5TZN

Structure of the viral immunoevasin m12 (Smith) bound to the natural killer cell receptor NKR-P1B (B6)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5tzna1	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	automated matches	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d5tzna2	Artifacts	Tags	Tags	Tags	C-terminal Tags	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D [auth W]	d5tznw_	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	automated matches	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	C-type lectin-like	8065452	3001261	SCOP2B (2022-06-29)
D [auth W]	SCOP2B Superfamily	C-type lectin-like	8065452	3001261	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00059	e5tznA1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)
D [auth W]	PF00059	e5tznW1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)
B [auth F]	PF12216	e5tznF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: m04 immunoevasin (From Topology)	T: m04 immunoevasin	F: PF12216	ECOD (1.6)
C [auth G]	PF12216	e5tznG1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: m04 immunoevasin (From Topology)	T: m04 immunoevasin	F: PF12216	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
D [auth W]	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D [auth W]	PF00059	Lectin C-type domain (Lectin_C)	Lectin C-type domain	This family includes both long and short form C-type	Domain
B [auth F], C [auth G]	PF12216	Immune evasion protein (m04gp34like)	Immune evasion protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D [auth W]	Killer cell lectin-like receptor subfamily B member 1B allele B	binding carbohydrate binding molecular transducer activity signaling receptor activity identical protein binding protein binding	regulation of immune effector process lymphocyte mediated immunity regulation of defense response regulation of natural killer cell mediated cytotoxicity regulation of response to biotic stimulus regulation of cellular process biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus response to biotic stimulus response to stress regulation of response to stress innate immune response leukocyte mediated immunity regulation of immune effector process lymphocyte mediated immunity regulation of defense response regulation of natural killer cell mediated cytotoxicity regulation of response to biotic stimulus regulation of cellular process biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus response to biotic stimulus response to stress regulation of response to stress innate immune response leukocyte mediated immunity regulation of immune system process response to external biotic stimulus natural killer cell mediated immunity regulation of biological process regulation of natural killer cell mediated immunity immune response response to other organism defense response regulation of innate immune response regulation of leukocyte mediated cytotoxicity biological regulation defense response to symbiont response to external stimulus leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity regulation of response to stimulus immune system process defense response to other organism natural killer cell mediated cytotoxicity regulation of immune response regulation of cell killing cellular process cell killing negative regulation of biological process negative regulation of lymphocyte mediated immunity negative regulation of natural killer cell mediated immunity negative regulation of immune response negative regulation of immune effector process negative regulation of response to external stimulus negative regulation of defense response negative regulation of natural killer cell mediated cytotoxicity negative regulation of response to biotic stimulus negative regulation of leukocyte mediated cytotoxicity negative regulation of cellular process negative regulation of cell killing negative regulation of response to stimulus negative regulation of immune system process negative regulation of leukocyte mediated immunity negative regulation of innate immune response	cell surface cellular anatomical entity cell periphery plasma membrane membrane external side of plasma membrane side of membrane
B [auth F], C [auth G]	Glycoprotein family protein m12	-	-	membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D [auth W]	IPR001304	C-type lectin-like	Domain
A, D [auth W]	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A, D [auth W]	IPR033992	Natural killer cell receptor-like, C-type lectin-like domain	Domain
A, D [auth W]	IPR016187	C-type lectin fold	Homologous Superfamily
B [auth F], C [auth G]	IPR022022	Immune evasion protein	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.