5U8Q

Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor in complex with IGF-I

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Growth factor receptor domain-like	8038246	3000398	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	L domain-like	8043995	3001010	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	L domain-like	8043994	3001010	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D [auth L]	V-set	e5u8qL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
A	fn3_1	e5u8qA4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3_1	ECOD (1.6)
A	fn3	e5u8qA6	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3	ECOD (1.6)
A	Recep_L_domain	e5u8qA5	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: Recep_L_domain	ECOD (1.6)
A	Furin-like_5	e5u8qA3	A: few secondary structure elements	X: EGF-like	H: Growth factor receptor domain (From Topology)	T: Growth factor receptor domain	F: Furin-like_5	ECOD (1.6)
B	Insulin	e5u8qB1	A: few secondary structure elements	X: Insulin-like (From Topology)	H: Insulin-like (From Topology)	T: Insulin-like	F: Insulin	ECOD (1.6)
C [auth H]	V-set_8	e5u8qH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D [auth L]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	1.10.100.10	Mainly Alpha	Orthogonal Bundle	Insulin-like, subunit E	Insulin-like	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
D [auth L]	Fv 24-60	V-KAPPA	Mus musculus (house mouse)	IGKV5-4301, IGKJ501	V-DOMAIN V-KAPPA	IG	FV-HEAVY_KAPPA	IMGT (202415-0)
C [auth H]	Fv 24-60	VH	Mus musculus (house mouse)	IGHV1S13701, IGHJ401	V-DOMAIN VH	IG	FV-HEAVY_KAPPA	IMGT (202415-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
D [auth L]	Light Chain	IGKV5	Kappa	insulin-like growth factor 1 receptor	SAbDab (2024-04-19)
C [auth H]	Heavy Chain	IGHV1	-	insulin-like growth factor 1 receptor	SAbDab (2024-04-19)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00757	Furin-like cysteine rich region (Furin-like)	Furin-like cysteine rich region	-	Domain
A	PF01030	Receptor L domain (Recep_L_domain)	Receptor L domain	-	Repeat
A	PF00041	Fibronectin type III domain (fn3)	Fibronectin type III domain	-	Domain
B	PF00049	Insulin/IGF/Relaxin family (Insulin)	Insulin/IGF/Relaxin family	Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
D [auth L]	Fv 24-60 light chain	-	-	-
A	Insulin-like growth factor 1 receptor	insulin-like growth factor binding protein binding binding growth factor binding insulin receptor substrate binding amide binding peptide hormone binding hormone binding insulin binding molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity insulin-like growth factor binding protein binding binding growth factor binding insulin receptor substrate binding amide binding peptide hormone binding hormone binding insulin binding molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity protein-hormone receptor activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity insulin receptor activity catalytic activity signaling receptor binding insulin receptor binding phosphatidylinositol 3-kinase binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein-containing complex binding G-protein alpha-subunit binding insulin-like growth factor receptor activity identical protein binding insulin-like growth factor I binding protein transporter activity transporter activity	cellular response to stimulus multicellular organismal process regulation of cellular process response to stimulus cell projection organization positive regulation of neuron projection regeneration regulation of cellular response to stress neuron projection development regeneration neuron projection regeneration positive regulation of developmental process multicellular organism development neuron differentiation cell differentiation anatomical structure development cellular response to stimulus multicellular organismal process regulation of cellular process response to stimulus cell projection organization positive regulation of neuron projection regeneration regulation of cellular response to stress neuron projection development regeneration neuron projection regeneration positive regulation of developmental process multicellular organism development neuron differentiation cell differentiation anatomical structure development positive regulation of cell projection organization response to wounding system development positive regulation of response to wounding developmental process regulation of biological process regulation of axon regeneration regulation of cell projection organization response to external stimulus nervous system development generation of neurons regulation of response to stimulus regulation of neuron projection regeneration regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization regulation of developmental process cellular developmental process regulation of response to external stimulus positive regulation of biological process cell development response to axon injury regulation of response to wounding positive regulation of response to stimulus cellular component organization neurogenesis positive regulation of response to external stimulus cellular response to stress axon regeneration positive regulation of neuron projection development response to stress regulation of response to stress cellular component organization or biogenesis positive regulation of cellular process plasma membrane bounded cell projection organization biological regulation axon development neuron development cellular process positive regulation of axon regeneration regulation of plasma membrane bounded cell projection organization cellular component disassembly protein-containing complex organization protein-containing complex disassembly regulation of protein-containing complex disassembly positive regulation of protein-containing complex disassembly organonitrogen compound metabolic process protein phosphorylation protein autophosphorylation phosphorylation cellular metabolic process primary metabolic process peptidyl-tyrosine modification peptidyl-tyrosine autophosphorylation organic substance metabolic process macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process peptidyl-tyrosine phosphorylation protein modification process phosphorus metabolic process cellular response to nitrogen compound response to organic substance response to endogenous stimulus response to organonitrogen compound response to peptide hormone cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to hormone response to chemical cellular response to organic substance cellular response to insulin-like growth factor stimulus cellular response to hormone stimulus regulation of cytokinesis positive regulation of cell division regulation of cell cycle process cytokinesis positive regulation of cell cycle regulation of cell division positive regulation of cytokinesis positive regulation of cell cycle process cell division cell cycle regulation of cell cycle cell cycle process regulation of signaling signaling regulation of JNK cascade regulation of signal transduction regulation of MAPK cascade intracellular signal transduction cell communication regulation of intracellular signal transduction JNK cascade intracellular signaling cassette MAPK cascade regulation of cell communication signal transduction ovulation cycle rhythmic process estrous cycle reproductive process multicellular organismal reproductive process response to ketone response to lipid response to progesterone response to steroid hormone cellular response to ketone cellular response to steroid hormone stimulus response to organic cyclic compound cellular response to organic cyclic compound cellular response to progesterone stimulus cellular response to lipid head development animal organ development brain development cerebellum development central nervous system development metencephalon development hindbrain development establishment of cell polarity establishment or maintenance of cell polarity negative regulation of hepatocyte apoptotic process regulation of epithelial cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death epithelial cell apoptotic process negative regulation of apoptotic process regulation of hepatocyte apoptotic process negative regulation of epithelial cell apoptotic process hepatocyte apoptotic process negative regulation of cellular process apoptotic process programmed cell death cell surface receptor signaling pathway insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway cellular response to dexamethasone stimulus response to glucocorticoid cellular response to glucocorticoid stimulus cellular response to corticosteroid stimulus response to corticosteroid response to dexamethasone cellular senescence axonogenesis plasma membrane bounded cell projection morphogenesis cell morphogenesis cell projection morphogenesis neuron projection morphogenesis cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis negative regulation of cholangiocyte apoptotic process cholangiocyte apoptotic process regulation of cholangiocyte apoptotic process cell population proliferation positive regulation of cell population proliferation positive regulation of osteoblast proliferation osteoblast proliferation regulation of cell population proliferation regulation of osteoblast proliferation response to nutrient levels response to zinc ion starvation cellular response to starvation cellular response to nutrient levels response to starvation cellular response to zinc ion starvation regulation of smooth muscle cell proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation muscle cell proliferation response to acid chemical response to L-glutamate response to amino acid response to nutrient response to vitamin E response to vitamin positive regulation of nucleobase-containing compound metabolic process regulation of macromolecule metabolic process DNA metabolic process nucleic acid metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process positive regulation of metabolic process positive regulation of DNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA metabolic process forebrain development pallium development telencephalon development hippocampus development limbic system development immune response immune system process phosphatidylinositol 3-kinase/protein kinase B signal transduction cellular response to growth factor stimulus response to transforming growth factor beta cellular response to transforming growth factor beta stimulus response to growth factor homeostatic process response to monosaccharide response to carbohydrate carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus cellular response to glucose stimulus intracellular glucose homeostasis response to hexose cellular response to carbohydrate stimulus cellular homeostasis chemical homeostasis response to glucose glucose homeostasis amyloid-beta clearance cellular response to mineralocorticoid stimulus response to mineralocorticoid cellular response to aldehyde cellular response to aldosterone response to aldosterone response to alcohol cellular response to alcohol heart development cardiac chamber development cardiac atrium development circulatory system development positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling regulation of steroid biosynthetic process positive regulation of steroid hormone biosynthetic process regulation of hormone biosynthetic process cellular biosynthetic process regulation of hormone metabolic process regulation of lipid metabolic process steroid metabolic process lipid biosynthetic process positive regulation of cellular metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of lipid metabolic process regulation of biological quality hormone biosynthetic process steroid biosynthetic process regulation of biosynthetic process regulation of steroid hormone biosynthetic process positive regulation of hormone metabolic process regulation of hormone levels regulation of steroid metabolic process regulation of cellular metabolic process hormone metabolic process regulation of cellular biosynthetic process positive regulation of steroid biosynthetic process biosynthetic process positive regulation of lipid biosynthetic process organic cyclic compound biosynthetic process positive regulation of steroid metabolic process positive regulation of hormone biosynthetic process regulation of lipid biosynthetic process positive regulation of cellular biosynthetic process lipid metabolic process response to ethanol adaptive thermogenesis multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process regulation of multicellular organismal process negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of cell communication negative regulation of response to stimulus negative regulation of signal transduction negative regulation of MAPK cascade positive regulation of MAPK cascade dendritic spine maintenance dendritic spine organization postsynapse organization cellular component maintenance cell junction organization neuron projection organization synapse organization response to mechanical stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus insulin receptor signaling pathway response to insulin cellular response to insulin stimulus positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion localization transport establishment of localization transcytosis vesicle-mediated transport cellular response to testosterone stimulus response to testosterone response to estradiol cellular response to estradiol stimulus muscle cell apoptotic process regulation of muscle cell apoptotic process negative regulation of muscle cell apoptotic process response to alkaloid response to nicotine cellular response to amyloid-beta response to amyloid-beta response to angiotensin cellular response to angiotensin	cell periphery sarcolemma plasma membrane membrane T-tubule cellular anatomical entity protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex transferase complex receptor complex plasma membrane protein complex alphav-beta3 integrin-IGF-1-IGF1R complex cell periphery sarcolemma plasma membrane membrane T-tubule cellular anatomical entity protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex transferase complex receptor complex plasma membrane protein complex alphav-beta3 integrin-IGF-1-IGF1R complex membrane protein complex somatodendritic compartment cell body neuronal cell body axon cell projection neuron projection plasma membrane bounded cell projection membrane microdomain membrane raft plasma membrane raft plasma membrane region caveola membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle insulin receptor complex plasma membrane signaling receptor complex
B	Insulin-like growth factor I	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity insulin receptor binding insulin-like growth factor receptor binding cell adhesion molecule binding protein-containing complex binding integrin binding protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity insulin receptor binding insulin-like growth factor receptor binding cell adhesion molecule binding protein-containing complex binding integrin binding hormone activity	regulation of molecular function positive regulation of molecular function regulation of DNA binding regulation of binding biological regulation positive regulation of binding positive regulation of DNA binding multicellular organismal process regulation of tumor necrosis factor production regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process negative regulation of tumor necrosis factor production regulation of molecular function positive regulation of molecular function regulation of DNA binding regulation of binding biological regulation positive regulation of binding positive regulation of DNA binding multicellular organismal process regulation of tumor necrosis factor production regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process negative regulation of tumor necrosis factor production organic substance metabolic process cytokine production organic substance biosynthetic process regulation of cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process cellular metabolic process negative regulation of metabolic process tumor necrosis factor superfamily cytokine production regulation of cellular metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process tumor necrosis factor production negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression regulation of tumor necrosis factor superfamily cytokine production biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of tumor necrosis factor superfamily cytokine production metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process regulation of protein stability regulation of biological quality protein stabilization cell activation myoblast proliferation cell population proliferation developmental process muscle structure development cellular developmental process cell differentiation anatomical structure development myoblast differentiation positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity macromolecule modification regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of protein modification process protein metabolic process activation of protein kinase B activity positive regulation of protein kinase activity positive regulation of cellular process organonitrogen compound metabolic process positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of phosphorylation multicellular organism development skeletal system development system development positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process positive regulation of gene expression positive regulation of cellular biosynthetic process myotube cell development cell development muscle cell differentiation myotube differentiation muscle cell development striated muscle cell differentiation animal organ development muscle organ development regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus response to external stimulus regulation of inflammatory response regulation of response to stimulus response to stress negative regulation of response to external stimulus regulation of response to stress regulation of neuroinflammatory response negative regulation of defense response inflammatory response negative regulation of neuroinflammatory response neuroinflammatory response positive regulation of transcription regulatory region DNA binding regulation of transcription regulatory region DNA binding cellular response to stimulus cell surface receptor signaling pathway signaling insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication signal transduction enzyme-linked receptor protein signaling pathway positive regulation of locomotion regulation of cell motility positive regulation of smooth muscle cell migration regulation of smooth muscle cell migration positive regulation of cell migration smooth muscle cell migration muscle cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion muscle hypertrophy system process muscle system process positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division mitotic cell cycle cellular component organization regulation of mitotic cell cycle positive regulation of cell cycle process cellular component organization or biogenesis cell cycle regulation of cell cycle cell cycle process mitotic nuclear division regulation of cell cycle process organelle fission positive regulation of nuclear division regulation of organelle organization positive regulation of cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division bone maturation bone mineralization bone mineralization involved in bone maturation developmental maturation tissue development ossification anatomical structure maturation biomineral tissue development ossification involved in bone maturation animal organ maturation bone development positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction positive regulation of response to stimulus positive regulation of insulin-like growth factor receptor signaling pathway regulation of insulin-like growth factor receptor signaling pathway regulation of signaling regulation of cell communication positive regulation of signaling negative regulation of signaling apoptotic mitochondrial changes regulation of release of cytochrome c from mitochondria regulation of programmed cell death negative regulation of cell communication negative regulation of release of cytochrome c from mitochondria negative regulation of apoptotic signaling pathway mitochondrion organization negative regulation of cellular component organization negative regulation of programmed cell death regulation of apoptotic process cell death negative regulation of signal transduction apoptotic signaling pathway release of cytochrome c from mitochondria negative regulation of apoptotic process negative regulation of organelle organization regulation of mitochondrion organization apoptotic process programmed cell death regulation of apoptotic signaling pathway mesenchyme development mesenchymal cell differentiation epithelial to mesenchymal transition amyloid precursor protein catabolic process regulation of amide metabolic process regulation of amyloid-beta formation regulation of amyloid precursor protein catabolic process negative regulation of amyloid precursor protein catabolic process amyloid-beta metabolic process amide metabolic process amyloid precursor protein metabolic process negative regulation of protein metabolic process amyloid-beta formation negative regulation of amyloid-beta formation negative regulation of amide metabolic process regulation of muscle adaptation positive regulation of cardiac muscle hypertrophy regulation of system process striated muscle hypertrophy regulation of muscle system process regulation of cardiac muscle hypertrophy regulation of muscle hypertrophy muscle adaptation positive regulation of muscle hypertrophy cardiac muscle hypertrophy positive regulation of multicellular organismal process regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway regulation of growth regulation of cardiac muscle tissue growth developmental growth regulation of cell differentiation positive regulation of developmental process regulation of organ growth regulation of heart growth cardiac muscle tissue growth muscle tissue development cardiac cell development positive regulation of developmental growth positive regulation of heart growth heart growth positive regulation of organ growth positive regulation of muscle cell differentiation regulation of muscle cell differentiation positive regulation of cardiac muscle tissue growth positive regulation of cell growth involved in cardiac muscle cell development regulation of developmental process cardiac muscle cell development regulation of striated muscle cell differentiation organ growth cell growth striated muscle tissue development positive regulation of cell differentiation positive regulation of striated muscle cell differentiation heart development regulation of multicellular organismal development regulation of developmental growth cardiac muscle tissue development developmental cell growth physiological muscle hypertrophy growth cardiac muscle cell differentiation regulation of cell growth involved in cardiac muscle cell development positive regulation of cell growth regulation of cell growth cardiocyte differentiation circulatory system development cell growth involved in cardiac muscle cell development positive regulation of growth physiological cardiac muscle hypertrophy response to heat response to abiotic stimulus response to temperature stimulus nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process tissue regeneration skeletal muscle tissue regeneration skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration maintenance of cell number regeneration pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process organophosphate catabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process regulation of ATP metabolic process cellular catabolic process regulation of purine nucleotide catabolic process regulation of small molecule metabolic process regulation of nucleotide metabolic process small molecule metabolic process purine ribonucleotide catabolic process nucleoside phosphate metabolic process organonitrogen compound catabolic process pyruvate metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process positive regulation of ATP metabolic process nucleoside diphosphate metabolic process positive regulation of carbohydrate metabolic process monocarboxylic acid metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process positive regulation of purine nucleotide catabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process positive regulation of glycolytic process organic cyclic compound catabolic process purine-containing compound metabolic process positive regulation of catabolic process ADP metabolic process purine ribonucleoside diphosphate metabolic process organic substance catabolic process purine ribonucleoside diphosphate catabolic process ribonucleotide catabolic process positive regulation of nucleotide catabolic process glycolytic process pyridine-containing compound metabolic process pyridine nucleotide metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process nucleotide metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process catabolic process positive regulation of nucleotide metabolic process purine nucleotide metabolic process ribonucleotide metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process ribonucleoside triphosphate metabolic process nucleotide catabolic process purine nucleoside triphosphate metabolic process carbohydrate metabolic process ADP catabolic process carboxylic acid metabolic process generation of precursor metabolites and energy regulation of catabolic process regulation of glycolytic process positive regulation of purine nucleotide metabolic process organophosphate metabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process positive regulation of small molecule metabolic process sexual reproduction regulation of reproductive process regulation of oogenesis reproductive process cellular process involved in reproduction in multicellular organism developmental process involved in reproduction female gamete generation gamete generation regulation of cell development oocyte development negative regulation of cell differentiation negative regulation of developmental process regulation of oocyte development multicellular organismal reproductive process oogenesis negative regulation of cell development negative regulation of reproductive process negative regulation of oocyte development germ cell development oocyte differentiation intracellular signal transduction positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of glycogen metabolic process carbohydrate biosynthetic process hexose metabolic process positive regulation of glucose metabolic process positive regulation of glycogen biosynthetic process energy reserve metabolic process regulation of glycogen metabolic process monosaccharide metabolic process regulation of glycogen biosynthetic process glucan biosynthetic process energy derivation by oxidation of organic compounds regulation of glucan biosynthetic process regulation of polysaccharide metabolic process polysaccharide metabolic process glucan metabolic process regulation of glucose metabolic process polysaccharide biosynthetic process glycogen metabolic process glycogen biosynthetic process regulation of polysaccharide biosynthetic process regulation of carbohydrate biosynthetic process glucose metabolic process fibroblast proliferation regulation of fibroblast proliferation positive regulation of fibroblast proliferation positive regulation of glycoprotein metabolic process organonitrogen compound biosynthetic process regulation of glycoprotein biosynthetic process positive regulation of glycoprotein biosynthetic process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process glycoprotein metabolic process regulation of glycoprotein metabolic process interleukin-1 production regulation of interleukin-1 beta production negative regulation of interleukin-1 beta production negative regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell proliferation vascular associated smooth muscle cell proliferation calcineurin-NFAT signaling cascade regulation of calcineurin-mediated signaling positive regulation of calcineurin-NFAT signaling cascade regulation of calcium-mediated signaling positive regulation of calcium-mediated signaling regulation of calcineurin-NFAT signaling cascade positive regulation of calcineurin-mediated signaling calcium-mediated signaling calcineurin-mediated signaling positive regulation of epithelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction organic hydroxy compound metabolic process alcohol metabolic process glycolate metabolic process primary alcohol metabolic process small GTPase-mediated signal transduction Ras protein signal transduction regulation of leukocyte activation regulation of cell activation positive regulation of cell activation T cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of immune system process positive regulation of immune system process regulation of leukocyte proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation regulation of activated T cell proliferation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation activated T cell proliferation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of mononuclear cell proliferation regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation regulation of T cell proliferation immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization transport positive regulation of establishment of protein localization positive regulation of secretion by cell protein localization to extracellular region positive regulation of protein transport localization regulation of secretion by cell secretion by cell positive regulation of secretion cellular macromolecule localization regulation of transport secretion organic substance transport regulation of establishment of protein localization establishment of protein localization to extracellular region export from cell regulation of protein transport protein secretion establishment of localization positive regulation of protein secretion regulation of protein secretion regulation of secretion positive regulation of transport protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization proteoglycan biosynthetic process proteoglycan metabolic process muscle cell apoptotic process smooth muscle cell apoptotic process regulation of muscle cell apoptotic process regulation of smooth muscle cell apoptotic process negative regulation of vascular associated smooth muscle cell apoptotic process vascular associated smooth muscle cell apoptotic process negative regulation of smooth muscle cell apoptotic process negative regulation of muscle cell apoptotic process regulation of vascular associated smooth muscle cell apoptotic process regulation of osteoblast differentiation osteoblast differentiation positive regulation of osteoblast differentiation peptidyl-amino acid modification tyrosine phosphorylation of STAT protein cell surface receptor signaling pathway via STAT peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation regulation of tyrosine phosphorylation of STAT protein regulation of peptidyl-tyrosine phosphorylation positive regulation of tyrosine phosphorylation of STAT protein peptidyl-tyrosine phosphorylation cell surface receptor signaling pathway via JAK-STAT chordate embryonic development embryo development trophectodermal cell proliferation embryo development ending in birth or egg hatching in utero embryonic development positive regulation of trophectodermal cell proliferation regulation of trophectodermal cell proliferation blastocyst growth blastocyst development wound healing response to wounding cellular response to nitrogen compound response to organic substance response to organonitrogen compound response to endogenous stimulus response to oxygen-containing compound response to nitrogen compound cellular response to amyloid-beta cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical cellular response to organic substance response to amyloid-beta hexose transmembrane transport glucose import carbohydrate transport positive regulation of transmembrane transport glucose transmembrane transport regulation of glucose import positive regulation of glucose transmembrane transport transmembrane transport regulation of glucose transmembrane transport regulation of transmembrane transport monosaccharide transmembrane transport positive regulation of glucose import carbohydrate transmembrane transport regulation of small GTPase mediated signal transduction regulation of Ras protein signal transduction positive regulation of Ras protein signal transduction positive regulation of small GTPase mediated signal transduction	cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane alphav-beta3 integrin-IGF-1-IGF1R complex membrane protein complex cellular anatomical entity membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane alphav-beta3 integrin-IGF-1-IGF1R complex membrane protein complex cellular anatomical entity membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen intracellular membrane-bounded organelle secretory granule lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle cytoplasm platelet alpha granule vesicle platelet alpha granule lumen extracellular region extracellular space insulin-like growth factor binding protein complex growth factor complex transport vesicle exocytic vesicle insulin-like growth factor ternary complex
C [auth H]	Fv 24-60 heavy chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR008266	Tyrosine-protein kinase, active site	Active Site
A	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
A	IPR000719	Protein kinase domain	Domain
A	IPR036941	Receptor L-domain superfamily	Homologous Superfamily
A	IPR006212	Furin-like repeat	Repeat
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR000494	Receptor L-domain	Domain
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A	IPR002011	Tyrosine-protein kinase, receptor class II, conserved site	Conserved Site
A	IPR003961	Fibronectin type III	Domain
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR006211	Furin-like cysteine-rich domain	Domain
A	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A	IPR016246	Tyrosine-protein kinase, insulin-like receptor	Family
A	IPR036116	Fibronectin type III superfamily	Homologous Superfamily
B	IPR022350	Insulin-like growth factor	Family
B	IPR022353	Insulin, conserved site	Conserved Site
B	IPR036438	Insulin-like superfamily	Homologous Superfamily
B	IPR022352	Insulin family	Family
B	IPR016179	Insulin-like	Domain
B	IPR022341	Insulin-like growth factor I	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P08069	growth delay due to insulin-like growth factor I resistance Alzheimer disease adrenal cortex carcinoma peripheral nervous system disease respiratory failure Lewy body dementia skin cancer congenital diaphragmatic hernia endometrial carcinoma peripheral neuropathy juvenile idiopathic arthritis atrial fibrillation breast cancer skin neoplasm Parkinson disease growth delay due to insulin-like growth factor I resistance Alzheimer disease adrenal cortex carcinoma peripheral nervous system disease respiratory failure Lewy body dementia skin cancer congenital diaphragmatic hernia endometrial carcinoma peripheral neuropathy juvenile idiopathic arthritis atrial fibrillation breast cancer skin neoplasm Parkinson disease breast carcinoma lung disease malignant glioma Congenital hernia of foramen of Morgagni endometrial cancer non-small cell lung carcinoma endometriosis osteosarcoma pancreatic intraductal papillary-mucinous carcinoma adrenal carcinoma intellectual disability pilocytic astrocytoma primitive neuroectodermal tumor astrocytic tumor atypical teratoid rhabdoid tumor breast disease squamous cell lung carcinoma diabetes mellitus medulloblastoma oligodendroglioma genetic endocrine growth disease ovarian cancer pancreatic intraductal papillary-mucinous neoplasm acute myeloid leukemia inborn carbohydrate metabolic disorder interstitial cystitis progressive supranuclear palsy large cell medulloblastoma cancer malignant ependymoma endocrine exophthalmos osteogenesis imperfecta fetal growth restriction glioblastoma pancreatic ductal adenocarcinoma hepatocellular carcinoma adenoma Pick disease intervertebral disc degenerative disorder attention deficit hyperactivity disorder, inattentive type Laron syndrome Silver-Russell syndrome spina bifida
B	Pharos: P05019	growth delay due to insulin-like growth factor type 1 deficiency acromegaly hypertensive disorder breast carcinoma muscular atrophy kidney disease adenoma Crohn disease Alzheimer disease precocious puberty pituitary gland adenoma microcystic adenoma pulmonary fibrosis Neoplasm Invasiveness skin neoplasm growth delay due to insulin-like growth factor type 1 deficiency acromegaly hypertensive disorder breast carcinoma muscular atrophy kidney disease adenoma Crohn disease Alzheimer disease precocious puberty pituitary gland adenoma microcystic adenoma pulmonary fibrosis Neoplasm Invasiveness skin neoplasm endometriosis cholestasis colitis coronary artery disease papillary adenoma pituitary adenocarcinoma demyelinating disease chronic kidney disease follicular thyroid adenoma urinary bladder cancer peripheral nervous system disease prostate cancer middle cerebral artery infarction breast cancer myopathy skin cancer corneal disease peripheral neuropathy amyotrophic lateral sclerosis medulloblastoma depressive disorder autism prostate disease hypopituitarism bipolar disorder ileocolitis Silver-Russell syndrome interstitial cystitis cancer neurodegenerative disease cerebrovascular disorder oligodendroglioma osteoporosis type 2 diabetes mellitus lung cancer pancreatic intraductal papillary-mucinous carcinoma malignant ependymoma pituitary tumor hyperglycemia astrocytic tumor hypoglycemia hypothyroidism inborn carbohydrate metabolic disorder breast disease myocardial ischemia Duchenne muscular dystrophy Sjogren syndrome invasive ductal breast carcinoma Emery-Dreifuss muscular dystrophy acute kidney failure osteogenesis imperfecta eye disease limb-girdle muscular dystrophy ovarian cancer lung carcinoma congenital diaphragmatic hernia pancreatic intraductal papillary-mucinous neoplasm alcohol abuse malignant glioma hepatocellular carcinoma pituitary cancer hyperinsulinism atopic eczema hypogonadism autoimmune disease psoriasis idiopathic interstitial pneumonia drug-induced liver injury intellectual disability ductal breast carcinoma in situ juvenile dermatomyositis obesity disorder Laron syndrome type 1 diabetes mellitus pancreatic ductal adenocarcinoma glioblastoma adrenal cortex carcinoma urinary bladder neoplasm lung disease pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia malignant mesothelioma Crohn's colitis delirium