5U1D

Cryo-EM structure of the human TAP ATP-Binding Cassette Transporter

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8057805	3002020	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ABC_membrane	e5u1dA3	A: alpha bundles	X: Type II ABC exporter transmembrane domain fold	H: Type I ABC exporter transmembrane domain fold (From Topology)	T: Type I ABC exporter transmembrane domain fold	F: ABC_membrane	ECOD (1.6)
A	ABC_tran_1	e5u1dA2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ABC_tran_1	ECOD (1.6)
B	ABC_membrane	e5u1dB3	A: alpha bundles	X: Type II ABC exporter transmembrane domain fold	H: Type I ABC exporter transmembrane domain fold (From Topology)	T: Type I ABC exporter transmembrane domain fold	F: ABC_membrane	ECOD (1.6)
B	ABC_tran_1	e5u1dB2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ABC_tran_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00664	ABC transporter transmembrane region (ABC_membrane)	ABC transporter transmembrane region	-	Family
A	PF00005	ABC transporter (ABC_tran)	ABC transporter	ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are comp ...	ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain Pfam:PF00664. These four domains may belong to a single polypeptide as in Swiss:P13569, or belong in different polypeptide chains.	Domain
B	PF00664	ABC transporter transmembrane region (ABC_membrane)	ABC transporter transmembrane region	-	Family
B	PF00005	ABC transporter (ABC_tran)	ABC transporter	ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are comp ...	ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain Pfam:PF00664. These four domains may belong to a single polypeptide as in Swiss:P13569, or belong in different polypeptide chains.	Domain
C [auth X]	PF05363	Herpesvirus US12 family (Herpes_US12)	Herpesvirus US12 family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Antigen peptide transporter 1	binding antigen binding peptide antigen binding peptide binding MHC class Ib protein binding protein binding signaling receptor binding MHC protein binding TAP1 binding TAP binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding binding antigen binding peptide antigen binding peptide binding MHC class Ib protein binding protein binding signaling receptor binding MHC protein binding TAP1 binding TAP binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ABC-type peptide antigen transporter activity ABC-type peptide transporter activity peptide transmembrane transporter activity ABC-type transporter activity active transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity transporter activity transmembrane transporter activity ATP-dependent activity ADP binding identical protein binding protein homodimerization activity protein dimerization activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity MHC class I protein binding cation binding metal ion binding TAP2 binding	response to stimulus immune response immune system process adaptive immune response protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport establishment of localization localization protein transport cellular macromolecule localization response to stimulus immune response immune system process adaptive immune response protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization cellular process transmembrane transport defense response response to stress peptide transport amide transport antigen processing and presentation antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of peptide antigen antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I establishment of localization in cell intracellular transport cytosol to endoplasmic reticulum transport	membrane-bounded organelle protein-containing complex intracellular anatomical structure MHC class I peptide loading complex organelle subcompartment membrane membrane protein complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle TAP complex organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure MHC class I peptide loading complex organelle subcompartment membrane membrane protein complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle TAP complex organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane centrosome microtubule organizing center cytoskeleton centriolar satellite intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle intracellular vesicle phagocytic vesicle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane vesicle endocytic vesicle endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment
B	Antigen peptide transporter 2	binding antigen binding peptide antigen binding peptide binding MHC class Ib protein binding protein binding signaling receptor binding MHC protein binding ABC-type peptide transporter activity peptide transmembrane transporter activity ABC-type transporter activity active transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity binding antigen binding peptide antigen binding peptide binding MHC class Ib protein binding protein binding signaling receptor binding MHC protein binding ABC-type peptide transporter activity peptide transmembrane transporter activity ABC-type transporter activity active transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity transporter activity transmembrane transporter activity ATP-dependent activity tapasin binding TAP1 binding TAP binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ABC-type peptide antigen transporter activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity cation binding metal ion binding	nitrogen compound transport transport organic substance transport establishment of localization peptide transport antigen processing and presentation localization amide transport immune system process antigen processing and presentation of peptide antigen peptide antigen transport antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of peptide antigen via MHC class I nitrogen compound transport transport organic substance transport establishment of localization peptide transport antigen processing and presentation localization amide transport immune system process antigen processing and presentation of peptide antigen peptide antigen transport antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I protein localization establishment of protein localization cellular localization protein transport cellular macromolecule localization macromolecule localization cellular process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains T cell mediated cytotoxicity lymphocyte mediated immunity T cell mediated immunity response to stimulus immune response leukocyte mediated cytotoxicity adaptive immune response immune effector process leukocyte mediated immunity cell killing antigen processing and presentation of peptide antigen via MHC class Ib antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent antigen processing and presentation via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of exogenous antigen transmembrane transport antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent regulation of immune effector process positive regulation of leukocyte mediated immunity regulation of cellular process positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of biological process positive regulation of response to stimulus regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of immune response positive regulation of leukocyte mediated cytotoxicity regulation of immune system process positive regulation of immune effector process positive regulation of adaptive immune response positive regulation of immune system process positive regulation of cellular process regulation of T cell mediated immunity regulation of biological process positive regulation of T cell mediated cytotoxicity regulation of adaptive immune response biological regulation regulation of leukocyte mediated cytotoxicity regulation of leukocyte mediated immunity regulation of T cell mediated cytotoxicity regulation of lymphocyte mediated immunity regulation of response to stimulus positive regulation of T cell mediated immunity regulation of immune response regulation of cell killing positive regulation of cell killing establishment of localization in cell intracellular transport cytosol to endoplasmic reticulum transport response to organic substance biological process involved in interspecies interaction between organisms response to other organism response to chemical response to bacterium response to external stimulus response to external biotic stimulus response to molecule of bacterial origin response to biotic stimulus	membrane-bounded organelle protein-containing complex intracellular anatomical structure MHC class I peptide loading complex organelle subcompartment membrane membrane protein complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle TAP complex organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure MHC class I peptide loading complex organelle subcompartment membrane membrane protein complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle TAP complex organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane nucleus membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen intracellular vesicle phagocytic vesicle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane vesicle endocytic vesicle endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment
C [auth X]	TAP transporter inhibitor ICP47	-	symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host immune response modulation by symbiont of host process response to host immune response symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host immune response modulation by symbiont of host process response to host immune response symbiont-mediated suppression of host antigen processing and presentation response to host response to external biotic stimulus modulation of process of another organism symbiont-mediated suppression of host adaptive immune response	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003439	ABC transporter-like, ATP-binding domain	Domain
A	IPR003593	AAA+ ATPase domain	Domain
A	IPR011527	ABC transporter type 1, transmembrane domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR017871	ABC transporter-like, conserved site	Conserved Site
A	IPR013305	ABC transporter Tap-like	Family
A	IPR036640	ABC transporter type 1, transmembrane domain superfamily	Homologous Superfamily
A	IPR039421	Type 1 protein exporter	Family
B	IPR003439	ABC transporter-like, ATP-binding domain	Domain
B	IPR003593	AAA+ ATPase domain	Domain
B	IPR011527	ABC transporter type 1, transmembrane domain	Domain
B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B	IPR005293	Antigen peptide transporter 2	Family
B	IPR017871	ABC transporter-like, conserved site	Conserved Site
B	IPR013305	ABC transporter Tap-like	Family
B	IPR036640	ABC transporter type 1, transmembrane domain superfamily	Homologous Superfamily
B	IPR039421	Type 1 protein exporter	Family
C [auth X]	IPR008026	Herpesvirus ICP47	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q03518	MHC class I deficiency lung carcinoma ulcerative colitis prostate cancer juvenile dermatomyositis medulloblastoma mucocutaneous lymph node syndrome oligodendroglioma allergic rhinitis pancreatic intraductal papillary-mucinous carcinoma Bare Lymphocyte Syndrome, Type I pituitary cancer cervical cancer psoriasis cutaneous lupus erythematosus MHC class I deficiency lung carcinoma ulcerative colitis prostate cancer juvenile dermatomyositis medulloblastoma mucocutaneous lymph node syndrome oligodendroglioma allergic rhinitis pancreatic intraductal papillary-mucinous carcinoma Bare Lymphocyte Syndrome, Type I pituitary cancer cervical cancer psoriasis cutaneous lupus erythematosus sarcoidosis esophageal adenocarcinoma subependymal giant cell astrocytoma hepatitis B virus infection intervertebral disc degenerative disorder large cell medulloblastoma lymphoma membranous glomerulonephritis multiple sclerosis ovarian cancer astrocytic tumor pancreatic intraductal papillary-mucinous neoplasm breast cancer coronary artery disease psoriatic arthritis cutaneous melanoma schizophrenia glioblastoma systemic lupus erythematosus IgA glomerulonephritis invasive ductal breast carcinoma lung cancer malignant ependymoma myocardial ischemia pancreatic ductal adenocarcinoma autism spectrum disorder pilocytic astrocytoma breast carcinoma Crohn disease rheumatoid arthritis dermatomyositis Sjogren syndrome Hashimoto thyroiditis Takayasu arteritis interstitial cystitis
B	Pharos: Q03519	MHC class I deficiency Liver Cirrhosis, Experimental ulcerative colitis lung cancer malignant colon neoplasm medulloblastoma osteosarcoma peripheral nervous system disease allergic rhinitis psoriasis bipolar disorder schizophrenia Crohn disease Takayasu arteritis endometriosis MHC class I deficiency Liver Cirrhosis, Experimental ulcerative colitis lung cancer malignant colon neoplasm medulloblastoma osteosarcoma peripheral nervous system disease allergic rhinitis psoriasis bipolar disorder schizophrenia Crohn disease Takayasu arteritis endometriosis head and neck cancer interstitial cystitis large cell medulloblastoma lung carcinoma malignant mesothelioma ovarian cancer peripheral neuropathy autism spectrum disorder psoriatic arthritis cervical cancer Sjogren syndrome cutaneous lupus erythematosus glioblastoma tuberculosis hepatitis B virus infection intervertebral disc degenerative disorder lymphoma malignant pancreatic neoplasm mucocutaneous lymph node syndrome pancreatic ductal adenocarcinoma pilocytic astrocytoma rheumatoid arthritis chronic obstructive pulmonary disease systemic lupus erythematosus cutaneous melanoma Hashimoto thyroiditis IgA glomerulonephritis juvenile dermatomyositis

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	ABC transporters	Tap-like ABC transporter

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	ATP Binding Cassette (ABC) Transporters	Transporter associated with antigen processing (TAP) bound to ICP47

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.