5UBM

Crystal structure of human C1s in complex with inhibitor gigastasin

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d5ubmb1	Small proteins	Complement control module/SCR domain	Complement control module/SCR domain	automated matches	automated matches	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Trypsin-like serine proteases	8032760	3000114	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Sushi/CCP/SCR domain	8032763	3000902	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00089	e5ubmA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: PF00089	ECOD (1.6)
B	PF00084	e5ubmB2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: PF00084	ECOD (1.6)
C [auth I]	F_UNCLASSIFIED	e5ubmI1	A: few secondary structure elements	X: Huristasin-like (From Topology)	H: Huristasin-like (From Topology)	T: Huristasin-like	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth I]	PF02822	e5ubmI2	A: few secondary structure elements	X: Huristasin-like (From Topology)	H: Huristasin-like (From Topology)	T: Huristasin-like	F: PF02822	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)
B	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00089	Trypsin (Trypsin)	Trypsin	-	Domain
B	PF00084	Sushi repeat (SCR repeat) (Sushi)	Sushi repeat (SCR repeat)	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Complement C1s subcomponent	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity identical protein binding protein binding	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response response to stimulus positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway regulation of biological process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response response to stimulus positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway regulation of biological process immune response biological regulation immunoglobulin mediated immune response adaptive immune response immune effector process regulation of response to stimulus immune system process B cell mediated immunity regulation of immune response activation of immune response biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	extracellular region extracellular space cellular anatomical entity blood microparticle
B	Complement C1s subcomponent	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity identical protein binding protein binding	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response response to stimulus positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway regulation of biological process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response response to stimulus positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway regulation of biological process immune response biological regulation immunoglobulin mediated immune response adaptive immune response immune effector process regulation of response to stimulus immune system process B cell mediated immunity regulation of immune response activation of immune response biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	extracellular region extracellular space cellular anatomical entity blood microparticle
C [auth I]	Gigastasin	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A	IPR018097	EGF-like calcium-binding, conserved site	Conserved Site
A	IPR001314	Peptidase S1A, chymotrypsin family	Family
A	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
A	IPR035914	Spermadhesin, CUB domain superfamily	Homologous Superfamily
A	IPR001254	Serine proteases, trypsin domain	Domain
A	IPR001881	EGF-like calcium-binding domain	Domain
A	IPR000436	Sushi/SCR/CCP domain	Domain
A	IPR000859	CUB domain	Domain
A	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
A	IPR000152	EGF-type aspartate/asparagine hydroxylation site	PTM
A	IPR024175	Peptidase S1A, complement C1r/C1S/mannan-binding	Family
A	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily
B	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
B	IPR018097	EGF-like calcium-binding, conserved site	Conserved Site
B	IPR001314	Peptidase S1A, chymotrypsin family	Family
B	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
B	IPR035914	Spermadhesin, CUB domain superfamily	Homologous Superfamily
B	IPR001254	Serine proteases, trypsin domain	Domain
B	IPR001881	EGF-like calcium-binding domain	Domain
B	IPR000436	Sushi/SCR/CCP domain	Domain
B	IPR000859	CUB domain	Domain
B	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
B	IPR000152	EGF-type aspartate/asparagine hydroxylation site	PTM
B	IPR024175	Peptidase S1A, complement C1r/C1S/mannan-binding	Family
B	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P09871	complement component C1s deficiency Ehlers-Danlos syndrome Hashimoto thyroiditis autoimmune hepatitis autoimmune disease Ehlers-Danlos syndrome, periodontal type 2 Hereditary Angioedema Types I and II esophageal adenocarcinoma subependymal giant cell astrocytoma hereditary angioedema type 2 invasive ductal breast carcinoma adrenal cortex carcinoma limb-girdle muscular dystrophy malignant colon neoplasm chronic kidney disease complement component C1s deficiency Ehlers-Danlos syndrome Hashimoto thyroiditis autoimmune hepatitis autoimmune disease Ehlers-Danlos syndrome, periodontal type 2 Hereditary Angioedema Types I and II esophageal adenocarcinoma subependymal giant cell astrocytoma hereditary angioedema type 2 invasive ductal breast carcinoma adrenal cortex carcinoma limb-girdle muscular dystrophy malignant colon neoplasm chronic kidney disease malignant mesothelioma myopathy diabetes mellitus pancreatic ductal adenocarcinoma Ehlers-Danlos syndrome, periodontal type 1 pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis gastric carcinoma ulcerative colitis head and neck cancer juvenile dermatomyositis angioedema lung cancer malignant ependymoma chronic obstructive pulmonary disease malignant pancreatic neoplasm cystic fibrosis non-small cell lung carcinoma Duchenne muscular dystrophy pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma Emery-Dreifuss muscular dystrophy Sjogren syndrome glioblastoma heart disease large cell medulloblastoma atopic eczema lung carcinoma Becker muscular dystrophy malignant glioma medulloblastoma dermatomyositis ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pituitary cancer
B	Pharos: P09871	complement component C1s deficiency Ehlers-Danlos syndrome Hashimoto thyroiditis autoimmune hepatitis autoimmune disease Ehlers-Danlos syndrome, periodontal type 2 Hereditary Angioedema Types I and II esophageal adenocarcinoma subependymal giant cell astrocytoma hereditary angioedema type 2 invasive ductal breast carcinoma adrenal cortex carcinoma limb-girdle muscular dystrophy malignant colon neoplasm chronic kidney disease complement component C1s deficiency Ehlers-Danlos syndrome Hashimoto thyroiditis autoimmune hepatitis autoimmune disease Ehlers-Danlos syndrome, periodontal type 2 Hereditary Angioedema Types I and II esophageal adenocarcinoma subependymal giant cell astrocytoma hereditary angioedema type 2 invasive ductal breast carcinoma adrenal cortex carcinoma limb-girdle muscular dystrophy malignant colon neoplasm chronic kidney disease malignant mesothelioma myopathy diabetes mellitus pancreatic ductal adenocarcinoma Ehlers-Danlos syndrome, periodontal type 1 pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis gastric carcinoma ulcerative colitis head and neck cancer juvenile dermatomyositis angioedema lung cancer malignant ependymoma chronic obstructive pulmonary disease malignant pancreatic neoplasm cystic fibrosis non-small cell lung carcinoma Duchenne muscular dystrophy pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma Emery-Dreifuss muscular dystrophy Sjogren syndrome glioblastoma heart disease large cell medulloblastoma atopic eczema lung carcinoma Becker muscular dystrophy malignant glioma medulloblastoma dermatomyositis ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pituitary cancer