UGS

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	SDR-like	8054262	3000038	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	SDR-like	8054262	3000038	SCOP2B (2022-06-29)
C [auth E]	SCOP2B Superfamily	SDR-like	8054262	3000038	SCOP2B (2022-06-29)
D [auth G]	SCOP2B Superfamily	SDR-like	8054262	3000038	SCOP2B (2022-06-29)
E [auth C]	SCOP2B Superfamily	SDR-like	8054262	3000038	SCOP2B (2022-06-29)
F [auth D]	SCOP2B Superfamily	SDR-like	8054262	3000038	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF13561	e5ugsB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF13561	ECOD (1.6)
A	PF13561	e5ugsA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF13561	ECOD (1.6)
C [auth E]	PF13561	e5ugsE1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF13561	ECOD (1.6)
D [auth G]	PF13561	e5ugsG1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF13561	ECOD (1.6)
E [auth C]	PF13561	e5ugsC1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF13561	ECOD (1.6)
F [auth D]	PF13561	e5ugsD1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF13561	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
C [auth E]	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
D [auth G]	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
E [auth C]	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
F [auth D]	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C [auth E], D [auth G], E [auth C], A, B, C [auth E], D [auth G], E [auth C], F [auth D]	PF13561	Enoyl-(Acyl carrier protein) reductase (adh_short_C2)	Enoyl-(Acyl carrier protein) reductase	This domain is found in Enoyl-(Acyl carrier protein) reductases.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C [auth E], D [auth G], E [auth C], A, B, C [auth E], D [auth G], E [auth C], F [auth D]	Enoyl-[acyl-carrier-protein] reductase [NADH]	fatty acid binding organic acid binding binding ion binding anion binding lipid binding carboxylic acid binding monocarboxylic acid binding small molecule binding NAD+ binding NAD binding nucleotide binding nucleoside phosphate binding purine nucleotide binding fatty acid binding organic acid binding binding ion binding anion binding lipid binding carboxylic acid binding monocarboxylic acid binding small molecule binding NAD+ binding NAD binding nucleotide binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding heterocyclic compound binding oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor trans-2-enoyl-CoA reductase (NADH) activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity enoyl-[acyl-carrier-protein] reductase (NADH) activity enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H)	oxoacid metabolic process cellular biosynthetic process cell wall organization or biogenesis lipid biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process cellular component biogenesis organic substance metabolic process mycolic acid biosynthetic process organic substance biosynthetic process Actinobacterium-type cell wall biogenesis small molecule metabolic process cellular component organization or biogenesis oxoacid metabolic process cellular biosynthetic process cell wall organization or biogenesis lipid biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process cellular component biogenesis organic substance metabolic process mycolic acid biosynthetic process organic substance biosynthetic process Actinobacterium-type cell wall biogenesis small molecule metabolic process cellular component organization or biogenesis peptidoglycan-based cell wall biogenesis fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process cellular metabolic process mycolic acid metabolic process carboxylic acid metabolic process primary metabolic process fatty acid biosynthetic process macromolecule biosynthetic process cell wall biogenesis biosynthetic process cell wall macromolecule biosynthetic process cellular lipid metabolic process cellular process metabolic process macromolecule metabolic process monocarboxylic acid metabolic process lipid metabolic process fatty acid elongation response to stimulus response to chemical response to antibiotic	cell periphery plasma membrane membrane cellular anatomical entity external encapsulating structure cell wall peptidoglycan-based cell wall

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C [auth E], D [auth G], E [auth C], A, B, C [auth E], D [auth G], E [auth C], F [auth D]	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B, C [auth E], D [auth G], E [auth C], A, B, C [auth E], D [auth G], E [auth C], F [auth D]	IPR014358	Enoyl-[acyl-carrier-protein] reductase (NADH)	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.