Annotations: 5TZ8

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EUF07765	e5tz8A4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: EUF07765	ECOD (1.6)
A	EUF07776	e5tz8A3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: EUF07776	ECOD (1.6)
A	EUF08038	e5tz8A2	A: alpha arrays	X: Glycosyl transferase TarS linker domain (From Topology)	H: Glycosyl transferase TarS linker domain (From Topology)	T: Glycosyl transferase TarS linker domain	F: EUF08038	ECOD (1.6)
A	Glycos_transf_2	e5tz8A1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2	ECOD (1.6)
B [auth C]	EUF07765	e5tz8C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: EUF07765	ECOD (1.6)
B [auth C]	EUF07776	e5tz8C4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: EUF07776	ECOD (1.6)
B [auth C]	EUF08038	e5tz8C3	A: alpha arrays	X: Glycosyl transferase TarS linker domain (From Topology)	H: Glycosyl transferase TarS linker domain (From Topology)	T: Glycosyl transferase TarS linker domain	F: EUF08038	ECOD (1.6)
B [auth C]	Glycos_transf_2	e5tz8C2	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2	ECOD (1.6)
C [auth B]	EUF07765	e5tz8B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: EUF07765	ECOD (1.6)
C [auth B]	EUF07776	e5tz8B2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: EUF07776	ECOD (1.6)
C [auth B]	EUF08038	e5tz8B4	A: alpha arrays	X: Glycosyl transferase TarS linker domain (From Topology)	H: Glycosyl transferase TarS linker domain (From Topology)	T: Glycosyl transferase TarS linker domain	F: EUF08038	ECOD (1.6)
C [auth B]	Glycos_transf_2	e5tz8B3	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth C], C [auth B]	PF00535	Glycosyl transferase family 2 (Glycos_transf_2)	Glycosyl transferase family 2	-	Family
A, B [auth C], C [auth B]	PF18674	TarS beta-glycosyltransferase C-terminal domain 1 (TarS_C1)	TarS beta-glycosyltransferase C-terminal domain 1	Beta-glycosyltransferase TarS is an enzyme responsible for the glycosylation of wall teichoic acid polymers of the S. aureus cell wall, a process that has been shown to be specifically responsible for methicillin resistance in MRSA. It contains a tri ...	Beta-glycosyltransferase TarS is an enzyme responsible for the glycosylation of wall teichoic acid polymers of the S. aureus cell wall, a process that has been shown to be specifically responsible for methicillin resistance in MRSA. It contains a trimerization domain composed of tandem carbohydrate binding motifs.The two C-terminally localized regions composed of a series of beta-sheets participate in an extensive trimerization interface and they assume an immunoglobulin-like fold. It is suggested that both carbohydrate binding domains may be involved in polyRboP binding, however unlike pullulanase, the CBMs of TarS are involved in the formation of an extensive trimerization interface [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C], C [auth B]	Glycosyl transferase	glycosyltransferase activity transferase activity catalytic activity cation binding ion binding binding metal ion binding small molecule binding	teichoic acid biosynthetic process cellular biosynthetic process cell wall organization or biogenesis carbohydrate derivative metabolic process organic acid biosynthetic process organic acid metabolic process cellular component biogenesis organic substance metabolic process organic substance biosynthetic process small molecule metabolic process cellular component organization or biogenesis carbohydrate derivative biosynthetic process peptidoglycan-based cell wall biogenesis small molecule biosynthetic process teichoic acid biosynthetic process cellular biosynthetic process cell wall organization or biogenesis carbohydrate derivative metabolic process organic acid biosynthetic process organic acid metabolic process cellular component biogenesis organic substance metabolic process organic substance biosynthetic process small molecule metabolic process cellular component organization or biogenesis carbohydrate derivative biosynthetic process peptidoglycan-based cell wall biogenesis small molecule biosynthetic process cellular metabolic process macromolecule biosynthetic process cell wall biogenesis biosynthetic process cell wall macromolecule biosynthetic process cellular process metabolic process macromolecule metabolic process teichoic acid metabolic process cellular component organization cell wall organization external encapsulating structure organization response to stimulus response to chemical response to antibiotic	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C], C [auth B]	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily
A, B [auth C], C [auth B]	IPR041038	TarS beta-glycosyltransferase C-terminal domain 1	Domain
A, B [auth C], C [auth B]	IPR001173	Glycosyltransferase 2-like	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.